흰강낭콩 (탄수화물 차단)
White Kidney Bean Extract (Phase 2)
📚 관련 논문 (8편)
1. Sci Rep. 2024 Jun 3;14(1):12685. doi: 10.1038/s41598-024-63443-8. Proprietary alpha-amylase inhibitor formulation from white kidney bean (Phaseolus vulgaris L.) promotes weight and fat loss: a 12-week, double-blind, placebo-controlled, randomized trial. Jäger R(1), Abou Sawan S(2), Purpura M(
1. Front Endocrinol (Lausanne). 2022 Oct 11;13:999715. doi: 10.3389/fendo.2022.999715. eCollection 2022. White common bean extract remodels the gut microbiota and ameliorates type 2 diabetes and its complications: A randomized double-blinded placebo-controlled trial. Feng Y(1)(2)(3), Zhu J(2)(4), Wang Q(1)(2), Cao H(1)(2)(5), He F(6)(7), Guan Y(8), Li D(1)(2), Yan J(1)(2), Yang J(1)(2), Xia Y(1)(2), Dong M(9), Hu F(10), Cao M(11), Wang J(12), Ding X(13), Feng Y(14), Zou H(15), Han Y(15), Sun S(16), Zhang J(16), Tang A(16), Jiang M(17), Deng Y(17), Gao J(18), Jia Y(18), Zhao W(6), Zhang F(1)(2)(3). Author information: (1)Department of Nutrition, Affiliated Hospital of Jiangnan University, Wuxi, China. (2)Clinical Evaluation Center for Functional Food, Affiliated Hospital of Jiangnan University, Wuxi, China. (3)Wuxi School of Medicine Jiangnan University, Wuxi, China. (4)Department of Infection Control, Affiliated Hospital of Jiangnan University, Wuxi, China. (5)Department of Endocrinology, Affiliated Hospital of Jiangnan University, Wuxi, China. (6)State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, China. (7)School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, China. (8)Yinglongqiao Community Health Service Center, Health Commision of Liangxi District, Wuxi, China. (9)Department of Health Promotion, Wuxi Center for Disease Control and Prevention, Wuxi, China. (10)Department of Functional Examination, Affiliated Hospital of Jiangnan University, Wuxi, China. (11)Special Ward, Affiliated Hospital of Jiangnan University, Wuxi, China. (12)Department of Urology, Affiliated Hospital of Jiangnan University, Wuxi, China. (13)Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (14)Mashan Community Healthcare Center, Health Commision of Binhu District, Wuxi, China. (15)Guangrui and Tongjiang Community Healthcare Center, Health Commision of Liangxi District, Wuxi, China. (16)Beidajie Community Healthcare Center, Health Commision of Liangxi District, Wuxi, China. (17)Yangming Community Healthcare Center, Health Commision of Liangxi District, Wuxi, Jiangsu, China. (18)Shanbei Community Healthcare Center, Health Commision of Liangxi District, Wuxi, China. OBJECTIVE: Excessive carbohydrate intake is a high risk factor for increased morbidity of type 2 diabetes (T2D). A novel regimen for the dietary care of diabetes that consists of a highly active α-amylase inhibitor derived from white common bean extract (WCBE) and sufficient carbohydrates intake was applied to attenuate T2D and its complications. Furthermore, the role of gut microbiota in this remission was also investigated. METHODS: We conducted a 4-month randomized double-blinded placebo-controlled trial. During the intense intervention period, ninety subjects were randomly assigned to the control group (Group C) and WCBE group (Group W). Subjects in Group C were supplemented with 1.5 g of maltodextrin as a placebo. Subjects in Group W took 1.5 g of WCBE half an hour before a meal. Fifty-five participants continued the maintenance intervention receiving the previous dietary intervention whereas less frequent follow-up. The variation in biochemical, vasculopathy and neuropathy indicators and the structure of the fecal microbiota during the intervention was analyzed. RESULT: Glucose metabolism and diabetic complications showed superior remission in Group W with a 0.721 ± 0.742% decline of glycosylated hemoglobin after 4 months. The proportion of patients with diabetic peripheral neuropathy (Toronto Clinical Scoring System, TCSS ≥ 6) was significantly lower in Group W than in Group C. Both the left and right sural sensory nerve conduction velocity (SNCV-left sural and SNCV-right sural) slightly decreased in Group C and slightly increased in Group W. Additionally, the abundances of Bifidobacterium, Faecalibacterium and Anaerostipes were higher in Group W, and the abundances of Weissella, Klebsiella, Cronobacter and Enterobacteriaceae_unclassified were lower than those in Group C at month 2. At the end of month 4, Bifidobacterium remained more abundant in Group W. CONCLUSION: To our knowledge, this is the first report of improvement to diabetes complications by using a dietary supplement in such a short-term period. The enrichment of SCFA-producing bacteria might be responsible for the attenuation of T2D and its complications. CLINICAL TRIAL REGISTRATION NUMBER: http://www.chictr.org.cn/edit.aspx?pid=23309&htm=4, identifier ChiCTR-IOR-17013656. Copyright © 2022 Feng, Zhu, Wang, Cao, He, Guan, Li, Yan, Yang, Xia, Dong, Hu, Cao, Wang, Ding, Feng, Zou, Han, Sun, Zhang, Tang, Jiang, Deng, Gao, Jia, Zhao and Zhang. DOI: 10.3389/fendo.2022.999715 PMCID: PMC9594986 PMID: 36303868 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
