SAMe

Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.

1. Neuropsychopharmacol Rep. 2025 Mar;45(1):e70008. doi: 10.1002/npr2.70008. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis. Urata M(1), Sakurai H(1), Ueno F(2), Maruki T(1), Tada T(1), Uchida T(3)(4), Matsumoto Y(1), Murao M(1), Tomita M(5)

Effects of S-Adenosylmethionine on Cognition in Animals and Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

2. J Alzheimers Dis. 2023;94(s1):S267-S287. doi: 10.3233/JAD-221076. Effects of S-Adenosylmethionine on Cognition in Animals and Humans: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Zhao Y(1)(2)(3), Zhang Y(1)(2)(4), Meng S(3), Chen B(1)(2), Dong X(3), Guo X(3), Guo F(1

Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults-a systematic review and meta-analysis.

3. Nutr Rev. 2020 Aug 1;78(8):647-666. doi: 10.1093/nutrit/nuz094. Influence of nutrients involved in one-carbon metabolism on DNA methylation in adults-a systematic review and meta-analysis. Amenyah SD(1)(2), Hughes CF(2), Ward M(2), Rosborough S(1), Deane J(1), Thursby SJ(1), Walsh CP(1), Kok

Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses.

4. Am J Psychiatry. 2016 Jun 1;173(6):575-87. doi: 10.1176/appi.ajp.2016.15091228. Epub 2016 Apr 26. Adjunctive Nutraceuticals for Depression: A Systematic Review and Meta-Analyses. Sarris J(1), Murphy J(1), Mischoulon D(1), Papakostas GI(1), Fava M(1), Berk M(1), Ng CH(1). Author information:

S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis.

5. PLoS One. 2015 Mar 16;10(3):e0122124. doi: 10.1371/journal.pone.0122124. eCollection 2015. S-adenosyl-L-methionine for the treatment of chronic liver disease: a systematic review and meta-analysis. Guo T(1), Chang L(1), Xiao Y(1), Liu Q(1). Author information: (1)Department of General Surger

The effect of S-adenosylmethionine on cognitive performance in mice: an animal model meta-analysis.

6. PLoS One. 2014 Oct 27;9(10):e107756. doi: 10.1371/journal.pone.0107756. eCollection 2014. The effect of S-adenosylmethionine on cognitive performance in mice: an animal model meta-analysis. Montgomery SE(1), Sepehry AA(2), Wangsgaard JD(1), Koenig JE(3). Author information: (1)Department of

Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis.

7. J Fam Pract. 2002 May;51(5):425-30. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. Soeken KL(1), Lee WL, Bausell RB, Agelli M, Berman BM. Author information: (1)University of Maryland, School of Nursing, Baltimore, MD, USA. ksoeken@compmed.umm.edu Comment in ACP J

A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease.

8. Alzheimers Dement. 2026 Apr;22(4):e71381. doi: 10.1002/alz.71381. A phase 2, randomized, multicenter, double-blind, placebo-controlled trial of S-adenosyl methionine in participants with mild cognitive impairment or dementia due to Alzheimer's disease. Holper S(1)(2)(3), Barnham KJ(3), Churil

Lowering plasma S-Adenosylhomocysteine (SAH) in healthy adults with elevated SAH and normal homocysteine using nutritional supplementation.

9. Nutr Metab Cardiovasc Dis. 2025 Dec;35(12):104221. doi: 10.1016/j.numecd.2025.104221. Epub 2025 Jul 5. Lowering plasma S-Adenosylhomocysteine (SAH) in healthy adults with elevated SAH and normal homocysteine using nutritional supplementation. Pohl F(1), Dominique A(1), Dufour J(2), Wang J(2),

Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial.

10. Environ Sci Technol. 2025 Jul 29;59(29):14905-14916. doi: 10.1021/acs.est.5c01597. Epub 2025 Jul 16. Metabolic Signature of Arsenic Exposure and Metabolism: The Folic Acid and Creatine Trial. Li W(1), Wu H(1), Goldsmith J(2), Glabonjat RA(1), Ilievski V(1), Balac O(1), Slavkovich V(1), Pint

Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial.

