비타민B1 (티아민)
Vitamin B1 (Thiamine)
📚 관련 논문 (19편)
1. J Glob Antimicrob Resist. 2018 Jun;13:231-236. doi: 10.1016/j.jgar.2018.01.005. Epub 2018 Feb 3. Evaluation of synergistic antimicrobial effect of vitamins (A, B1, B2, B6, B12, C, D, E and K) with antibiotics against resistant bacterial strains. Shahzad S(1), Ashraf MA(2), Sajid M(2), Shahzad
2. Anticancer Res. 2002 Mar-Apr;22(2A):927-9. Influence of vitamin B1 on sanazole activity under irradiation. A study in vitro. Heinrich E(1), Getoff N. Author information: (1)Ludwig Boltzmann Institute for Radiation Chemistry and Radiation Biology, The University of Vienna, Austria. The effec
3. Cochrane Database Syst Rev. 2001;(2):CD001498. doi: 10.1002/14651858.CD001498. Thiamine for Alzheimer's disease. Rodríguez-Martín JL(1), Qizilbash N, López-Arrieta JM. Author information: (1)Iberoamerican Cochrane Centre, Department of Epidemiology, Hospital de la Santa Creu i Sant Pau, Sant
4. Cochrane Database Syst Rev. 2000;(2):CD001498. doi: 10.1002/14651858.CD001498. Thiamine for Alzheimer's disease. Rodríguez-Martín JL(1), López-Arrieta JM, Qizilbash N. Author information: (1)Departamento de Psicobiología, Universidad Nacional de Educación a Distancia, Ciudad Universitaria s/n
1. Nutr Clin Pract. 2026 Apr;41(2):498-505. doi: 10.1002/ncp.70073. Epub 2025 Nov 24. Thiamin supplementation on mitigating kidney injury and mortality in patients with septic shock: A systematic review and meta-analysis of randomized controlled trials. Wang G(1), Liao X(2), Liao Y(3), Han D(1). Author information: (1)Department of Respiratory and Critical Care Medicine, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, China. (2)Neurocritical Rehabilitation Unit, Care Alliance Jinchen Rehabilitation Hospital of Chengdu, Chengdu, Sichuan, China. (3)Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. BACKGROUND: The effectiveness of thiamin supplementation in mitigating renal injury and mortality outcomes in patients with septic shock remains uncertain. This systematic review and meta-analysis aimed to determine the efficacy of thiamin in patients with septic shock. MATERIALS AND METHODS: A systematic search was made of PubMed, Embase, Cochrane Library, and clinicaltrials.gov, without language restrictions. Randomized controlled trials (RCTs) on treatment of septic shock with thiamin, compared with placebo or blank, were reviewed. Studies were pooled to risk ratios (RRs) and weighted mean differences, with 95% confidence intervals (CIs). Six RCTs (enrolling 438 patients) met the inclusion criteria. RESULTS: Thiamin showed significant effects on in-hospital mortality (RR 0.80, 95% CI 0.65-0.99; P = 0.04) and renal replacement therapy (RR 0.48, 95% CI 0.31-0.74; P = 0.0009). CONCLUSION: Thiamin was associated with a reduction in in-hospital mortality and the use of renal replacement therapy in patients with septic shock. Thiamin should be considered for patients with septic shock. © 2025 American Society for Parenteral and Enteral Nutrition. DOI: 10.1002/ncp.70073 PMID: 41277404 [Indexed for MEDLINE]
2. J Pharm Health Care Sci. 2025 Oct 21;11(1):88. doi: 10.1186/s40780-025-00495-6. Natural relief for premenstrual syndrome (PMS): a double-blind clinical trial on the efficacy and safety of PMSoff. Saghafi F(1), Zare P(2), Hatamizadeh N(3), Malmir M(4), Sahebnasagh A(5). Author information: (1)Department of Clinical Pharmacy, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (2)Student Research Committee, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (3)Research and Clinical Center for Infertility, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. (4)Department of Chemistry, College of Science, University of Tehran, Tehran, Iran. (5)Clinical Research Center, Department of Internal Medicine , Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, North Khorasan Province, Iran. masoomehsahebnasagh@gmail.com. BACKGROUND: Premenstrual syndrome (PMS) is a prevalent and often debilitating health conditions affecting women of reproductive age. The natural PMSoff supplement contains several active ingredients, including spirulina, whey protein, calcium citrate, vitamin B1, chamomile, turmeric, marigold, lavender, saffron, valerian, and aftimoon. This clinical trial aimed to assess the efficacy and safety of PMSoff, a natural supplement, in alleviating the symptoms of PMS. METHODS: In this double-blind, randomized trial, women diagnosed with PMS were randomly assigned to receive either PMSoff or placebo. The primary objective of the study was to evaluate the impact of PMSoff on symptom severity, with secondary objectives focusing on safety and adherence. The primary outcome of this study was the severity of PMS symptoms, evaluated using the Daily Record of Severity of Problems (DRSP) questionnaire. The secondary outcome focused on the presence of premenstrual dysphoric disorder (PMDD), a more severe and debilitating form of PMS. Symptom severity was assessed at multiple time points: pre-intervention, one month post-intervention, and two months post-intervention. RESULTS: Of the 255 randomized participants, 218 (85.4%) patients aged 14 to 30 years were enrolled and completed the clinical trial. No significant difference was observed between groups at baseline characteristics. Medication adherence in the first and second month of treatment was reported 72%. Following one month of treatment, the intervention group showed a significant reduction in DRSP scores compared to the control group (P-value = 0.043). This reduction became even more pronounced after two months of taking the supplement (P-value = 0.001). In patients with PMDD, a more severe form of PMS, a statistically significant difference emerged two months after the intervention (P-value = 0.04), indicating that the PMSoff was effective in alleviating PMDD-related symptoms, particularly during the second month of treatment. CONCLUSION: The results of this randomized placebo-controlled clinical trial were suggestive of the use of PMSoff in patients with PMS and PMDD to ameliorate its unpleasant symptoms, with sustained improvements observed over two months of treatment. Our findings suggest that PMSoff could be a viable alternative or adjunct to conventional pharmacological treatments for PMS and PMDD. Further studies are still demanded to explore the long-term effects, mechanisms of action, and broader applicability of this supplement. TRIAL REGISTRATION: Trial Registry Date: 2025-03-02, Trial Registry number: IRCT20190810044500N30. © 2025. The Author(s). DOI: 10.1186/s40780-025-00495-6 PMCID: PMC12538989 PMID: 41121435 Conflict of interest statement: Declarations. Ethics approval and consent to participate: Study protocols were approved by the local Ethics Committee of Shahid Sadoughi University of Medical Sciences (Ethics ID: IR.SSU.MEDICINE.REC.1402.179). Following a health-screening questionnaire, all volunteers provided a written informed consent. Before the intervention, study protocol, benefits, and possible side effects were described for patients. Understandable written informed consent was obtained for all patients prior to participation in the study. This trial was performed in accordance with the Declaration of Helsinki and Good Clinical Practice Guidelines. Consent for publication: Consent for publication was agreed upon in the written consent forms signed by all subjects for publication of identifying information/images in a publication. Competing interests: The authors declare no competing interests.
