쐐기풀
Stinging Nettle
📚 관련 논문 (25편)
1. Am J Nephrol. 2014;40(5):393-8. doi: 10.1159/000368724. Epub 2014 Nov 6. Internet claims on dietary and herbal supplements in advanced nephropathy: truth or myth. Vamenta-Morris H(1), Dreisbach A, Shoemaker-Moyle M, Abdel-Rahman EM. Author information: (1)University of Virginia Health System,
2. Ann Allergy Asthma Immunol. 2004 Aug;93(2 Suppl 1):S45-54. doi: 10.1016/s1081-1206(10)61486-x. Complementary and alternative interventions in asthma, allergy, and immunology. Bielory L(1). Author information: (1)Department of Medicine, Pediatrics, and Ophthalmology, Division of Allergy, Immu
3. Cochrane Database Syst Rev. 2013 May 31;2013(5):CD010538. doi: 10.1002/14651858.CD010538. Topical herbal therapies for treating osteoarthritis. Cameron M(1), Chrubasik S. Author information: (1)School ofHealth and Sport Sciences,University of the SunshineCoast,MaroochydoreDC, Australia. mcam
1. Crit Rev Food Sci Nutr. 2013;53(5):507-16. doi: 10.1080/10408398.2012.691916. Plant food supplements with anti-inflammatory properties: a systematic review (II). Di Lorenzo C(1), Dell'Agli M, Badea M, Dima L, Colombo E, Sangiovanni E, Restani P, Bosisio E. Author information: (1)Department of Pharmacological and Biomolecular Sciences, Universit`a degli Studi di Milano, Via Balzaretti 9, Milano, Italy. The aim of this systematic review is to summarize the evidence for or against the efficacy of plant food supplements (PFS) for coping inflammatory conditions by considering epidemiological and human intervention studies. The review considers six botanical species commonly used as food supplements/medicinals: Urtica dioica L., Symphytum officinalis L., Calendula officinalis L., Curcuma longa L., Boswellia serrata Roxb., and Harpagophytum procumbens L. The search retrieved 579 publications. By removing the duplicates and applying the inclusion/exclusion criteria, the final number of papers was 47. No epidemiological data were found. The bibliographic search found no paper regarding the anti-inflammatory effects of Calendula officinalis L. and Symphytum officinalis L. by oral use. In spite of the long-term traditional use for inflammatory disorders, Curcuma longa L. and Harpagophytum procumbens L. warrant further investigation, whereas the efficacy of Urtica dioica L, even if the available data on hard endpoints are promising, requires other trials. Boswellia serrata Roxb. was found to be the most promising, since it shows the best efficacy for the treatment of pain/inflammatory conditions. In conclusion, it is advisable to conduct further studies with more homogeneous population and larger number of subjects by avoiding the heterogeneity of the herbal preparations considered. DOI: 10.1080/10408398.2012.691916 PMID: 23391017 [Indexed for MEDLINE]
2. Pediatr Hematol Oncol. 2012 May;29(4):335-44. doi: 10.3109/08880018.2012.670368. Use of complementary and alternative medicine in children with cancer: effect on survival. Karalı Y(1), Demirkaya M, Sevinir B. Author information: (1)Department of Pediatrics, Uludag University, Medical Faculty, Bursa, Turkey. The objective of the present study was to determine the type, frequency, the reason why complementary and alternative medicine (CAM) treatments are used, the factors related with their use, and the effects of CAM usage on long-term survival. Families of a total of 120 children with cancer between 0-18 years of age, including 50 (41.7%) girls and 70 (58.3%) boys, participated in our study. The authors found that 88 patients (73.3%) used at least one CAM method, the most common (95.5%) of which was biologically based therapies. Most frequently used biologically based therapies were dietary supplements and herbal products. The most commonly used dietary supplement or herbal product was honey (43.2%) or stinging nettle (43.2%), respectively. We found that patients used such CAM methods as complementary to, but not instead of, conventional therapy. Sixty-nine out of 88 patient families (78.4%) shared the CAM method they used with their physicians. No statistically significant relation was found between socioeconomic, sociodemographic, or other factors or items and CAM use. The mean follow-up period of the CAM users and nonusers groups was 79.4 ± 36.7 (21.3-217.9) and 90.9 ± 50.3 (27.4-193.7) months, respectively. Five-year survival rates for CAM users and nonusers were found as 81.5% and 86.5%, respectively (P > .05). In conclusion, families of children with cancer use complementary and alternative treatment frequently. They do not attempt to replace conventional treatment with CAM. Higher rates of CAM use was found in families with higher educational level. CAM usage did not affect the long-term survival. DOI: 10.3109/08880018.2012.670368 PMID: 22568796 [Indexed for MEDLINE]
3. Arthritis Res Ther. 2010;12(1):105. doi: 10.1186/ar2909. Epub 2010 Feb 8. Is Phytalgic(R) a goldmine for osteoarthritis patients or is there something fishy about this nutraceutical? A summary of findings and risk-of-bias assessment. Christensen R, Bliddal H. Comment on Arthritis Res Ther. 2009;11(6):R192. doi: 10.1186/ar2891. A food supplement containing fish oils, urtica dioica, zinc, and vitamin E (Phytalgic) for osteoarthritis (OA) has now been tested in a placebo-controlled trial for 3 months and according to the authors has a very large clinical effect, considerably larger than that of any other known product. Even experts endorsing nutraceuticals for OA symptoms would probably agree that a nutraceutical with an effect size above 0.5 is rarely seen. Despite our concerns about the fact that trial registration took place after the study was completed and the likelihood that patients would note the taste of fish, a circumstance that would lead to detection bias, we consider these data promising though with a high risk of bias. DOI: 10.1186/ar2909 PMCID: PMC2875636 PMID: 20156334 [Indexed for MEDLINE]
