로디올라 (지구력)
Rhodiola (Endurance)
📚 관련 논문 (16편)
1. Nutrients. 2025 Mar 7;17(6):940. doi: 10.3390/nu17060940. The Impact of Rhodiola Rosea Extract on Strength Performance in Alternative Bench-Press and Bench-Pull Exercises Under Resting and Mental Fatigue Conditions: A Randomized, Triple-Blinded, Placebo-Controlled, Crossover Trial. Marcos-Fru
2. J Int Soc Sports Nutr. 2024 Dec;21(1):2433744. doi: 10.1080/15502783.2024.2433744. Epub 2024 Nov 27. Salidroside and exercise performance in healthy active young adults - an exploratory, randomized, double-blind, placebo-controlled study. Schwarz NA(1)(2), Stratton MT(1), Colquhoun RJ(1)(2),
3. Int J Environ Res Public Health. 2021 Jun 29;18(13):6953. doi: 10.3390/ijerph18136953. Effects of Short-Term Golden Root Extract (Rhodiola rosea) Supplementation on Resistance Exercise Performance. Williams TD(1), Langley HN(1), Roberson CC(1), Rogers RR(1), Ballmann CG(1). Author informatio
4. Phytother Res. 2023 Oct;37(10):4414-4428. doi: 10.1002/ptr.7950. Epub 2023 Jul 26. Rhodiola rosea supplementation on sports performance: A systematic review of randomized controlled trials. Sanz-Barrio PM(1), Noreen EE(2), Gilsanz-Estebaranz L(3), Lorenzo-Calvo J(4), Martínez-Ferrán M(5), Pa
5. Nutrients. 2021 Aug 20;13(8):2861. doi: 10.3390/nu13082861. Plant Adaptogens-History and Future Perspectives. Todorova V(1), Ivanov K(1), Delattre C(2)(3), Nalbantova V(1), Karcheva-Bahchevanska D(1), Ivanova S(1). Author information: (1)Department of Pharmacognosy and Pharmaceutical Chemistr
1. Ann Agric Environ Med. 2026 Mar 25;33(1):3-11. doi: 10.26444/aaem/213417. Epub 2025 Dec 9. Clinical evidence for the adaptogenic effects of Withania somnifera and Rhodiola rosea - A systematic review with molecular interpretation of psychometric outcomes. Łuszczak J(1), Kocki J(2). Author information: (1)Department of Biology with Genetics, Medical University, Lublin, Poland. (2)Department of Clinical Genetics, Medical University, Lublin, Poland. INTRODUCTION AND OBJECTIVE: Adaptogens are plant-derived substances that enhance the body's resilience to physical and psychological stress, with Withania somnifera and Rhodiola rosea being among the most studied representatives. The aim of this review is to evaluate the adaptogenic effects of W. somnifera and R. rosea based on randomized controlled trials (RCTs). REVIEW METHODS: A systematic literature search was performed using the key words: 'ashwagandha', 'Withania somnifera', 'Rhodiola rosea', and 'plant adaptogen'. Twenty-four studies met the inclusion criteria - 19 on W. somnifera and 5 on R. rosea. BRIEF DESCRIPTION OF THE STATE OF KNOWLEDGE: The analyzed trials involved 10-590 participants, aged 18-75 years, both healthy individuals and patients with stress-related or functional disorders. Interventions included standardized extracts at daily doses of 120-1000 mg for W. somnifera and 290-1500 mg for R. rosea, with supplementation lasting 3-16 weeks. Reported benefits included reduction of stress and anxiety, alleviation of depressive symptoms, improved sleep quality, enhancement of cognitive functions, increased muscle strength and recovery, and favourable hormonal changes. Methodological heterogeneity, short intervention periods, and small sample sizes remain limitations. SUMMARY: Evidence from RCTs confirms that W. somnifera and R. rosea exert multi-dimensional adaptogenic effects, improving psychophysical health and supporting stress resilience. Their mechanisms involve regulation of the hypothalamic-pituitary-adrenal axis, neurotransmission, immune and hormonal pathways. Further long-term, high-quality clinical trials, supplemented with molecular and systemic approaches, are required to consolidate their role in integrative, evidence-based medicine. DOI: 10.26444/aaem/213417 PMID: 41906501 [Indexed for MEDLINE]
