비타민E (토코트리에놀)

Vitamin E and cognitive function: A systematic review of clinical evidence.

1. Nutr Res. 2026 Jan;145:66-86. doi: 10.1016/j.nutres.2025.11.009. Epub 2025 Nov 24. Vitamin E and cognitive function: A systematic review of clinical evidence. Amin AM(1), Mostafa H(2). Author information: (1)Department of Clinical Pharmacy, Faculty of Pharmacy, Tokat Gaziosmanpaşa University

Effect of Vitamin E on Serum Adiponectin and Leptin in Adults: A Systematic Review and Meta-analysis.

2. J Diet Suppl. 2025;22(6):939-957. doi: 10.1080/19390211.2025.2561143. Epub 2025 Oct 8. Effect of Vitamin E on Serum Adiponectin and Leptin in Adults: A Systematic Review and Meta-analysis. Karimi M(1), Alipour S(2), Pirzad S(3), Ahmadizad S(4), Bassami M(5), Asbaghi O(6). Author information

Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis.

3. Sci Rep. 2025 Sep 30;15(1):33954. doi: 10.1038/s41598-025-11160-1. Effect of tocotrienol-rich fraction (TRF) on lipid profile in hyperlipidemic experimental animal model: a systematic review and meta-analysis. Abdah HW(1), Hanafi NI(1), Abdul Muid S(1)(2), Ibrahim N(3)(4), Mohd Kasim NA(5)(6)

Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis.

4. J Gastroenterol Hepatol. 2024 Dec;39(12):2545-2554. doi: 10.1111/jgh.16723. Epub 2024 Aug 16. Vitamin E improves serum markers and histology in adults with metabolic dysfunction-associated steatotic liver disease: Systematic review and meta-analysis. Chee NM(1), Sinnanaidu RP(1), Chan WK(1).

Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans.

5. J Pak Med Assoc. 2024 Jun;74(6):1124-1129. doi: 10.47391/JPMA.9227. Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans. Rafique S(1), Khan DA(2), Farhat K(3), Khan MA(4), Noor M(3), Sharif M(3). Author information: (1)Department

Health Benefits of Palm Tocotrienol-Rich Fraction: A Systematic Review of Randomized Controlled Trials.

6. Nutr Rev. 2025 Feb 1;83(2):307-328. doi: 10.1093/nutrit/nuae061. Health Benefits of Palm Tocotrienol-Rich Fraction: A Systematic Review of Randomized Controlled Trials. Looi AD(1), Palanisamy UD(1), Moorthy M(1), Radhakrishnan AK(1). Author information: (1)Jeffrey Cheah School of Medicine and

Benefit of Asian pigmented rice bioactive compound and its implication in breast cancer: a systematic review.

7. F1000Res. 2023 Apr 5;12:371. doi: 10.12688/f1000research.130329.1. eCollection 2023. Benefit of Asian pigmented rice bioactive compound and its implication in breast cancer: a systematic review. Nafisah W(1), Nugraha AP(2), Nugroho A(3), Sakinah AI(4), Nusantara DS(5), Philia J(6), Iqbal Kur

Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

8. Adv Nutr. 2023 Sep;14(5):1159-1169. doi: 10.1016/j.advnut.2023.06.006. Epub 2023 Jun 14. Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Phang SCW(1), Ahmad B(2), Abdul Kadir K(2), M

Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response.

9. Nutrients. 2023 Apr 12;15(8):1854. doi: 10.3390/nu15081854. Molecular Mechanism of Tocotrienol-Mediated Anticancer Properties: A Systematic Review of the Involvement of Endoplasmic Reticulum Stress and Unfolded Protein Response. Pang KL(1)(2), Mai CW(3), Chin KY(1). Author information: (1)De

Pharmacokinetics and bioavailability of tocotrienols in healthy human volunteers: a systematic review.

10. J Pak Med Assoc. 2023 Mar;73(3):603-610. doi: 10.47391/JPMA.6008. Pharmacokinetics and bioavailability of tocotrienols in healthy human volunteers: a systematic review. Sharif M(1), Khan DA(2), Farhat K(2), Noor M(3), Khan MA(4), Rafique S(5). Author information: (1)Department of Pharmacolog

Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial.

11. Nutrients. 2025 Jun 30;17(13):2179. doi: 10.3390/nu17132179. Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial. Sharif R(1), Wai MK(1), Choon OT(2), Abdul Hafid SR(3), Lee TY(4). Author i

Reduction of disease activity in rheumatoid arthritis by tocotrienol-rich fraction supplementation: a randomized, double-blind, placebo-controlled trial.