11. Am J Clin Nutr. 2025 Apr;121(4):910-920. doi: 10.1016/j.ajcnut.2025.02.001. Epub 2025 Feb 5. Folic acid supplementation in children with sickle cell disease: a randomized double-blind noninferiority cross-over trial. Williams BA(1), McCartney H(2), Singer J(3), Devlin AM(4), Vercauteren S(5)

Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: A monocentric, randomized, cross-over, double-blind, placebo-controlled clinical trial.

12. Biomed Pharmacother. 2022 Dec;156:113930. doi: 10.1016/j.biopha.2022.113930. Epub 2022 Oct 27. Efficacy of a food supplement based on S-adenosyl methionine and probiotic strains in subjects with subthreshold depression and mild-to-moderate depression: A monocentric, randomized, cross-over, d

Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial.

13. Orphanet J Rare Dis. 2022 Nov 14;17(1):417. doi: 10.1186/s13023-022-02567-4. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Imbard A(1)(2)(3), Toumazi A(#)(4)(5), Magréault S(#)(6)(7), Garcia-Segarra N(#)(8)(9), Schlemmer D(10

[The results of phase III multicenter open randomized controlled study REM-Chol-III-16 in patients with intrahepatic cholestasis syndrome caused by chronic diffuse liver diseases].

14. Ter Arkh. 2021 Dec 15;93(12):1470-1476. doi: 10.26442/00403660.2021.12.201266. [The results of phase III multicenter open randomized controlled study REM-Chol-III-16 in patients with intrahepatic cholestasis syndrome caused by chronic diffuse liver diseases]. [Article in Russian; Abstract av

Pharmacokinetics and food impact assessment of ademetionine enteric-coated tablet as an endogenous substance drug in healthy Chinese volunteers.

15. J Clin Pharm Ther. 2022 Jun;47(6):738-744. doi: 10.1111/jcpt.13601. Epub 2022 Jan 3. Pharmacokinetics and food impact assessment of ademetionine enteric-coated tablet as an endogenous substance drug in healthy Chinese volunteers. Zhang J(1), Liu H(1), Tang L(2), Lin H(1), Yao Y(1), Tong Y(2)

Effects of S-adenosyl-L-Methionine Combined with Ursodesoxycholic Acid on Serum Endotoxin, MMP-9 and IL-18 in Neonates with Cholestasis.

45. J Coll Physicians Surg Pak. 2021 Dec;31(12):1445-1448. doi: 10.29271/jcpsp.2021.12.1445. Effects of S-adenosyl-L-Methionine Combined with Ursodesoxycholic Acid on Serum Endotoxin, MMP-9 and IL-18 in Neonates with Cholestasis. Zeng L(1), Li M(1), Cen Y(1), Wang Z(2). Author information: (1)D

Improved Chemosensitivity in Metastatic Castration-Resistant Prostate Cancer: The Synergistic Effects of S-Adenosylmethionine and Cabazitaxel.

45. Cancer Med. 2026 Apr;15(4):e71784. doi: 10.1002/cam4.71784. Improved Chemosensitivity in Metastatic Castration-Resistant Prostate Cancer: The Synergistic Effects of S-Adenosylmethionine and Cabazitaxel. Arpino R(1), Cadoni F(1), Pagano C(2), Coppola L(2), Del Vecchio V(3)(4), Nigam A(3), Mos

Lack of Cancer Specificity of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 in Combination With Recombinant Methioninase In Vitro.

9. Anticancer Res. 2026 Feb;46(2):705-712. doi: 10.21873/anticanres.17980. Lack of Cancer Specificity of Methionine Adenosyltransferase 2A (MAT2A) Inhibitor AG-270 in Combination With Recombinant Methioninase In Vitro. Kim J(1)(2)(3), Han Q(1), Li S(1), Kang BM(1)(2), Mizuta K(1)(2), Asano Y(1)(2

The Simultaneous Treatment of PC-3 Cells with the DNA-Demethylating Agent Decitabine and S-Adenosylmethionine Leads to Synergistic Anticancer Effects.

4. Genes (Basel). 2024 Dec 20;15(12):1634. doi: 10.3390/genes15121634. The Simultaneous Treatment of PC-3 Cells with the DNA-Demethylating Agent Decitabine and S-Adenosylmethionine Leads to Synergistic Anticancer Effects. Schmidt T(1), Sticht C(2). Author information: (1)Department of Anatomy an

The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity.

