MSM (메틸설포닐메탄)

Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis.

1. J Integr Med. 2025 Jul;23(4):357-369. doi: 10.1016/j.joim.2025.04.008. Epub 2025 May 3. Effects of dietary supplements on patients with osteoarthritis: A systematic review and network meta-analysis. Chen CS(1), Wen L(1), Yang F(2), Deng YC(1), Ji JH(1), Chen RJ(3), Chen Z(1), Chen G(4), Gu J

Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis.

2. Br J Sports Med. 2018 Feb;52(3):167-175. doi: 10.1136/bjsports-2016-097333. Epub 2017 Oct 10. Dietary supplements for treating osteoarthritis: a systematic review and meta-analysis. Liu X(1)(2), Machado GC(3), Eyles JP(1)(2)(4), Ravi V(1)(2), Hunter DJ(1)(2). Author information: (1)Departmen

Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents.

3. Am J Sports Med. 2015 Mar;43(3):734-44. doi: 10.1177/0363546514533777. Epub 2014 May 27. Chondroprotection and the prevention of osteoarthritis progression of the knee: a systematic review of treatment agents. Gallagher B(1), Tjoumakaris FP(2), Harwood MI(2), Good RP(2), Ciccotti MG(2), Free

Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis.

4. Osteoarthritis Cartilage. 2008 Nov;16(11):1277-88. doi: 10.1016/j.joca.2008.03.002. Epub 2008 Apr 15. Systematic review of the nutritional supplements dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) in the treatment of osteoarthritis. Brien S(1), Prescott P, Bashir N, Lewith H, Lewi

Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence.

5. Arthritis Res Ther. 2006;8(4):R127. doi: 10.1186/ar2016. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Ameye LG(1), Chee WS. Author information: (1)Nutrition and Health Department, Nestlé Research Center, Vers-chez-les-B

[Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations].

6. Ter Arkh. 2025 Jun 8;97(5):419-426. doi: 10.26442/00403660.2025.05.203272. [Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations]. [Article in Russian; Abstract available in Russian from the publisher] Naumov AV(1), Unkovskiy AV(1), Khovasova NO(1), Foke

Using the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA.

7. Nutrients. 2025 May 23;17(11):1761. doi: 10.3390/nu17111761. Using the Rise and Fall of Oxidative Stress and Inflammation Post-Exercise to Evaluate the Effect of Methylsulfonylmethane Supplementation on Immune Response mRNA. McFarlin BK(1)(2), Curtis JH(1), du Preez HN(3), McFarlin MA(1)(2).

A chewing gum containing ethylenediaminetetraaceticacid (EDTA), methyl sulfonyl methane (MSM) and xylitol works comparable to chlorehexidine mouthrinse.

8. Sci Rep. 2024 Nov 15;14(1):28200. doi: 10.1038/s41598-024-79551-4. A chewing gum containing ethylenediaminetetraaceticacid (EDTA), methyl sulfonyl methane (MSM) and xylitol works comparable to chlorehexidine mouthrinse. Shakhsi Niaee M(1)(2), Hedayatipanah M(3), Torkzaban P(3), Mohammadi T(4).

[Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D(3) and a combination of chondroitin sulfate and glucosamine hydrochloride in the treatment of primary osteoarthritis of the knee joint].

9. Ter Arkh. 2023 Dec 28;95(12):1141-1150. doi: 10.26442/00403660.2023.12.202540. [Comparative efficacy of a combination of undenatured type II collagen, Boswellic acids, methylsulfonylmethane, vitamins C and D(3) and a combination of chondroitin sulfate and glucosamine hydrochloride in the treat

Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial.

10. Nutrients. 2023 Jun 30;15(13):2995. doi: 10.3390/nu15132995. Methylsulfonylmethane Improves Knee Quality of Life in Participants with Mild Knee Pain: A Randomized, Double-Blind, Placebo-Controlled Trial. Toguchi A(1), Noguchi N(1), Kanno T(1), Yamada A(2). Author information: (1)Department o

Methylsulfonylmethane and Sesame Seed Oil Improve Dyslipidemia and Modulate Polyunsaturated Fatty Acid Metabolism in Two Mouse Models of Diabetes.

11. J Med Food. 2022 Jun;25(6):607-617. doi: 10.1089/jmf.2021.0196. Methylsulfonylmethane and Sesame Seed Oil Improve Dyslipidemia and Modulate Polyunsaturated Fatty Acid Metabolism in Two Mouse Models of Diabetes. Fili CV(1), Lin L(2)(3), Chapman J(2), Hamilton D(1), Yates CR(2). Author informa

The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial.