12. Eur J Nutr. 2025 Jun 24;64(5):227. doi: 10.1007/s00394-025-03742-6. Reduction of disease activity in rheumatoid arthritis by tocotrienol-rich fraction supplementation: a randomized, double-blind, placebo-controlled trial. Zainal Z(1), Othman AZ(2), Rahim AA(3), Meganathan P(3), Radhakrishnan

Effects of tocotrienol-enriched oat supplementation on metabolic profile, nutritional status and health-related quality of life among patients with metabolic syndrome.

13. Food Funct. 2025 Mar 3;16(5):1847-1863. doi: 10.1039/d4fo03307h. Effects of tocotrienol-enriched oat supplementation on metabolic profile, nutritional status and health-related quality of life among patients with metabolic syndrome. Norazman CW(1), Mohd Sopian M(2), Lee LK(1). Author inform

Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination.

14. F1000Res. 2024 Feb 22;13:135. doi: 10.12688/f1000research.137005.1. eCollection 2024. Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination. Radhakris

Assessing the efficacy of tocotrienol-rich fraction vitamin E in obese children with non-alcoholic fatty liver disease: a single-blind, randomized clinical trial.

15. BMC Pediatr. 2024 Aug 20;24(1):529. doi: 10.1186/s12887-024-04993-8. Assessing the efficacy of tocotrienol-rich fraction vitamin E in obese children with non-alcoholic fatty liver disease: a single-blind, randomized clinical trial. Al-Baiaty FDR(1), Ishak S(2), Mohd Zaki F(3), Masra F(2), Ab

Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study.

24. Acta Oncol. 2023 Sep;62(9):1066-1075. doi: 10.1080/0284186X.2023.2249225. Epub 2023 Aug 30. Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study. Raunkilde L(1)(2)(3), Hansen TF(

Phase II trial of delta-tocotrienol in neoadjuvant breast cancer with evaluation of treatment response using ctDNA.

2. Sci Rep. 2023 May 24;13(1):8419. doi: 10.1038/s41598-023-35362-7. Phase II trial of delta-tocotrienol in neoadjuvant breast cancer with evaluation of treatment response using ctDNA. Kjær IM(1)(2), Kahns S(3), Timm S(4)(5), Andersen RF(3)(4), Madsen JS(3)(5), Jakobsen EH(4)(6), Tabor TP(7)(8),

Role of δ-tocotrienol and resveratrol supplementation in the regulation of micro RNAs in patients with metabolic syndrome: A randomized controlled trial.

13. Complement Ther Med. 2023 Jun;74:102950. doi: 10.1016/j.ctim.2023.102950. Epub 2023 Apr 20. Role of δ-tocotrienol and resveratrol supplementation in the regulation of micro RNAs in patients with metabolic syndrome: A randomized controlled trial. Fatima S(1), Khan DA(2), Fatima F(3), Aamir M(

Hepato-Protective Effects of Delta-Tocotrienol and Alpha-Tocopherol in Patients with Non-Alcoholic Fatty Liver Disease: Regulation of Circulating MicroRNA Expression.

36. Int J Mol Sci. 2022 Dec 21;24(1):79. doi: 10.3390/ijms24010079. Hepato-Protective Effects of Delta-Tocotrienol and Alpha-Tocopherol in Patients with Non-Alcoholic Fatty Liver Disease: Regulation of Circulating MicroRNA Expression. Pervez MA(1), Khan DA(1), Gilani STA(1), Fatima S(1), Ijaz A(

δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial.

30. Metab Syndr Relat Disord. 2023 Feb;21(1):25-34. doi: 10.1089/met.2022.0052. Epub 2022 Sep 20. δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial. Fatima S(1), Khan DA(1), A

Radiation Countermeasure Gamma-Tocotrienol Inhibits Accumulation of Lipid Peroxidation Products in the Serum of Nonhuman Primates Exposed to Partial- or Total-Body Radiation-A Hallmark of Inhibition of Irradiation-Induced Ferroptosis?

42. Int J Mol Sci. 2026 Apr 9;27(8):3387. doi: 10.3390/ijms27083387. Radiation Countermeasure Gamma-Tocotrienol Inhibits Accumulation of Lipid Peroxidation Products in the Serum of Nonhuman Primates Exposed to Partial- or Total-Body Radiation-A Hallmark of Inhibition of Irradiation-Induced Ferro

Evaluation of Combined Treatment With Atorvastatin and SREBP2 Inhibitors Against Colorectal Cancer Cells Under Two-dimensional and Three-dimensional Culture Models.