4. Arthritis Res Ther. 2009;11(6):R192. doi: 10.1186/ar2891. Epub 2009 Dec 16. Phytalgic, a food supplement, vs placebo in patients with osteoarthritis of the knee or hip: a randomised double-blind placebo-controlled clinical trial. Jacquet A(1), Girodet PO, Pariente A, Forest K, Mallet L, Moore N. Author information: (1)Department of Pharmacology, University of Bordeaux, 146 rue Léo Saignat, 33076, Bordeaux, France. docteur.alain.jacquet@wanadoo.fr Comment in Arthritis Res Ther. 2010;12(1):105. doi: 10.1186/ar2909. INTRODUCTION: The medicinal treatment of osteoarthritis (OA) is mostly symptomatic to relieve pain and incapacity with analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), drugs with well-known risks. Complementary medicines might reduce the symptoms of OA and decrease the need for NSAIDs. This study tested the effects of a food supplement, Phytalgic, on pain and function in patients with osteoarthritis and their use of analgesic and NSAIDs. METHODS: A randomized double-blind parallel-groups clinical trial compared Phytalgic (fish-oil, vitamin E, Urtica dioica) to a placebo for three months, in 81 patients with OA of the knee or hip using NSAIDs and/or analgesics regularly. The main outcome measures were use of NSAIDs (in Defined Daily Doses per day - DDD/day) or analgesics (in 500 mg paracetamol-equivalent tablets per week (PET/week) measured each month, and Western Ontario-McMaster University Osteo-Arthritis Index (WOMAC) function scales. RESULTS: After three months of treatment, the mean use of analgesics in the active arm (6.5 PET/week) vs. the placebo arm (16.5) was significantly different (P < 0.001) with a group mean difference of -10.0 (95% CI: -4.9 to -15.1). That of NSAIDs in the active arm (0.4 DDD/day) vs the placebo arm (1.0 DDD/day) was significantly different (P = 0.02) with a group mean difference of - 0.7 DDD/day (95% CI: -0.2 to -1.2). Mean WOMAC scores for pain, stiffness and function in the active arm (respectively 86.5, 41.4 and 301.6) vs the placebo arm (resp. 235.3, 96.3 and 746.5) were significantly different (P < 0.001) with group mean differences respectively of -148.8 (95% CI: -97.7 to -199.9), -54.9 (95% CI: -27.9 to -81.9) and -444.8 (95% CI: -269.1 to -620.4). CONCLUSIONS: The food supplement tested appeared to decrease the need for analgesics and NSAIDs and improve the symptoms of osteoarthritis. TRIAL REGISTRATION: Clinicaltrials.gov NCT00666523. DOI: 10.1186/ar2891 PMCID: PMC3003499 PMID: 20015358 [Indexed for MEDLINE]
5. Front Pharmacol. 2022 Jun 8;13:821810. doi: 10.3389/fphar.2022.821810. eCollection 2022. Effectiveness and Safety of Ayurvedic Medicines in Type 2 Diabetes Mellitus Management: A Systematic Review and Meta-Analysis. Chattopadhyay K(1)(2), Wang H(1), Kaur J(1), Nalbant G(1), Almaqhawi A(3), Kundakci B(1), Panniyammakal J(4), Heinrich M(5), Lewis SA(1), Greenfield SM(6), Tandon N(7), Biswas TK(8), Kinra S(9), Leonardi-Bee J(1)(2). Author information: (1)Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom. (2)The Nottingham Centre for Evidence-Based Healthcare: A JBI Centre of Excellence, Nottingham, United Kingdom. (3)Department of Family and Community Medicine, College of Medicine, King Faisal University, Alahsa, Saudi Arabia. (4)Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, India. (5)Centre for Pharmacognosy and Phytotherapy, School of Pharmacy, University College London, London, United Kingdom. (6)Institute of Applied Health Research, University of Birmingham, Birmingham, United Kingdom. (7)Department of Endocrinology, Metabolism and Diabetes, All India Institute of Medical Sciences, New Delhi, India. (8)Department of Kayachikitsa, J B Roy State Ayurvedic Medical College and Hospital, Kolkata, India. (9)Department of Non-communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom. Introduction: Many Ayurvedic medicines have the potential for managing type 2 diabetes mellitus (T2DM), with previous systematic reviews demonstrating effectiveness and safety for specific Ayurvedic medicines. However, many of the reviews need updating and none provide a comprehensive summary of all the Ayurvedic medicines evaluated for managing T2DM. Objective: The objective of this systematic review was to evaluate and synthesize evidence on the effectiveness and safety of Ayurvedic medicines for managing T2DM. Inclusion criteria: Published and unpublished RCTs assessing the effectiveness and safety of Ayurvedic medicines for managing T2DM in adults. Methods: The JBI systematic review methodology was followed. A comprehensive search of sources (including 18 electronic databases) from inception to 16 January 2021 was made. No language restrictions were applied. Data synthesis was conducted using narrative synthesis and random effects meta-analyses, where appropriate. Pooled results are reported as mean differences (MD) with 95% confidence intervals (CI). Results: Out of 32,519 records identified from the searches, 219 articles were included in the systematic review representing 199 RCTs (21,191 participants) of 98 Ayurvedic medicines. Overall, in the studies reviewed the methodology was not adequately reported, resulting in poorer methodological quality scoring. Glycated hemoglobin (HbA1c) was reduced using Aegle marmelos (L.) Corrêa (MD -1.6%; 95% CI -3 to -0.3), Boswellia serrata Roxb. (-0.5; -0.7 to -0.4), Gynostemma pentaphyllum (Thunb.) Makino (-1; -1.5 to -0.6), Momordica charantia L. (-0.3; -0.4 to -0.1), Nigella sativa L. (-0.4; -0.6 to -0.1), Plantago ovata Forssk. (-0.9; -1.4 to -0.3), Tinospora cordifolia (Willd.) Hook.f. and Thomson (-0.5; -0.6 to -0.5), Trigonella foenum-graecum L. (-0.6; -0.9 to -0.4), and Urtica dioica L. (-1.3; -2.4 to -0.2) compared to control. Similarly, fasting blood glucose (FBG) was reduced by 4-56 mg/dl for a range of Ayurvedic medicines. Very few studies assessed health-related quality of life (HRQoL). Adverse events were not reported in many studies, and if reported, these were mostly none to mild and predominately related to the gastrointestinal tract. Conclusion: The current evidence suggests the benefit of a range of Ayurvedic medicines in improving glycemic control in T2DM patients. Given the limitations of the available evidence and to strengthen the evidence base, high-quality RCTs should be conducted and reported. Copyright © 2022 Chattopadhyay, Wang, Kaur, Nalbant, Almaqhawi, Kundakci, Panniyammakal, Heinrich, Lewis, Greenfield, Tandon, Biswas, Kinra and Leonardi-Bee. DOI: 10.3389/fphar.2022.821810 PMCID: PMC9213670 PMID: 35754481 Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor AS and reviewer ONP declared a past co-authorship with the author MH.