2. Nutrients. 2026 Feb 24;18(5):724. doi: 10.3390/nu18050724. Effects of Rhodiola rosea on Physical and Decision-Making Performance in Football Players: A Randomised Controlled Trial. Dou Y(1), Wang Y(1), Zhang W(1), Jiang Y(2), Zhang J(1), Yang T(1), Han Z(1), Li Y(1), Liu C(3), Ren D(1). Author information: (1)China Football College, Beijing Sport University, Beijing 100084, China. (2)China Institute of Sport Science, General Administration of Sport of China, Beijing 100061, China. (3)School of Sport Science, Beijing Sport University, Beijing 100084, China. Objectives: To determine whether four weeks of Rhodiola rosea (RHO) supplementation improves intermittent exercise performance, post-exercise blood lactate concentrations, and decision-making under fatigue in competitive football players. Methods: Twenty-four male competitive football players completed a randomised, double-blind, placebo-controlled 4-week intervention (RHO vs. placebo). Outcomes included Yo-Yo IR2, repeated-sprint ability (RSA), post-RSA blood lactate (0, 3, 5 min), football-specific technical tests (passing and shooting), a video-based decision-making task (reaction time and accuracy), GPS-derived match running metrics, countermovement jump (CMJ), foot tapping (TAP), and haematological markers. Results: Yo-Yo IR2 performance significantly improved in the RHO group (p = 0.012) and was superior to the placebo group (p = 0.046). For RSA, mean sprint time improved significantly from pre- to post-intervention in the RHO group (p = 0.017), whereas no significant change was observed in the placebo group. Post-intervention, mean sprint time was significantly better in RHO than placebo (p = 0.041), with no between-group difference observed at baseline. Best sprint time showed no between-group difference (p = 0.723). Post-exercise blood lactate concentrations were significantly lower in RHO than placebo at 0, 3, and 5 min (all p < 0.05). Under fatigue, the RHO group demonstrated faster reaction time (p = 0.042) and higher decision accuracy (p = 0.049) than placebo. Additionally, the RHO group showed significant pre- to post-intervention improvements in passing and shooting performance (p < 0.05), with between-group differences observed only for short-pass performance. Match total and high-speed running distances were higher in RHO, accompanied by increases in haemoglobin and haematocrit (p < 0.05). Conclusions: Four weeks of Rhodiola rosea supplementation enhanced high-intensity intermittent performance and decision-making under fatigue, with findings suggesting improved performance maintenance rather than increased peak sprint capacity. DOI: 10.3390/nu18050724 PMCID: PMC12986682 PMID: 41829897 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
3. Nutrients. 2025 Nov 28;17(23):3736. doi: 10.3390/nu17233736. Dose-Response Effects of Short-Term Rhodiola rosea (Golden Root Extract) Supplementation on Anaerobic Exercise Performance and Cognitive Function in Resistance-Trained Athletes: A Randomized, Crossover, Double-Blind, and Placebo-Controlled Study. Koozehchian MS(1), Newton AT(1), Mabrey G(1), Bonness FM(1), Rafajlovska R(1), Naderi A(2). Author information: (1)Department of Kinesiology, Jacksonville State University, Jacksonville, AL 36265, USA. (2)Department of Sport Physiology, Boroujerd Branch, Azad University, Boroujerd 6915136111, Iran. Background: Rhodiola rosea (RR) is marketed as an adaptogen; however, evidence for acute/short-term effects-and especially dose-response effects-in trained adults across performance and cognition is limited. Objective: Test whether RR improves resistance performance (strength, power) and executive function in resistance-trained adults using a randomized crossover with placebo and a capsule-free baseline. Methods: In a randomized, double-blind, crossover trial with four conditions-no-capsule control (CON), placebo (PL), low-dose RR (LDRR), and high-dose RR (HDRR). Twenty-seven resistance-trained adults completed the conditions. Day-7 testing included bench press (BP) and leg press (LP) 1-repetition maximum (1RM); a third set to failure at 60% 1RM with set-3 volume; Tendo mean/peak power; a 30 s Wingate; and the Stroop Color-Word Test. Secondary endpoints were Rating of Perceived Exertion (RPE), Readiness to perform using a Visual Analog Scale (VAS), and hemodynamics. Results: Versus CON, LDRR increased BP 1RM (+5.59 kg; p = 0.003), set-3 repetitions (+4.30; p < 0.001), set-3 volume (+168.6 kg; p < 0.001), and mean power (+29.7 W; p = 0.026). HDRR increased set-3 repetitions (+2.78; p = 0.005) and peak power (+34.2 W; p = 0.026), with a trend for set-3 volume (p = 0.086). LP 1RM exceeded CON with LDRR (+35.7 kg; p < 0.001) and HDRR (+47.7 kg; p < 0.001); contrasts vs. PL were significant. Wingate outcomes showed no consistent effects. Stroop improved vs. CON across all sections: Word +10.5 to +17.4 counts (p < 0.05), Color +6.1 to +12.0 (p ≤ 0.03), and Color-Word +10.2 to +18.9 (p < 0.001). Conclusions: Short-term RR consumption, regardless of dose or gender, improved resistance performance and significantly enhanced Stroop outcomes, with minimal changes in anaerobic cycling and RPE, and no consistent acute hemodynamic effects. DOI: 10.3390/nu17233736 PMCID: PMC12693935 PMID: 41374026 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
