들깨유
Perilla Oil
📚 관련 논문 (21편)
1. J Nutr Sci Vitaminol (Tokyo). 2025;71(2):133-139. doi: 10.3177/jnsv.71.133. Adding Lemon and n-3 PUFA-Rich Oil to Tomato Juice Preload to a Carbohydrate Meal Ameliorates Early Glycemic and Insulin Responses in Young Healthy Women: A Randomized Crossover Trial. Higuchi Y(1), Kajiyama S(2)(3),
2. Nutrients. 2023 Oct 16;15(20):4388. doi: 10.3390/nu15204388. Effects of Varied Omega-3 Fatty Acid Supplementation on Postpartum Mental Health and the Association between Prenatal Erythrocyte Omega-3 Fatty Acid Levels and Postpartum Mental Health. Harauma A(1), Yoshihara H(2), Hoshi Y(3), Hama
3. Lipids Health Dis. 2022 Feb 10;21(1):20. doi: 10.1186/s12944-022-01630-0. Effects of marine-derived and plant-derived omega-3 polyunsaturated fatty acids on erythrocyte fatty acid composition in type 2 diabetic patients. Liu H(1), Wang F(2), Liu X(3), Xie Y(4), Xia H(1), Wang S(1), Sun G(5).
4. Toxicol Pathol. 2008 Apr;36(3):459-64. doi: 10.1177/0192623308315358. Epub 2008 Mar 18. A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers. Cho YM(1), Imai T, Ota Y, Hasumu
5. Biol Pharm Bull. 1998 Oct;21(10):1050-6. doi: 10.1248/bpb.21.1050. Effects of dietary unsaturated fatty acid and chronic carbon tetrachloride treatment on the accumulation of oxidation products, alpha-tocopherol and liver injury in mice. Yasuda S(1), Watanabe S, Kobayashi T, Okuyama H. Autho
6. Carcinogenesis. 1996 Sep;17(9):1897-901. doi: 10.1093/carcin/17.9.1897. Synergistic suppression of azoxymethane-induced foci of colonic aberrant crypts by the combination of beta-carotene and perilla oil in rats. Komaki C(1), Okuno M, Onogi N, Moriwaki H, Kawamori T, Tanaka T, Mori H, Muto Y.
7. Front Nutr. 2022 May 2;9:861880. doi: 10.3389/fnut.2022.861880. eCollection 2022. Beneficial Effects of a Low-Glycemic Diet on Serum Metabolites and Gut Microbiota in Obese Women With Prevotella and Bacteriodes Enterotypes: A Randomized Clinical Trial. Hur HJ(1), Wu X(2), Yang HJ(1), Kim MJ(
1. Food Funct. 2022 Mar 7;13(5):2768-2781. doi: 10.1039/d1fo03508h. Perilla seed oil in combination with nobiletin-rich ponkan powder enhances cognitive function in healthy elderly Japanese individuals: a possible supplement for brain health in the elderly. Hashimoto M(1), Matsuzaki K(1), Maruyama K(2), Hossain S(3), Sumiyoshi E(1), Wakatsuki H(1), Kato S(4), Ohno M(4), Tanabe Y(1), Kuroda Y(5), Yamaguchi S(6), Kajima K(2), Ohizumi Y(7), Shido O(1). Author information: (1)Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan. michio1@med.shimane-u.ac.jp. (2)Sankyo Holdings Co., Ltd, Fuji, Shizuoka, Japan. (3)Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Dhaka, Bangladesh. (4)Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Shimane, Japan. (5)Department of Internal Medicine III, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan. (6)Shimane Prefecture Hospital Bureau, Izumo, Shimane, Japan. (7)Kansei Fukushi Research Institute, Tohoku Fukushi University, Sendai, Miyagi, Japan. Perilla (Perilla frutescens) seed oil (PO), rich in α-linolenic acid (ALA), can improve cognitive function in healthy elderly Japanese people. Here, supplements containing either PO alone or PO with nobiletin-rich air-dried immature ponkan powder were examined for their effects on cognitive function in 49 healthy elderly Japanese individuals. Patients were enrolled in a 12-month randomized, double-blind, parallel-armed study. Randomized participants in the PO group received soft gelatin capsules containing 1.47 mL (0.88 g of ALA) of PO daily, and those in the PO + ponkan powder (POPP) group received soft gelatin capsules containing both 1.47 mL of PO and 1.12 g ponkan powder (2.91 mg of nobiletin) daily. At the end of intervention, the POPP group showed significantly higher cognitive index scores than the PO group. The pro-cognitive effects of POPP treatment were accompanied by increases in ALA and docosahexaenoic acid levels in red blood cell plasma membranes, serum brain-derived neurotropic factor (BDNF) levels, and biological antioxidant potential. We demonstrate that 12-month intervention with POPP enhances serum BDNF and antioxidant potential, and may improve age-related cognitive impairment in healthy elderly people by increasing red blood cell ω-3 fatty acid levels. Clinical Trial Registry, UMIN000040863. DOI: 10.1039/d1fo03508h PMID: 35171190 [Indexed for MEDLINE]