2. Nutr J. 2009 Oct 28;8:52. doi: 10.1186/1475-2891-8-52. Lowering the glycemic index of white bread using a white bean extract. Udani JK(1), Singh BB, Barrett ML, Preuss HG. Author information: (1)Medicus Research LLC, Northridge, CA 91325, USA. jay.udani@medicusresearch.com BACKGROUND: Phase 2((R)) is a dietary supplement derived from the common white kidney bean (Phaseolus vulgaris). Phase 2 has been shown to inhibit alpha-amylase, the complex carbohydrate digesting enzyme, in vitro. The inhibition of alpha-amylase may result in the lowering of the effective Glycemic Index (GI) of certain foods. The objective of this study was to determine whether the addition of Phase 2 would lower the GI of a commercially available high glycemic food (white bread). METHODS: An open-label 6-arm crossover study was conducted with 13 randomized subjects. Standardized GI testing was performed on white bread with and without the addition of Phase 2 in capsule and powder form, each in dosages of 1500 mg, 2000 mg, and 3000 mg. Statistical analysis was performed by one-way ANOVA of all seven treatment groups using unadjusted multiple comparisons (t tests) to the white bread control. RESULTS: For the capsule formulation, the 1500 mg dose had no effect on the GI and the 2000 mg and 3000 mg capsule doses caused insignificant reductions in GI. For the powder, the 1500 mg and 2000 mg doses caused insignificant reductions in the GI, and the 3000 mg dose had a significant effect (-20.23 or 34.11%, p = 0.023) CONCLUSION: Phase 2 white bean extract appears to be a novel and potentially effective method for reducing the GI of existing foods without modifying their ingredient profile. TRIAL REGISTRATION: Trial Registration: ISRCTN50347345. DOI: 10.1186/1475-2891-8-52 PMCID: PMC2776021 PMID: 19860922 [Indexed for MEDLINE]
3. Int J Med Sci. 2007 Jan 24;4(1):45-52. doi: 10.7150/ijms.4.45. A Dietary supplement containing standardized Phaseolus vulgaris extract influences body composition of overweight men and women. Celleno L(1), Tolaini MV, D'Amore A, Perricone NV, Preuss HG. Author information: (1)Cosmetic Research Center, dell'Università Cattolica di Roma, Rome, Italy. BACKGROUND: More than one billion human adults worldwide are overweight and, therefore, are at higher risk of developing cardiovascular diseases, diabetes, and a variety of other chronic perturbations. Many believe that use of natural dietary supplements could aid in the struggle against obesity. So-called "starch blockers" are listed among natural weight loss supplements. Theoretically, they may promote weight loss by interfering with the breakdown of complex carbohydrates thereby reducing, or at least slowing, the digestive availability of carbohydrate-derived calories and/or by providing resistant starches to the lower gastrointestinal tract. AIMS: The present research study examines a dietary supplement containing 445 mg of Phaseolus vulgaris extract derived from the white kidney bean, previously shown to inhibit the activity of the digestive enzyme alpha amylase, on body composition of overweight human subjects. METHODS: A randomized, double-blinded, placebo-controlled study was conducted on 60 pre-selected, slightly overweight volunteers, whose weight had been essentially stable for at least six months. The volunteers were divided into two groups, homogeneous for age, gender, and body weight. The test product containing Phaseolus vulgaris extract and the placebo were taken one tablet per day for 30 consecutive days before a main meal rich in carbohydrates. Each subject's body weight, fat and non-fat mass, skin fold thickness, and waist/hip/thigh circumferences were measured. RESULTS: After 30 days, subjects receiving Phaseolus vulgaris extract with a carbohydrate-rich, 2000- to 2200-calorie diet had significantly (p<0.001) greater reduction of body weight, BMI, fat mass, adipose tissue thickness, and waist,/hip/ thigh circumferences while maintaining lean body mass compared to subjects receiving placebo. CONCLUSION: The results indicate that Phaseolus vulgaris extract produces significant decrements in body weight and suggest decrements in fat mass in the face of maintained lean body mass. DOI: 10.7150/ijms.4.45 PMCID: PMC1796956 PMID: 17299581 [Indexed for MEDLINE] Conflict of interest statement: Conflict of Interests: The authors declare no conflict of interests.
