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The Effect of Vitamin E Supplementation on Serum Aminotransferases in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis.

1. Nutrients. 2023 Aug 25;15(17):3733. doi: 10.3390/nu15173733. The Effect of Vitamin E Supplementation on Serum Aminotransferases in Non-Alcoholic Fatty Liver Disease (NAFLD): A Systematic Review and Meta-Analysis. Vogli S(1), Naska A(1), Marinos G(1), Kasdagli MI(1), Orfanos P(1). Author info

Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

2. Adv Nutr. 2023 Sep;14(5):1159-1169. doi: 10.1016/j.advnut.2023.06.006. Epub 2023 Jun 14. Effects of Tocotrienol-Rich Fraction Supplementation in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Phang SCW(1), Ahmad B(2), Abdul Kadir K(2), M

Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis.

3. Nutrients. 2022 Dec 21;15(1):14. doi: 10.3390/nu15010014. Vitamin E Intake and Risk of Prostate Cancer: A Meta-Analysis. Loh WQ(1), Youn J(1)(2), Seow WJ(1). Author information: (1)Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, 1

Interventional study with vitamin E in cardiovascular disease and meta-analysis.

4. Free Radic Biol Med. 2022 Jan;178:26-41. doi: 10.1016/j.freeradbiomed.2021.11.027. Epub 2021 Nov 25. Interventional study with vitamin E in cardiovascular disease and meta-analysis. Violi F(1), Nocella C(2), Loffredo L(2), Carnevale R(3), Pignatelli P(4). Author information: (1)Mediterranea C

Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials.

5. PLoS One. 2021 Jul 23;16(7):e0255205. doi: 10.1371/journal.pone.0255205. eCollection 2021. Effects of tocotrienols supplementation on markers of inflammation and oxidative stress: A systematic review and meta-analysis of randomized controlled trials. Khor BH(1)(2), Tiong HC(1), Tan SC(3), Won

The effects of tocotrienols intake on obesity, blood pressure, inflammation, liver and glucose biomarkers: a meta-analysis of randomized controlled trials.

6. Crit Rev Food Sci Nutr. 2022;62(26):7154-7167. doi: 10.1080/10408398.2021.1911926. Epub 2021 Apr 28. The effects of tocotrienols intake on obesity, blood pressure, inflammation, liver and glucose biomarkers: a meta-analysis of randomized controlled trials. Li F(1), Xu B(1), Soltanieh S(2), Za

The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials.

7. Complement Ther Med. 2020 Aug;52:102450. doi: 10.1016/j.ctim.2020.102450. Epub 2020 May 25. The effects of tocotrienol supplementation on lipid profile: A meta-analysis of randomized controlled trials. Zuo S(1), Wang G(1), Han Q(1), Xiao H(2), O Santos H(3), Avelar Rodriguez D(4), Khani V(5)

Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial.

8. Nutrients. 2025 Jun 30;17(13):2179. doi: 10.3390/nu17132179. Tocotrienol-Enriched Beverage Enhances Psychological Well-Being, Antioxidant Defense, and Genomic Stability in Older Adults: A Randomized Controlled Trial. Sharif R(1), Wai MK(1), Choon OT(2), Abdul Hafid SR(3), Lee TY(4). Author in

Reduction of disease activity in rheumatoid arthritis by tocotrienol-rich fraction supplementation: a randomized, double-blind, placebo-controlled trial.

9. Eur J Nutr. 2025 Jun 24;64(5):227. doi: 10.1007/s00394-025-03742-6. Reduction of disease activity in rheumatoid arthritis by tocotrienol-rich fraction supplementation: a randomized, double-blind, placebo-controlled trial. Zainal Z(1), Othman AZ(2), Rahim AA(3), Meganathan P(3), Radhakrishnan A

Effects of tocotrienol-enriched oat supplementation on metabolic profile, nutritional status and health-related quality of life among patients with metabolic syndrome.

10. Food Funct. 2025 Mar 3;16(5):1847-1863. doi: 10.1039/d4fo03307h. Effects of tocotrienol-enriched oat supplementation on metabolic profile, nutritional status and health-related quality of life among patients with metabolic syndrome. Norazman CW(1), Mohd Sopian M(2), Lee LK(1). Author inform

Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination.

11. F1000Res. 2024 Feb 22;13:135. doi: 10.12688/f1000research.137005.1. eCollection 2024. Single-centre, randomised clinical trial of the immunomodulatory mechanisms of daily supplementation of palm tocotrienol-rich fraction in healthy human volunteers following influenza vaccination. Radhakris

Assessing the efficacy of tocotrienol-rich fraction vitamin E in obese children with non-alcoholic fatty liver disease: a single-blind, randomized clinical trial.