2. Int Arch Allergy Immunol. 2000 Jun;122(2):137-42. doi: 10.1159/000024369. Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism. Okamoto M(1), Mitsunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, Harada S, Tanizaki Y, Kataoka M, Niiya K, Harada M. Author information: (1)Department of Medicine, Misasa Medical Branch, Tottori, Japan. Makoto@cc.okayama-u.ac.jp BACKGROUND: Dietary sources of alpha-linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with asthma, as has been reported with the consumption of other long-chain n-3 fatty acids. METHODS: The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n-3 fatty acids). Group A consisted of patients in whom the leucocyte generation of LTC4 was suppressed by dietary perilla seed oil. Group B consisted of those in whom LTC4 generation was not suppressed. RESULTS: LTC4 generation by leucocytes decreased significantly in group A after 2 (p < 0.05) and 4 weeks (p < 0.05); conversely, it increased significantly in group B after 4 weeks (p < 0.05). The two study groups differed significantly in terms of LTC4 generation by leucocytes after 4 weeks of dietary supplementation (p < 0.05). Ventilatory parameters such as peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05). Values of PEF, FVC, FEV(1) and maximum expiratory flow at 25% of the forced vital capacity (V(25)) differed significantly between groups A and B prior to dietary supplementation. Serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol and phospholipid were significantly decreased by dietary supplementation in group A after 4 weeks. Serum levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, LDL cholesterol and phospholipid differed significantly between the two study groups prior to dietary supplementation. Serum levels of triglyceride and LDL cholesterol differed significantly between the two study groups after 4 weeks of dietary supplementation. CONCLUSIONS: Dietary supplementation with perilla seed oil in selected patients with asthma suppresses the generation of LTC4 and is associated with clinical features such as respiratory function and lipometabolism. Copyright 2000 S. Karger AG, Basel. DOI: 10.1159/000024369 PMID: 10878492 [Indexed for MEDLINE]
3. Intern Med. 2000 Feb;39(2):107-11. doi: 10.2169/internalmedicine.39.107. Effects of dietary supplementation with n-3 fatty acids compared with n-6 fatty acids on bronchial asthma. Okamoto M(1), Mitsunobu F, Ashida K, Mifune T, Hosaki Y, Tsugeno H, Harada S, Tanizaki Y. Author information: (1)Department of Medicine, Misasa Medical Branch, Okayama University Medical School, Tohaku-gun, Tottori. OBJECTIVE: The effects of perilla seed oil (n-3 fatty acids) on bronchial asthma were compared with the effects of corn oil (n-6 fatty acids) in relation to the pulmonary function and the generation of leukotriene B4 (LTB4) and C4 (LTC4) by leucocytes. METHODS AND SUBJECTS: 14 asthmatic subjects were divided randomly into two groups: one group (7 subjects) consumed perilla seed oil-rich supplementation and the other group (7 subjects) consumed corn oil-rich supplementation for 4 weeks. Generation of LTs by leucocytes and respiratory function were compared between the two groups. RESULTS: The generation of LTB4 and LTC4 by leucocytes tended to increase in subjects (N=7) with corn oil-rich supplementation, and decrease in subjects (N=7) with perilla seed oil-rich supplementation. Significant differences between the two groups were observed in the generation of LTB4 at 2 weeks (p<0.05) and LTC4 at 2 weeks (p<0.05) after dietary supplementation. Significant increases in the value of PEF (p<0.05), FVC (p<0.01), FEV(1.0) (p<0.05) and V(25) (p<0.05) were found in subjects who received perilla seed oil supplementation for 4 weeks. And significant differences in the value of FVC (p<0.05) and FEV(1.0) (p<0.05) were observed between the two groups after 4 weeks of dietary supplementation. CONCLUSION: These results suggest that perilla seed oil-rich supplementation is useful for the treatment of asthma in terms of suppression of LTB4 and LTC4 generation by leucocytes, and improvement of pulmonary function. DOI: 10.2169/internalmedicine.39.107 PMID: 10732825 [Indexed for MEDLINE]
