라즈베리잎 (출산)
Raspberry Leaf (Labor)
📚 관련 논문 (10편)
1. Aust N Z J Obstet Gynaecol. 2022 Aug;62(4):506-510. doi: 10.1111/ajo.13496. Epub 2022 Feb 21. Survey of Raspberry Leaf Tea in pregnancy. Farnaghi S(1), Braniff K(1). Author information: (1)Department of Obstetrics and Gynaecology, Mackay Base Hospital, Mackay, Queensland, Australia. Comment
2. BMC Complement Med Ther. 2021 Feb 9;21(1):56. doi: 10.1186/s12906-021-03230-4. Biophysical effects, safety and efficacy of raspberry leaf use in pregnancy: a systematic integrative review. Bowman R(1), Taylor J(1), Muggleton S(1), Davis D(2)(3). Author information: (1)University of Canberra,
3. J Matern Fetal Neonatal Med. 2013 Feb;26(3):306-12. doi: 10.3109/14767058.2012.722732. Epub 2012 Oct 24. Herb remedies during pregnancy: a systematic review of controlled clinical trials. Dante G(1), Pedrielli G, Annessi E, Facchinetti F. Author information: (1)Mother-Infant Department, Univ
1. J Diet Suppl. 2019;16(6):649-658. doi: 10.1080/19390211.2018.1472713. Epub 2018 Jun 29. A Purported Detoxification Supplement Does Not Improve Body Composition, Waist Circumference, Blood Markers, or Gastrointestinal Symptoms in Healthy Adult Females. Tinsley G(1), Urbina S(2), Santos E(3), Villa K(2), Foster C(2), Wilborn C(2)(4), Taylor L(2). Author information: (1)Department of Kinesiology and Sport Management, Texas Tech University , Lubbock , TX , USA. (2)Department of Exercise and Sports Science, Human Performance Lab, University of Mary Hardin-Baylor , Belton , TX , USA. (3)Department of Cardiology, Cardiac Rehabilitation, Scott & White Medical Center , Temple , TX , USA. (4)Department of Physical Therapy, University of Mary Hardin-Baylor , Belton , TX , USA. Numerous popular "detoxification" supplements claim to promote the removal of harmful compounds from the body, thereby alleviating gastrointestinal symptoms, improving body composition, and enhancing overall health. The present double-blind, randomized, placebo-controlled trial was conducted to examine the effects of a purported detoxification supplement in healthy young adult females. Participants were randomly assigned to consume a multi-ingredient supplement or placebo daily for four weeks. The supplement contained 1,350 mg/serving of a proprietary blend of papaya leaf, cascara sagrada bark, slippery elm bark, peppermint leaf, red raspberry leaf, fenugreek seed, ginger root, and senna leaf. Body composition, waist circumferences, symptoms of gastrointestinal distress, and blood safety markers were evaluated before and after supplementation. Twenty-two participants completed the study, and data were analyzed via two-way mixed ANOVA and t tests. No beneficial or harmful effects of supplementation were found for body composition, waist circumference, gastrointestinal symptoms, or blood markers. These results indicate that consuming a commercially available dietary supplement that purportedly provides detoxification and body composition benefits is apparently safe in healthy young adult females but does not provide any beneficial effects for body composition or gastrointestinal symptoms. DOI: 10.1080/19390211.2018.1472713 PMID: 29958034 [Indexed for MEDLINE]
2. Nutr Metab (Lond). 2015 Aug 6;12:27. doi: 10.1186/s12986-015-0025-2. eCollection 2015. Identification of a botanical inhibitor of intestinal diacylglyceride acyltransferase 1 activity via in vitro screening and a parallel, randomized, blinded, placebo-controlled clinical trial. Velliquette RA(1), Grann K(2), Missler SR(1), Patterson J(1), Hu C(3), Gellenbeck KW(3), Scholten JD(1), Randolph RK(3). Author information: (1)Department of Analytical Sciences, Amway R&D, 7575 Fulton St., Building 50-2D, Ada, MI 49355 USA. (2)Nutrition Product Development, Food, Beverages and Chewables, Amway R&D, Ada, MI 49355 USA. (3)Nutrition Product Development, Supplements, Nutrilite Health Institute, Buena Park, CA 90622 USA. BACKGROUND: Diacylglyceride acyltransferase 1 (DGAT1) is the enzyme that adds the final fatty acid on to a diacylglyceride during triglyceride (TG) synthesis. DGAT1 plays a key