3. Nutrients. 2025 Jul 4;17(13):2227. doi: 10.3390/nu17132227. l-Carnitine and Alpha-Lipoic Acid Fail to Improve Anaerobic and Aerobic Performance in Trained Cyclists Despite a Reduction in Blood Lactate Concentration. de Rozas A(1), Pérez-Díaz JJ(1), Muros JJ(2), Sánchez-Muñoz C(1), Rufían-Henares JÁ(3), Zabala M(1), Salas-Montoro JA(1). Author information: (1)Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18071 Granada, Spain. (2)Department of Didactics of Body Expression, University of Granada, 18071 Granada, Spain. (3)Department of Nutrition and Food Sciences, Institute of Nutrition and Food Sciences, Biomedical Research Center, University of Granada, 18071 Granada, Spain. Background/Objectives: This study aimed to evaluate the effects of four weeks of combined Acetyl-l-Carnitine and alpha-lipoic acid (ALA) supplementation on anaerobic and aerobic performance and fatigue resistance in trained cyclists, hypothesizing improvements in maximal aerobic power (MAP), Wingate test performance, and reduced lactate accumulation. Methods: In a double-blind, randomized trial, 41 male trained cyclists (age: 36 ± 12 years; MAP: 4.35 ± 0.60 W·kg-1) were assigned to a supplement group (SUP, n = 19; 1200 mg/day Acetyl-l-Carnitine, 300 mg/day ALA, 1.1 mg Vitamin B1, 2.5 µg Vitamin B12) or placebo group (PLA, n = 22) for four weeks. Performance was assessed pre- and post-intervention via counter-movement jumps (CMJs), Wingate tests (WG1, WG2), and a graded exercise test (GXT). Blood lactate ([La-]) was measured post-Wingate. A three-way mixed ANOVA analyzed Wingate performance (session, order, and group), and a two-way ANOVA assessed MAP and fatigue effects. Results: MAP increased by 3.4% (314 ± 32 W to 324 ± 37 W; p = 0.005) with no group interaction (p = 0.457). Wingate peak power showed main effects for order (p < 0.001) and session (p = 0.011) but no group interaction (p = 0.676). SUP reduced [La-] by 1.5 mmol·L-1 post-WG2 in POST (p = 0.049). No significant group differences were found for CMJ or fatigue metrics. Conclusions: Four weeks of Acetyl-l-Carnitine and ALA supplementation did not enhance aerobic or anaerobic performance in trained cyclists, despite reducing blood lactate after high-intensity exercise, suggesting no ergogenic benefits. DOI: 10.3390/nu17132227 PMCID: PMC12252364 PMID: 40647331 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
4. Nutrients. 2025 May 27;17(11):1821. doi: 10.3390/nu17111821. Impact of Vitamin B1 and Vitamin B2 Supplementation on Anxiety, Stress, and Sleep Quality: A Randomized, Double-Blind, Placebo-Controlled Trial. Tao Y(1), Wu M(1), Su B(1), Lin H(1), Li Q(1), Zhong T(1), Xiao Y(1), Yu X(1). Author information: (1)Faculty of Medicine, Macau University of Science and Technology, Avenida Wai Long Taipa, Macau. Background: Anxiety, stress, and sleep disturbances significantly affect overall health. Research suggests that vitamins B1 and B2 may play a role in mood regulation and neuroprotection. This study aimed to investigate the effects of vitamin B1 and B2 supplementation in alleviating anxiety and stress and improving sleep quality. Methods: This study was a parallel randomized, double-blind, placebo-controlled clinical trial. Participants (n = 43) were randomized to receive one of the following two interventions: 100 mg of vitamin B1 and 100 mg of vitamin B2 or placebo. Intervention outcomes were assessed at baseline and week four, including SAS (Self-Rating Anxiety Scale), PSS (Perceived Stress Scale), PSQI (Sleep Quality Index), ESS (Sleepiness Scale), and measurement of urinary vitamin B1 and B2 levels. Results: After four weeks, urinary vitamin B1 levels increased from 158 ± 108.9 ng to 1333.1 ± 1204.5 ng (p < 0.01), and urinary vitamin B2 levels increased from 308.0 ± 198.3 ng to 6123.2 ± 4847.2 ng in the supplement group (p < 0.01). The PSS scores decreased significantly in the supplement group from 21.5 ± 4.1 to 15.5 ± 4.5 (p < 0.05), while the placebo group showed a change from 20.3 ± 4.3 to 19.8 ± 5.5. Vitamins B1 and B2 did not have a significant effect on anxiety improvement (p > 0.05). The PSQI scores decreased in the supplement group from 8.0 ± 3.12 to 6.3 ± 2.0 (p < 0.05), while the placebo group worsened from 5.7 ± 2.7 to 7.4 ± 2.9. Meanwhile, the ESS scores in the supplement group decreased from 13.0 ± 3.4 to 9.1 ± 3.9 (p < 0.05), demonstrating a significant improvement compared to the placebo group. Conclusions: The clinical trial findings demonstrated that while vitamin B1 and B2 supplements helped reduce stress, enhance sleep, and reduce sleepiness, they had no discernible impact on reducing anxiety. Future studies should focus on the long-term effects of vitamin B1 and B2 supplements, exploring the combined effects of combined vitamin B1 and B2 medications for the treatment of stress and sleep disorders. DOI: 10.3390/nu17111821 PMCID: PMC12157762 PMID: 40507089 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