4. Nutrients. 2025 Nov 25;17(23):3694. doi: 10.3390/nu17233694. The Effect of Short-Term Rhodiola rosea Supplementation on Simulated Game Time, Perceived Fatigue, and Performance in Basketball Players. Wang J(1), Zhao H(2)(3), Yu L(4), Zhao K(5), Jiang W(6), Liu S(6), Dai J(6), Xu L(6), Sun P(7), Yun H(1)(2)(8), Liu C(2). Author information: (1)School of Physical Education, Zhejiang Guangsha Vocational and Technical University of Construction, Jinhua 322100, China. (2)School of Sport Science, Beijing Sport University, Beijing 100084, China. (3)Department of Physical Education, Jiangnan University, Wuxi 214122, China. (4)The School of Arts, Beijing Sport University, Beijing 100084, China. (5)China Volleyball Academy, Beijing Sport University, Beijing 100084, China. (6)Sport Coaching College, Beijing Sport University, Beijing 100084, China. (7)Physical Education Department, Dalian Medical University, Dalian 116044, China. (8)Faculty of Health Sciences and Sports, Macao Polytechnic University, Macao 999078, China. Objectives: This study aims to evaluate the effects of short-term Rhodiola rosea supplementation on simulated game performance, perceived fatigue, and aerobic capacity in basketball players. Methods: A total of 48 professional male basketball players participated in this study. The participants were randomly divided into a Rhodiola rosea group (RHO group, n = 24) and a Control group (CTR group, n = 24). During the experiment, the RHO group received continuous 28-day Rhodiola rosea supplementation, while the CTR group received empty capsules without being informed. Statistical analysis was performed using SPSS 22.0 software. A two-way mixed ANOVA (2 × 2) group (CTR/RHO) × time (Pre-test/Post-test) was conducted to compare differences. Results: In comparison to the CTR group, the RHO group showed significant differences in total completion time in the simulated game (p = 0.046), heart rate 60 s after the simulated game (p = 0.026), 5 km run (p = 0.027), YO-YO test (p = 0.036), VO2max (p = 0.034) and total antioxidant capacity (p = 0.044) compared to the CTR group. Within the RHO group, pre- and post-test comparisons revealed significant improvements in total completion time (p = 0.000), heart rate 30 s (p = 0.021) and 60 s (p = 0.016) after the simulated game, RPE score (p = 0.030), Countermovement jump test (p = 0.036), 5 km run (p = 0.000), YO-YO test (p = 0.000), VO2max (p = 0.000) and Superoxide Dismutase (p = 0.011). Conclusions: Short-term Rhodiola rosea supplementation can improve sprint performance and reduce perceived fatigue in basketball players during simulated games, enhance aerobic work capacity, and delay fatigue. DOI: 10.3390/nu17233694 PMCID: PMC12694508 PMID: 41373984 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
5. Ophthalmic Physiol Opt. 2025 Nov;45(7):2054-2062. doi: 10.1111/opo.70005. Epub 2025 Aug 27. Can Rhodiola rosea supplementation mitigate digital eye strain? A triple-blinded placebo-controlled study. Lara PM(1), Vera J(1)(2), Marcos-Frutos D(3), Alix-Fages C(4), Jiménez-Martínez P(4), García-Ramos A(3)(5), Redondo B(1)(2). Author information: (1)CLARO (Clinical and Laboratory Applications of Research in Optometry) Research Group, Department of Optics, Faculty of Sciences, University of Granada, Granada, Spain. (2)New England College of Optometry, Boston, Massachusetts, USA. (3)Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. (4)Department of Health Research, ICEN Canary University, Santa Cruz, Spain. (5)Department of Sports Sciences and Physical Conditioning, Faculty of Education, Universidad Católica de la Santísima Concepción, Concepción, Chile. PURPOSE: This study aimed to assess the impact of Rhodiola rosea (RR) supplementation on the dynamics of the accommodative response and digital eye strain (DES) symptoms following 30-min visual tasks with different levels of cognitive demand. METHODS: Eighteen young adults (mean age ± SD: 24.6 ± 4.0 years) participated in this