4. Nutr Res. 2026 Apr 3;150:49-61. doi: 10.1016/j.nutres.2026.04.001. Online ahead of print. White kidney bean extract reduces body weight and adiposity with acceptable safety in adults with overweight and obese: a systematic review and meta-analysis. Shi N(1), Wang R(2), Cao X(1), Huang Z(1), Lin F(1), Xu R(1), Zhang Q(3). Author information: (1)Zhejiang Chinese Medical University, Hangzhou, China. (2)Department of TCM Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. (3)Department of TCM Gynecology, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China. Electronic address: zhaqin01@163.com. The global prevalence of overweight and obesity has risen sharply in recent decades, becoming a major public health concern. White kidney bean (Phaseolus vulgaris L.) extract (WKBE), rich in α-amylase inhibitors, may delay carbohydrate digestion and reduce energy intake. We hypothesized that WKBE could significantly improve key anthropometric outcomes in adults with overweight and obese compared with placebo, with acceptable safety. To test this hypothesis, we systematically searched four databases from inception to January 31, 2026, for randomized controlled trials of oral WKBE. Eight randomized controlled trials (n = 543) met the inclusion criteria. Random-effects meta-analyses showed reductions in weight (MD -1.62 kg, 95% confidence interval [CI] -1.99 to -1.25), body mass index (MD -0.58 kg/m², 95% CI -0.73 to -0.43), fat mass (MD -1.17 kg, 95% CI -1.80 to -0.55), waist (MD -1.58 cm, 95% CI -2.19 to -0.96), and hip (MD -0.99 cm, 95% CI -1.94 to -0.05) (all P < .05). No significant differences were observed in fasting blood glucose, triglycerides, or random insulin. No serious adverse events related to WKBE were reported. These findings indicate that WKBE may serve as a generally well-tolerated, nonpharmacological adjunct for weight management. In the future, further large-scale, high-quality, and long-term trials are warranted to confirm its efficacy and clarify its potential role in metabolic health. Copyright © 2026 Elsevier Inc. All rights reserved. DOI: 10.1016/j.nutres.2026.04.001 PMID: 42066439 Conflict of interest statement: Author declarations The authors declare that they have no conflicts of interest, financial or nonfinancial, related to this research. All authors affirm that the study was conducted independently and without any influence from external sources.
5. Food Sci Nutr. 2025 Oct 2;13(10):e71043. doi: 10.1002/fsn3.71043. eCollection 2025 Oct. Unraveling the Anti-Obesity Potential of White Kidney Bean α-Amylase Inhibitors: Mechanistic Insights From Enzyme Kinetics to Gut Microbiota Modulation. Yan J(1)(2), Zhao J(3), Naizemuding P(4), Zhao W(5), Sun J(1)(2), Wang Y(1)(2), Yang J(1)(2), Li D(1)(2), Zhang F(1)(2)(6), Cao H(1)(2). Author information: (1)Affiliated Hospital of Jiangnan University Wuxi Jiangsu People's Republic of China. (2)Wuxi School of Medicine Jiangnan University Wuxi Jiangsu People's Republic of China. (3)Suzhou Langbang Nutrition Co. Ltd Suzhou Jiangsu People's Republic of China. (4)China Mengniu Dairy Company Limited Shanghai People's Republic of China. (5)School of Food Science and Technology Jiangnan University Wuxi Jiangsu People's Republic of China. (6)Yixing Institute of Food and Biotechnology Co. Ltd. Yixing China. The global rise in obesity, driven largely by excessive carbohydrate consumption, highlights the demand for innovative dietary interventions targeting starch digestion. This study investigates the anti-obesity effects of α-amylase inhibitors (α-AI) extracted from white kidney beans, employing a multidisciplinary strategy encompassing botanical screening, enzyme kinetics, clinical trials, and gut microbiota profiling. Among 10 varieties evaluated, the A10 strain from Jilin Province demonstrated the highest α-AI activity, characterized by noncompetitive inhibition that remains effective across varying starch concentrations. In an 8-week randomized controlled trial, α-AI supplementation significantly reduced body weight, BMI, waist circumference, and hip circumference compared to placebo. Further, 16S rRNA sequencing revealed dual mechanisms: enrichment of SCFA-producing bacteria (e.g., Bifidobacterium and Bacteroides ovatus) and modulation of microbial lipid metabolic pathways. These results highlight α-AI as a dual-action anti-obesity agent, combining direct enzymatic inhibition with microbiome-mediated metabolic effects. By bridging phytochemical characterization with clinical outcomes, this work proposes a novel therapeutic approach that simultaneously targets carbohydrate absorption and gut microbial ecology, supporting the development of standardized α-AI formulations as potential nutraceuticals for metabolic syndrome. © 2025 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. DOI: 10.1002/fsn3.71043 PMCID: PMC12491653 PMID: 41049421 Conflict of interest statement: The authors declare no conflicts of interest.