5. J Nutr Sci. 2025 May 8;14:e34. doi: 10.1017/jns.2025.22. eCollection 2025. Effect of vitamin B1 supplementation on bone turnover markers in adults: an exploratory single-arm pilot study. Hara A(1), Takazawa C(1), Tsujiguchi H(1), Zhao J(1), Nakamura M(1), Kasahara T(1), Shimizu Y(2), Nakamura H(1). Author information: (1)Department of Hygiene and Public Health, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. (2)Department of Nursing, Faculty of Health Sciences, Komatsu University, Komatsu, Ishikawa, Japan. Although B vitamins have been shown to play beneficial roles in bone health, the effects of vitamin B1 in humans are still unclear. This study aimed to investigate the effects of vitamin B1 supplementation on middle-aged and older adults. This single-armed trial study included community-dwelling adults in Japan and used a pre- and post-test design. The participants were given 28.0 mg of vitamin B1 supplementation per day for 1 month in addition to their daily usual diet. The effect of this treatment on bone turnover markers and metabolism was evaluated at baseline and after 1 month. Forty-two participants were enrolled (mean age, 58.6 ± 10.4 years; 36 women). The vitamin B1 levels in whole blood increased significantly from baseline after vitamin B1 supplementation. The level of serum tartrate-resistant acid phosphatase 5b (TRACP 5b), a bone resorption marker, reduced significantly (378 ± 135 vs. 335 ± 120 mU/dL, p < 0.001), while the level of N-terminal propeptide of type I procollagen (P1NP), a marker specific to bone formation, did not change. Moreover, the serum phosphorus and parathyroid hormone (PTH) concentrations did not change, whereas the corrected serum calcium concentrations increased and vitamin D concentrations decreased. The serum TRACP 5b levels decreased after vitamin B1 supplementation in the middle-aged and older adults. Further definitive trials are needed to determine the efficacy of vitamin B1 in improving bone health. © The Author(s) 2025. DOI: 10.1017/jns.2025.22 PMCID: PMC12075007 PMID: 40371216 [Indexed for MEDLINE] Conflict of interest statement: The authors have no conflicts of interest to declare.
6. Int J Mol Sci. 2025 Mar 27;26(7):3090. doi: 10.3390/ijms26073090. The Pivotal Role of Thiamine Supplementation in Counteracting Cardiometabolic Dysfunctions Associated with Thiamine Deficiency. Ritorto G(1), Ussia S(1), Mollace R(1)(2), Serra M(1), Tavernese A(3), Palma E(4), Muscoli C(1), Mollace V(1)(5), Macrì R(1). Author information: (1)Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. (2)Department of Experimental Medicine, University "Tor Vergata" of Rome, 00133 Rome, Italy. (3)Department of Medicine and Surgery, University Campus Bio-Medico of Rome, 00128 Rome, Italy. (4)Veterinary Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy. (5)Renato Dulbecco Institute, Lamezia Terme, 88046 Catanzaro, Italy. The isolation, structural elucidation, and synthesis of pure thiamin were achieved in 1936, marking a milestone in vitamin research. As an organic compound soluble in water, thiamin is essential for carbohydrate metabolism in plants and animals, and in its active form-as part of the thiamin pyrophosphate coenzyme-performs these functions. Thereby, thiamin represents an essential vitamin to human health and is involved in several pathways that regulate several pathophysiological mechanisms. Cardiovascular disease is significantly impacted by thiamine imbalance and its supplementation offers substantial improvements to the associated conditions. In this comprehensive review, we aimed to examine the dual role of thiamine deficiency and accumulation, focusing on an analysis of the causes of thiamine deficiency. We detailed the effects of thiamine deficiency on metabolism and on cardiovascular risk and heart failure, explaining the molecular mechanisms involved in metabolic dysfunction, and highlighting the role of B1 vitamin supplementation in diabetes mellitus management and atherosclerosis development and progression. Indeed, B1 supplementation counteracts oxidative stress and inflammation, significantly ameliorating glycemic and lipemic profiles. Additionally, we reported the beneficial effects of thiamine in counteracting cardiotoxicity induced by cancer therapy. Although preclinical data strongly support the benefits of thiamine, clinical trial findings are in contrast and contradictory, hampered by limitations such as small sample sizes and inadequate follow-up. Further research is needed to investigate thiamine's potential benefits, overcoming current study limitations and evaluating its use as a supplemental therapy alongside standard treatments in different high-cardiovascular-risk conditions. DOI: 10.3390/ijms26073090 PMCID: PMC11988323 PMID: 40243711 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.