placebo-controlled, triple-blind, balanced crossover study. Participants completed four sessions separated by 1 week in a randomised order. The sessions differed in the supplement (RR or placebo) and cognitive demand of the visual task (Stroop test or control video). The supplementation consisted of 1200 mg of RR or placebo per day for 4 days (two 300 mg capsules every 12 h) and a washout period of 3 days was allowed before the subsequent condition. The lag and variability of the accommodative response were measured at 500, 40 and 20 cm using an open-field autorefractor, and DES symptoms were assessed using a 10-item questionnaire. RESULTS: RR supplementation caused a reduction in the variability of accommodation (p = 0.007) and the perceived levels of 'Blurred vision when looking into the distance at the end of the near task' (p = 0.009). However, the lag of accommodation (p = 0.15) and the remainder of the DES symptoms were unaffected by the ingestion of RR (p > 0.05 in all cases). The reduction in the variability of accommodation after RR intake was observed at 40 and 20 cm (p-values <0.001 and 0.04, respectively), but not at far distance (500 cm, p = 0.40). CONCLUSIONS: These findings show that RR supplementation (1200 mg/day for 4 days) produced a reduction in the variability of accommodation and one of the assessed DES symptoms, suggesting that it could be considered as a potential strategy to prevent or manage DES. However, further research is needed to determine its clinical relevance and optimise dosage and timing. © 2025 The Author(s). Ophthalmic and Physiological Optics published by John Wiley & Sons Ltd on behalf of College of Optometrists. DOI: 10.1111/opo.70005 PMCID: PMC12682093 PMID: 40873122 [Indexed for MEDLINE] Conflict of interest statement: The authors report no conflicts of interest.
6. Neuropsychopharmacol Rep. 2025 Mar;45(1):e70008. doi: 10.1002/npr2.70008. Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis. Urata M(1), Sakurai H(1), Ueno F(2), Maruki T(1), Tada T(1), Uchida T(3)(4), Matsumoto Y(1), Murao M(1), Tomita M(5), Baba H(6), Kato M(7), Tsuboi T(1), Watanabe K(1). Author information: (1)Department of Neuropsychiatry, Kyorin University Faculty of Medicine, Tokyo, Japan. (2)Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. (3)Uchida Clinic, Tokyo, Japan. (4)Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan. (5)Oizumi Hospital, Tokyo, Japan. (6)Department of Psychiatry & Behavioral Science, Juntendo University Graduate School of Medicine, Tokyo, Japan. (7)Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan. BACKGROUND: Mild depression lacks a consistent definition across diagnostic criteria and rating scales, posing challenges to standardizing treatment strategies. International guidelines predominantly recommend psychotherapy as the first-line treatment for mild depression, while the use of antidepressants remains contentious. Supplements such as omega-3 fatty acids, St. John's Wort, and magnesium have garnered attention as alternative therapeutic options for depression. This systematic review aims to assess the efficacy of pharmacological interventions, including supplements, in the treatment of mild depression. METHODS: Comprehensive searches were performed in PubMed and Embase through November 2024 to identify randomized controlled trials (RCTs) investigating pharmacotherapy or supplements for mild depression diagnosed using standardized criteria. Eligible studies underwent screening and risk of bias assessment utilizing the ROB2 tool. Data on remission rates, symptom improvement, dropout rates, and adverse events were extracted, with meta-analyses conducted where applicable. RESULTS: Eight RCTs comprising 1049 participants met inclusion criteria. Among the agents studied, St. John's Wort was analyzed in two trials, both comparing it to fluoxetine. A meta-analysis found no significant difference in response rates between the two treatments (risk ratio [RR] = 0.96, 95% CI: 0.78-1.18) or dropout rates (RR = 1.08, 95% CI: 0.62-1.88). For other agents, single studies evaluated their effects. Eicosapentaenoic acid and Rhodiola rosea demonstrated significant improvements in depressive symptoms compared to placebo. In non-blinded trials, magnesium chloride showed efficacy in alleviating depressive symptoms. Other interventions, such as lavender, lemon balm, and transcranial