R-리포산

Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial.

1. J Clin Pharmacol. 2020 Aug;60(8):1099-1106. doi: 10.1002/jcph.1605. Epub 2020 Mar 25. Gastrointestinal Tolerability and Absorption of R- Versus R,S-Lipoic Acid in Progressive Multiple Sclerosis: A Randomized Crossover Trial. Cameron M(1)(2), Taylor C(1), Lapidus J(1)(3), Ramsey K(1)(3), Koop

Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing.

2. J Enzyme Inhib Med Chem. 2014 Apr;29(2):297-302. doi: 10.3109/14756366.2012.759951. Epub 2013 Jan 30. Effects of alpha lipoic acid and its R+ enantiomer supplemented to hyperbaric oxygen therapy on interleukin-6, TNF-α and EGF production in chronic leg wound healing. Nasole E(1), Nicoletti C

Bioactive Substances Characterization in Probiotic-Fermented Guava (Psidium guajava L.) Juice and Systematic Evaluation of its Anti-Hyperglycemic Activity.

3. Plant Foods Hum Nutr. 2026 Feb 18;81(1):22. doi: 10.1007/s11130-025-01466-w. Bioactive Substances Characterization in Probiotic-Fermented Guava (Psidium guajava L.) Juice and Systematic Evaluation of its Anti-Hyperglycemic Activity. Xu Y(1), Xiong T(2), Kang X(1), Ma F(1), Zhang L(1), Zhao M(1

Preclinical Evaluation of a Pilocarpine-(R)-Lipoic Acid Eye Drop for Presbyopia.

4. Transl Vis Sci Technol. 2025 Nov 3;14(11):17. doi: 10.1167/tvst.14.11.17. Preclinical Evaluation of a Pilocarpine-(R)-Lipoic Acid Eye Drop for Presbyopia. Robb E(1), Triyasakorn K(1), Christidhis J(1), Buffington J(1), Mamarian ML(2), Kandula M(3)(4), Apparsundaram S(3)(4), York JM(1)(2)(5)(6)

LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration.

5. BMC Musculoskelet Disord. 2025 May 9;26(1):457. doi: 10.1186/s12891-025-08703-y. LC-MS/MS based metabolomics reveals the mechanism of skeletal muscle regeneration. Yi L(1), Wang K(#)(1), Liufu S(1), Chen W(1), Chen B(1), Liu X(1), Liu C(1), Liu J(1), Xu X(1), Ma H(2)(3)(4). Author informatio

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid.

6. Nat Commun. 2023 Jun 15;14(1):3548. doi: 10.1038/s41467-023-39151-8. Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid. Lechner S(1), Steimbach RR(2)(3), Wang L(4)(5), Deline ML(6), Chang YC(1), Fromme T(6)(7), Klingenspor M(6)(7)(8), Matthias P(4)

Iron-doped cross-linked lipoic acid nano-aggregates for ferroptosis-mediated cancer treatment.

7. Acta Biomater. 2023 Mar 15;159:289-299. doi: 10.1016/j.actbio.2023.01.029. Epub 2023 Jan 25. Iron-doped cross-linked lipoic acid nano-aggregates for ferroptosis-mediated cancer treatment. Tan J(1), Zhou X(1), Zhang S(2). Author information: (1)College of Biomedical Engineering and National E

Dietary Antioxidant-Constructed Nanodrugs Can High-Efficiently Kill Cancer Cells while Protecting Noncancer Cells.

8. ACS Appl Mater Interfaces. 2022 Nov 9;14(44):49508-49520. doi: 10.1021/acsami.2c12043. Epub 2022 Oct 31. Dietary Antioxidant-Constructed Nanodrugs Can High-Efficiently Kill Cancer Cells while Protecting Noncancer Cells. Liao C(1), Wang X(2), Zhou X(1), Wang D(3), Zhang Z(3), Liu Y(4), Wu X(1)

Quaternary Ammonium Salts Anchored on Cross-Linked (R)-(+)-Lipoic Acid Nanoparticles for Drug-Resistant Tumor Therapy.

9. ACS Appl Mater Interfaces. 2021 Dec 8;13(48):56850-56857. doi: 10.1021/acsami.1c16293. Epub 2021 Nov 29. Quaternary Ammonium Salts Anchored on Cross-Linked (R)-(+)-Lipoic Acid Nanoparticles for Drug-Resistant Tumor Therapy. Zhou X(1), Dai X(1)(2), Tan J(1), Wu X(1), Zhou X(1), Liao C(1), Zhan

Anti-Diabetic Effects of Isolated Lipids from Natural Sources through Modulation of Angiogenesis.