7. Dev Psychol. 2025 Aug;61(8):1427-1440. doi: 10.1037/dev0001829. Epub 2024 Dec 19. Language processing in breastfed infants at risk of thiamine deficiency benefits from maternal thiamine supplementation. Baldwin DA(1), Measelle J(1), Gallivan L(1), Sanchirico A(1), Weinstein N(1), Bala A(1), Chan K(2), Gallant J(2), Borath M(3), Kroeun H(4), Wieringa FT(5), Green TJ(6), Whitfield KC(2). Author information: (1)Department of Psychology, University of Oregon. (2)Department of Applied Human Nutrition, Mount Saint Vincent University. (3)Cambodian Ministry of Planning. (4)Helen Keller International. (5)Institut de recherche pour le developpement. (6)South Australian Health and Medical Research Institute. In a double-blind, randomized controlled trial, we investigated relationships between infants' exposure to thiamine and their language-processing ability. Three hundred thirty-five lactating Cambodian mothers of 161 female/174 male infants received either 0, 1.2, 2.4, or 10 mg of thiamine daily, from 2 to 24 weeks postpartum. We assessed infants' language processing at 24 weeks via the infant-directed speech (IDS) task, measuring attentional enhancement to IDS versus adult-directed speech. Maternal thiamine supplementation displayed a small but statistically significant dose-response relationship to the magnitude of infants' IDS-elicited attentional enhancement (adjusted R² = 0.022, p = .011). As well, only infants whose mothers received a daily thiamine supplement of 10 mg showed fully robust IDS-related attentional enhancement. These findings showcase the IDS Task for monitoring the integrity of infants' language processing and underscore the importance of adequate thiamine early in life for ensuring optimal language development. (PsycInfo Database Record (c) 2025 APA, all rights reserved). DOI: 10.1037/dev0001829 PMID: 39699595 [Indexed for MEDLINE]
8. Nutrients. 2024 Dec 4;16(23):4187. doi: 10.3390/nu16234187. Evaluation of the Efficacy of the Addition of a Combination of Pyrimidine Nucleotides and Vitamin B1 and B12 to Standard Treatment in the Management of Painful Radiculopathy and in the Quality of Life of Patients. Monfort J(1)(2), Carrión-Barberà I(1)(2), Tío L(2), Marante J(3), López Vázquez A(4), Bas T(5), Fernandez-Fuente-Burson L(6), Caracuel MA(7), Oliveros-Cid A(8), Gallart V(9), Romera-López C(10), Román JA(11), Abejón D(12), Roca Ruíz LJ(13), Gurt A(14), Ojeda F(1)(2), Grima P(15), Aldonza R(16). Author information: (1)Departament of Rheumatology, Hospital del Mar, 08003 Barcelona, Spain. (2)Hospital del Mar Research Institute, 08003 Barcelona, Spain. (3)Hospital Universitario Jerez de la Frontera, 11407 Cádiz, Spain. (4)Hospital de Orense, 32005 Ourense, Spain. (5)Department of Traumatology and Orthopaedic Surgery, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain. (6)Hospital Quirónsalud Infanta Luisa, 41010 Sevilla, Spain. (7)Hospital Universitario Reina Sofía, 14004 Córdoba, Spain. (8)Hospital Viamed Montecanal, 50012 Zaragoza, Spain. (9)Hospital Universitario Doctor Peset, 46017 Valencia, Spain. (10)Hospital General Universitario de Elche, 03203 Elche, Spain. (11)Department of Rheumatology, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain. (12)Hospital Universitario Quirónsalud Madrid, 28223 Madrid, Spain. (13)Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain. (14)CAP Vila Olímpica, 08005 Barcelona, Spain. (15)Affinity Petcare, 08902 Barcelona, Spain. (16)Ferrer Internacional, S.A., 08029 Barcelona, Spain. Background/Objectives: Radiculopathy leads to pain, consequently reducing patient's quality of life (QoL). Research indicates that certain nucleotides, such as cytidine and uridine, along with vitamins B1 and B12, may help alleviate pain and enhance QoL. This study assessed the impact of adding a supplement containing cytidine and uridine nucleotides and vitamins B1 and B12, alongside standard treatment, on radiculopathy-associated pain. Methods: A multicenter, prospective, two-cohort, randomized, open-label study was conducted. The control group received standard treatment, while the experimental group received standard treatment plus the supplement. The primary endpoint was pain reduction measured by a Visual Analog Scale (VAS). Secondary endpoints included functional improvement (Roland Morris questionnaire), clinical improvement (Clinical Global Impression [CGI] scale), and QoL improvement (EQ-5D-5L questionnaire). Results: A total of 122 patients were included from 17 centers across Spain. Both groups showed pain improvement, but the VAS reduction (control: 24.58 vs. experimental: 31.35) was not statistically significant. The Roland Morris score decreased significantly in the experimental group (estimate: -1.70, 95% CI -3.29 to -0.10; p = 0.038), and these patients were 5 times more likely to progress to a better CGI category (OR = 0.20, 95% CI 0.07 to 0.57; p = 0.003). No significant differences were observed in EQ-5D-5L scores or analgesic consumption. Conclusions: The addition of supplemental pyrimidine nucleotides and vitamins B1 and B12 to standard of care treatment improved radiculopathy functional and clinical outcomes. Regarding pain, however, although there was a numerical improvement, it did not reach statistical significance. DOI: 10.3390/nu16234187 PMCID: PMC11644542 PMID: 39683579 [Indexed for MEDLINE] Conflict of interest statement: Author Pedro Grima was an employer of Ferrer Internacional S.A. at the beginning of the study and was employed by the company Affinity Petcare. Rebeca Aldonza is full-time employee of Ferrer Internacional S.A. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Ferrer Internacional, S.A. The funder was not involved in the collection, analysis and interpretation of data.
