비타민K2 (MK-4)

Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: prospective cohort study and individual participant meta-analysis.

1. BMJ. 2020 Feb 12;368:m131. doi: 10.1136/bmj.m131. Comparison of risk factor associations in UK Biobank against representative, general population based studies with conventional response rates: prospective cohort study and individual participant meta-analysis. Batty GD(1)(2), Gale CR(3)(4), K

A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre-diabetes.

2. Biofactors. 2020 Jan;46(1):21-37. doi: 10.1002/biof.1569. Epub 2019 Oct 1. A systematic review on the mechanisms of vitamin K effects on the complications of diabetes and pre-diabetes. Karamzad N(1)(2)(3), Maleki V(1)(2), Carson-Chahhoud K(4)(5), Azizi S(1)(2), Sahebkar A(6)(7)(8), Gargari BP

The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial.

3. Arch Osteoporos. 2023 Jun 20;18(1):83. doi: 10.1007/s11657-023-01288-w. The additive effect of vitamin K supplementation and bisphosphonate on fracture risk in post-menopausal osteoporosis: a randomised placebo controlled trial. Moore AE(1), Dulnoan D(1), Voong K(2), Ayis S(3), Mangelis A(3),

Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study.

4. Eur J Pharmacol. 2015 Aug 15;761:273-8. doi: 10.1016/j.ejphar.2015.06.014. Epub 2015 Jun 11. Menaquinone-7 as a novel pharmacological therapy in the treatment of rheumatoid arthritis: A clinical study. Abdel-Rahman MS(1), Alkady EA(2), Ahmed S(3). Author information: (1)Department of Pharmac

Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women.

5. J Bone Miner Metab. 2014 Mar;32(2):142-50. doi: 10.1007/s00774-013-0472-7. Epub 2013 May 24. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. Koitaya N(1), Sekiguchi M, Tousen Y, Nishide Y, Morit

Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women.

6. Nutr J. 2012 Nov 12;11:93. doi: 10.1186/1475-2891-11-93. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Sato T(1), Schurgers LJ, Uenishi K. Author information: (1)Fine Chemical Laboratory, J-OIL MILLS, INC, 1746 Nakashinden, Fukuroi-city, Shizuoka, 437-1111, J

Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight.

7. Br J Nutr. 2012 Sep 28;108(6):1017-24. doi: 10.1017/S000711451100626X. Epub 2011 Dec 5. Association of vitamin K status with adiponectin and body composition in healthy subjects: uncarboxylated osteocalcin is not associated with fat mass and body weight. Knapen MH(1), Schurgers LJ, Shearer M

Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women.

8. J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):15-21. doi: 10.3177/jnsv.55.15. Effect of low dose vitamin K2 (MK-4) supplementation on bio-indices in postmenopausal Japanese women. Koitaya N(1), Ezaki J, Nishimuta M, Yamauchi J, Hashizume E, Morishita K, Miyachi M, Sasaki S, Ishimi Y. Author i

Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women.

9. Osteoporos Int. 2007 Jul;18(7):963-72. doi: 10.1007/s00198-007-0337-9. Epub 2007 Feb 8. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Knapen MH(1), Schurgers LJ, Vermeer C. Author information: (1)CARIM, University of Maastricht, Maas

Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis.

10. J Bone Miner Metab. 2003;21(3):161-5. doi: 10.1007/s007740300025. Vitamin K(2) (menaquinone 4) reduces serum undercarboxylated osteocalcin level as early as 2 weeks in elderly women with established osteoporosis. Miki T(1), Nakatsuka K, Naka H, Kitatani K, Saito S, Masaki H, Tomiyoshi Y, Mor

Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency.

11. RETRACTED ARTICLE Bone. 2002 Jul;31(1):114-8. doi: 10.1016/s8756-3282(02)00783-4. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. Sato Y(1), Honda Y, Kaji M, Asoh T, Hosokawa K, Kondo I, Satoh K. Author information: (1)

Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients.

12. Bone. 1998 Sep;23(3):291-6. doi: 10.1016/s8756-3282(98)00108-2. Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients. Sato Y(1), Honda Y, Kuno H, Oizumi K. Author information: (1)Department of Neurology, Futase Social Insurance Hospital,

A double-blind randomised controlled trial assessing the effect of menaquinone producing probiotics on vitamin K status.