12. BMC Pediatr. 2024 Aug 20;24(1):529. doi: 10.1186/s12887-024-04993-8. Assessing the efficacy of tocotrienol-rich fraction vitamin E in obese children with non-alcoholic fatty liver disease: a single-blind, randomized clinical trial. Al-Baiaty FDR(1), Ishak S(2), Mohd Zaki F(3), Masra F(2), Ab

Effects of long-term intake of carotenoid-enriched eggs on healthy people: a randomized controlled study.

13. Food Funct. 2024 Jul 1;15(13):7032-7045. doi: 10.1039/d4fo00910j. Effects of long-term intake of carotenoid-enriched eggs on healthy people: a randomized controlled study. Lu Y(1)(2), Hao YJ(3), Zhou X(4), Huang F(5), Li C(5), Wang J(4), Miao Z(6), Chen S(6), Zhang Y(2), Pan Z(2), Yin S(2),

Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study.

14. Acta Oncol. 2023 Sep;62(9):1066-1075. doi: 10.1080/0284186X.2023.2249225. Epub 2023 Aug 30. Delta tocotrienol as a supplement to FOLFOXIRI in first-line treatment of metastatic colorectal cancer. A randomized, double-blind, placebo-controlled phase II study. Raunkilde L(1)(2)(3), Hansen TF(

Randomised single centre double-blind placebo controlled phase II trial of Tocovid SupraBio in combination with pentoxifylline in patients suffering long-term gastrointestinal adverse effects of radiotherapy for pelvic cancer: The PPALM study.

15. Radiother Oncol. 2022 Mar;168:130-137. doi: 10.1016/j.radonc.2022.01.024. Epub 2022 Jan 29. Randomised single centre double-blind placebo controlled phase II trial of Tocovid SupraBio in combination with pentoxifylline in patients suffering long-term gastrointestinal adverse effects of radio

Tocotrienol-Rich Vitamin E (Tocovid) Improved Nerve Conduction Velocity in Type 2 Diabetes Mellitus Patients in a Phase II Double-Blind, Randomized Controlled Clinical Trial.

2. Nutrients. 2021 Oct 25;13(11):3770. doi: 10.3390/nu13113770. Tocotrienol-Rich Vitamin E (Tocovid) Improved Nerve Conduction Velocity in Type 2 Diabetes Mellitus Patients in a Phase II Double-Blind, Randomized Controlled Clinical Trial. Chuar PF(1), Ng YT(1), Phang SCW(1), Koay YY(1), Ho JI(1)

A double-blind randomised controlled trial on the effect of Tocovid, a tocotrienol-rich capsule on postoperative atrial fibrillation at the National Heart Institute, Kuala Lumpur: an interim blinded analysis.

13. J Cardiothorac Surg. 2021 Nov 24;16(1):340. doi: 10.1186/s13019-021-01721-6. A double-blind randomised controlled trial on the effect of Tocovid, a tocotrienol-rich capsule on postoperative atrial fibrillation at the National Heart Institute, Kuala Lumpur: an interim blinded analysis. Musa A

Novel Antioxidative Activity of Astaxanthin and Its Synergistic Effect with Vitamin E.

37. J Nutr Sci Vitaminol (Tokyo). 2019;65(Supplement):S109-S112. doi: 10.3177/jnsv.65.S109. Novel Antioxidative Activity of Astaxanthin and Its Synergistic Effect with Vitamin E. Kogure K(1). Author information: (1)Department of Pharmaceutical Health Chemistry, Institute of Biomedical Sciences

Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets.

17. J Cell Physiol. 2019 Feb;234(2):1147-1164. doi: 10.1002/jcp.27075. Epub 2018 Aug 1. Anticancer properties of tocotrienols: A review of cellular mechanisms and molecular targets. Montagnani Marelli M(1), Marzagalli M(1), Fontana F(1), Raimondi M(1), Moretti RM(1), Limonta P(1). Author infor

Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review.

17. Int J Mol Sci. 2016 Sep 22;17(10):1605. doi: 10.3390/ijms17101605. Synergistic Anticancer Effect of Tocotrienol Combined with Chemotherapeutic Agents or Dietary Components: A Review. Eitsuka T(1), Tatewaki N(2), Nishida H(3), Nakagawa K(4), Miyazawa T(5)(6). Author information: (1)Faculty of

The use of delta-tocotrienol and lovastatin for anti-osteoporotic therapy.