role in the repackaging of dietary TG into circulating TG rich chylomicrons. A growing amount of research has indicated that an exaggerated postprandial circulating TG level is a risk indicator for cardiovascular and metabolic disorders. The aim of this research was to identify a botanical extract that inhibits intestinal DGAT1 activity and attenuates postprandial hypertriglyceridemia in overweight and obese humans. METHODS: Twenty individual phytochemicals and an internal proprietary botanical extract library were screened with a primary cell-free DGAT1 enzyme assay that contained dioleoyl glycerol and palmitoleoyl Coenzyme A as substrates plus human intestinal microsomes as the DGAT1 enzyme source. Botanical extracts with IC50 values < 100 μg/mL were evaluated in a cellular DGAT1 assay. The cellular DGAT1 assay comprised the analysis of (14)C labeled TG synthesis in cells incubated with (14)C-glycerol and 0.3 mM oleic acid. Lead botanical extracts were then evaluated in a parallel, double-blind, placebo-controlled clinical trial. Ninety healthy, overweight and obese participants were randomized to receive 2 g daily of placebo or individual botanical extracts (the investigational product) for seven days. Serum TG levels were measured before and after consuming a high fat meal (HFM) challenge (0.354 L drink/shake; 77 g fat, 25 g carbohydrate and 9 g protein) as a marker of intestinal DGAT1 enzyme activity. RESULTS: Phenolic acids (i.e., gallic acid) and polyphenols (i.e., cyanidin) abundantly found in nature appeared to inhibit DGAT1 enzyme activity in vitro. Four polyphenolic rich botanical extracts were identified from in vitro evaluation in both cell-free and cellular model systems: apple peel extract (APE), grape extract (GE), red raspberry leaf extract (RLE) and apricot/nectarine extract (ANE) (IC50 = 1.4, 5.6, and 10.4 and 3.4 μg/mL, respectively). In the seven day clinical trial, compared to placebo, only GE significantly reduced the baseline subtracted change in serum TG AUC following consumption of the HFM (AUC = 281 ± 37 vs. 181 ± 30 mg/dL*h, respectively; P = 0.021). Chromatographic characterization of the GE revealed a large number of closely eluting components containing proanthocyanidins, catechins, anthocyanins and their secondary metabolites that corresponded with the observed DGAT1 enzyme inhibition in the cell-free model. CONCLUSION: These data suggest that a dietary GE has the potential to attenuate postprandial hypertriglyceridemia in part by the inhibition of intestinal DGAT1 enzyme activity without intolerable side effects. TRIAL REGISTRATION: This trial was registered with ClinicalTrials.gov NCT02333461. DOI: 10.1186/s12986-015-0025-2 PMCID: PMC4526202 PMID: 26246845
3. Nutrients. 2025 Sep 1;17(17):2849. doi: 10.3390/nu17172849. Effects of Raspberry Leaf Tea Polyphenols on Postprandial Glucose and Insulin Responses in Healthy Adults. Alkhudaydi HMS(1)(2), Spencer JPE(1). Author information: (1)Department of Food and Nutritional Sciences, School of Chemistry, Food and Pharmacy, University of Reading, Reading RG6 6DZ, UK. (2)Food Science and Nutrition Department, Faculty of Science, Taif University, Taif 26571, Saudi Arabia. Background: Dietary polyphenols, particularly flavonoids, have been associated with improved glycemic control and reduced risk of type 2 diabetes. Raspberry leaf (RL) is a rich but underexplored source of such bioactives, including ellagitannins, flavonoids, and phenolic acids. While raspberry fruit has received some attention in nutritional science, the metabolic effects of raspberry leaf-especially its influence on postprandial glucose and insulin responses-remain largely unstudied. Objective: This study is the first to investigate the acute effects of RL tea consumption on postprandial blood glucose and insulin levels in healthy individuals following intake of common dietary carbohydrates (sucrose and glucose). Methods: In a randomized crossover study, 22 healthy adults (12 males, 10 females) consumed 50 g of glucose or sucrose with or without 10 g of RL tea in four separate