6. Mini Rev Med Chem. 2022;22(3):550-563. doi: 10.2174/1389557521666210929143112. Effects of Urtica dioica on Metabolic Profiles in Type 2 Diabetes: A Systematic Review and Meta-analysis of Clinical Trials. Tabrizi R(1)(2), Sekhavati E(3), Nowrouzi-Sohrabi P(4)(5), Rezaei S(4)(6), Tabari P(7), Ghoran SH(8)(9), Jamali N(5), Jalali M(10), Moosavi M(7), Kolahi AA(11), Bettampadi D(12), Sahebkar A(13)(14), Safiri S(15)(16)(17). Author information: (1)Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. (2)Clinical Research Development Unit of Vali Asr Hospital, Fasa University of Medical Sciences, Fasa, Iran. (3)Larestan University of Medical Sciences, Larestan, Fars, Iran. (4)Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. (5)Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. (6)Department of Clinical Nutrition, School of Health & Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran. (7)Clinical Education Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. (8)Department of Chemistry, Faculty of Basic Sciences, Golestan University, Gorgan, Iran. (9)Department of Medical Nanotechnology, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran. (10)Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. (11)Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. (12)Center for Immunization and Infection Research in Cancer (CIIRC), H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. (13)Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. (14)Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran | School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. (15)Research Center for Integrative Medicine in Aging, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran. (16)Department of Community Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. (17)Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. BACKGROUND: Several studies have investigated the effect of Urtica dioica (UD) consumption on metabolic profiles in patients with type 2 diabetes mellitus (T2DM); however, the findings are inconsistent. This systematic review and meta-analysis of clinical trials were performed to summarize the evidence of the effects of UD consumption on metabolic profiles in patients with T2DM. METHODS: Eligible studies were retrieved from searches of PubMed, Embase, Scopus, Web of Science, Cochrane Library, and Google Scholar databases until December 2019. Cochran (Q) and I-square statistics were used to examine heterogeneity across included clinical trials. Data were pooled using a fixed-effect or random-effects model and expressed as weighted mean difference (WMD) and 95% confidence interval (CI). RESULTS: Among 1485 citations, thirteen clinical trials were found to be eligible for the current metaanalysis. UD consumption significantly decreased levels of fasting blood glucose (FBG) (WMD = - 17.17 mg/dl, 95% CI: -26.60, -7.73, I2 = 93.2%), hemoglobin A1c (HbA1c) (WMD = -0.93, 95% CI: - 1.66, -0.17, I2 = 75.0%), C-reactive protein (CRP) (WMD = -1.09 mg/dl, 95% CI: -1.64, -0.53, I2 = 0.0%), triglycerides (WMD = -26.94 mg/dl, 95 % CI = [-52.07, -1.82], P = 0.03, I2 = 90.0%), systolic blood pressure (SBP) (WMD = -5.03 mmHg, 95% CI = -8.15, -1.91, I2 = 0.0%) in comparison to the control groups. UD consumption did not significantly change serum levels of insulin (WMD = 1.07 μU/ml, 95% CI: -1.59, 3.73, I2 = 63.5%), total-cholesterol (WMD = -6.39 mg/dl, 95% CI: -13.84, 1.05, I2 = 0.0%), LDL-cholesterol (LDL-C) (WMD = -1.30 mg/dl, 95% CI: -9.95, 7.35, I2 = 66.1%), HDL-cholesterol (HDL-C) (WMD = 6.95 mg/dl, 95% CI: -0.14, 14.03, I2 = 95.4%), body max index (BMI) (WMD = -0.16 kg/m2, 95% CI: -1.77, 1.44, I2 = 0.0%), and diastolic blood pressure (DBP) (WMD = -1.35 mmHg, 95% CI: -2.86, 0.17, I2= 0.0%) among patients with T2DM. CONCLUSION: UD consumption may result in an improvement in levels of FBS, HbA1c, CRP, triglycerides, and SBP, but did not affect levels of insulin, total-, LDL-, and HDL-cholesterol, BMI, and DBP in patients with T2DM. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. DOI: 10.2174/1389557521666210929143112 PMID: 34587883 [Indexed for MEDLINE]
7. Phytother Res. 2020 Feb;34(2):282-294. doi: 10.1002/ptr.6535. Epub 2019 Dec 4. The effect of nettle (Urtica dioica) supplementation on the glycemic control of patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Ziaei R(1), Foshati S(2), Hadi A(3), Kermani MAH(2), Ghavami A(2), Clark CCT(4), Tarrahi MJ(5). Author information: (1)Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. (2)Student Research Committee, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. (3)Halal Research Center of IRI, FDA, Tehran, Iran. (4)Faculty Research Centre for Sport, Exercise and Life Sciences, Coventry University, Coventry, UK. (5)Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran. Type 2 diabetes mellitus (T2DM) is a major health problem, worldwide, that is associated with increased morbidity and mortality. Several randomized controlled clinical trials (RCTs) have investigated the effect of nettle (Urtica dioica) supplementation on markers of glycemic status in patients with T2DM, with conflicting results. Therefore, the present study assessed the effect of nettle on some glycemic parameters in patients with T2DM. A comprehensive search was conducted in PubMed, Scopus, Cochrane Library, and Web of Science, from database inception up to June 2019, to identify RCTs investigating the effect of nettle supplementation on glycemic markers, including fasting blood sugar (FBS) concentrations, insulin levels, homeostasis model assessment-estimated insulin resistance index, and glycosylated hemoglobin percentage in adults with T2DM. The Cochrane Collaboration tool was used to assess the methodological quality of the included studies. Results of this meta-analysis were reported based on the random effects model. Eight RCTs, comprising 401 participants, were included in the present systematic review and meta-analysis. Based on the Cochrane Collaboration risk of bias tool, five studies were considered as good quality, one was fair, and two studies were poor, respectively. The results of the meta-analysis revealed a significant reduction in FBS concentrations (weighted mean difference [WMD]: -18.01 mg/dl, 95% confidence interval [CI]: -30.04 to -5.97, p < .001, I2 = 94.6%) following nettle supplementation. However, no significant reduction was observed in insulin levels (WMD: 0.83 Hedges' g, 95% CI: -0.26 to 1.92, p = .13, I2 = 89.4%), homeostasis model assessment-estimated insulin resistance index (WMD: -0.22, 95% CI: -0.83 to 0.40, p = .49, I2 = 69.2%), or glycosylated hemoglobin percentage (WMD: -0.77%, 95% CI: -1.77 to 0.22, p = .12, I2 = 83.0%). The findings of the present study suggest that nettle supplementation may be effective in controlling FBS for T2DM patients. However, further studies are needed to confirm the veracity of these results. © 2019 John Wiley & Sons, Ltd. DOI: 10.1002/ptr.6535 PMID: 31802554 [Indexed for MEDLINE]