18. Anticancer Res. 2026 May;46(5):2403-2415. doi: 10.21873/anticanres.18126. Evaluation of Combined Treatment With Atorvastatin and SREBP2 Inhibitors Against Colorectal Cancer Cells Under Two-dimensional and Three-dimensional Culture Models. Ishii K(1), Tauchi Y(2), Yano T(2)(3). Author inform

6-O-Carboxypropyl-α-Tocotrienol Enhances the Anticancer Effects of Bortezomib Without Suppressing NRF1 and NRF3 in Colorectal Cancer Cells.

37. Anticancer Res. 2026 May;46(5):2375-2386. doi: 10.21873/anticanres.18124. 6-O-Carboxypropyl-α-Tocotrienol Enhances the Anticancer Effects of Bortezomib Without Suppressing NRF1 and NRF3 in Colorectal Cancer Cells. Ishii K(1), Yano T(2)(3). Author information: (1)Laboratory of Molecular Broma

Extrusion and Pancreatin Superdosing Modulate the Metabolic Impact of 20% Chlorella vulgaris Inclusion in Broiler Diets.

10. J Anim Physiol Anim Nutr (Berl). 2026 Apr 26. doi: 10.1111/jpn.70064. Online ahead of print. Extrusion and Pancreatin Superdosing Modulate the Metabolic Impact of 20% Chlorella vulgaris Inclusion in Broiler Diets. Mendes AR(1)(2)(3), Martins CF(1)(2)(3)(4), Spínola MP(2)(3), Carvalho DFP(1),

Exploring the role of tocotrienol-rich fraction (TRF) in ameliorating neuroinflammation.

14. Inflammopharmacology. 2026 Apr 20. doi: 10.1007/s10787-026-02249-8. Online ahead of print. Exploring the role of tocotrienol-rich fraction (TRF) in ameliorating neuroinflammation. Tan JY(1), Retinasamy T(2), Lee VLL(3), Radhakrishnan AK(4), Yeong KY(5). Author information: (1)School of Scie

Tocotrienol-rich vitamin E complex in CADASIL (T3CAD): a randomised, double-blind, placebo-controlled trial.

35. EClinicalMedicine. 2026 Mar 30;94:103853. doi: 10.1016/j.eclinm.2026.103853. eCollection 2026 Apr. Tocotrienol-rich vitamin E complex in CADASIL (T3CAD): a randomised, double-blind, placebo-controlled trial. Chabriat H(1)(2)(3), Biard L(4)(3), Guey S(1)(2)(3), Alili N(1), Machado C(1)(5), J

Microbial biopriming and germination cooperatively remodel brown lentil seeds (Lens culinaris L.) metabolome and antidiabetic functionality.

17. NPJ Sci Food. 2026 Apr 13. doi: 10.1038/s41538-026-00824-5. Online ahead of print. Microbial biopriming and germination cooperatively remodel brown lentil seeds (Lens culinaris L.) metabolome and antidiabetic functionality. Ghallab DS(1), Ghareeb DA(2)(3)(4), Shawer EE(5), Othman AA(5), Elat

Effect of vitamin E on cerebrovascular function: a systematic review.

10. Nutr Neurosci. 2026 Apr 11:1-15. doi: 10.1080/1028415X.2026.2655229. Online ahead of print. Effect of vitamin E on cerebrovascular function: a systematic review. Jansen S(1)(2), Graham CJ(2)(3), Mills DE(1)(2), Bliss ES(1)(2)(4). Author information: (1)School of Health, Psychological and Med

A Computational Strategy to Identify Hub Genes in Pathway Analysis of Gamma Tocotrienol-treated MCF-7 Cells and Molecular Docking Study Using Selected Phytochemicals as Therapeutic Agents.

50. Curr Med Chem. 2026 Mar 13. doi: 10.2174/0109298673426080251208093226. Online ahead of print. A Computational Strategy to Identify Hub Genes in Pathway Analysis of Gamma Tocotrienol-treated MCF-7 Cells and Molecular Docking Study Using Selected Phytochemicals as Therapeutic Agents. Kumari D

Modulation of tocotrienol's bone effects by osteocytes: a perspective.

26. Front Pharmacol. 2026 Feb 19;17:1773544. doi: 10.3389/fphar.2026.1773544. eCollection 2026. Modulation of tocotrienol's bone effects by osteocytes: a perspective. Zahanordin NN(1), Ng PY(2), Chin KY(1). Author information: (1)Department of Pharmacology, Faculty of Medicine, Universiti Kebang