sessions. Blood glucose and insulin levels were measured at fasting and at 15, 30, 60, 90, and 120 min post-ingestion. A total of 37 polyphenolic compounds were identified in the RL infusion using LC-MS, following a 5-minute hot water extraction. The contents of ellagitannins, flavonoids, and phenolic acids were 38 mg, 7 mg, and 4 mg per 10 g of RL, respectively, contributing to a total polyphenol content of 50 mg per 10 g. Results: When RL tea was consumed with sucrose, postprandial blood glucose levels were significantly reduced at 15 and 30 min by 1.19 ± 0.88 mmol/L (25.59% reduction, p = 0.001) and 2.03 ± 1.05 mmol/L (43.57% reduction, p = 0.0004), respectively. Insulin concentrations were also significantly lower at 15 min (113.90 ± 59.58 pmol/L, p = 0.019), 30 min (161.76 ± 91.96 pmol/L, p = 0.0008), and 60 min (139.44 ± 75.96 pmol/L, p = 0.025). No significant differences were observed with glucose ingestion. Conclusions: This study provides the first clinical evidence that RL tea can blunt early postprandial glycemic and insulinemic responses to sucrose in healthy individuals. The data suggest that these effects are likely mediated by relatively low levels of polyphenols-particularly ellagic acid-through inhibition of carbohydrate-digesting enzymes such as α-glucosidase and β-fructofuranosidase. These findings support the potential of RL tea as a simple, dietary approach to modulate glucose metabolism and warrant further investigation in populations at risk for metabolic disorders. DOI: 10.3390/nu17172849 PMCID: PMC12430597 PMID: 40944237 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflicts of interest.
4. BMC Complement Med Ther. 2024 Apr 22;24(1):169. doi: 10.1186/s12906-024-04465-7. Raspberry leaf (Rubus idaeus) use in pregnancy: a prospective observational study. Bowman RL(1), Taylor J(2), Davis DL(3). Author information: (1)University of Canberra, Canberra, Australia. Rebekah.Bowman@health.nsw.gov.au. (2)University of Canberra, Canberra, Australia. (3)University of Canberra and ACT Government, Health Directorate, Canberra, Australia. BACKGROUND: Raspberry leaf use during pregnancy in Australia is widespread. There has been little research exploring the potential beneficial or harmful effects of raspberry leaf on pregnancy, labour, and birth. More research is needed to appropriately inform childbearing women and maternity healthcare professionals on the effects of raspberry leaf so that women can make informed choices. METHODS: This study aimed to determine associations between raspberry leaf use in pregnancy and augmentation of labour and other secondary outcomes. Data was derived from questionnaires which captured demographic information and herbal use in pregnancy. Clinical outcomes were accessed from the maternity services' clinical database. Data analysis was conducted in R via package 'brms' an implementation for Bayesian regression models. RESULTS: A total of 91 completed records were obtained, 44 exposed to raspberry leaf and 47, not exposed. A smaller proportion of women in the raspberry leaf cohort had augmentation of labour, epidural anaesthesia, instrumental births, caesarean section, and postpartum haemorrhage. A larger proportion had vaginal birth and length of all phases of labour were shorter. Under these conditions the use of raspberry leaf was strongly predictive of women not having their labours medically augmented. CONCLUSIONS: While our study demonstrated that raspberry leaf was strongly predictive of women not having their labours medically augmented, the results cannot be relied on or generalised to the wider population of pregnant women. While there were no safety concerns observed in our study, this should not be taken as evidence that raspberry leaf is safe. A randomised controlled trial is urgently needed to provide women and healthcare providers with robust evidence on which to base practice. © 2024. The Author(s). DOI: 10.1186/s12906-024-04465-7 PMCID: PMC11034164 PMID: 38649906 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that they have not competing interests.