12. Nutrients. 2021 Oct 15;13(10):3620. doi: 10.3390/nu13103620. The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial. Miller L(1)(2), Thompson K(2), Pavlenco C(2), Mettu VS(3), H

Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial.

13. J Craniomaxillofac Surg. 2021 Aug;49(8):711-718. doi: 10.1016/j.jcms.2021.02.012. Epub 2021 Feb 22. Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticula

Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study.

14. Osteoarthritis Cartilage. 2021 May;29(5):667-677. doi: 10.1016/j.joca.2021.01.011. Epub 2021 Feb 19. Efficacy and safety of a supplement combination on hand pain among people with symptomatic hand osteoarthritis an internet-based, randomised clinical trial the RADIANT study. Liu X(1), Robbi

Pharmacokinetic assessment of constituents of Boswellia serrata, pine bark extracts, curcumin in combination including methylsulfonylmethane in healthy volunteers.

15. J Pharm Pharmacol. 2020 Jan;72(1):121-131. doi: 10.1111/jphp.13184. Epub 2019 Oct 13. Pharmacokinetic assessment of constituents of Boswellia serrata, pine bark extracts, curcumin in combination including methylsulfonylmethane in healthy volunteers. Liu X(1)(2), Hunter DJ(1)(2), Eyles J(1)(

Tendon homeostasis and regeneration: Interplay of cells, immune response, and bioactive compounds.

1. Mech Ageing Dev. 2026 Apr 1;231:112180. doi: 10.1016/j.mad.2026.112180. Online ahead of print. Tendon homeostasis and regeneration: Interplay of cells, immune response, and bioactive compounds. Mencarelli N(1), Carradori S(2), Gallorini M(3). Author information: (1)Department of Pharmacy, "G

Effects of dietary supplementation of methylsulfonylmethane on performance, egg quality, serum biochemical parameters, and malondialdehyde levels in feed-restricted laying hens.

2. Res Vet Sci. 2026 Jun;205:106167. doi: 10.1016/j.rvsc.2026.106167. Epub 2026 Mar 29. Effects of dietary supplementation of methylsulfonylmethane on performance, egg quality, serum biochemical parameters, and malondialdehyde levels in feed-restricted laying hens. Yilmaz E(1), Gur C(2), Gul M(

Efficacy of a multi-nutrient dietary supplement on improving decision fatigue in video gamers.

5. Front Nutr. 2025 Nov 21;12:1680030. doi: 10.3389/fnut.2025.1680030. eCollection 2025. Efficacy of a multi-nutrient dietary supplement on improving decision fatigue in video gamers. Seesurn B(1), Batllori R(1), Watson SN(1). Author information: (1)Senescence Life Sciences Pte. Ltd, Singapore,

Anti-Inflammatory and Antioxidant Effects of Topical Formulations Containing Plant Extracts, Methylsulfonylmethane, and Peptiskin(®) in In Vitro Models of Arthritis.

47. Pharmaceuticals (Basel). 2025 Aug 26;18(9):1270. doi: 10.3390/ph18091270. Anti-Inflammatory and Antioxidant Effects of Topical Formulations Containing Plant Extracts, Methylsulfonylmethane, and Peptiskin(®) in In Vitro Models of Arthritis. Hoang TX(1)(2), Dang NM(1), Bae KG(3), Kim JY(1). A

Methylsulfonylmethane Mitigates Neurobehavioral Impairment, Oxidative Stress, Changes in Trace Elements and Clock Expression in Alcohol and Circadian-Disrupted C57BL/6J Mice Brain.

28. Neurochem Res. 2025 Sep 12;50(5):299. doi: 10.1007/s11064-025-04551-3. Methylsulfonylmethane Mitigates Neurobehavioral Impairment, Oxidative Stress, Changes in Trace Elements and Clock Expression in Alcohol and Circadian-Disrupted C57BL/6J Mice Brain. Latha Laxmi IP(1), Tamizhselvi R(2). Au

Comparative Analysis of Benchtop NMR and HPLC-UV for Illicit Drug Mixtures.