10. Curr Mol Pharmacol. 2022;15(4):589-606. doi: 10.2174/1874467214666210902121337. Anti-Diabetic Effects of Isolated Lipids from Natural Sources through Modulation of Angiogenesis. Sajadimajd S(1), Khosravifar M(2), Bahrami G(3)(4). Author information: (1)Department of Biology, Faculty of Scien

"One-stitch" bioorthogonal prodrug activation based on cross-linked lipoic acid nanocapsules.

11. Biomaterials. 2021 Jun;273:120823. doi: 10.1016/j.biomaterials.2021.120823. Epub 2021 Apr 17. "One-stitch" bioorthogonal prodrug activation based on cross-linked lipoic acid nanocapsules. Wang L(1), Jing P(2), Tan J(1), Liao C(1), Chen Y(1), Yu Y(1), Zhang S(3). Author information: (1)Colle

Cross-linked (R)-(+)-lipoic acid nanoparticles with prodrug loading for synergistic cancer therapy.

12. J Mater Chem B. 2021 Feb 14;9(6):1583-1591. doi: 10.1039/d0tb02425b. Epub 2021 Jan 20. Cross-linked (R)-(+)-lipoic acid nanoparticles with prodrug loading for synergistic cancer therapy. Yang F(1), Chen Y(1), Zhang J(1), Liao C(1), Zhang S(1). Author information: (1)College of Biomedical En

Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria.

13. Front Bioeng Biotechnol. 2020 Aug 20;8:965. doi: 10.3389/fbioe.2020.00965. eCollection 2020. Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria. Chen B(1)(2), Foo JL(1)(2), Ling H(1)(2), Chang MW(1)(2). Author infor

Effect of an oral supplementation with a formula containing R-lipoic acid in glaucoma patients.

14. Arch Soc Esp Oftalmol (Engl Ed). 2020 Mar;95(3):120-129. doi: 10.1016/j.oftal.2019.11.009. Epub 2020 Jan 21. Effect of an oral supplementation with a formula containing R-lipoic acid in glaucoma patients. [Article in English, Spanish] Sanz-González SM(1), Raga-Cervera J(2), Aguirre Lipperhe

[Lipoic acid: physiological role and prospects for clinical application].

15. Vopr Pitan. 2019;88(4):6-11. doi: 10.24411/0042-8833-2019-10035. Epub 2019 Jul 15. [Lipoic acid: physiological role and prospects for clinical application]. [Article in Russian] Tutelyan VA(1), Makhova AA(1), Pogozheva AV(1), Shikh EV(1), Elizarova EV(1), Khotimchenko SA(1). Author informa

Ex-vivo absorption study of lysine R-lipoate salt, a new pharmaceutical form of R-ALA.

29. Eur J Pharm Sci. 2018 Jun 15;118:200-207. doi: 10.1016/j.ejps.2018.03.025. Epub 2018 Mar 26. Ex-vivo absorption study of lysine R-lipoate salt, a new pharmaceutical form of R-ALA. Amenta F(1), Buccioni M(2), Ben DD(2), Lambertucci C(2), Navia AM(2), Ngouadjeu Ngnintedem MA(2), Ricciutelli M

(R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo.

17. Antioxid Redox Signal. 2000 Fall;2(3):473-83. doi: 10.1089/15230860050192251. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Hagen TM(1), Vinarsky V, Wehr CM, Ames BN. Author information: (1)De

(R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate.

12. FASEB J. 1999 Feb;13(2):411-8. doi: 10.1096/fasebj.13.2.411. (R)-alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. Hagen TM(1), Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames

R-lipoic acid overdosing affects platelet life span via ROS mediated autophagy.

42. Platelets. 2018 Nov;29(7):695-701. doi: 10.1080/09537104.2017.1356450. Epub 2017 Oct 6. R-lipoic acid overdosing affects platelet life span via ROS mediated autophagy. Liu J(1), Song Q(1), Huang Y(1), Sun W(1), Lu D(1), Zhou B(1). Author information: (1)a Jiangsu Center for Safety Evaluation

The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects.

31. Altern Med Rev. 2007 Dec;12(4):343-51. The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects. Carlson DA(1), Smith AR, Fischer SJ, Young KL, Packer L. Author information: (1)GeroNova Research, Inc., 4677 Meade St, Richmond, California

Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.

7. Brain Res. 2006 Oct 20;1116(1):206-14. doi: 10.1016/j.brainres.2006.07.109. Epub 2006 Aug 30. Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes. Price SA(1), Gardiner NJ, Duran-Jimenez B, Zeef LA, Obrosova IG, Tomlinson DR. Author information: (1)Facult