electroacupuncture stimulation, were as effective as antidepressants. Conversely, S-adenosylmethionine did not produce significant improvements relative to placebo. CONCLUSION: This review demonstrates that certain supplements, such as eicosapentaenoic acids and Rhodiola rosea, are therapeutic options for mild depression. However, no RCTs compared antidepressants directly to placebo for mild depression. The paucity of high-quality RCTs exclusively targeting mild depression limits definitive conclusions, warranting further rigorous research. © 2025 The Author(s). Neuropsychopharmacology Reports published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Neuropsychopharmacology. DOI: 10.1002/npr2.70008 PMCID: PMC11867163 PMID: 40014460 [Indexed for MEDLINE] Conflict of interest statement: MU has received speaker honoraria from Sumitomo Pharma and Janssen Pharmaceutical over the last 3 years. HS received grants from the Japan Society for the Promotion of Science, the Japan Research Foundation Clinical Pharmacology, and the Takeda Science Foundation, and an honorarium from Viatris, Eisai, Takeda Pharmaceutical, Otsuka Pharmaceutical, Meiji Seika Pharma, Shionogi Pharma, Yoshitomiyakuhin, Sumitomo Pharma, Kyowa Pharmaceutical, MSD, and Lundbeck Japan. HS is an Editorial Board member of Neuropsychopharmacology Reports and a corresponding author of this article. To minimize bias, they were excluded from all editorial decision‐making related to the acceptance of this article for publication. FU has received grants from the Nakatani Foundation, the Canadian Institutes of Health Research (CIHR), and the Brain & Behavior Research Foundation (BBRF); manuscript fees from Dainippon Sumitomo Pharma; and consultant fees from WCG Clinical and Uchiyama Underwriting within the past three years. TM has nothing to declare. T. Tada has received speaker honoraria from Dainippon Sumitomo Pharma and Otsuka Pharmaceutical. TU has nothing to declare. YM received an honorarium from Sumitomo Pharma, Janssen Pharmaceutical, and Meiji Seika Pharma. MM received an honorarium from Sumitomo Pharma, Yoshitomiyakuhin. MT has nothing to declare. HB received grant funding from the Japan Society for the Promotion of Science and speaker's honoraria from Otsuka Pharmaceutical, Sumitomo Dainippon Pharma, Viatris, MSD, Meiji Seika Pharma, Eli Lilly, Yoshitomi Yakuhin, Janssen Pharmaceutical, Kyowa Pharmaceutical, Mitsubishi Tanabe Pharma, Pfizer, Esai, Takeda Pharmaceutical, Lundbeck Japan, Mochida, Sawai, Kowa, EA Pharma, and Mylan EPD. MK has received grant funding from AMED, the Japanese Ministry of Health, Labour and Welfare, the Japan Society for the Promotion of Science, SENSHIN Medical Research Foundation, the Japan Research Foundation for Clinical Pharmacology, and the Japanese Society of Clinical Neuropsychopharmacology, and consulting fees from Sumitomo Pharma Co. Ltd., Shionogi & Co. Ltd., Otsuka Pharmaceutical Co. Ltd., Lundbeck Japan K.K., Boehringer Ingelheim Co. Ltd., and Takeda Pharmaceutical Co. Ltd.; payment or honoraria for lectures, presentations, speakers' bureaus, manuscript writing, or educational events from Sumitomo Pharma Co. Ltd., Otsuka Pharmaceutical Co. Ltd., Meiji Seika Pharma Co. Ltd., Shionogi & Co. Ltd., Mitsubishi Tanabe Pharma Corporation, Takeda Pharmaceutical Co. Ltd., Lundbeck Japan K.K., Viatris Inc., Eisai Co. Ltd., and Kyowa Pharmaceutical Industry Co. Ltd. T. Tsuboi received grants from the Japan Society for the Promotion of Science and an honorarium from Takeda Pharmaceutical, Otsuka Pharmaceutical, Meiji Seika Pharma, Shionogi Pharma, Yoshitomiyakuhin, Sumitomo Pharma, Kyowa Pharmaceutical, MSD, Nippon Boehringer Ingelheim, Mylan EPD, Mitsubishi Tanabe Pharma, Viatris, Mochida Pharmaceutical, Janssen Pharmaceutical, TEIJIN PHARMA, and Lundbeck Japan. KW has received consultant fees from Boehringer Ingelheim, Daiichi Sankyo, Eisai, Lundbeck Japan, Luye Pharma, Mitsubishi Tanabe Pharma, Nippon Chemiphar, Ono Pharmaceutical, Otsuka Pharmaceutical, Sumitomo Pharma, and Takeda Pharmaceutical, received grant funding from AMED, the Japan Society for the Promotion of Science, and speaker honoraria from Boehringer Ingelheim, Eisai, Janssen Pharmaceutical, Kyowa Pharmaceutical, Lundbeck Japan, Meiji Seika Pharma, Mitsubishi Tanabe Pharma, MSD, Otsuka Pharmaceutical, Shionogi, Sumitomo Pharma, Takeda Pharmaceutical, and Viatris.