4. Phytother Res. 2023 Jun;37(6):2230-2241. doi: 10.1002/ptr.7728. Epub 2023 Jan 13. Perilla seed oil improves bone health by inhibiting bone resorption in healthy Japanese adults: A 12-month, randomized, double-blind, placebo-controlled trial. Matsuzaki K(1), Hossain S(1)(2), Wakatsuki H(1), Tanabe Y(1), Ohno M(3), Kato S(3), Shido O(1), Hashimoto M(1). Author information: (1)Department of Environmental Physiology, Faculty of Medicine, Shimane University, Izumo, Shimane, Japan. (2)Department of Biochemistry and Molecular Biology, Jahangirnagar University, Savar, Bangladesh. (3)Kato Hospital, Jinjukai Healthcare Corporation, Kawamoto, Japan. Accumulating evidence suggests the beneficial effect of omega-3 polyunsaturated fatty acids (PUFAs) on bone mineral density (BMD). However, the effects of perilla (Perilla frutescens) seed oil (PO), a rich source of α-linoleic acid (LNA), on human bone have not yet been elucidated. This randomized, double-blind, placebo-controlled trial investigated the effects of long-term PO intake on bone health in Japanese adults. After screening for eligibility, 52 participants (mean age 54.2 ± 6.4 years) were randomly assigned to placebo (n = 25) and PO (n = 27) groups, which received 7.0 ml of olive oil and PO daily, respectively. At baseline and 12-month, quantitative ultrasound of the right calcaneus was measured with an ultrasound bone densitometer and percentage of the Young Adult Mean (%YAM) was calculated. Serum levels of tartrate-resistant acid phosphatase 5b (TRACP-5b), and bone alkaline phosphatase (BALP) were evaluated. In addition, PUFA levels in the erythrocyte plasma membrane (RBC-PM), serum biological antioxidant potential (BAP), and diacron reactive oxygen metabolites (d-ROM) were evaluated. Compared with the placebo group, %YAM levels increased and serum TRACP-5b levels decreased significantly in the PO group at 12-month, while serum BALP levels remained unchanged. Moreover, RBC-PM LNA levels and BAP/d-ROM ratios increased significantly in the PO compared with the placebo group. These results suggest that long-term PO intake may improve age-related BMD decline by suppressing bone resorption and increasing LNA levels. © 2023 John Wiley & Sons Ltd. DOI: 10.1002/ptr.7728 PMID: 36637040 [Indexed for MEDLINE]
5. Methods Protoc. 2021 Jul 6;4(3):46. doi: 10.3390/mps4030046. Perilla Oil and Bifidobacterium for Alleviating Fear of Cancer Recurrence in Breast Cancer Survivors: Study Protocol for a Three-Arm Phase II Randomized Controlled Study (POB Study). Sasaki Y(1), Honyashiki M(2), Kinoshita T(3), Matsui A(3), Nakashoji A(3), Inagawa T(4), Ikezawa S(4), Yoshimura N(4), Yamamura R(5), Amano M(6), Tomo Y(1), Tachimori H(1), Matsuoka YJ(7)(8), Okubo R(1). Author information: (1)Department of Clinical Epidemiology, Translational Medical Center, National Center of Neurology and Psychiatry, Tokyo 187-8551, Japan. (2)Department of Psychiatry, Tokyo Medical University, Tokyo 113-8510, Japan. (3)Department of Breast Surgery, National Hospital Organization Tokyo Medical Center, Tokyo 187-8551, Japan. (4)Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, Tokyo 187-8551, Japan. (5)Division of Biomedical Oncology, Institute for Genetic Medicine, Hokkaido University, Sapporo 060-0815, Japan. (6)Toyosato Hospital, Ibaraki 529-1168, Japan. (7)Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo 104-0045, Japan. (8)Lifestyle Medicine, Cooperative Graduate Program, The Jikei University Graduate School of Medicine, Tokyo 105-8461, Japan. The fear of cancer recurrence (FCR) is the most common and most severe unmet need among cancer survivors. Safe treatments for the FCR that are easily disseminated are greatly needed. Our primary aim is a preliminary evaluation of the efficacy and effect size of perilla oil, which is rich in omega-3 fatty acids, and Bifidobacterium, a probiotic, on FCR in breast cancer survivors after the completion of chemotherapy. This study has been planned as an exploratory clinical study (phase II) and will be conducted as a three-arm, 12-week parallel group, masked-rater randomized controlled trial. Fifteen participants will be randomized with 1:1:1 allocation to receive Bifidobacterium plus perilla oil, Bifidobacterium alone, or no intervention (control). Interventions will end within 12 weeks after the random allocation of each participant. The participants will be outpatients with invasive breast cancer aged 20 years or older whose chemotherapy was completed at least 6 months before registration; hormone therapy may be ongoing. The primary outcome will be severity of FCR at 12 weeks assessed by masked raters using the 4-item Concerns about Recurrence Scale concerning overall fear of recurrence. The study protocol for the current study is registered in the Japan Registry of Clinical Trials (jRCTs031200029). DOI: 10.3390/mps4030046 PMCID: PMC8293445 PMID: 34287371 Conflict of interest statement: The authors declare that they have no competing interests.