5. BMC Musculoskelet Disord. 2022 Jul 7;23(1):650. doi: 10.1186/s12891-022-05612-2. Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial. Henrotin Y(1)(2)(3), Cozannet RL(4), Fança-Berthon P(4), Truillet R(5), Cohen-Solhal M(6), DunnGalvin G(7), Grouin JM(8), Doolan A(7). Author information: (1)musculoSKeletal Innovative Research Lab (mSKIL), The Center for Interdisciplinary Research On Medicines (CIRM), Department of Motricity Center, Institute of Pathology, University of Liège, CHU Sart-Tilman, level 5, 4000, Liège, Belgium. yhenrotin@uliege.be. (2)Department of Physical Therapy and Rehabilitation, Princess Paola Hospital, Vivalia, Marche-en-Famenne, Belgium. yhenrotin@uliege.be. (3)Artialis SA, GIGA Tower, CHU Sart-Tilman, Avenue de l'hôpital, 4000, Liège, Belgium. yhenrotin@uliege.be. (4)Naturex SA, Avignon, France. (5)Atlanstat SA, Les Espaces Océane, 3, rue Jules Verne, 44400, Rezé, France. (6)BIOSCAR Inserm U1132 and Department of Rheumatology, Université de Paris, Hôpital 10 Lariboisière, 75010, Paris, France. (7)Atlantia Clinical Trials, Heron House Offices, Blackpool, T23 R50R, Cork, Ireland. (8)Department of Statistics, Rouen University, Rouen, France. BACKGROUND: Osteoarthritis (OA) is the most frequent cause of disability in elderly people. In daily practice, the main objective of the physician is to reduce patient symptoms using treatments without adverse effects. However, the most prescribed treatment to manage OA symptoms remains nonsteroidal anti-inflammatory drugs which are associated with severe adverse effects. Therefore, we need a safe alternative to managing OA. One candidate is Rubus idaeus leaf extracts known to inhibit inflammatory responses. OBJECTIVE: This study aimed to evaluate the effects of a 12-weeks intervention with an ethanolic extract from Rubus idaeus leaf on symptoms of knee osteoarthritis. METHOD: The study was a randomized, double-blind, placebo-controlled, monocentric trial of 198 participants with femorotibial osteoarthritis. Participants were randomized equally to receive one daily during 3 months either 1 capsule of Rubus idaeus leaf extract 400 mg, 1 capsule of Rubus idaeus leaf extract 200 mg, or 1 capsule of placebo. The participants were assessed at baseline and after one and three months of treatment. The primary endpoint was an absolute change of the Western Ontario McMaster osteoarthritis index (WOMAC) pain subscale. The secondary endpoints were WOMAC global score, stiffness and function sub-scales, knee pain VAS score at walking, the Short Form (SF)-36, the Short Physical Performance Battery (SPPB), the 20-m walk test, and the International Physical Activity Questionnaire (IPAQ) and Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) responders rate. Statistical analyses were conducted on the intent-to-treat (ITT) population. RESULTS: In the Intention-to-treat population, WOMAC pain was not significantly modified by Rubus idaeus leaf extract compared to placebo. In contrast, Rubus idaeus leaf extract 400 mg after 12 weeks of treatment significantly reduced pain measured by the VAS. The mean pain decrease induced by Rubus ideaus leaf extract was over -7 mm which is clinically relevant and reached a clinically statistical difference compared to placebo with the highest dose. Rubus Ideaus was not significantly more efficient than the placebo on WOMAC global score, stiffness, and physical function subscores, IPAQ, SF-36, walking distance in treadmill test, SPPB, and evaluation of associated treatments needed to manage OA. CONCLUSION: Rubus idaeus leaf extract was well tolerated and effective to relieve pain in a patient with knee osteoarthritis. TRIAL REGISTRATION: NCT03703024 (11/10/2018). © 2022. The Author(s). DOI: 10.1186/s12891-022-05612-2 PMCID: PMC9261022 PMID: 35799169 [Indexed for MEDLINE] Conflict of interest statement: YH received consulting fees from Naturex and is the founder and president of Artialis SA. RT from Atlanstats and JMG supported statistical analysis. RLC and PB are employees of Naturex. GDG and AD are employees of Atlantia. MCS has no disclosed conflicts of interest.