9. Life Sci. 2015 Mar 15;125:42-8. doi: 10.1016/j.lfs.2014.12.012. Epub 2014 Dec 20. The use of delta-tocotrienol and lovastatin for anti-osteoporotic therapy. Abdul-Majeed S(1), Mohamed N(2), Soelaiman IN(3). Author information: (1)Department of Life Sciences, School of Pharmacy, International

Alkaloid extracts of Ficus species and palm oil-derived tocotrienols synergistically inhibit proliferation of human cancer cells.

2. Nat Prod Res. 2015;29(22):2137-40. doi: 10.1080/14786419.2014.991927. Epub 2014 Dec 17. Alkaloid extracts of Ficus species and palm oil-derived tocotrienols synergistically inhibit proliferation of human cancer cells. Abubakar IB(1), Lim KH(2), Loh HS(1)(3). Author information: (1)a Faculty

Vitamin E-drug interactions: molecular basis and clinical relevance.

46. Nutr Res Rev. 2014 Dec;27(2):215-31. doi: 10.1017/S0954422414000146. Epub 2014 Sep 16. Vitamin E-drug interactions: molecular basis and clinical relevance. Podszun M(1), Frank J(1). Author information: (1)Institute of Biological Chemistry and Nutrition, University of Hohenheim,D-70599Stuttg

Tocotrienol-rich fraction, [6]-gingerol and epigallocatechin gallate inhibit proliferation and induce apoptosis of glioma cancer cells.

2. Molecules. 2014 Sep 12;19(9):14528-41. doi: 10.3390/molecules190914528. Tocotrienol-rich fraction, [6]-gingerol and epigallocatechin gallate inhibit proliferation and induce apoptosis of glioma cancer cells. Rahman AA(1), Makpol S(2), Jamal R(3), Harun R(3), Mokhtar N(3), Ngah WZ(4). Author i

Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK.

45. BMC Complement Altern Med. 2014 Aug 16;14:303. doi: 10.1186/1472-6882-14-303. Polysaccharopeptide enhanced the anti-cancer effect of gamma-tocotrienol through activation of AMPK. Liu J, Lau EY, Chen J, Yong J, Tang KD, Lo J, Ng IO, Lee TK(1), Ling MT. Author information: (1)Australian Prosta

Finding of synergistic and cancel effects on the aroxyl radical-scavenging rate and suppression of prooxidant effect for coexistence of α-tocopherol with β-, γ-, and δ-tocopherols (or -tocotrienols).

35. J Agric Food Chem. 2014 Aug 13;62(32):8101-13. doi: 10.1021/jf502049k. Epub 2014 Jul 30. Finding of synergistic and cancel effects on the aroxyl radical-scavenging rate and suppression of prooxidant effect for coexistence of α-tocopherol with β-, γ-, and δ-tocopherols (or -tocotrienols). Ou

Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation.

2. PLoS One. 2013 Jul 22;8(7):e68762. doi: 10.1371/journal.pone.0068762. Print 2013. Effects of late administration of pentoxifylline and tocotrienols in an image-guided rat model of localized heart irradiation. Sridharan V(1), Tripathi P, Sharma S, Corry PM, Moros EG, Singh A, Compadre CM, Hau

Rice Bran Consumption Improves Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

29. Nutrients. 2024 Dec 30;17(1):114. doi: 10.3390/nu17010114. Rice Bran Consumption Improves Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Park SY(1), Kim Y(1), Park MJ(1), Kim JY(1). Author information: (1)Department of Food Science and Biotechnology, S

Daily supplementation of tocotrienol-rich fraction or alpha-tocopherol did not induce immunomodulatory changes in healthy human volunteers.

46. Br J Nutr. 2009 Mar;101(6):810-5. doi: 10.1017/S0007114508039998. Daily supplementation of tocotrienol-rich fraction or alpha-tocopherol did not induce immunomodulatory changes in healthy human volunteers. Radhakrishnan AK(1), Lee AL, Wong PF, Kaur J, Aung H, Nesaretnam K. Author information

Vitamin E and cognitive function: A systematic review of clinical evidence.

14. Nutr Res. 2026 Jan;145:66-86. doi: 10.1016/j.nutres.2025.11.009. Epub 2025 Nov 24. Vitamin E and cognitive function: A systematic review of clinical evidence. Amin AM(1), Mostafa H(2). Author information: (1)Department of Clinical Pharmacy, Faculty of Pharmacy, Tokat Gaziosmanpaşa Universit