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Effects of a Scutellaria baicalensis/Crataegus laevigata, magnesium and chromium supplement on stressed individuals: A randomised, double-blind, placebo-controlled, crossover trial.

1. J Psychopharmacol. 2025 Dec;39(12):1420-1436. doi: 10.1177/02698811251381261. Epub 2025 Nov 5. Effects of a Scutellaria baicalensis/Crataegus laevigata, magnesium and chromium supplement on stressed individuals: A randomised, double-blind, placebo-controlled, crossover trial. Dodd F(1), Weis

Safety and pharmacokinetics evaluation of oroxylin A in Chinese healthy volunteers: a phase I, double-blind, placebo-controlled, single ascending dose, multiple dose, and food effect study.

2. Clin Transl Oncol. 2026 Mar;28(3):1016-1029. doi: 10.1007/s12094-025-04017-6. Epub 2025 Sep 3. Safety and pharmacokinetics evaluation of oroxylin A in Chinese healthy volunteers: a phase I, double-blind, placebo-controlled, single ascending dose, multiple dose, and food effect study. Yang F(

The Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants with Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study.

3. Nutrients. 2025 Feb 26;17(5):809. doi: 10.3390/nu17050809. The Effects of Combined Scutellaria and Saffron Supplementation on Mood Regulation in Participants with Mild-to-Moderate Depressive Symptoms: A Randomized, Double-Blind, Placebo-Controlled Study. Dormal V(1)(2), Suchareau M(3), Copine

Effects of Acacia catechu and Scutellaria baicalensis extract on cognitive function in a healthy adult population: a double-blind, randomized, placebo-controlled trial.

4. Nutr Neurosci. 2025 Aug;28(8):975-986. doi: 10.1080/1028415X.2024.2442425. Epub 2024 Dec 19. Effects of Acacia catechu and Scutellaria baicalensis extract on cognitive function in a healthy adult population: a double-blind, randomized, placebo-controlled trial. Krieger JM(1), Hagele AM(1), M

A study on the impact of gargling with compound Scutellaria baicalensis Georgi on oral health and microflora changes in fixed orthodontic patients: An experimental study.

5. Medicine (Baltimore). 2024 Aug 23;103(34):e39397. doi: 10.1097/MD.0000000000039397. A study on the impact of gargling with compound Scutellaria baicalensis Georgi on oral health and microflora changes in fixed orthodontic patients: An experimental study. Zhang P(1)(2), Chen SG(1)(2), Wang JT

Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study.

6. Clin Transl Sci. 2021 Sep;14(5):2017-2024. doi: 10.1111/cts.13063. Epub 2021 Jun 22. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Li L(1), Gao H(2

Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study.

7. J Ethnopharmacol. 2021 Jun 28;274:114052. doi: 10.1016/j.jep.2021.114052. Epub 2021 Mar 19. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. Dong

Baicalin inhibits Chlamydia trachomatis growth by impairing elementary body infectivity.

8. Microb Pathog. 2026 Apr;213:108339. doi: 10.1016/j.micpath.2026.108339. Epub 2026 Jan 29. Baicalin inhibits Chlamydia trachomatis growth by impairing elementary body infectivity. Su X(1), Chen Y(2), Xu Q(2), Zhou L(1), Lin S(1), Wang N(1), Xue Y(2), Chen W(3). Author information: (1)Guangdo

Integrative network pharmacology and experimental validation of multi-target synergy against multidrug-resistant klebsiella pneumoniae via PI3K/AKT-MAPK pathway disruption.

9. Naunyn Schmiedebergs Arch Pharmacol. 2026 Feb;399(4):5157-5171. doi: 10.1007/s00210-025-04765-w. Epub 2025 Oct 29. Integrative network pharmacology and experimental validation of multi-target synergy against multidrug-resistant klebsiella pneumoniae via PI3K/AKT-MAPK pathway disruption. Man

Angelica sinensis and Scutellaria baicalensis synergistically alleviates metabolic dysfunction-associated steatohepatitis via promoting adipose tissue-to-liver tissue communication.

10. Phytomedicine. 2025 Nov 25;148:157329. doi: 10.1016/j.phymed.2025.157329. Epub 2025 Sep 24. Angelica sinensis and Scutellaria baicalensis synergistically alleviates metabolic dysfunction-associated steatohepatitis via promoting adipose tissue-to-liver tissue communication. Zhao M(1), Tao X(

Wogonin induces mitochondrial apoptosis and synergizes with venetoclax in diffuse large B-cell lymphoma.