38. Biochem Biophys Res Commun. 2024 Jul 5;716:150011. doi: 10.1016/j.bbrc.2024.150011. Epub 2024 Apr 27. The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tum

8-Cl-Ado and 8-NH(2)-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia.

50. Leukemia. 2024 Jun;38(6):1236-1245. doi: 10.1038/s41375-024-02222-w. Epub 2024 Apr 20. 8-Cl-Ado and 8-NH(2)-Ado synergize with venetoclax to target the methionine-MAT2A-SAM axis in acute myeloid leukemia. Guo J(1)(2), Buettner R(3), Du L(3), Li Z(3), Liu W(3), Su R(4), Chen Z(4), Che Y(4),

Pharmacology and pharmacokinetics of tazemetostat.

26. Cancer Chemother Pharmacol. 2024 May;93(5):509-517. doi: 10.1007/s00280-024-04658-4. Epub 2024 Mar 23. Pharmacology and pharmacokinetics of tazemetostat. Orleni M(1)(2)(3), Beumer JH(4)(5)(6). Author information: (1)Cancer Therapeutics Program, UPMC Hillman Cancer Center, Room G27E, Hillman

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.

42. J Biol Chem. 2024 Jan;300(1):105492. doi: 10.1016/j.jbc.2023.105492. Epub 2023 Nov 23. Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition. Bedard GT(1), Gilaj N(2), Peregrina K(3), Brew I(1), Tosti E(4), Shaffer K(5), Tyler PC(5), Edelmann

Exposure concentration ratios and biological responses play a critical role in determining the joint toxicity of TiO(2) nanoparticles and As(V) to the organism: The case study in marine algae Phaeodactylum tricornutum.

21. Sci Total Environ. 2024 Jan 20;909:168508. doi: 10.1016/j.scitotenv.2023.168508. Epub 2023 Nov 16. Exposure concentration ratios and biological responses play a critical role in determining the joint toxicity of TiO(2) nanoparticles and As(V) to the organism: The case study in marine algae P

S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-κB Activation.

43. Int J Mol Sci. 2021 Aug 27;22(17):9286. doi: 10.3390/ijms22179286. S-Adenosylmethionine Increases the Sensitivity of Human Colorectal Cancer Cells to 5-Fluorouracil by Inhibiting P-Glycoprotein Expression and NF-κB Activation. Mosca L(1), Pagano M(1)(2), Borzacchiello L(1), Mele L(3), Russo A

Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase.

28. J Toxicol Sci. 2021;46(1):31-42. doi: 10.2131/jts.46.31. Reduction of fatty liver in rats by nicotinamide via the regeneration of the methionine cycle and the inhibition of aldehyde oxidase. Yokouchi C(1)(2), Nishimura Y(3), Goto H(3), Sato M(3), Hidoh Y(1), Takeuchi K(1), Ishii Y(2). Autho

Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients.

5. Clin Ther. 2009 Dec;31(12):2860-72. doi: 10.1016/j.clinthera.2009.12.016. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Kim J(1),

Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers.

28. Clin Ther. 2009 Feb;31(2):311-20. doi: 10.1016/j.clinthera.2009.02.010. Pharmacokinetic properties of S-adenosylmethionine after oral and intravenous administration of its tosylate disulfate salt: a multiple-dose, open-label, parallel-group study in healthy Chinese volunteers. Yang J(1), He

Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations.

19. Ageing Res Rev. 2025 Feb;104:102634. doi: 10.1016/j.arr.2024.102634. Epub 2024 Dec 6. Betaine and aging: A narrative review of findings, possible mechanisms, research perspectives, and practical recommendations. Zawieja E(1), Chmurzynska A(2). Author information: (1)Department of Human Nutr

S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review.

16. Nutrients. 2024 Oct 28;16(21):3668. doi: 10.3390/nu16213668. S-Adenosylmethionine (SAMe) for Liver Health: A Systematic Review. Baden KER(1), McClain H(1), Craig E(1), Gibson N(1), Draime JA(1), Chen AMH(1). Author information: (1)School of Pharmacy, Cedarville University, Cedarville, OH 4531