6. J Cosmet Dermatol. 2020 Mar;19(3):671-676. doi: 10.1111/jocd.13305. Epub 2020 Jan 24. Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial. Rattanawiwatpong P(1), Wanitphakdeedecha R(2), Bumrungpert A(1), Maiprasert M(1). Author information: (1)Master of Science Program in Anti-Aging & Regenerative Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand. (2)Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. BACKGROUND: Skin aging has many manifestations such as wrinkles, uneven skin tone, and dryness. Both intrinsic and extrinsic factors, especially ultraviolet light-induced oxidative radicals, contribute to the etiology of aging. Human skin requires both water- and lipid-soluble nutrient components, including hydrophilic and lipophilic antioxidants. Vitamins C and E have important protective effects in the aging process and require exogenous supply. Raspberry leaf extracts contain botanical actives that have the potential to hydrating and moisturizing skin. Topical products with these ingredients may therefore combine to provide improved anti-aging effects over single ingredients. OBJECTIVES: To evaluate the anti-aging and brightening effects of an encapsulated serum containing vitamin C (20% w/w), vitamin E, and European raspberry (Rubus idaeus) leaf cell culture extract. METHODS: Fifty female volunteers aged 30-65 years were allocated one capsule of serum for topical application on one side of the face for 2 months, in addition to self-use of facial skin products. Both test (treated) and contralateral (untreated) sides were dermatologically assessed after 4 and 8 weeks. Skin color (melanin index), elasticity, radiance, moisture, and water evaporation were measured by Mexameter MX18® , Cutometer® , Glossymeter GL200® , Corneometer CM825® , and Tewameter TM300® instruments, respectively (Courage + Khazaka Electronic GmbH). Skin microtopography parameters, smoothness (SEsm), roughness (SEr), scaliness (SEsc), and wrinkles (SEw), were measured by Visioscan® VC98 USB (Courage + Khazaka Electronic GmbH), and gross lifting effects were measured by VECTRA® H1 (Canfield Scientific), and adverse reactions and satisfaction were also assessed. RESULTS: Skin color, elasticity, and radiance were significantly improved. The smoothness, scaliness, and wrinkles were also revealed significant improvement. Mild adverse reactions were tingling and tightness. CONCLUSIONS: The vitamin C, vitamin E, and raspberry leaf cell culture extract serum has anti-aging and brightening effects of skin. © 2020 The Authors. Journal of Cosmetic Dermatology published by Wiley Periodicals, Inc. DOI: 10.1111/jocd.13305 PMCID: PMC7027822 PMID: 31975502 [Indexed for MEDLINE] Conflict of interest statement: No conflict of interests has been declared.
7. J Midwifery Womens Health. 2001 Mar-Apr;46(2):51-9. doi: 10.1016/s1526-9523(01)00095-2. Raspberry leaf in pregnancy: its safety and efficacy in labor. Simpson M(1), Parsons M, Greenwood J, Wade K. Author information: (1)Holistic Nurses Association, State of New South Wales. OBJECTIVE: Many women consume the raspberry leaf herb during their pregnancies in the belief that it shortens labor and makes labor "easier." METHODOLOGY: Because of the paucity of research regarding this herb, particularly in relation to pregnancy and birth, the authors undertook a double-blind, randomized, placebo-controlled trial. The sample consisted of 192 low-risk, nulliparous women who birthed their babies between May 1999 and February 2000 at a large tertiary-level hospital in Sydney, Australia. The aim of the study was to identify the effect and safety of raspberry leaf tablets (2 x 1.2 g per day), consumed from 32 weeks' gestation until labor, on labor and birth outcomes. RESULTS: Raspberry leaf, consumed in tablet form, was found to cause no adverse effects for mother or baby, but contrary to popular belief, did not shorten the first stage of labor. The only clinically significant findings were a shortening of the second stage of labor (mean difference = 9.59 minutes) and a lower rate of forceps deliveries between the treatment group and the control group (19.3% vs. 30.4%). No significant relationship was found between tablet consumption and birth outcomes. CONCLUSION: The lack of significant differences between the groups on measures expected to demonstrate the effect of raspberry leaf ingestion during pregnancy on labor prompted consideration of the issue of effectiveness of dosage level. Suggestions for further research are offered. DOI: 10.1016/s1526-9523(01)00095-2 PMID: 11370690 [Indexed for MEDLINE]
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