6. Zhonghua Yu Fang Yi Xue Za Zhi. 2019 Jun 6;53(6):570-575. doi: 10.3760/cma.j.issn.0253-9624.2019.06.006. [Effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia]. [Article in Chinese; Abstract available in Chinese from the publisher] Wang F(1), Liu HC(1), Liu XS(2), Dong SN(1), Pan D(1), Yang LG(1), Sun GJ(1). Author information: (1)Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing 210009, China. (2)Diabetes Specialist Clinic, Guanlin Hospital, Yixing 214251, China. Objective: To determine the effects of ω-3 polyunsaturated fatty acids from different sources on glucolipid metabolism in type 2 diabetic patients with dyslipidemia. Methods: We recruited participants from the diabetes specialist clinic at the Guanlin hospital in Yixing city, Jiangsu Province from February 2017 to March 2017. A total of 180 subjects were randomly assigned to 3 g/day fish oil (FO), perilla oil (PO), or fish oil mixed with linseed oil (FLO) for 6 months. The basic conditions and fasting venous blood sample were obtained from each study subject at baseline, after 6 months of intervention. Serum glucose and lipid metabolism were investigated. Results: A total of 156 subjects aged (62.6±8.6) years completed the final follow-up after 6 months (FO,54 subjects; PO,52 subjects; FLO,50 subjects). Among them,59 patients (37.8%) were male. Serum glucose, glycated hemoglobin, C peptide, insulin and homeostasis model assessment-insulin resistance were not significantly different among the three groups after 6 months. Serum triglyceride decreased, whereas high-density lipoprotein cholesterol increased in FO [1.33 (1.05,1.93) mmol/L, (1.36±0.29) mmol/L, respectively] compared with PO [1.71 (1.23, 2.17) mmol/L, (1.23±0.22) mmol/L, respectively] and FLO [1.51 (1.12, 2.22) mmol/L, (1.29±0.30) mmol/L, respectively] (P<0.05). Serum low-density lipoprotein cholesterol and apolipoprotein B decreased in PO [(2.60±0.57) mmol/L,(0.96±0.23) g/L, respectively] compared with FO [(2.89±0.76) mmol/L, (1.07±0.30) g/L, respectively] (P<0.05). Serum lipoprotein(a) decreased in FLO [130.7 (63.3,270.6) mg/L] compared with FO [137.4 (58.7,333.2) mg/L] (P<0.05). Serum free fatty acid decreased in FLO [(0.43±0.15) mmol/L] compared with PO [(0.53±0.22) mmol/L] (P<0.05). Conclusion: The effects of ω-3 PUFA from different sources on glucose metabolism in type 2 diabetic patients with dyslipidemia are similar. Each of them has a good application prospect in improving lipid metabolism. Publisher: 目的： 探讨不同来源ω-3多不饱和脂肪酸（PUFA）对2型糖尿病合并血脂异常人群糖脂代谢的影响。 方法： 于2017年2—3月在江苏省宜兴市官林医院糖尿病专科门诊招募180例2型糖尿病合并血脂异常患者，采用随机数字法分为鱼油组、紫苏油组和鱼油+亚麻油组，每组60例，每日分别给予3 g鱼油、紫苏油和鱼油+亚麻油胶囊，持续时间6个月。在基线和干预6个月时收集研究对象的基本情况等，并采集空腹血，测定糖、脂代谢指标，比较不同干预组间差异。 结果： 共有156例对象完成6个月的干预研究，年龄为（62.6±8.6）岁，男性占37.8%（59例），其中鱼油组54例，紫苏油组52例，鱼油+亚麻油组50例。糖代谢与基线相比，3组C肽、胰岛素、稳固模型评估胰岛素抵抗指数（HOMA-IR）均降低（P值均<0.05），紫苏油组和鱼油+亚麻油组血糖、糖化血红蛋白（HbA1c）降低（P值均<0.05）。脂代谢与基线相比，3组总胆固醇、非高密度蛋白胆固醇（HDL-C）、载脂蛋白A1均降低（P值均<0.05），鱼油组和紫苏油组甘油三酯（TG）降低（P<0.05），紫苏油组和鱼油+亚麻油组载脂蛋白B（Apo B）、脂蛋白（a）降低（P值均<0.05）。干预6个月后，3组间血糖、糖化血红蛋白、C肽、胰岛素、HOMA-IR差异无统计学意义（P>0.05）；鱼油组TG低于紫苏油组和鱼油+亚麻油组（P<0.05），HDL-C高于紫苏油组和鱼油+亚麻油组（P<0.05）；紫苏油组低密度脂蛋白胆固醇、Apo B均低于鱼油组（P值均<0.05）；鱼油+亚麻油组脂蛋白（a）低于鱼油组（P<0.05），游离脂肪酸低于紫苏油组（P<0.05）。 结论： 动物性来源、植物性来源和动植物性来源兼有的ω-3 PUFA对2型糖尿病合并血脂异常人群糖代谢方面的影响相似，对脂代谢方面的影响各有优势。. DOI: 10.3760/cma.j.issn.0253-9624.2019.06.006 PMID: 31177752 [Indexed for MEDLINE]
7. J Oleo Sci. 2019 Jun 6;68(6):511-515. doi: 10.5650/jos.ess19008. Epub 2019 May 16. Role of Omega-3 Polyunsaturated Fatty Acids in Mental Health－Studies from Japan. Hamazaki K(1). Author information: (1)Department of Public Health, Faculty of Medicine, University of Toyama. Omega-3 polyunsaturated fatty acids is a generic term that encompasses eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are abundant in fish, and α-linolenic acid, which is abundant in perilla oil. These fatty acids became well known following an epidemiological study conducted in Greenland about 50 years ago. EPA formulations, with their putative prophylactic effect against cardiovascular disease, first became clinically available in the 1990s in Japan. There were reports of their association with mental health, especially depression, and from around the year 2000 several epidemiological studies and clinical trials were conducted. This article introduces the epidemiological studies and clinical trials conducted in Japan and the knowledge gained. DOI: 10.5650/jos.ess19008 PMID: 31092794 [Indexed for MEDLINE]