11. Toxicol Appl Pharmacol. 2024 Nov;492:117103. doi: 10.1016/j.taap.2024.117103. Epub 2024 Sep 13. Wogonin induces mitochondrial apoptosis and synergizes with venetoclax in diffuse large B-cell lymphoma. Lin Y(1), Jiang X(2), Zhao M(3), Li Y(2), Jin L(2), Xiang S(2), Pei R(4), Lu Y(5), Jiang L

Bioflavonoid Baicalein Modulates Tetracycline Resistance by Inhibiting Efflux Pump in Staphylococcus aureus.

12. Microb Drug Resist. 2024 Sep;30(9):363-371. doi: 10.1089/mdr.2024.0099. Epub 2024 Aug 12. Bioflavonoid Baicalein Modulates Tetracycline Resistance by Inhibiting Efflux Pump in Staphylococcus aureus. Moulick S(1)(2), Roy DN(2). Author information: (1)TCG Lifesciences Private Limited, Kolkata

Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells.

13. Molecules. 2024 May 25;29(11):2503. doi: 10.3390/molecules29112503. Baicalin and Baicalein Enhance Cytotoxicity, Proapoptotic Activity, and Genotoxicity of Doxorubicin and Docetaxel in MCF-7 Breast Cancer Cells. Bernasinska-Slomczewska J(1), Hikisz P(1), Pieniazek A(1), Koceva-Chyla A(2). Au

Pharmacokinetic analysis of antiviral drug ritonavir across the blood-brain barrier and its interaction with Scutellaria baicalensis using multisite microdialysis in rats.

14. J Pharm Biomed Anal. 2024 Aug 1;245:116162. doi: 10.1016/j.jpba.2024.116162. Epub 2024 Apr 18. Pharmacokinetic analysis of antiviral drug ritonavir across the blood-brain barrier and its interaction with Scutellaria baicalensis using multisite microdialysis in rats. Sun CK(1), Kung YY(2), L

Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in Ehrlich solid tumor.

15. Biomed Pharmacother. 2022 Feb;146:112599. doi: 10.1016/j.biopha.2021.112599. Epub 2021 Dec 27. Baicalin; a promising chemopreventive agent, enhances the antitumor effect of 5-FU against breast cancer and inhibits tumor growth and angiogenesis in Ehrlich solid tumor. Shehatta NH(1), Okda TM(

Exploring the synergistic mechanism of Gegen Qinlian Decoction on the Wnt signaling pathway using an integrated strategy of network pharmacology and RNA-seq.

10. J Ethnopharmacol. 2021 Oct 5;278:114283. doi: 10.1016/j.jep.2021.114283. Epub 2021 Jun 30. Exploring the synergistic mechanism of Gegen Qinlian Decoction on the Wnt signaling pathway using an integrated strategy of network pharmacology and RNA-seq. Li Y(1), Gong Y(1), Zhang X(1), Wang J(2),

Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement.

19. Curr Issues Mol Biol. 2024 Oct 29;46(11):12133-12151. doi: 10.3390/cimb46110720. Exploring the Benefits of Herbal Medicine Composite 5 (HRMC5) for Skin Health Enhancement. Ha R(1), Cho WK(2), Kim E(2), Jang SJ(2), Kim JD(1), Yi CG(3), Moh SH(2). Author information: (1)Department of Beauty In

Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation.

35. Am J Physiol Endocrinol Metab. 2020 Jan 1;318(1):E52-E61. doi: 10.1152/ajpendo.00221.2019. Epub 2019 Nov 26. Combined effects of Scutellaria baicalensis with metformin on glucose tolerance of patients with type 2 diabetes via gut microbiota modulation. Shin NR(1), Gu N(2), Choi HS(3), Kim H(

Rationale and design to assess the efficacy and safety of HT047 in patients with acute ischemic stroke: A multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase II trial.

26. Medicine (Baltimore). 2019 Oct;98(43):e17655. doi: 10.1097/MD.0000000000017655. Rationale and design to assess the efficacy and safety of HT047 in patients with acute ischemic stroke: A multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase II trial. Heo SH(1), Song

Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers.

19. Clin Drug Investig. 2016 Sep;36(9):713-724. doi: 10.1007/s40261-016-0418-7. Multiple-Ascending-Dose Pharmacokinetics and Safety Evaluation of Baicalein Chewable Tablets in Healthy Chinese Volunteers. Pang H(1)(2), Xue W(2), Shi A(3), Li M(2), Li Y(2), Cao G(2), Yan B(2), Dong F(2), Xiao W(4)

Preclinical Evaluation of Baicalin for the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis.