8. Public Health Nutr. 2000 Dec;3(4A):459-72. doi: 10.1017/s1368980000000549. Phytotherapy for benign prostatic hyperplasia. Wilt TJ(1), Ishani A, Rutks I, MacDonald R. Author information: (1)Minneapolis VA Center for Chronic Diseases Outcomes Research, MN 55417, USA. wilt.timothy@minneapolis.va.gov OBJECTIVE: To systematically review the existing evidence regarding the efficacy and safety of phytotherapeutic compounds used to treat men with symptomatic benign prostatic hyperplasia (BPH). DESIGN: Randomized trials were identified searching MEDLINE (1966--1997), EMBASE, Phytodok, the Cochrane Library, bibliographies of identified trials and review articles, and contact with relevant authors and drug companies. The studies were included if men had symptomatic benign prostatic hyperplasia, the intervention was a phytotherapeutic preparation alone or combined, a control group received placebo or other pharmacologic therapies for BPH, and the treatment duration was at least 30 days. Key data were extracted independently by two investigators. RESULTS: A total of 44 studies of six phytotherapeutic agents (Serenoa repens, Hypoxis rooperi, Secale cereale, Pygeum africanum, Urtica dioica, Curcubita pepo) met inclusion criteria and were reviewed. Many studies did not report results in a method allowing meta-analysis. Serenoa repens, extracted from the saw palmetto, is the most widely used phytotherapeutic agent for BPH. A total of 18 trials involving 2939 men were reviewed. Compared with men receiving placebo, men taking Serenoa repens reported greater improvement of urinary tract symptoms and flow measures. Serenoa repens decreased nocturia (weighted mean difference (WMD) = -0.76 times per evening; 95% CI = -1.22 to -0.32; n = 10 studies) and improved peak urine flow (WMD = 1.93 ml s(-1); 95% CI = 0.72 to 3.14, n = 8 studies). Men treated with Serenoa repens rated greater improvement of their urinary tract symptoms versus men taking placebo (risk ratio of improvement = 1.72; 95% CI = 1.21 to 2.44, n = 8 studies). Improvement in symptoms of BPH was comparable to men receiving the finasteride. Hypoxis rooperi (n = 4 studies, 519 men) was also demonstrated to be effective in improving symptom scores and flow measures compared with placebo. For the two studies reporting the International Prostate Symptom Score, the WMD was -4.9 IPSS points (95% CI = -6.3 to -3.5, n = 2 studies) and the WMD for peak urine flow was 3.91 ml s(-1) (95% CI = 0.91 to 6.90, n = 4 studies). Secale cereale (n = 4 studies, 444 men) was found to modestly improve overall urological symptoms. Pygeum africanum (n = 17 studies, 900 men) may be a useful treatment option for BPH. However, review of the literature has found inadequate reporting of outcomes which currently limit the ability to estimate its safety and efficacy. The studies involving Urtica dioica and Curcubita pepo are limited although these agents may be effective combined with other plant extracts such as Serenoa and Pygeum. Adverse events due to phytotherapies were reported to be generally mild and infrequent. CONCLUSIONS: Randomized studies of Serenoa repens, alone or in combination with other plant extracts, have provided the strongest evidence for efficacy and tolerability in treatment of BPH in comparison with other phytotherapies. Serenoa repens appears to be a useful option for improving lower urinary tract symptoms and flow measures. Hypoxis rooperi and Secale cereale also appear to improve BPH symptoms although the evidence is less strong for these products. Pygeum africanum has been studied extensively but inadequate reporting of outcomes limits the ability to conclusively recommend it. There is no convincing evidence supporting the use of Urtica dioica or Curcubita pepo alone for treatment of BPH. Overall, phytotherapies are less costly, well tolerated and adverse events are generally mild and infrequent. Future randomized controlled trials using standardized preparations of phytotherapeutic agents with longer study durations are needed to determine their long-term effectiveness in the treatment of BPH. DOI: 10.1017/s1368980000000549 PMID: 11276294 [Indexed for MEDLINE]
9. Emerg Med J. 2024 Oct 23;41(11):691-693. doi: 10.1136/emermed-2024-213915. Nettle-induced Urticaria Treatment Study (NUTS): demonstrating the joy of research through a randomised, blinded, placebo-controlled trial. Raman R(1), Beddis T(2), Bonhomme P(2), Currer M(2), Day D(2), Haigh C(2), Pitt E(2), Robertson A(2), Robertson H(2), Roy B(2), Wood J(2). Author information: (1)Emergency Department, Victoria Hospital, NHS Fife, Kirkcaldy, UK rajendra.raman@nhs.scot. (2)Emergency Department, Victoria Hospital, NHS Fife, Kirkcaldy, UK. The use of dock leaves to ease the discomfort of nettle stings is a well-known folk remedy in the British Isles, yet has never been tested in a clinical trial. A group of Emergency Department doctors designed and conducted the Nettle-induced Urticaria Treatment Study (NUTS) as a research training and team-building exercise to address this gap in the Emergency Medicine evidence base. © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ. DOI: 10.1136/emermed-2024-213915 PMID: 39074965 [Indexed for MEDLINE] Conflict of interest statement: Competing interests: None declared.
10. Sultan Qaboos Univ Med J. 2024 May;24(2):209-215. doi: 10.18295/squmj.3.2024.022. Epub 2024 May 27. Comparison of the Effect of Cumin Cyminum and Nettle Oral Drops on the Breast Milk Sufficiency Indicators in New Mothers. Farshad F(1), Sahebzad ES(2)(3), Kheirkhah M(3), Khani MS(3), Azmoude E(4). Author information: (1)School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran. (2)Department of Midwifery and Reproductive Health, School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. (3)Midwifery & Reproductive Health, Iran University of Medical Sciences, Tehran, Iran. (4)Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran. OBJECTIVES: This study aimed to compare the effects of green cumin (Cuminum cyminum) and nettle (Urtica dioica L.) oral drops on the indicators of breast milk adequacy in lactating mothers. Due to the presence of phytoestrogens in the combinations of cumin and nettle, it is stipulated that they may have milk-increasing properties. METHODS: A triple-blind, randomised, controlled clinical trial was conducted on 117 lactating mothers who had given birth to healthy infants aged 10-15 days and who received cumin oral drops (n = 39), nettle oral drops (n = 39) or placebo (n = 39) from August 2020 to March 2021. The participants were recruited from a regional public health care centre affiliated with Iran University of Medical Sciences of Tehran, Tehran, Iran. The 3 study groups received 15 drops thrice a day for 4 weeks. Infant weight, breastfeeding frequency, number of wet diapers, diaper weight and frequency of infant defecation were evaluated before and after the intervention. RESULTS: At the beginning of the trial, no statistically significant differences were observed between the 3 groups for infant weight (P = 0.891), breastfeeding frequency (P = 0.921), number of wet diapers (P = 0.783), diaper weight (P = 0.841) and frequency of infant defecation (P = 0.898). However, following the intervention, the mean scores of all indicators were significantly higher in the experimental groups than in the placebo group (P <0.001). In addition, all the indicators in the cumin group increased significantly compared to those in the nettle group (P <0.001). CONCLUSION: Considering the effectiveness of cumin and nettle drops in increasing milk and the availability of these native plants in Iran, it is suggested that they, especially cumin, be used postpartum to increase breast milk production. © Copyright 2024, Sultan Qaboos University Medical Journal, All Rights Reserved. DOI: 10.18295/squmj.3.2024.022 PMCID: PMC11139373 PMID: 38828258 [Indexed for MEDLINE] Conflict of interest statement: CONFLICTS OF INTEREST: The authors declare no conflict of interest.