8. Curr Alzheimer Res. 2019;16(2):146-155. doi: 10.2174/1567205016666181212153720. Outcomes of Perilla Seed Oil as an Additional Neuroprotective Therapy in Patients with Mild to Moderate Dementia: A Randomized Control Trial. Kamalashiran C(1), Sriyakul K(1), Pattaraarchachai J(1), Muengtaweepongsa S(2). Author information: (1)Chulabhron International College of Medicine, Thammasat University, Klonglaung, Pathum Thani, Thailand. (2)Faculty of Medicine Ringgold Standard Institution, Thammasat University, Klonglaung, Pathum Thani, Thailand. BACKGROUND: Dementia is a common medical disorder in the elderly. Oxidative stress plays a major role in the process of cognitive decline in dementia. Perilla seed oil demonstrates its neuroprotective effects via anti-oxidative mechanisms against dementia. We investigate neuroprotective effects of perilla seed oil as an additional treatment in patients with mild to moderate dementia. METHOD: A double-blind, randomized-control trial (perilla seed oil versus placebo) in patients with mild to moderate dementia was conducted. Perilla seed oil or placebo was added on with standard treatment for six months. Cognitive function was compared at nine months after enrollment. RESULT: 182 patients, with 94 in the experimental group and 88 in the placebo group, were able to complete the study. Cognitive function is not significantly different compared between groups. However, the total cholesterol and LDL cholesterol were significantly lower in the experimental group. Perilla seed oil had no adverse effect to kidney, liver, blood components or glucose metabolism. CONCLUSION: Perilla seed oil as additional neuroprotective therapy in patients with mild to moderate dementia does not improve cognitive function. Perilla seed oil significantly reduced total cholesterol and LDL cholesterol. A clinical trial is needed to prove the benefit of cholesterol-lowering effects with perilla seed oil in human. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. DOI: 10.2174/1567205016666181212153720 PMID: 30543172 [Indexed for MEDLINE]
9. Appetite. 2018 Jul 1;126:147-155. doi: 10.1016/j.appet.2018.04.004. Epub 2018 Apr 7. A mind cleared by walnut oil: The effects of polyunsaturated and saturated fat on extinction learning. Miller HC(1), Struyf D(1), Baptist P(1), Dalile B(2), Van Oudenhove L(2), Van Diest I(3). Author information: (1)KULeuven, Health, Behavior and Psychopathology, Belgium. (2)KULeuven, Translational Research in GastroIntestinal Disorders, Belgium. (3)KULeuven, Health, Behavior and Psychopathology, Belgium. Electronic address: ilse.vandiest@kuleuven.be. The treatment of anxiety-based psychopathology often hinges upon extinction learning. Research in nutritional neuroscience has observed that the regular consumption of perilla oil (50% alpha-linolenic acid (ALA)) facilitates extinction learning in rats (Yamamoto et al., 1988). However, acute facilitation of extinction learning by oils rich in ALA has not been reported for rats or humans, though the acute consumption of rapeseed oil (10% ALA) has been observed to improve cognitive processing speed in humans (Jones, Sünram-Lea, & Wesnes, 2012). For this reason, the present laboratory work examined the effects of adding walnut oil (12% ALA) to a chocolate milkshake on the acquisition, generalization, and extinction of a fear-based prediction in young adults. It compared performance between subjects. The other participants consumed a similar milkshake with either an equicaloric amount of cream (saturated fat), or with no added fat (control). Acquisition and generalization of the fear-based prediction were similar for all groups. However, those who consumed walnut oil extinguished most rapidly and profoundly. Implications for extinction learning are discussed. Copyright © 2018 Elsevier B.V. All rights reserved. DOI: 10.1016/j.appet.2018.04.004 PMID: 29634989 [Indexed for MEDLINE]