9. Nutrients. 2024 Sep 10;16(18):3045. doi: 10.3390/nu16183045. Efficacy and Safety of the Combination of Palmitoylethanolamide, Superoxide Dismutase, Alpha Lipoic Acid, Vitamins B12, B1, B6, E, Mg, Zn and Nicotinamide for 6 Months in People with Diabetic Neuropathy. Didangelos T(1), Karlafti E(1), Kotzakioulafi E(1), Giannoulaki P(2), Kontoninas Z(1), Kontana A(1), Evripidou P(1), Savopoulos C(1), Birkenfeld AL(3)(4)(5), Kantartzis K(3)(4)(5). Author information: (1)Diabetes Center, 1st Propaedeutic Department of Internal Medicine, Aristotle University of Thessaloniki, AHEPA Hospital, 54636 Thessaloniki, Greece. (2)Department of Clinical Nutrition and Dietetics, AHEPA Hospital, 54636 Thessaloniki, Greece. (3)Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University of Tübingen, 72076 Tübingen, Germany. (4)Institute for Diabetes Research and Metabolic Diseases (IDM), Helmholtz Centre Munich, University of Tübingen, 72076 Tübingen, Germany. (5)German Center for Diabetes Research (DZD), 85764 München-Neuherberg, Germany. AIM: To investigate the efficacy of Palmitoylethanolamide (PEA, 300 mg), Superoxide Dismutase (SOD, 70 UI), Alpha Lipoic Acid (ALA, 300 mg), vitamins B6 (1.5 mg), B1 (1.1 mg), B12 (2.5 mcg), E (7.5 mg), nicotinamide (9 mg), and minerals (Mg 30 mg, Zn 2.5 mg) in one tablet in people with Diabetic Neuropathy (DN). PATIENTS-METHODS: In the present pilot study, 73 people (age 63.0 ± 9.9 years, 37 women) with type 2 Diabetes Mellitus (DMT2) (duration 17.5 ± 7.3 years) and DN were randomly assigned to receive either the combination of ten elements (2 tablets/24 h) in the active group (n = 36) or the placebo (n = 37) for 6 months. We used the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measured vibration perception threshold (VPT) with biothesiometer, and Cardiovascular Autonomic Reflex Tests (CARTs). Nerve function was assessed by DPN Check [sural nerve conduction velocity (SNCV) and amplitude (SNAP)]. Sudomotor function was assessed with SUDOSCAN, which measures electrochemical skin conductance in hands and feet (ESCH and ESCF). Pain score (PS) was assessed with Pain DETECT questionnaire. Quality of life was assessed by questionnaire. RESULTS: In the active group, there was a large improvement of pain (PS from 20.9 to 13.9, p < 0.001). There was also a significant improvement of vitamin B12 (B12) levels, MNSIQ, SNCV, VPT, and ESCF (222.1 vs. 576.3 pg/ mL, p < 0.001; 6.1 vs. 5.9, p = 0.017; 28.8 vs. 30.4, p = 0.001; 32.1 vs. 26.7, p = 0.001; and 72.2 vs. 74.8, p < 0.001 respectively). In the placebo group, neither pain (21.6 vs. 21.7, p = 0.870) or any other aforementioned parameters changed significantly, and MNSIE worsened (2.9 vs. 3.4, p < 0.001). As a result, changes from baseline to follow-up in pain, B12 levels, VPT, and MNSIQ differed significantly between the two groups (p < 0.001, 0.025, 0.009, and <0.001, respectively). CARTs, SNAP, ESCH did not significantly change in either of the two groups. CONCLUSIONS: The combination of the ten elements in one tablet for 6 months at a daily dose of two tablets in people with DN significantly improves pain, vibration perception threshold, and B12 levels. DOI: 10.3390/nu16183045 PMCID: PMC11434759 PMID: 39339645 [Indexed for MEDLINE] Conflict of interest statement: E.Kot. is currently an employee at Nestlé Research, Lausanne, Switzerland. The study was conducted prior to her employment. The other authors declare no conflicts of interest.