11. Clin Pract. 2024 Jan 23;14(1):188-197. doi: 10.3390/clinpract14010016. Phytotherapy Might Have a Role in Reducing Unnecessary Prostate Biopsies: Results from an Exploratory, Randomized Controlled Trial of Two Different Phytotherapeutic Agents. Cai T(1)(2), Tamanini I(1), Puglisi M(1), Bizzotto L(3), Rizzo M(4), Liguori G(4), Gallelli L(5), Palmieri A(6), Bjerklund Johansen TE(2)(7)(8). Author information: (1)Department of Urology, Santa Chiara Regional Hospital, 38122 Trento, Italy. (2)Institute of Clinical Medicine, University of Oslo, 0313 Oslo, Norway. (3)Centro Servizi Sanitari (CST), 38121 Trento, Italy. (4)Department of Urology, University of Trieste, 34127 Trieste, Italy. (5)Department of Health Science, School of Medicine, University of Catanzaro, 88100 Catanzaro, Italy. (6)Department of Urology, University of Naples Federico II, 80138 Naples, Italy. (7)Department of Urology, Oslo University Hospital, 0450 Oslo, Norway. (8)Institute of Clinical Medicine, University of Aarhus, 8000 Aarhus, Denmark. BACKGROUND: We aimed to evaluate the impact of two different phytotherapeutic agents on decision making regarding prostate biopsy for patients with higher-than-normal prostate-specific antigen (PSA) levels. METHODS: From June 2022 to May 2023, all patients attending two urological institutions due to higher-than-normal PSA levels were randomized to receive either oral capsules of Curcuma Longa, Boswellia, Pinus pinaster and Urtica dioica (Group A) or Serenoa Repens 320 mg (Group B) for 3 months. At the follow-up visit after 3 months, all patients underwent PSA tests and multiparametric magnetic resonance imaging (mpMRI). RESULTS: In the per-protocol analysis, data from 66 patients in Group A and 76 in Group B were analyzed. Fifty patients in Group A (75.7%) showed a significant reduction in total PSA compared to forty-nine in Group B (64.4%) (p < 0.001). Twenty-eight patients had PI-RADS III or higher in mpMRI: twelve in Group A and fourteen in Group B. Twenty-three patients (34.8%) in Group A and fifty-nine (77.6%) in Group B (p < 0.001) underwent prostate biopsy based on the mpMRI findings and PSA values. Three patients in Group A showed a significant reduction in total PSA values while having positive mpMRI findings (6%) compared with nine in Group B (19.5%) (p < 0.001). On the contrary, 7 patients in Group A did not show significant reduction in total PSA values and had negative mpMRI findings (43%) compared to 22 in Group B (81.4%) (p < 0.001). CONCLUSIONS: In conclusion, a three-month course of a combination of Curcuma Longa, Boswellia, Pinus pinaster and Urtica dioica seems to be an interesting tool to avoid unnecessary prostate biopsies among men with higher-than-normal PSA levels. DOI: 10.3390/clinpract14010016 PMCID: PMC10888467 PMID: 38391402 Conflict of interest statement: The authors declare no conflicts of interest.
12. Arch Razi Inst. 2022 Aug 31;77(4):1371-1375. doi: 10.22092/ARI.2022.358133.2159. eCollection 2022 Aug. Effect of Supplementation of Different Levels of Urtica dioica Seeds to the Diet on the Immune Response and Microbial Composition of the Gastrointestinal Tract of Broiler Chickens. Jaafar Abed R(1), Abdul-Lateef Ali N(2). Author information: (1)College of Education for Pure Sciences, Wasit University, Wasit. Iraq. (2)College of Agriculture, AL-Qasim Green University, Babylon, Iraq. This experiment was conducted in the poultry field of the Department of Animal Production, College of Agriculture, Al-Qasim Green University in order to assess the effect of adding different levels of Urtica dioica seeds to the diet on the immune response and microbial composition of the gastrointestinal tract of broiler chickens. This study was performed on 180 one-day-old unsexed broiler chickens (Ross 380) which were randomly divided into four treatments, with 45 birds per treatment and 3 replicates in each treatment (15 birds per replicate). The treatments were conducted as follows: First treatment (control) without the addition of Urtica dioica seeds to the diet, second treatment: the addition of 5g/kg Urtica dioica seeds, third treatment: the addition of 10g/kg Urtica dioica seeds, and treatment Fourth: the addition of 15g/kg Urtica dioica seeds. The experiment included the following traits: antibody titer against Newcastle disease, investigating sensitivity against Newcastle disease, the relative weight of bursa of Fabricius, bursa of Fabricius index, as well as estimating the total number of bacteria, Coliform bacteria, and Lactobacillus bacteria. The results indicated that the addition of Urtica dioica seeds led to significant improvement in cellular immunity (DHT) and antibody titer against Newcastle disease (ELISA), as well as significant improvement in the relative weight of bursa of Fabricius and bursa of Fabricius index, a significant decrease in the logarithmic number of total aerobic bacteria and Coliform bacteria, as well as a significant increase in the logarithmic number of Lactobacillus bacteria in the Duodenum contents for the small intestine and the Ceca, compared to the control treatment. Based on the obtained results, it can be concluded that the addition of Urtica dioica seeds to the diet can improve the immune traits and microbial compositions of the digestive tract of broiler chickens. DOI: 10.22092/ARI.2022.358133.2159 PMCID: PMC9985781 PMID: 36883160 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have no conflict of interest.
13. Clin Otolaryngol. 2023 Mar;48(2):151-157. doi: 10.1111/coa.13989. Epub 2022 Dec 5. Therapeutic effects of Rosa canina, Urtica dioica and Tanacetum vulgare herbal combination in treatment of tinnitus symptoms: A double-blind randomised clinical trial. Khosravi MH(1), Atefi A(2), Mehri A(3), Sodeifian F(4), Yousefi J(5), Bagheri Hagh A(5), Sohrabpour S(6), Kazemi F(7), Ajalloueian M(8), Saeedi M(8). Author information: (1)Department of Research, Arka Education and Clinical Research Consultants, Tehran, Iran. (2)Student Research Committee, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. (3)Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran. (4)Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran. (5)Department of Otorhinolaryngology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. (6)Otorhinolaryngology Research Center, Tehran University of Medical Sciences, Tehran, Iran. (7)Student Research Committee, Qazvin University of Medical Sciences, Qazvin, Iran. (8)New Hearing Technologies Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. OBJECTIVE: To evaluate the effect of Neurotec® herbal capsule (100 mg twice a day for 3 months) on the tinnitus symptoms in comparison with the placebo. DESIGN: A double-blind randomised clinical trial. SETTING: Otolaryngology clinic of Baqiyatallah Hospital. PARTICIPANTS: Patients suffering from subjective tinnitus. MAIN OUTCOME MEASURES: Pure tone audiometry was measured at .5, 1, 2, 4 and 6 kHz frequencies before and after the third month of intervention. In addition, Tinnitus Handicap Inventory (THI) questionnaire as well as visual analogue scale (VAS) for tinnitus loudness, daily annoyance, daily life or sleep disturbance, daily perception and mood alteration were evaluated. RESULTS: Finally, 103 (69 males and 34 females) patients with a mean age of 51.33 ± 13.91 years were analysed. In contrast with control group, patients in intervention group showed a remarkable decrease in THI score after 3 months of treatment (p < .05). Although both groups had improvements in VAS scores, mood disturbance, daily tinnitus perception and daily life alteration scores were only improved in the intervention group. The mean pure tone air and bone conduction were not significantly different between the control and the intervention group at baseline and 3 months after the intervention at .5, 1, 2 and 4 kHz (p > .05). CONCLUSION: A 3-month treatment with Neurotec capsules in addition to patient education is of benefit for managing symptoms in patients with chronic tinnitus. © 2022 John Wiley & Sons Ltd. DOI: 10.1111/coa.13989 PMID: 36268807 [Indexed for MEDLINE]