10. Trials. 2016 Jun 18;17(1):291. doi: 10.1186/s13063-016-1419-9. Efficacy and safety of Yirui capsule in patients with hyperlipidemia: study protocol for a multicenter, randomized, double-blind, placebo-controlled trial. Dai L(1)(2), Zhong LL(1)(2), Cao Y(3), Chen W(4), Cheng Y(5), Lin XF(6), Bian ZX(1)(2), Lu AP(7)(8). Author information: (1)School of Chinese Medicine, Hong Kong Baptist University, 4/F, Jockey Club School of Chinese Medicine Building, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong. (2)Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China. (3)Health Management Center, the First Affiliated Hospital of Jinan University, No. 613 Huangpu Avenue West, Tianhe District, Guangzhou, China. (4)Outpatient Department, Guangdong No. 2 Provincial People's Hospital, No. 466 Xingang Middle Road, Haizhu District, Guangzhou, China. (5)Department of Cardiology, Hexian Memorial Affiliated Hospital of Southern Medical University, No. 2 East Road of Qinghe, Shiqiao, Panyu District, Guangzhou, China. (6)Department of Cardiology, the Fifth Affiliated Hospital, Sun Yat-Sen University, No. 52 East Road of Meihua, Xiangzhou District, Zhuhai, China. (7)School of Chinese Medicine, Hong Kong Baptist University, 4/F, Jockey Club School of Chinese Medicine Building, 7 Baptist University Road, Kowloon Tong, Kowloon, Hong Kong. aipinglu@hkbu.edu.hk. (8)Hong Kong Chinese Medicine Clinical Study Centre, Hong Kong Baptist University, 7 Baptist University Road, Kowloon Tong, Hong Kong, China. aipinglu@hkbu.edu.hk. BACKGROUND: Hyperlipidemia is a common disease in China. Although 88.9 % of the Chinese population taking lipid-lowering medications has already used a statin, only 61.5 % of the population has reached the goal of low-density lipoprotein cholesterol. Thus, many patients in China seek help from Traditional Chinese Medicine. Yirui capsules are an innovative Chinese Medicine which are designed to improve the blood lipid state in patients with hyperlipidemia. However, there is still a lack of high-quality evidence from clinical trials to support the application. Therefore, we designed a clinical trial to evaluate the safety and efficacy of Yirui capsules for use by patients with hyperlipidemia. METHODS/DESIGN: This is a multicenter, randomized, double-blinded, placebo-controlled trial. Based on lifestyle modification therapy, eligible patients will randomly be assigned to the Yirui capsule or the placebo group. The primary outcome is the percentage of participants who reach the goal of 30 % low-density lipoprotein cholesterol decline at treatment end-point. The secondary outcomes include the changes from baseline to treatment endpoint in low-density lipoprotein cholesterol, total cholesterol, triglyceride, high-density lipoprotein cholesterol, apolipoprotein A, apolipoprotein B, non-high-density lipoprotein cholesterol, MOS 36-Item Short-Form Health Survey scoring, total and individual item scoring of symptomatic grading and quantifying scale, and body mass index. DISCUSSION: The main ingredients of the Yirui capsule are perilla oil, Folium Ginkgo (Yinxingye), Radix Salviae miltiorrhizae (Danshen), Fructus Crataegi (Shanzha), Rhizoma Alismatis (Zexie), and Radix Notoginseng (Sanqi), which are expected to improve the blood lipid state. This randomized placebo-controlled trial will comprehensively evaluate the effectiveness and safety of Yirui capsules against hyperlipidemia in the hope of providing a new adjunctive Chinese medicine option for clinical practice in dyslipidemia treatment. TRIAL REGISTRATION: ChiCTR-IOR-15006496 . Registered on 29 May 2015. PROTOCOL VERSION: WXJ.YRJN-HBT-V1.0 (21 Jan 2015). DOI: 10.1186/s13063-016-1419-9 PMCID: PMC4912805 PMID: 27316679 [Indexed for MEDLINE]