13. Benef Microbes. 2026 Apr 16:1-15. doi: 10.1163/18762891-bja00117. Online ahead of print. A double-blind randomised controlled trial assessing the effect of menaquinone producing probiotics on vitamin K status. Muilwijk M(1)(2)(3), Kremers S(1)(2)(3), Schurgers LJ(4), Stolaki M(5), Bakker SJ

Effect of Vitamin K Supplementation on Testosterone Production in a Rat Model of Late-Onset Hypogonadism.

14. Foods. 2026 Mar 18;15(6):1070. doi: 10.3390/foods15061070. Effect of Vitamin K Supplementation on Testosterone Production in a Rat Model of Late-Onset Hypogonadism. Murakami R(1), Ohsaki Y(1)(2), Ito H(1), Ho HJ(1)(3), Agista AZ(1)(2), Chiang YF(4), Chen YL(4), Maekawa M(5), Hirose T(6)(7),

Extraction, LC-QTOF-MS profiling of bacterial menaquinone (MK) and characterization of CuFe(2)O(4) nanoparticles loaded MK: potential anti-cancer via gene expression.

15. Sci Rep. 2025 Dec 6;16(1):1194. doi: 10.1038/s41598-025-30886-6. Extraction, LC-QTOF-MS profiling of bacterial menaquinone (MK) and characterization of CuFe(2)O(4) nanoparticles loaded MK: potential anti-cancer via gene expression. Farsi RM(1), Abdelwahab MS(2). Author information: (1)Facul

A Small Molecule Inhibits Xanthomonas oryzae pv. oryzae by Targeting MenG.

10. J Agric Food Chem. 2025 Oct 15;73(41):25867-25874. doi: 10.1021/acs.jafc.5c07913. Epub 2025 Oct 6. A Small Molecule Inhibits Xanthomonas oryzae pv. oryzae by Targeting MenG. Hu S(1), Sun J(1), Li B(1), Chen Y(1), Ma Z(1). Author information: (1)State Key Laboratory of Rice Biology and Breedi

Menaquinone-4 inhibits the formation and vulnerability of atherosclerotic plaques in apolipoprotein E knockout mice by decreasing the uptake of the oxidized low-density lipoprotein in macrophages.

34. Eur J Pharmacol. 2025 Sep 15;1003:177970. doi: 10.1016/j.ejphar.2025.177970. Epub 2025 Jul 17. Menaquinone-4 inhibits the formation and vulnerability of atherosclerotic plaques in apolipoprotein E knockout mice by decreasing the uptake of the oxidized low-density lipoprotein in macrophages.

A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation.

20. ACS Chem Neurosci. 2025 Aug 6;16(15):2812-2828. doi: 10.1021/acschemneuro.5c00111. Epub 2025 Jul 3. A New Class of Vitamin K Analogues Containing the Side Chain of Retinoic Acid Have Enhanced Activity for Inducing Neuronal Differentiation. Hirota Y(1), Sato T(2), Watanabe R(1), Takeda K(3)(4

Vitamin K2 Attenuates Mitochondrial Damage in Renal Proximal Tubular Cells.

8. J Agric Food Chem. 2025 Sep 3;73(35):21857-21868. doi: 10.1021/acs.jafc.5c01320. Epub 2025 May 21. Vitamin K2 Attenuates Mitochondrial Damage in Renal Proximal Tubular Cells. Ho H(1), Aoki N(1), Eguchi M(1), Gao M(1), Suzuki H(1), Mikami M(1), Chiba H(1)(2), Hui SP(1). Author information: (1

Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening.

49. Proc Natl Acad Sci U S A. 2025 May 20;122(20):e2426532122. doi: 10.1073/pnas.2426532122. Epub 2025 May 15. Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening. Jun DJ(1), Schumacher MM(1), Jo Y(1), Faulkner RA(1), Yang Y(2), Tsien J(2), Qin T(

Warfarin Treatment is Associated With Lower Postmortem Brain Vitamin K Concentrations in Older Adults.

33. J Nutr. 2025 Aug;155(8):2711-2716. doi: 10.1016/j.tjnut.2025.04.035. Epub 2025 May 6. Warfarin Treatment is Associated With Lower Postmortem Brain Vitamin K Concentrations in Older Adults. Shea MK(1), Israel EA(2), Fu X(2), James BD(3), Agarwal P(3), Schneider JA(4), Booth SL(2). Author in

Effects of Varying Dietary Concentrations of Menadione Nicotinamide Bisulphite (VK(3)) on Growth Performance, Muscle Composition, Liver and Muscle Menaquinone-4 Concentration, and Antioxidant Capacities of Coho Salmon (Oncorhynchus kisutch) Alevins.