14. Vet Med Sci. 2022 Mar;8(2):660-667. doi: 10.1002/vms3.721. Epub 2022 Jan 12. Effects of dietary stinging nettle (Urtica dioica) on hormone stress and selected serum biochemical parameters of broilers subjected to chronic heat stress. Mirsaiidi Farahani M(1), Hosseinian SA(1). Author information: (1)Department of Clinical Science, School of Veterinary Medicine, Shiraz University, Shiraz, Iran. BACKGROUND: Heat stress is one of the most critical problems confronting the poultry industry. Stinging nettle (SN) is a medicinal plant with potent antioxidant properties. OBJECTIVE: The goal of this study was to evaluate the effects of dietary SN at two different levels (2 and 4%) on the serum levels of cortisol and some selected parameters of broilers exposed to chronic heat stress. METHODS: A total of 240 broiler chickens were randomly assigned to six dietary groups as follows: (1) control: fed the basal diet; (2) HS: heat-stressed broiler fed the basal diet; (3) HS-SN2: heat-stressed broiler fed 2% dietary SN; (4) HS-SN4: heat-stressed broilers fed 4% SN; (5) SN2: no heat-stressed broilers fed the basal diet supplemented with 2% SN; (6) SN4: no heat-stressed broilers fed the basal diet supplemented with 4% SN. Diet supplementation with SN was performed from days 14 to 35 and chronic heat stress was induced from days 22 to 29. The serum parameters were evaluated on days 14, 21, 29 and 35. RESULTS: HS had higher serum levels of cortisol, total cholesterol (TC), aspartate aminotransferase, alanine aminotransferase and creatine kinase (CK) compared to the other treatments. HS-SN4 had significantly lower cortisol, TC, alanine aminotransferase and CK compared to HS and HS-SN2. CONCLUSIONS: The inclusion of 4% SN powder in the broilers' diet alleviated the negative effects of heat stress by decreasing cortisol, TC and tissue damage indices. It seems that dietary SN could be used as a feed additive in the poultry diet for improving the health status and defence mechanisms of the birds under stressful conditions. © 2022 The Authors. Veterinary Medicine and Science published by John Wiley & Sons Ltd. DOI: 10.1002/vms3.721 PMCID: PMC8959287 PMID: 35023316 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest.
15. Int J Environ Res Public Health. 2021 Apr 1;18(7):3671. doi: 10.3390/ijerph18073671. A Placebo-Controlled, Pseudo-Randomized, Crossover Trial of Botanical Agents for Gulf War Illness: Reishi Mushroom (Ganoderma lucidum), Stinging Nettle (Urtica dioica), and Epimedium (Epimedium sagittatum). Younger J(1), Donovan EK(2), Hodgin KS(1), Ness TJ(3). Author information: (1)Department of Psychology, University of Alabama at Birmingham, CH 233, 1300 University Boulevard, Birmingham, AL 35233, USA. (2)Department of Psychology, Virginia Commonwealth University, White House, 806 West Franklin Street, Richmond, VA 23284, USA. (3)Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, BMR2-208, 901 19th Street South, Birmingham, AL 35205, USA. This report is third in a three-part clinical trial series screening potential treatments for Gulf War Illness (GWI). The goal of the project was to rapidly identify agents to prioritize for further efficacy research. We used a placebo-controlled, pseudo-randomized, crossover design to test the effects of reishi mushroom (Ganoderma lucidum), stinging nettle (Uritca dioica), and epimedium (Epimedium sagittatum) in 29 men with GWI. Participants completed 30 days of symptom reports for baseline, then a botanical line consisting of 30 days of placebo, followed by 30 days each of lower-dose and higher-dose botanical. After completing a botanical line, participants were randomized to complete the protocol with another botanical, until they completed three botanical trials. GWI symptom severity, pain, and fatigue were contrasted between the four conditions (baseline, placebo, lower-dose, higher dose) using linear mixed models. GWI symptom severity was unchanged from placebo in the reishi lower-dose condition (p = 0.603), and was higher in the higher-dose condition (p = 0.012). Symptom severity was not decreased from placebo with lower-dose stinging nettle (p = 0.604), but was significantly decreased with higher-dose stinging nettle (p = 0.048). Epimedium showed no significant decreases of GWI symptoms in the lower (p = 0.936) or higher (p = 0.183) dose conditions. Stinging nettle, especially at higher daily dosages, may help reduce the symptoms of GWI. Epimedium does not appear to beneficially affect GWI symptom severity, and reishi may exaggerate symptoms in some GWI sufferers. These results are in a small sample and are preliminary. Further research is required to determine if stinging nettle is indeed helpful for the treatment of GWI, and what dosage is optimal. This trial was registered on ClinicalTrials.gov (NCT02909686). DOI: 10.3390/ijerph18073671 PMCID: PMC8037868 PMID: 33915962 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest.
16. Pak J Biol Sci. 2020 Jan;23(10):1338-1344. doi: 10.3923/pjbs.2020.1338.1344. Urtica Dioica Root Extract on Clinical and Biochemical Parameters in Patients with Benign Prostatic Hyperplasia, Randomized Controlled Trial. Akbar Karami A, Sheikhsoleimani M, Reza Memarzadeh M, Haddadi E, Bakhshpour M, Mohammadi N, Mehdi Mirhashemi S. BACKGROUND AND OBJECTIVES: Benign Prostatic Hyperplasia (BPH) is a common urological disorder as men get older. BPH can cause uncomfortable urinary tract symptoms. Given the high incidence of the disease, further research is an undeniable necessity for its better management. In this research, the efficacy of Urtica Dioica root extract (UDE) on clinical and biochemical parameters were evaluated in this type of patients. MATERIALS AND METHODS: Participants were 60 men with BPH that randomly allocated to two equal groups (Intervention = 30 and Comparison = 30). Block balanced Randomization method was performed using a computer by a trained nurse. Intervention and comparison groups received 450 mg day-1 UDE and placebo as tablets for 12 weeks, respectively. The main outcome was changes in International Prostate Symptoms Score (IPSS) from baseline to end of treatment. Data were collected by completing a standard questionnaire and performing relevant tests based on common laboratory methods. RESULTS: UDE had an intermediate effect on IPSS, a small effect on serum high-sensitivity C-reactive protein (hs-CRP), intermediate to large effect on malondialdehyde (MDA) levels and intermediate effect on superoxide dismutase (SOD) activity. The magnitude of the effects of UDE on other parameters was overall negligible compared to the comparison and not significant. No side effects were seen in these patients following tablet usage. CONCLUSION: UDE consumption for 12 weeks among BPH patients had clinically significant effects on IPSS, serum hs-CRP, MDA and SOD activity. DOI: 10.3923/pjbs.2020.1338.1344 PMID: 32981268 [Indexed for MEDLINE]