11. J Tradit Chin Med. 2013 Apr;33(2):170-5. doi: 10.1016/s0254-6272(13)60120-x. Perilla oil and exercise decrease expressions of tumor necrosis factor-alpha, plasminogen activator inhibitor-1 and highly sensitive C-reactive protein in patients with hyperlipidemia. Wei M(1), Xiong P, Zhang L, Fei M, Chen A, Li F. Author information: (1)First Affiliated Hospital to Soochow University, Suzhou 215006, China. weimg@sina.com OBJECTIVE: To verify the effects of perilla oil on the regulation of blood lipid levels in patients with hyperlipidemia. METHODS: Blood was taken from patients prior to and 8 weeks following treatment with perilla oil. Different ways to test for indexes which correlate to hyperlipidemia were performed. Some indexes, which correlate with inflammation and injury to endothelial cells, were tested using enzyme linked immunosorbent assays. RESULTS: Serum lipid levels [triglyceride (TG), total cholesterol (TC), and low-density lipoprotein-cholesterol (LDL-C)] changed significantly after 56 days of treatment. Differences were noted as early as 28 days after treatment began (P < 0.05). Treatment with perilla oil showed statistically significant recovery levels of high-density lipoprotein-cholesterol (HDL-C) after 28 and 56 days of treatment. Plasma lipids levels were significantly lower after 56 days of treatment (P < 0.05). Perilla oil reduced blood lipid levels in patients, and the regulation of cell signaling factor levels had no adverse effects on patients' liver or kidney function, or blood routine examinations. CONCLUSION: Perilla oil treatment is safe in clinical use, can regulate blood lipid levels and protects the function of endothelial cells. DOI: 10.1016/s0254-6272(13)60120-x PMID: 23789212 [Indexed for MEDLINE]
12. Int J Obes (Lond). 2008 Dec;32(12):1841-7. doi: 10.1038/ijo.2008.197. Epub 2008 Oct 21. Greater fat oxidation with diacylglycerol oil consumption for 14 days compared with triacylglycerol oil consumption in overweight men and women. Hibi M(1), Takase H, Yasunaga K, Yamaguchi T, Shiiba D, Saito S, Yokoyama R, Kudo N, Katsuragi Y, Meguro S, Shimizu A, Tokimitsu I. Author information: (1)Health Care Food Research Laboratories, Kao Corporation, Sumida-ku, Tokyo, Japan. hibi.masanobu@kao.co.jp BACKGROUND: Several studies have reported increased fat oxidation with diacylglycerol (DAG) oil consumption. However, the effects of long-term DAG oil consumption on energy metabolism remain to be investigated. OBJECTIVE: The objective of this study was to compare the effects of 14 days of either DAG or triacylglycerol (TAG) oil consumption on substrate oxidation, energy expenditure (EE) and dietary fat oxidation. DESIGN: Eight males and six females participated in this randomized, double-blind, crossover feeding study. Each patient consumed the 14-day controlled test diet containing either 10 g day(-1) of DAG or TAG oil for acclimatization before a respiratory chamber measurement, followed by a 2-week washout period between diet treatments. Substrate oxidation and EE were measured in the respiratory chamber at the end of each dietary treatment. The patients consumed test oil as 15% of total caloric intake in the respiratory chamber (mean test oil intake was 36.1+/-6.6 g day(-1)). RESULTS: Twenty-four hour fat oxidation was significantly greater with 14 days of DAG oil consumption compared with TAG oil consumption (78.6+/-19.6 and 72.6+/-14.9 g day(-1), respectively, P<0.05). There were no differences in body weight or body composition between diet treatments. Dietary fat oxidation was determined using the recovery rate of (13)CO(2) in breath, and was significantly enhanced with DAG oil consumption compared with TAG oil consumption, measured over 22 h after ingestion of (13)C-labelled triolein. Resting metabolic rate (RMR) was significantly greater with DAG oil consumption compared with TAG oil consumption (1766+/-337 and 1680+/-316 kcal day(-1), respectively, P<0.05). CONCLUSION: Consumption of DAG oil for 14 days stimulates both fat oxidation and RMR compared with TAG oil consumption, which may explain the greater loss of body weight and body fat with DAG oil consumption that has been observed in weight-loss studies. DOI: 10.1038/ijo.2008.197 PMID: 18936764 [Indexed for MEDLINE]