40. Planta Med. 2025 Nov;91(13):706-729. doi: 10.1055/a-2615-8249. Epub 2025 Jul 24. Preclinical Evaluation of Baicalin for the Treatment of Diabetic Nephropathy: A Systematic Review and Meta-Analysis. An H(#)(1), Liu L(#)(1), He T(#)(1), Chen X(1), Jin X(1)(2), Zhou X(1)(2), Gao W(1)(2). Autho

The effects of flavonoid baicalein on miRNA expressions in cancer: a systematic review.

50. Naunyn Schmiedebergs Arch Pharmacol. 2025 Sep;398(9):11331-11348. doi: 10.1007/s00210-025-04078-y. Epub 2025 Mar 28. The effects of flavonoid baicalein on miRNA expressions in cancer: a systematic review. Khandan M(1), Khazeei Tabari MA(1), Rahimi SM(2), Hassani M(3), Bagheri A(4)(5). Autho

Review on the pharmacological effects and pharmacokinetics of scutellarein.

29. Arch Pharm (Weinheim). 2024 Sep;357(9):e2400053. doi: 10.1002/ardp.202400053. Epub 2024 Jun 7. Review on the pharmacological effects and pharmacokinetics of scutellarein. Lai J(1), Li C(2). Author information: (1)Department of Anorectal Surgery, The Third People's Hospital of Chengdu, Cheng

Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms.

14. Neurochem Res. 2024 Jan;49(1):14-28. doi: 10.1007/s11064-023-04026-3. Epub 2023 Sep 16. Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms. Wang C(1), Gao MQ(2). Author information: (1)Department of Clinic

Changes in the Gut Microbiota after the Use of Herbal Medicines in Overweight and Obese Individuals: A Systematic Review.

5. Nutrients. 2023 May 5;15(9):2203. doi: 10.3390/nu15092203. Changes in the Gut Microbiota after the Use of Herbal Medicines in Overweight and Obese Individuals: A Systematic Review. Huang M(1), Cople-Rodrigues CDS(2), Waitzberg DL(3), Rocha IMGD(3), Curioni CC(4). Author information: (1)Postg

Mechanistic Role of Scutellaria baicalensis Georgi in Breast Cancer Therapy.

13. Am J Chin Med. 2023;51(2):279-308. doi: 10.1142/S0192415X23500155. Epub 2023 Jan 18. Mechanistic Role of Scutellaria baicalensis Georgi in Breast Cancer Therapy. Yu P(1), Li J(1), Luo Y(1), Sun J(1), Hu Y(2), Lin B(3), Meng X(1), Xiang L(1). Author information: (1)State Key Laboratory of Sou

Modulation of diverse oncogenic signaling pathways by oroxylin A: An important strategy for both cancer prevention and treatment.

39. Phytomedicine. 2022 Oct;105:154369. doi: 10.1016/j.phymed.2022.154369. Epub 2022 Aug 1. Modulation of diverse oncogenic signaling pathways by oroxylin A: An important strategy for both cancer prevention and treatment. Sajeev A(1), Hegde M(1), Daimary UD(1), Kumar A(1), Girisa S(1), Sethi G(2

Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis.

47. RETRACTED ARTICLE J Healthc Eng. 2022 Apr 11;2022:3594210. doi: 10.1155/2022/3594210. eCollection 2022. Recent Progress in Traditional Chinese Medicines and Their Mechanism in the Treatment of Allergic Rhinitis. Mao D(1), He Z(1), Li L(1), Lei Y(1), Xiao M(1), Zhang H(1), Zhang F(1). Autho

Therapeutic efficacy and safety of Yinzhihuang granules with phototherapy in neonatal pathologic jaundice: An updated systematic review and meta-analysis.

28. Phytomedicine. 2022 Jun;100:154051. doi: 10.1016/j.phymed.2022.154051. Epub 2022 Mar 16. Therapeutic efficacy and safety of Yinzhihuang granules with phototherapy in neonatal pathologic jaundice: An updated systematic review and meta-analysis. Feng Q(1), Huang Z(2), Su L(3), Fan Y(3), Guan Y

Wogonin and its analogs for the prevention and treatment of cancer: A systematic review.

37. Phytother Res. 2022 May;36(5):1854-1883. doi: 10.1002/ptr.7386. Epub 2022 Jan 31. Wogonin and its analogs for the prevention and treatment of cancer: A systematic review. Banik K(1)(2), Khatoon E(1)(2), Harsha C(1)(2), Rana V(1)(2), Parama D(1)(2), Thakur KK(1)(2), Bishayee A(3), Kunnumakka