17. J Diet Suppl. 2021;18(1):31-43. doi: 10.1080/19390211.2020.1727076. Epub 2020 Feb 21. Efficacy and Safety of a Traditional Herbal Combination in Patients with Type II Diabetes Mellitus: A Randomized Controlled Trial. Mehrzadi S(1), Mirzaei R(2), Heydari M(3), Sasani M(4), Yaqoobvand B(5), Huseini HF(5). Author information: (1)Razi Drug Research Center, Iran University of Medical Sciences, Tehran, Iran. (2)Avesta Pharmed Hakim, Tehran, Iran. (3)Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. (4)Diabetic Clinic of Diabetic Society, Karaj, Iran. (5)Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran. BACKGROUND: Capparis spinosa, Rosa canina, Securidaca securigera, Silybum marianum, Urtica dioica, Trigonella foenum-graecum and Vaccinium arctostaphylos are used traditionally as an herbal combination for treatment of diabetic patients in Iran. Despite the clinical evidence supporting their use in solitary form, no controlled human study has determined the efficacy and safety of their combination in treatment of diabetic patients. METHODS: A total 150 type II diabetic patients of both sexes under the oral anti-hyperglycemic drugs treatment (maximum 10 mg glyburide and 1000 mg metformin daily) were randomly assigned to three groups. The patients in each group received either herbal combination or placebo or metformin capsule daily for three months, without any change in their previous oral anti-hyperglycemic drugs dosage. Herbal combination, placebo and metformin capsules matched by shape and color were prepared in the Institute of Medicinal Plants Karaj, Iran. To assess the efficacy and safety of the treatments, the patients fasting plasma glucose, HbA1c, lipid profile, liver enzymes and renal function were determined at the beginning of the study and after three months. RESULTS: Results showed that after three months, the fasting plasma glucose, HbA1c and cholesterol levels in herbal combination were decreased significantly as compared to placebo group (20% and 12% respectively) and also compared to base line (25% and 15% respectively). The herbal combination was as effective as metformin in reduction of FPG (p = 0.001, p = 0.001) and HbA1c (p = 0.028 and p = 0.050 respectively) compared to placebo. No notable hepatic, renal and gastrointestinal side effects were observed in the trial groups. CONCLUSION: The results suggest that traditional herbal combination may safely improve glycemic control in type II diabetic patients with no significant adverse effect. [Formula: see text]. DOI: 10.1080/19390211.2020.1727076 PMID: 32081056 [Indexed for MEDLINE]
18. Galen Med J. 2019 Oct 9;8:e1389. doi: 10.31661/gmj.v8i0.1389. eCollection 2019. Efficacy of a Persian Herbal Remedy and Electroacupuncture on Metabolic Profiles and Anthropometric Parameters in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial. Rouhani M(1)(2), Motavasselian M(1), Taghipoor A(3), Layegh P(4), Asili J(5), Hamedi SS(1), Badiee Avval S(1). Author information: (1)School of Persian and Complementary Medicine, Mashhad University of Medical Science, Mashhad, Iran. (2)Students Research Committee, Mashhad University of Medical Science, Mashhad, Iran. (3)Department of Biostatistics and Epidemiology, School of Health, Mashhad University of Medical Sciences Mashhad, Iran. (4)Department of Radiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. (5)Department of Pharmacognosy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. BACKGROUND: The most prevalent endocrine disorder in women of reproductive age is polycystic ovary syndrome (PCOS). The purpose of this study was to evaluate the efficaciousness of a Persian herbal remedy, as well as electroacupuncture and the combination of them on metabolic profiles and anthropometric parameters in these patients. MATERIALS AND METHODS: Eighty overweight women with PCOS were randomly divided into four groups. All of them received metformin 1000 mg and the second group received 5 g of herbal medicine per day (main components: Foeniculum vulgare, Urtica dioica, and Daucus carota), the third group were subjected to 20 electroacupuncture sessions, and the fourth group received both therapies. RESULTS: After 12 weeks, the body fat and body mass index decreased the most in the herbal medicine+electroacupuncture group, and waist to hip ratio decreased the most in the electroacupuncture group. A significant decrease was also observed in fasting insulin, homeostasis model assessment of insulin resistance. A significant increase was seen in the quantitative insulin sensitivity check index in all intervention groups, but there was no noteworthy difference in these parameters in the control group. Total cholesterol and low-density lipoprotein cholesterol decreased significantly in the electroacupuncture groups and herbal medicine+electroacupuncture. Also, a significant decrease was observed in triglycerides, aspartate aminotransferase, and alanine aminotransferase in the herbal medicine groups and herbal medicine+electroacupuncture. CONCLUSION: It is advisable to use this herbal remedy and electroacupuncture for better treatment of metabolic complications and overweight problems in these patients. Copyright© 2019, Galen Medical Journal. DOI: 10.31661/gmj.v8i0.1389 PMCID: PMC8344036 PMID: 34466504
19. Biomolecules. 2019 Jul 20;9(7):292. doi: 10.3390/biom9070292. Antihypertensive Indigenous Lebanese Plants: Ethnopharmacology and a Clinical Trial. Samaha AA(1)(2)(3)(4), Fawaz M(2), Salami A(5), Baydoun S(6), Eid AH(7)(8). Author information: (1)Lebanese International University, Beirut, P.O. Box 146404, Lebanon. (2)Faculty of Health Sciences, Beirut Arab University, Beirut, P.O. Box 11-5020, Lebanon. (3)Lebanese University, Faculty of Public Health IV, Zahle, P.O. Box 6573/14, Lebanon. (4)Rayak University Hospital, Rayak, P.O. Box 1200, Lebanon. (5)Lebanese University, Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Faculty of Sciences (V), Nabatieh, P.O. Box 6573/14, Lebanon. (6)Research Center for Environment and Development, Beirut Arab University, Bekaa, P.O. Box 11-5020, Lebanon. safaa.baydoun@bau.edu.lb. (7)Department of Pharmacology and Toxicology, American University of Beirut, Beirut, P.O. Box 11-0236, Lebanon. ae81@aub.edu.lb. (8)Department of Biomedical Sciences, Qatar University, Doha, P.O. Box 2713, Qatar. ae81@aub.edu.lb. Hypertension is highly prevalent among the Lebanese adult population and is indeed the major cause of mortality in Lebanon. Traditional use of antihypertensive medicinal plants has long been practiced. The aim of this study is to document this traditional knowledge and clinically test the antihypertensive capacity of three of the most commonly used wild plant species Mentha longifolia, Viola odorata and Urtica dioica. Ethno-pharmacological data was collected by personal interviews with herbalists and traditional healers using a semi structured survey questionnaire and assessing relative frequency of citation (RFC). The clinical study was conducted by a randomized, blind, placebo-controlled trial in 29 subjects with mild hypertension distributed in four groups, three plant extract treatments and one placebo. Systolic (SBP) and diastolic blood pressures (DBP) as well as mean arterial blood pressures (MAP) were monitored at weeks 4, 8, 12 and 16 during the treatment with 300 mL/day of plant extract. Results showed that M. longifolia, U. dioica and V. odorata exhibited the highest values of RCF (0.95) followed by Allium ampeloprasum (0.94), Apium graveolens (0.92) and Crataegus azarolus (0.90). The clinical trial revealed dose- and duration-dependent significant reductions in SBP, DBP and MAP of subjects treated with M. longifolia, U. dioica or V. odorata. Our findings indicate that extracts of these plants present an effective, safe and promising potential as a phyto-therapuetical approach for the treatment of mild hypertension. More research on the phytochemistry, pharmacological effects and the underlying mechanisms is necessary. DOI: 10.3390/biom9070292 PMCID: PMC6681041 PMID: 31330767 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