10. J Affect Disord. 2025 Jan 15;369:35-42. doi: 10.1016/j.jad.2024.09.131. Epub 2024 Sep 22. Effects of a food supplement containing phosphatidylserine on cognitive function in Chinese older adults with mild cognitive impairment: A randomized double-blind, placebo-controlled trial. Duan H(1), Xu N(1), Yang T(2), Wang M(3), Zhang C(3), Zhao J(3), Li Z(1), Chen Y(2), Yan J(4), Zhang M(1), Li W(1), Yue Z(5), Ma F(2), He R(6), Huang G(7). Author information: (1)Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. (2)Department of Epidemiology & Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. (3)Community Health Service Center, Sanhuailu Street, Binhai New District, Tianjin, China. (4)Department of Social Medicine and Health Management, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China. (5)BYHEALTH Institute of Nutrition & Health, Guangzhou, China. (6)BYHEALTH Institute of Nutrition & Health, Guangzhou, China. Electronic address: herk@by-health.com. (7)Department of Nutrition and Food Science, School of Public Health, Tianjin Medical University, Tianjin, China; Key Laboratory of Prevention and Control of Major Diseases in the Population, Ministry of Education, Tianjin Medical University, Tianjin, China; Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, China; The Province and Ministry Co-Sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin, China. Electronic address: huangguowei@tmu.edu.cn. BACKGROUND: Phosphatidylserine (PS) and α-Linolenic acid (ALA), are positively associated with cognitive function, but their combination effects and possible mechanisms remain unclear. We aimed to explore the effects on cognition and potential mechanism of the supplements. METHODS: This randomized, double-blind, placebo-controlled trial recruited 190 MCI patients in Tianjin, China, and randomly assigned in intervention group and placebo group. Each group consumed two capsules every day for 12 months. Each capsule for intervention group contains 144 mg ALA, 31.5 mg PS and 3.6 mg Ginkgo total flavonoids as main functional components, with 0.48 mg Vitamin B1 (as thiamine hydrochloride), 0.48 mg Vitamin B6 (as pyridoxine hydrochloride) and 90 μg folic acid as supplement. Capsules for placebo group were identical but contain no active ingredients. Cognitive function, serum n-3 polyunsaturated fatty acids (PUFAs) and neurotransmitters were assessed at baseline and 12 months. Linear mixed effects model and causal mediation analysis were conducted to explore the effects and potential mechanism of the intervention. RESULTS: A total of 190 participants (mean [SD] age, 67.95 [5.62] years; 70 (36.8 %) male and 120 (63.2 %) female) were randomized to the placebo group (n = 95) and intervention group (n = 95). Compared with placebo group, the intervention group had statistically significant improvements in arithmetic testing (β, 0.688; 95 % CI, 0.103-1.274), the similarity test (β, 1.070; 95 % CI, 0.472-1.667) and short-term memory (β, 0.600; 95 % CI, 0.399-0.800). Besides, the intervention group had statistically significant increases in serum ALA (β, 1.620; 95 % CI, 0.967-2.265), DHA (β, 2.797; 95 % CI, 1.075-4.532), EPA (β, 1.472; 95 % CI, 0.296-2.643), acetylcholine (β, 0.441; 95 % CI, 0.415-0.468), GABA (β, 0.009; 95 % CI, 0.001-0.016) and 5-HT (β, 0.160; 95 % CI, 0.081-0.238) compared to the placebo group. And the intervention may improve short-term memory by increasing serum ALA levels (average causal mediation effect = 0.132, 95 % CI, 0.053-0.225) with 19.7 % mediation proportion. CONCLUSIONS: This food supplement containing phosphatidylserine could improve different cognitive functions of MCI patients, especially short-term memory, and increase serum n-3 PUFAs and neurotransmitters levels. Serum ALA level might play a mediation role. Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved. DOI: 10.1016/j.jad.2024.09.131 PMID: 39317299 [Indexed for MEDLINE] Conflict of interest statement: Declaration of competing interest The authors declare no conflict of interest, financial or otherwise.
11. Clin Cardiol. 2024 Jul;47(7):e24309. doi: 10.1002/clc.24309. Role of Thiamine Supplementation in the Treatment of Chronic Heart Failure: An Updated Meta-Analysis of Randomized Controlled Trials. He S(1), Wang S(2), Xu T(2), Wang S(2), Qi M(2), Chen Q(2), Lin L(2), Wu H(2), Gan P(2). Author information: (1)Department of Hand and Foot Surgery, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China. (2)Department of Intensive Care Rehabilitation, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Taizhou, Zhejiang, China. BACKGROUND: Chronic heart failure (CHF) has always posed a significant threat to human survival and health. The efficacy of thiamine supplementation in CHF patients remains uncertain. HYPOTHESIS: Receiving supplementary thiamine may not confer benefits to patients with CHF. METHODS: A comprehensive search was conducted across the Cochrane Library, PubMed, EMBASE, ClinicalTrials.gov, and Web of Science databases up until May 2023 to identify articles investigating the effects of thiamine supplementation in CHF patients. Predefined criteria were utilized for selecting data on study characteristics and results. RESULTS: Seven randomized, double-blind, controlled trials (five parallel trials and two crossover trials) involving a total of 274 patients were enrolled. The results of the meta-analysis pooling these studies did not reveal any significant effect of thiamine treatment compared with placebo on left ventricular ejection fraction (WMD = 1.653%, 95% CI: -1.098 to 4.405, p = 0.239, I2 = 61.8%), left ventricular end-diastolic volume (WMD = -6.831 mL, 95% CI: -26.367 to 12.704, p = 0.493, I2 = 0.0%), 6-min walking test (WMD = 16.526 m, 95% CI: -36.582 to 69.634, p = 0.542, I2 = 66.3%), N-terminal pro-B type natriuretic peptide (WMD = 258.150 pg/mL, 95% CI: -236.406 to 752.707, p = 0.306, I2 = 21.6%), or New York Heart Association class (WMD = -0.223, 95% CI: -0.781 to 0.335, p = 0.434, I2 = 87.1%). However, it effectively improved the status of thiamine deficiency (TD). CONCLUSIONS: Our meta-analysis indicates that thiamine supplementation does not have a direct therapeutic effect on CHF, except for correcting TD. © 2024 The Author(s). Clinical Cardiology published by Wiley Periodicals LLC. DOI: 10.1002/clc.24309 PMCID: PMC11212003 PMID: 38940395 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