7. Nutrients. 2025 Feb 14;17(4):681. doi: 10.3390/nu17040681. Effects of the Combined Supplementation of Caffeine and Rhodiola Rosea with Resistance Training on Lower Limb Explosive Power in Male Volleyball Players. Wang Z(1), Du H(1), Li H(2), Zhao K(1), Zhao B(1), Ma Y(1), Zhang J(1), Wu K(1), Jiang W(1), Liu C(2). Author information: (1)Chinese College of Volleyball, Beijing Sport University, Beijing 100084, China. (2)School of Sport Science, Beijing Sport University, Beijing 100084, China. BACKGROUND: This study investigated the effects of combined Rhodiola rosea (RHO) and caffeine (CAF) supplementation on lower limb explosive power and fatigue recovery in volleyball players, aiming to validate their potential synergistic effects. METHODS: A randomized, double-blind, placebo-controlled design was implemented involving 48 male volleyball athletes allocated into four groups: placebo (CTR), Rhodiola rosea (RHO), caffeine (CAF), and combined (RHO + CAF). Over four weeks, participants engaged in twice-weekly high-intensity lower limb resistance training, with performance evaluated through multiple tests, including two-step-approach jump height, countermovement jump (CMJ), five-jump test (5 JT), continuous 20 vertical jumps, and intermittent jump recovery alongside Rate of Perceived Exertion (RPE) assessments. RESULTS: Results showed that the combined supplementation (RHO + CAF) group exhibited significant improvement across multiple performance metrics. In particular, the combined group demonstrated the highest increases in jump height and the least power decline during high-frequency jumps, outperforming the CTR and other supplementation groups (p < 0.05). Additionally, RHO + CAF supplementation significantly lowered RPE scores, particularly in the final week of training, indicating improved perceived fatigue and recovery. CONCLUSIONS: This study suggests that combining RHO and CAF optimizes high-intensity performance by enhancing explosive power, reducing fatigue, and improving recovery, presenting an effective nutritional strategy for volleyball athletes. DOI: 10.3390/nu17040681 PMCID: PMC11857981 PMID: 40005009 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.
8. J Diet Suppl. 2024;21(4):495-511. doi: 10.1080/19390211.2023.2301398. Epub 2024 Jan 11. Effects of the PREMEN-CALM® in the Management of the Premenstrual Syndrome: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Herrera A(1), Al Adib M(1)(2), Rodríguez AB(1), Carrasco C(1). Author information: (1)Neuroimmunophysiology and Chrononutrition Research Group, Department of Physiology, Faculty of Sciences/Medicine, University of Extremadura, Badajoz, Spain. (2)Obstetrics & Gynecology clinics "Miriam Gine", Almendralejo, Spain. Premenstrual syndrome is a common disorder in women of reproductive age characterized by a variety of cyclical symptoms with a great impact on their lifestyle. Available pharmacological options include both antidepressants and oral contraceptives, both of which have side effects, are expensive and not always effective. Vitamins, minerals and plant extracts have been proven to alleviate the symptomatology of the premenstrual syndrome. For this reason, the purpose of this study was to test the effectiveness of a commercial phytotherapeutic dietary supplement (PREMEN-CALM®: γ-aminobutyric acid, Rhodiola rosea L., Vitex agnus-castus, vitamin B6 and melatonin) as an alternative treatment for this condition. A randomized, double-blind, and placebo-controlled pilot study was performed. Participants (n = 42) were assessed before and after 3 months of taking the supplement (n = 21) or the placebo (n = 21). Outcome measures include antioxidant and inflammatory biomarkers, body composition, subjective sleep quality, mood state profile, quality of life, and certain characteristics of the menstrual cycle. The within-group analysis revealed a significant improvement in the total antioxidant status (1.49 ± 0.34 vs reference value 1, p = 0.002), mood state profile (p = 0.02), and affective symptoms (p = 0.01) in the women receiving the commercial phytotherapeutic dietary supplement PREMEN-CALM®. On the contrary, the between-group analysis showed no statistical differences, suggesting a plausible placebo effect. The phytotherapeutic supplement PREMEN-CALM® might be effective in treating or alleviating the symptoms of the premenstrual syndrome without adverse events. Integrative medicine approaches in the clinical practice may help improve the health of women suffering from this and other gynecological conditions. DOI: 10.1080/19390211.2023.2301398 PMID: 38213037 [Indexed for MEDLINE]