13. Nutrition. 2006 May;22(5):534-8. doi: 10.1016/j.nut.2005.10.006. Epub 2006 Feb 10. Effects of cooking plant oils on recurrent aphthous stomatitis: a randomized, placebo-controlled, double-blind trial. Hamazaki K(1), Itomura M, Hamazaki T, Sawazaki S. Author information: (1)Division of Clinical Application, Department of Clinical Sciences, Institute of Natural Medicine, University of Toyama, Toyama, Japan. hamazaki@ms.toyama-mpu.ac.jp OBJECTIVE: One-third of the total population seems to develop minor recurrent aphthous stomatitis (RAS) during their lifetime. However, well-controlled dietary intervention studies to prevent minor RAS are very rare. The objective of the present study was to investigate whether the prevalence of RAS decreased with perilla oil (rich in alpha-linolenic acid). METHODS: Thirty subjects (8 men and 22 women) who had minor RAS at least once a month were randomly allocated to a soybean oil group or a perilla oil group in a double-blind manner (experimental phase) after a run-in phase of 4 mo during which subjects used a reference oil, the most popular cooking oil in Japan, or a 50/50 mixture of soybean oil and rapeseed oil. During the experimental phase, subjects were asked to use soybean oil or perilla oil as the sole cooking oil for 8 mo. Blood samples were collected at the start and end of the experimental phase for fatty acid analysis of total plasma phospholipid fraction. Occurrence and needed days for healing of minor RAS were recorded during the two phases and compared. RESULTS: alpha-Linolenic acid concentrations in the plasma phospholipid fraction increased significantly in both groups during the experimental phase to a similar extent. The prevalence of minor RAS in the experimental phase decreased significantly in both groups compared with the run-in phase to a similar extent, without intergroup differences. CONCLUSION: Perilla oil, which is rich in alpha-linolenic acid, was not superior to soybean oil in preventing minor RAS. There was a possibility that avoiding rapeseed oil might be beneficial for prevention of minor RAS. DOI: 10.1016/j.nut.2005.10.006 PMID: 16472981 [Indexed for MEDLINE]
14. Prostaglandins Leukot Essent Fatty Acids. 2003 Mar;68(3):207-12. doi: 10.1016/s0952-3278(02)00271-5. Bioavailability of omega-3 essential fatty acids from perilla seed oil. Kurowska EM(1), Dresser GK, Deutsch L, Vachon D, Khalil W. Author information: (1)KGK Synergize, Inc., One London Place, 255 Queens Avenue, Suite 1030, London, Ont., Canada N6A 5R8. kurowska@kgksynergize.com Increased dietary intake of fish oil omega-3 fatty acids, eicosapentanoic acid and docosohexanoic acid, and their precursor, alpha-linolenic acid (ALA), is associated with various health benefits. Enteric-coating (Entrox), which improves stability of omega-3 capsules, has been shown to facilitate fish oil absorption after chronic treatment. To assess the effect of Entrox coating on the short-term bioavailability of ALA administered in the form of ALA-rich Perilla seed oil, 12 healthy subjects (6 males and 6 females) received in a random order Entrox-coated and non-coated ALA formulations, each as a single 6g dose separated by a 3-week washout period. Measurements of plasma ALA concentrations from 0 to 24h showed no difference in ALA pharmacokinetics between the two formulations. However, significantly greater increases in plasma ALA levels from baseline to 24h were observed after ingestion of Entrox vs. non-coated product, suggesting a possible benefit of Entrox with long-term treatment. DOI: 10.1016/s0952-3278(02)00271-5 PMID: 12591004 [Indexed for MEDLINE]
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