12. Nutr Rev. 2025 Feb 1;83(2):280-306. doi: 10.1093/nutrit/nuae043. Effect of nutritional interventions on the psychological symptoms of premenstrual syndrome in women of reproductive age: a systematic review of randomized controlled trials. Robinson J(1), Ferreira A(1), Iacovou M(2), Kellow NJ(1)(2). Author information: (1)Department of Nutrition, Dietetics and Food, Monash University, Notting Hill, Victoria, Australia. (2)Department of Molecular and Translational Science, Centre of Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, Victoria, Australia. CONTEXT: Premenstrual syndrome (PMS) affects approximately 48% of women of reproductive age worldwide. It can lead to functional impairment, lower quality of life, and decreased work productivity. Despite the availability of medical treatment options, women are seeking alternative interventions because of concerns of harmful side effects and limited evidence of efficacy associated with pharmacological treatments. To date, high-quality research investigating the effects of dietary and nutrient intervention on PMS is limited. OBJECTIVE: This systematic review investigated the effect of nutritional interventions on the psychological symptoms of PMS. DATA SOURCES: Five electronic databases were searched for randomized controlled trials (RCTs) published in English from inception to October 2022. Trials eligible for inclusion were nutritional intervention studies involving women of reproductive age that measured PMS-associated psychological outcomes. DATA EXTRACTION: Articles were selected using prespecified inclusion criteria. Data screening and extraction and risk-of-bias assessments were conducted by 3 independent reviewers using article screening software and the Cochrane Risk of Bias 2 tool. DATA ANALYSIS: Thirty-two articles reporting on 31 RCTs involving 3254 participants, ranging in age from 15 to 50 years were included and narratively reviewed. Only 1 of the included studies had a low risk of bias. Treatment with vitamin B6, calcium, and zinc consistently had significant positive effects on the psychological symptoms of PMS. There was insufficient evidence to support the effects of vitamin B1, vitamin D, whole-grain carbohydrates, soy isoflavones, dietary fatty acids, magnesium, multivitamin supplementation, or PMS-specific diets. CONCLUSIONS: There is some evidence to support the use of nutritional interventions for improving psychological symptoms of PMS. However, more research using consistent protocols, procedures to minimize risk of bias, intention-to-treat analysis, and clearer reporting is required to provide conclusive nutritional recommendations for improving PMS-related psychological outcomes. PROSPERO REGISTRATION NO: CRD42022369999. © The Author(s) 2024. Published by Oxford University Press on behalf of the International Life Sciences Institute. DOI: 10.1093/nutrit/nuae043 PMCID: PMC11723155 PMID: 38684926 [Indexed for MEDLINE]
13. Clin Nutr. 2023 Dec;42(12):2443-2456. doi: 10.1016/j.clnu.2023.09.009. Epub 2023 Oct 5. A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations. Han SM(1), Huang F(2), Derraik JGB(3), Vickers MH(1), Devaraj S(4), Redeuil K(5), Campos-Giménez E(5), Pang WW(6), Godfrey KM(7), Chan SY(8), Thakkar SK(4), Cutfield WS(9); NiPPeR Study Group. Collaborators: Albert BB, Barton SJ, Binia A, Cavanagh M, Chang HF, Chong YS, Chong MF, Conlon C, Cooper C, Costello P, Cox V, Creagh C, Depczynski M, El-Heis S, Hammond J, Harvey NC, Jagtap M, Kenealy T, Nield H, O'Sullivan JM, Satianegara G, Silva-Zolezz I, Soh SE, Tay V, Taylor R, Tham E, Titcombe P, Wall C, Wong R, Woon G, Han Z. Author information: (1)Liggins Institute, The University of Auckland, Auckland, New Zealand. (2)Nestlé Research, Société des Produits Nestlé SA, Beijing, China. (3)Liggins Institute, The University of Auckland, Auckland, New Zealand; Department of Paediatrics: Child and Youth Health, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. (4)Nestlé Research, Société des Produits Nestlé SA, Singapore. (5)Nestlé Research, Société des Produits Nestlé SA, Lausanne, Switzerland. (6)Global Centre for Asian Women's Health, Dean's Office, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore. (7)MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. (8)Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research, Singapore. (9)Liggins Institute, The University of Auckland, Auckland, New Zealand; A Better Start - National Science Challenge, The University of Auckland, Auckland, New Zealand. Electronic address: w.cutfield@auckland.ac.nz. BACKGROUND & AIMS: Optimal maternal vitamin status during pregnancy and lactation is essential to support maternal and infant health. For instance, vitamin D3 is involved in infant bone development, and B-vitamins are involved in various metabolic processes, including energy production. Through a double-blind randomised controlled trial, we investigated the effects of maternal supplementation from preconception throughout pregnancy until birth on human milk (HM) concentrations of vitamin D3 and B-vitamins. In addition, we aimed to characterise longitudinal changes in milk concentrations of these vitamins. METHODS: Both control and intervention supplements contained calcium, iodine, iron, β-carotene, and folic acid, while the intervention also contained zinc, vitamins B2, B6, B12, and D3, probiotics, and myo-inositol. HM samples were collected across 4 time points from 1 week to 3 months post-delivery from 158 mothers in Singapore, and 7 time points from 1 week to 12 months from 180 mothers in New Zealand. HM vitamin D was quantified using supercritical fluid chromatography and B-vitamins with mass spectrometry. Potential intervention effects on HM vitamins D3, B2, B6, and B9, as well as other B-vitamin (B1 and B3) concentrations were assessed using linear mixed models with a repeated measures design. RESULTS: Over the first 3 months of lactation, HM 25-hydroxyvitamin D3 concentrations were 20% (95% CI 8%, 33%, P = 0.001) higher in the intervention group, with more marked effects in New Zealand. There were no observed intervention effects on HM concentrations of vitamins B1, B2, B3, B6, and B9. In New Zealand mothers, longitudinally, vitamin D3 concentrations gradually increased from early lactation up to 12 months, while vitamins B1 and B2 peaked at 6 weeks, B3 at 3 weeks, and B6 and B9 at 3 months. CONCLUSIONS: Maternal supplementation during preconception and pregnancy increased HM vitamin D, but not B-vitamin concentrations in lactation. Further studies are required to examine the discrete benefits of vitamin D supplementation starting preconception vs during pregnancy, and to further characterise the effects of supplementation on later offspring health outcomes. CLINICAL TRIAL REGISTRATION: Registered at ClinicalTrials.gov on the 16 July 2015 (identifier NCT02509988); Universal Trial Number U1111-1171-8056. This study was academic-led by the EpiGen Global Research Consortium. Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. DOI: 10.1016/j.clnu.2023.09.009 PMID: 38411017 [Indexed for MEDLINE]