9. J Diet Suppl. 2021;18(6):597-613. doi: 10.1080/19390211.2020.1822486. Epub 2020 Oct 20. Effects of Concurrent Training and a Multi-Ingredient Performance Supplement Containing Rhodiola rosea and Cordyceps sinensis on Body Composition, Performance, and Health in Active Men. Kreipke PhD VC(1), Moffatt PhD RJ(1), Tanner Ma CJ(2), Ormsbee PhD MJ(1)(3). Author information: (1)Department of Nutrition, Food and Exercise Sciences, Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, USA. (2)Department of Kinesiology, Human Performance Laboratory, East Carolina University, Greenville, NC, USA. (3)Discipline of Biokinetics, Exercise and Leisure Sciences, University of KwaZulu-Natal, Durban, South Africa. INTRODUCTION: Supplementation with Rhodiola Rosea (RR) and Cordyceps Sinensis (CS) has been shown to improve aerobic performance, but their influence on concurrent training (resistance training plus high intensity interval training) outcomes has not been established. The purpose of this study was to determine the effects of supplementation with a multi-ingredient performance supplement (MIPS) containing RR and CS during a 14-week training and testing program on body composition, weekly exercise training outcomes, overall training and performance outcomes, and hormone profiles. METHODS: Active college-aged men (N = 21) were stratified into either a MIPS or a placebo (PLA) group. Both groups completed 14 weeks of training and testing. Body composition, overall training outcomes, and blood sample collection occurred at weeks 0, 7, and 14, while training performance was evaluated weekly. RESULTS: Both groups improved (p < 0.05) percent body fat (-1.3%), bench press (+4%) and squat strength (+8%), with no difference between groups. Serum cortisol concentrations significantly decreased (-11%) but there were no differences between groups. No other changes in blood hormone profiles occurred. Weekly exercise performance data suggests that MIPS improved sprint performance, bench press lifting volume, and total workload, but this did not lead to improved overall training performance compared to PLA over the14-week study. CONCLUSION: Despite MIPS improving certain aspects of weekly training performance, supplementation with MIPS for 14 weeks did not improve body composition, overall training and performance outcomes, or blood biomarkers of health in response to concurrent training in young men compared to PLA. This study was registered with clinicaltrials. gov (NCT02383017). DOI: 10.1080/19390211.2020.1822486 PMID: 33078636 [Indexed for MEDLINE]
10. J Diet Suppl. 2021;18(5):507-516. doi: 10.1080/19390211.2020.1790709. Epub 2020 Jul 29. The Acute Effects of a Multi-Ingredient Herbal Supplement on Performance Fatigability: A Double-Blind, Randomized, and Placebo-Controlled Trial. Ryan ED(1)(2), Gerstner GR(3), Mota JA(4), Trexler ET(5), Giuliani HK(1)(2), Blue MNM(6), Hirsch KR(7), Smith-Ryan AE(2)(8). Author information: (1)Neuromuscular Assessment Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. (2)Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. (3)Department of Human Movement Sciences, Old Dominion University, Norfolk, VA, USA. (4)Department of Kinesiology, University of Alabama, Tuscaloosa, AL, USA. (5)Stronger By Science LLC, Chapel Hill, NC, USA. (6)Human Biomechanics and Physiology Lab, Department of Exercise Science, High Point University, High Point, NC, USA. (7)Center for Translational Research in Aging and Longevity, University of Arkansas for Medical Sciences, Little Rock, AR, USA. (8)Applied Physiology Laboratory, Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. The purpose of the present study was to examine the acute effects of an herbal supplement containing a 70:30 blend of Rhaponticum carthamoides extract and Rhodiola rosea extract, respectively, on performance fatigability and the affective responses prior to and following exercise. Thirty men (age = 22.3 ± 4.1 years) volunteered for this randomized, placebo-controlled, double-blind, cross-over study. Following familiarization, participants visited the laboratory on three separate occasions where they consumed one 350 mg dose, a 175 mg dose of the supplement plus 175 mg of maltodextrin, or