7. Biology (Basel). 2025 Apr 20;14(4):447. doi: 10.3390/biology14040447. Effects of Varying Dietary Concentrations of Menadione Nicotinamide Bisulphite (VK(3)) on Growth Performance, Muscle Composition, Liver and Muscle Menaquinone-4 Concentration, and Antioxidant Capacities of Coho Salmon (Onco

Low phylloquinone intake deteriorates endothelial function in normolipidemic and dyslipidaemic mice.

33. J Nutr Biochem. 2025 Jun;140:109867. doi: 10.1016/j.jnutbio.2025.109867. Epub 2025 Feb 18. Low phylloquinone intake deteriorates endothelial function in normolipidemic and dyslipidaemic mice. Kij A(1), Kieronska-Rudek A(2), Bar A(1), Czyzynska-Cichon I(1), Strus M(3), Kozien L(3), Wiecek G(

Short-term impact of vitamin K2 supplementation on biochemical parameters and lipoprotein fractions.

36. Electrophoresis. 2025 Feb;46(3-4):152-166. doi: 10.1002/elps.202400058. Epub 2024 Aug 2. Short-term impact of vitamin K2 supplementation on biochemical parameters and lipoprotein fractions. Barna M(1)(2), Dunovska K(1), Cepova J(1), Werle J(1), Prusa R(1), Bjørklud G(3), Melichercik P(2), K

Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health.

8. Curr Issues Mol Biol. 2024 Jul 4;46(7):7001-7031. doi: 10.3390/cimb46070418. Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health. Sadler RA(1), Shoveller AK(1), Shandilya UK(1), Charchoglyan A(2)(3), Wagter-Lesperance L(2)(4), Bridle B

Vitamin K Status Based on K1, MK-4, MK-7, and Undercarboxylated Prothrombin Levels in Adolescent and Adult Patients with Cystic Fibrosis: A Cross-Sectional Study.

29. Nutrients. 2024 Apr 29;16(9):1337. doi: 10.3390/nu16091337. Vitamin K Status Based on K1, MK-4, MK-7, and Undercarboxylated Prothrombin Levels in Adolescent and Adult Patients with Cystic Fibrosis: A Cross-Sectional Study. Krzyżanowska-Jankowska P(1), Nowak J(1), Karaźniewicz-Łada M(2), Jamk

Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity.

1. Nutrients. 2023 Sep 4;15(17):3854. doi: 10.3390/nu15173854. Recent Advances in Nutraceuticals for the Treatment of Sarcopenic Obesity. Kim YC(1), Ki SW(1), Kim H(1), Kang S(1), Kim H(1), Go GW(1). Author information: (1)Department of Food and Nutrition, Hanyang University, Seoul 04763, Republi

Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis.

39. Free Radic Biol Med. 2023 Sep;206:33-49. doi: 10.1016/j.freeradbiomed.2023.06.022. Epub 2023 Jun 24. Menaquinone-4 prevents medication-related osteonecrosis of the jaw through the SIRT1 signaling-mediated inhibition of cellular metabolic stresses-induced osteoblast apoptosis. Cui Y(1), Zhan

The relationship between serum vitamin K concentration and coronary artery calcification in middle-aged and elderly people.

39. Clin Chim Acta. 2022 Jun 1;531:325-330. doi: 10.1016/j.cca.2022.04.1001. Epub 2022 May 2. The relationship between serum vitamin K concentration and coronary artery calcification in middle-aged and elderly people. Xu C(1), Cunqing Y(1), Chun G(1), Min W(2), Jun L(3), Xueyun H(1), Jiaxin F(1)

Effect of vitamin K3 supplementation on immunoglobulin G concentration in colostrum of periparturient Holstein dairy cows.

11. Anim Sci J. 2022 Jan-Dec;93(1):e13706. doi: 10.1111/asj.13706. Effect of vitamin K3 supplementation on immunoglobulin G concentration in colostrum of periparturient Holstein dairy cows. Kuroiwa T(1)(2), Ohtani Y(3), Obara Y(3), Terada F(3), Watanabe K(4), Shirakawa H(4), Komai M(4), Satoh H(