20. Complement Ther Med. 2019 Jun;44:166-173. doi: 10.1016/j.ctim.2019.04.003. Epub 2019 Apr 4. Urtica dioica in comparison with placebo and acupuncture: A new possibility for menopausal hot flashes: A randomized clinical trial. Kargozar R(1), Salari R(2), Jarahi L(3), Yousefi M(4), Pourhoseini SA(5), Sahebkar-Khorasani M(1), Azizi H(6). Author information: (1)School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. (2)Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. (3)Department of Community Medicine, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. (4)Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. (5)Department of Gynecology and Obstetrics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. (6)Department of Chinese and Complementary Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: azizih@mums.ac.ir. Comment in Complement Ther Med. 2020 Nov;54:102212. doi: 10.1016/j.ctim.2019.102212. OBJECTIVES: The purpose of this research was to investigate the effect of Urtica dioica in comparison with placebo, acupuncture and combined therapy on hot flashes and quality of life in postmenopausal women. METHODS: In a double-blinded randomized controlled trial, patients were treated for 7 weeks then followed up 4 weeks. Seventy-two postmenopausal women who reported at least 20 hot flashes attacks per week were randomly allocated into one of the 4 groups of Urtica dioica 450 mg/day and acupuncture 11 sessions (A), acupuncture and placebo (B), sham acupuncture and Urtica dioica (C), and sham acupuncture and placebo (D). The primary outcomes were the change in hot flashes score from baseline to the end of treatment and follow up; and the change in the quality of life (MENQOL) from baseline to the end of treatment. Secondary outcomes included changes in FSH, LH, and ESTRADIOL levels from baseline to the end of treatment. The trial was conducted from October 2017 to July 2018 in Acupuncture clinic of a teaching hospital in Iran. RESULTS: A total of 72 women 45-60 years old were enrolled, and 68 were included in the analyses. The median (IQR) hot flashes score decreased in the A group by 20.2 (31.7) and 21.1 (25.1), B group by 19 (18) and 17.3 (27), C group by 14.6 (25.4) and 20.8 (13), and D group by 1.6 (11.6) and 1 (13.3) at the end of treatment and follow up (P < 0.0001, P < 0.0001); no significant difference between A, B and C groups. The mean (SD) of MENQOL score decreased in the A group by 42.6 (21.1), B group by 40.7 (29.8), C group by 37.8 (26.8) and D group by 9.8 (14.3) at the end of treatment (P = 0.001); no significant difference between A, B and C groups. CONCLUSIONS: Urtica dioica can decrease menopausal hot flashes and increase the quality of life of postmenopausal women better than placebo-sham control but same as acupuncture. The combination of Urtica dioica and acupuncture did not add to the effects of those therapies. Copyright © 2019 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.ctim.2019.04.003 PMID: 31126551 [Indexed for MEDLINE]
21. Niger J Clin Pract. 2018 Jan;21(1):38-42. doi: 10.4103/1119-3077.224788. Effect of a galactagogue herbal tea on breast milk production and prolactin secretion by mothers of preterm babies. Özalkaya E(1), Aslandoğdu Z(1), Özkoral A(2), Topcuoğlu S(1), Karatekin G(1). Author information: (1)Neonatal Intensive Care Unit, Istanbul, Turkey. (2)Zeynep Kamil Maternity and Children's Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey. BACKGROUND AND OBJECTIVES: Poor breast milk production is the most frequent cause of breastfeeding failure in preterm babies. The aim of our study is to evaluate the effect of herbal tea mixture containing stinging nettle (Natal, Hipp) on breast milk production and serum prolactin levels of mothers, and weight gain of preterm babies. MATERIALS AND METHODS: We enrolled mothers and their babies who were less than 37 gestational week and less than 2000 g, fed with orogastric tube without any contraindication of enteral feeding in neonatal intensive care unit between November 2010 and June 2011. The mothers of treatment group (n = 32) were consuming commercially available herbal mixture tea for 1 week. The mothers control group (n = 21) received only the same advice on supportive measures as group I. Mothers in the placebo group (n = 32) were given fruit tea for 1 week. The daily breast milk production of mothers and weight gain of preterm babies were recorded. Also, serum prolactin levels of the mothers were measured. RESULTS: Increase of the milk production from the first to the seventh day was more prominent in mothers using herbal tea mixture. Increased rate in the amount of milk was 80% in the treatment, 34.3% in the placebo and 30% in the control group (P = 0.000). There was no statistically significant difference in weight gain of babies between the two groups, due to formula feeding in case of insufficient breast milk. Serum prolactin levels of the mothers at the beginning and on the seventh day showed no significant difference. CONCLUSIONS: In mothers with premature babies and who are treated in neonatal intensive care unit, consumption of galactogogue herbal tea will increase lactation and prevent lack of human milk without any adverse effect. DOI: 10.4103/1119-3077.224788 PMID: 29411721 [Indexed for MEDLINE]
22. J Evid Based Complementary Altern Med. 2017 Oct;22(4):603-608. doi: 10.1177/2156587217696929. Epub 2017 Mar 21. Silymarin, Olibanum, and Nettle, A Mixed Herbal Formulation in the Treatment of Type II Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. Khalili N(1), Fereydoonzadeh R(1), Mohtashami R(2), Mehrzadi S(3), Heydari M(4), Huseini HF(5). Author information: (1)1 Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran. (2)2 Religion and Medicine Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. (3)3 Iran University of Medical Sciences, Tehran, Iran. (4)4 Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. (5)5 Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran. Silybum marianum (L) Gaertn (milk thistle) seeds, Urtica dioica L (nettle) leaves, and Boswellia serrata (olibanum gum) resin are used traditionally by Iranian diabetic patients. The aim of this study was to evaluate the antihyperglycemic effects of these herbs in an herbal formulation in patients with type II diabetes mellitus. Sixty patients diagnosed as type II diabetes mellitus with fasting blood glucose level from 150 to 180 mg/dL, glycosylated hemoglobin level from 7.5% to 8.5%, and on oral antihyperglycemic drugs, were allocated to receive the mix herbal formulation or placebo for 90 days in a double-blind randomized placebo-controlled clinical trial. The mean serum fasting blood glucose, glycosylated hemoglobin, and triglyceride in the herbal drug group were significantly less than placebo group's values after 3 months of the intervention. The study showed a potential antihyperglycemic and triglyceride lowering effect of the herbal formulation, while it did not have any significant cholesterol or blood pressure lowering effect. DOI: 10.1177/2156587217696929 PMCID: PMC5871270 PMID: 29228792 [Indexed for MEDLINE] Conflict of interest statement: Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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