14. BMC Nephrol. 2023 Dec 14;24(1):372. doi: 10.1186/s12882-023-03423-8. Effects of a low-protein nutritional formula with dietary counseling in older adults with chronic kidney disease stages 3-5: a randomized controlled trial. Yang WC(1), Hsieh HM(1), Chen JP(2), Liu LC(1), Chen CH(3)(4)(5)(6). Author information: (1)Department of Food and Nutrition, Taichung Veterans General Hospital, Taichung, Taiwan. (2)Biostatistics Group, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. (3)Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, No. 1650, Sect. 4, Taiwan Boulevard, Taichung, Taiwan. cschen920@yahoo.com. (4)Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University School of Medicine, Taichung, Taiwan. cschen920@yahoo.com. (5)Department of Life Science, Tunghai University, Taichung, Taiwan. cschen920@yahoo.com. (6)Program in Tissue Engineering and Regenerative Medicine, College of Medicine, National Chung-Hsing University, Taichung, Taiwan. cschen920@yahoo.com. BACKGROUND: Although combining a low-protein diet (LPD) with oral nutritional supplements increases treatment adherence and nutritional status in patients with chronic kidney disease (CKD), the effect of this combination approach in older adults remains unclear. This study examined the impact of a 6% low-protein formula (6% LPF) with diet counseling in older adults with stage 3-5 CKD. METHODS: In this three-month randomized controlled study, 66 patients (eGFR < 60 mL/min/1.73 m2, non-dialysis, over 65 years of age) were randomly assigned to an intervention group (LPD plus a 6% LPF) or control group (LPD alone). The 6% LPF comprised 400 kcal, 6 g of protein, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and various micronutrients. All data were collected at baseline and after three months, including physical performance based on hand grip strength (HGS) and gait speed, nutritional status using Mini Nutritional Assessment-Short Form (MNA-SF) scores, body composition through bioelectrical impedance analysis, and dietary intake from 24-h dietary records. RESULTS: This study incorporated 47 participants (median age, 73; median eGFR, 36 ml/min/1.73 m2; intervention group: 24; control group: 23). The intervention group exhibited significant differences in HGS and gait speed, and micronutrient analysis revealed significantly higher monounsaturated fatty acids (MUFA), EPA, DHA, calcium, iron, zinc, copper, thiamine, riboflavin, niacin, B6, B12, and folic acid intake than the control group. MNA-SF scores, macronutrient intake, and body composition did not differ significantly between the two groups. CONCLUSIONS: Compared to LPD counseling alone, an LPD prescription with 6% LPF in older adults with CKD stages 3-5 helped relieve physical deterioration and increased micronutrient intake after three months. TRIAL REGISTRATION: ClinicalTrials.gov NCT05318014 (retrospectively registered on 08/04/2022). © 2023. The Author(s). DOI: 10.1186/s12882-023-03423-8 PMCID: PMC10720150 PMID: 38097963 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests.
15. Int J Med Sci. 2023 Aug 15;20(10):1272-1281. doi: 10.7150/ijms.86738. eCollection 2023. A functional evaluation of anti-fatigue and exercise performance improvement following vitamin B complex supplementation in healthy humans, a randomized double-blind trial. Lee MC(1), Hsu YJ(1), Shen SY(2), Ho CS(1), Huang CC(1)(3). Author information: (1)Graduate Institute of Sports Science, National Taiwan Sport University, Taoyuan City 333325, Taiwan. (2)Graduate Institute of Applied Science and Engineering, Fu-Jen Catholic University, New Taipei City, 242062, Taiwan. (3)Tajen University, Pingtung 907101, Taiwan. B vitamins play a crucial role in maintaining fundamental cellular functions and various essential metabolic pathways in the body. Although they do not directly provide energy, each B vitamin acts as a cofactor in energy metabolism processes. Based on the evidence presented above, we hypothesized that a 28-day supplementation of vitamin B would enhance physical performance and reduce physical fatigue. The objective of this study was to evaluate the anti-fatigue effect of vitamin B supplementation, specifically vitamin B1, B2, B6, and B12, and its potential to improve exercise performance. We employed a randomized double-blind crossover design with a 28-day supplementation period. Sixteen male and sixteen female subjects, aged 20-30 years, were divided into two groups: the placebo group (n=16, equal gender distribution) and the Ex PLUS® group (n=16, equal gender distribution). The participants received either placebo or Ex PLUS® (one tablet per day) for 28 consecutive days. Following the intervention, there was a 14-day wash-out period during which the subjects did not receive any further interventions. After supplementation with Ex PLUS®, we found a significant increase in the running time by 1.26-fold (p < 0.05) to exhaustion compared to that before supplementation and that in the placebo group. In addition, the Ex PLUS® supplementation group presented significantly reduced blood lactate and blood ammonia concentrations during exercise and at rest after exercise compared with placebo (p < 0.05). In conclusion, 28 consecutive days of vitamin B complex (Ex PLUS®) supplementation significantly improved exercise endurance performance and reduced exercise fatigue biochemical metabolites in not athletes. In addition, it does not cause adverse effects in humans when taken at appropriate doses. © The author(s). DOI: 10.7150/ijms.86738 PMCID: PMC10542023 PMID: 37786445 [Indexed for MEDLINE] Conflict of interest statement: Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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