11. Magn Reson Chem. 2025 Nov;63(11):895-911. doi: 10.1002/mrc.70022. Epub 2025 Aug 18. Comparative Analysis of Benchtop NMR and HPLC-UV for Illicit Drug Mixtures. Verma S(1), Bogun B(2), Robinson JA(1), Holland DJ(1). Author information: (1)University of Canterbury, Christchurch, New Zealand. (

Methylsulfonylmethane-Regulated Hybrid Electrolyte for Stable Zn Anode and Suppressed Mn Dissolution.

14. Small. 2025 Jul;21(27):e2503938. doi: 10.1002/smll.202503938. Epub 2025 May 16. Methylsulfonylmethane-Regulated Hybrid Electrolyte for Stable Zn Anode and Suppressed Mn Dissolution. Wang H(1), Kang J(2), Liu G(1), Li X(1), Zhang C(1), Wan W(1), Li S(1), Huang Y(3), Wang C(1). Author informa

Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise.

14. Animals (Basel). 2025 Jan 14;15(2):215. doi: 10.3390/ani15020215. Methylsulfonylmethane (MSM) Supplementation in Adult Horses Supports Improved Skeletal Muscle Inflammatory Gene Expression Following Exercise. Barshick MR(1), Ely KM(1), Mogge KC(1), Chance LM(1), Johnson SE(1). Author informa

Dietary Supplementation with Methylsulfonylmethane and Myo-Inosito Supports Hair Quality and Fecal Microbiome in Poodles.

11. Animals (Basel). 2024 Dec 17;14(24):3643. doi: 10.3390/ani14243643. Dietary Supplementation with Methylsulfonylmethane and Myo-Inosito Supports Hair Quality and Fecal Microbiome in Poodles. Zhang J(1), Guo D(1), Zhang L(2), Li D(3), Deng B(1). Author information: (1)Guangdong Provincial Key

The effect of combined hydrolyzed type 2 collagen, methylsulfonylmethane, glucosamine sulfate and chondroitin sulfate supplementation on knee osteoarthritis symptoms.

49. Turk J Phys Med Rehabil. 2024 Jan 15;70(2):259-268. doi: 10.5606/tftrd.2024.13735. eCollection 2024 Jun. The effect of combined hydrolyzed type 2 collagen, methylsulfonylmethane, glucosamine sulfate and chondroitin sulfate supplementation on knee osteoarthritis symptoms. Ayhan FF(1)(2), Dem

MSM Supplementation Is Associated with Reduced Inflammation and Improved Innate Immune Response following In Vitro LPS-Stimulation in Humans after a Bout of Downhill Running.

45. Muscles. 2023 May 6;2(2):204-217. doi: 10.3390/muscles2020015. MSM Supplementation Is Associated with Reduced Inflammation and Improved Innate Immune Response following In Vitro LPS-Stimulation in Humans after a Bout of Downhill Running. McFarlin BK(1)(2), Vingren JL(1)(2), Hill DW(1), Bridg

Additive Effects of Dietary Supplementation with Zeolite and Methyl-Sulfonyl-Methane on Growth Performance and Interleukin Levels of Broiler Chickens.

31. J Poult Sci. 2023 Jan 25;60(1):2023003. doi: 10.2141/jpsa.2023003. Additive Effects of Dietary Supplementation with Zeolite and Methyl-Sulfonyl-Methane on Growth Performance and Interleukin Levels of Broiler Chickens. Lim CI(1)(2), Ryu KS(1). Author information: (1)Department of Animal Scie

Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells.

27. J Diet Suppl. 2023;20(6):950-962. doi: 10.1080/19390211.2022.2153957. Epub 2022 Dec 5. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. Clement K(1)(2), McGill MR(1)(2)(3), Miousse IR(4), Young SG(1), Melnyk S(5), Koturbash I(1)(2)

Effect of Dietary Methylsulfonylmethane Supplementation on Growth Performance, Hair Quality, Fecal Microbiota, and Metabolome in Ragdoll Kittens.

30. Front Microbiol. 2022 Jul 4;13:838164. doi: 10.3389/fmicb.2022.838164. eCollection 2022. Effect of Dietary Methylsulfonylmethane Supplementation on Growth Performance, Hair Quality, Fecal Microbiota, and Metabolome in Ragdoll Kittens. Guo D(1), Zhang L(1), Zhang L(1), Han S(1), Yang K(1), Li

Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis.

36. BMC Oral Health. 2025 Jan 16;25(1):78. doi: 10.1186/s12903-025-05447-y. Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis. Beder M(1), Yemenoglu H(2), Bostan SA(2), Kose O(2), Karakas SM(3), Mercantepe T