a placebo. Participants completed feeling, arousal, and mood surveys at supplement ingestion and following testing. Ninety minutes following ingestion, participants performed five sets of 30 maximal, concentric, leg extension muscle actions at 180°/sec, with one minute of rest between sets. Peak torque, average torque, and total work were calculated for each set, and the rating of perceived exertion (RPE) was assessed after each set. Data were analyzed with a repeated measures analysis of variance and intent-to-treat approach. For the performance variables, there was no interaction (p ≥ 0.317) or treatment effect (p ≥ 0.660), however, all torque variables decreased across sets and plateaued at sets 4-5, whereas RPE increased across sets (p < 0.001). For the affective responses, there was no interaction (p ≥ 0.781) or treatment effect (p ≥ 0.314); however, participants felt better, had an improved mood, and felt more aroused following testing (p < 0.047). This combination of herbal extracts likely does not acutely influence performance fatigability during high-intensity, repeated muscle actions. DOI: 10.1080/19390211.2020.1790709 PMID: 32723193 [Indexed for MEDLINE]
11. Nutrients. 2019 Oct 3;11(10):2357. doi: 10.3390/nu11102357. Rhodiola/Cordyceps-Based Herbal Supplement Promotes Endurance Training-Improved Body Composition But Not Oxidative Stress and Metabolic Biomarkers: A Preliminary Randomized Controlled Study. Liao YH(1), Chao YC(2), Sim BY(2), Lin HM(3), Chen MT(4), Chen CY(5). Author information: (1)Department of Exercise and Health Science, National Taipei University of Nursing and Health Sciences, Taipei City 112, Taiwan. (2)Department of Exercise and Health Sciences, University of Taipei, Taipei City 111, Taiwan. (3)Department of Aquatic Sports, University of Taipei, Taipei City 111, Taiwan. (4)School of Liberal Education, Shih Chien University, Taipei City 104, Taiwan. (5)Department of Exercise and Health Sciences, University of Taipei, Taipei City 111, Taiwan. fish0510@gmail.com. Rhodiola crenulata (R) and Cordyceps sinensis (C) are commonly used herbs that promote health in traditional Chinese medicine. These two herbs have also been shown to exhibit anti-inflammation and antioxidant functions. Regular endurance training reveals potent endurance capacity, body composition improvement, and metabolic-related biomarker benefits. However, it is not known whether the combination of Rhodiola crenulata and Cordyceps sinensis (RC) supplementation during endurance training provides additive health benefits. The purpose of this study was to investigate the effects of 8-week endurance training plus RC supplementation on body composition, oxidative stress, and metabolic biomarkers in young sedentary adults. METHODS: Fourteen young sedentary adults (8M/6F) participated in this double-blind randomized controlled study. Participants were assigned to exercise training with placebo groups (PLA, n = 7, 4M/3F; age: 21.4 ± 0.4 years) and exercise training with the RC group (RC, 20 mg/kg/day; n = 7, 4M/3F; age: 21.7 ± 0.4 years). Both groups received identical exercise training for eight weeks. The body composition, circulating oxidative stress, and blood metabolic biomarkers were measured before and after the 8-week intervention. RESULTS: Improvement in body composition profiles were significantly greater in the RC group (body weight: p = 0.044, BMI: p = 0.003, upper extremity fat mass: p = 0.032, lower extremity muscle mass: p = 0.029, trunk fat mass: p = 0.011) compared to the PLA group after training. The blood lipid profile and systemic oxidative stress makers (thiobarbituric reactive substanceand total antioxidant capacity) did not differ between groups. Although endurance training markedly improved endurance capacity and glycemic control ability (i.e., fast blood glucose, insulin, and HOMA index), there were no differences in these variables between treatments. CONCLUSIONS: In this preliminary investigation, we demonstrated that an 8-week RC supplementation (20 mg/kg/day) faintly enhanced endurance training-induced positive adaptations in body composition in young sedentary individuals, whereas the blood lipid profile and systemic oxidative stress states were not altered after such intervention. DOI: 10.3390/nu11102357 PMCID: PMC6835767 PMID: 31623349 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
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