6. Altern Ther Health Med. 2007 Jul-Aug;13(4):32-7. Blocking carbohydrate absorption and weight loss: a clinical trial using a proprietary fractionated white bean extract. Udani J(1), Singh BB. Author information: (1)University of California, Los Angeles School of Medicine, USA. BACKGROUND: A proprietary fractionated white bean extract of Phaseolus vulgaris has been shown in vitro to inhibit the digestive enzyme alpha-amylase. This may prevent or delay the digestion of complex carbohydrates, potentially resulting in weight loss. METHODS: A 4-week randomized, double-blind, placebo-controlled study of 25 healthy subjects consuming 1000 mg of a proprietary fractioned white bean extract or an identical placebo twice a day before meals in conjunction with a multi-component weight-loss program, including diet, exercise, and behavioral intervention, was conducted. RESULTS: Both groups reduced their weight and waist size significantly from baseline. The active group lost 6.0 lbs (P=.0002) and 2.2 in (P=.0050), and the placebo group lost 4.7 lbs (P=.0016) and 2.1 in (P=.0001). The differences between groups were not significant (weight P=.4235, waist size P=.8654). Through subsequent exploratory analysis to investigate group findings further, subjects were stratified by total dietary carbohydrate intake. This probative analysis revealed that the tertile of subjects who had consumed the most carbohydrates demonstrated significant reductions in both weight (8.7 lbs vs 1.7 lbs, P=.0412) and waist size (3.3 in vs 1.3 in P=.0100) compared with placebo subjects in the same tertile of carbohydrate intake. CONCLUSION: Subjects who adhere to a program including dietary modification, exercise, and behavioral intervention can significantly reduce their weight and waist size in a short period of time. In an exploratory analysis of data, the tertile of subjects who ate the most carbohydrates experienced a significant reduction in both weight and waist size with the addition of the white bean extract compared to the placebo group of the same tertile of carbohydrate consumption. Longer studies with a larger pool of subjects are required to validate these findings. PMID: 17658120 [Indexed for MEDLINE]
7. Altern Med Rev. 2004 Mar;9(1):63-9. Blocking carbohydrate absorption and weight loss: a clinical trial using Phase 2 brand proprietary fractionated white bean extract. Udani J(1), Hardy M, Madsen DC. Author information: (1)UCLA School of Medicine, Integrative Medicine Program, Northridge Hospital, 8250 Roscoe Blvd, Suite 240, Northridge, CA 91325, USA. Jay.Udani@CHW.edu BACKGROUND: Phase 2' starch neutralizer brand bean extract product ("Phase 2") is a water-extract of a common white bean (Phaseolus vulgaris) that has been shown in vitro to inhibit the digestive enzyme alpha-amylase. Inhibiting this enzyme may prevent the digestion of complex carbohydrates, thus decreasing the number of carbohydrate calories absorbed and potentially promoting weight loss. METHODS: Fifty obese adults were screened to participate in a randomized, double-blind, placebo-controlled study evaluating the effects of treatment with Phase 2 versus placebo on weight loss. Participants were randomized to receive either 1500 mg Phase 2 or an identical placebo twice daily with meals. The active study period was eight weeks. Thirty-nine subjects completed the initial screening process and 27 subjects completed the study. RESULTS: The results after eight weeks demonstrated the Phase 2 group lost an average of 3.79 lbs (average of 0.47 lb per week) compared with the placebo group, which lost an average of 1.65 lbs (average of 0.21 lb per week), representing a difference of 129 percent (p=0.35). Triglyceride levels in the Phase 2 group were reduced an average of 26.3 mg/dL, more than three times greater a reduction than observed in the placebo group (8.2 mg/dL) (p=0.07). No adverse events during the study were attributed to the study medication. CONCLUSION: Clinical trends were identified for weight loss and a decrease in triglycerides, although statistical significance was not reached. Phase 2 shows potential promise as an adjunct therapy in the treatment of obesity and hypertriglyceridemia and further studies with larger numbers of subjects are warranted to conclusively demonstrate effectiveness. PMID: 15005645 [Indexed for MEDLINE]
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