리코펜

Effects of carotenoid supplementation on liver enzymes in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

1. BMC Complement Med Ther. 2025 Dec 23;26(1):25. doi: 10.1186/s12906-025-05201-5. Effects of carotenoid supplementation on liver enzymes in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials. Heydari SS(1)(2), Bideshki MV(3)(4), Akbarzadeh

The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis.

2. Clin Exp Dent Res. 2025 Dec;11(6):e70215. doi: 10.1002/cre2.70215. The Impact of Antioxidant Adjuncts on Periodontal Health in Type 2 Diabetes Patients: A Meta-Analysis. Abdulla SA(1), Abdalla BA(2), Muhammed AA(3), Elawamy HA(4), Hawda SM(1), Mohamed N(4), Abduallah EH(5), Younis MYG(1), Als

Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis.

3. Int J Mol Sci. 2025 Jul 25;26(15):7224. doi: 10.3390/ijms26157224. Association of Lycopene and Male Reproductive Health: Systematic Review and Meta-Analysis. Viña I(1), Viña JR(2). Author information: (1)IVB Wellness Lab, C/Colón 12, 46004 Valencia, Spain. (2)Department of Biochemistry and Mo

Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis.

4. Nutrients. 2024 Jul 10;16(14):2213. doi: 10.3390/nu16142213. Antioxidant Lipid Supplement on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis. Wan S(1)(2), Wu W(2), Zhang Y(1), He J(3), Wang X(4), An P(2), Luo J(5), Zhu Y(6), Luo Y(1)(2). Author information: (1)College of F

Diet-derived circulating antioxidants, periodontitis and dental caries: A Mendelian randomization study.

5. J Periodontal Res. 2024 Oct;59(5):951-958. doi: 10.1111/jre.13260. Epub 2024 Apr 2. Diet-derived circulating antioxidants, periodontitis and dental caries: A Mendelian randomization study. Gao Y(1)(2)(3), Huang D(1)(2)(3)(4), Liu Y(1)(2)(3)(4), Qiu Y(1)(2)(3)(4), Lu S(1)(2)(3)(4). Author in

Not all carotenoids can reduce the risk of gastric cancer: a systematic review with meta-analysis.

6. BMC Gastroenterol. 2024 Jan 29;24(1):51. doi: 10.1186/s12876-024-03139-5. Not all carotenoids can reduce the risk of gastric cancer: a systematic review with meta-analysis. Han W(1)(2), Zhang W(2), Ren X(3)(4). Author information: (1)Department of General Surgery, Lanzhou University Second Ho

The Effects of Lycopene and Tomato Consumption on Cardiovascular Risk Factors in Adults: A Grade Assessment Systematic Review and Meta-analysis.

7. Curr Pharm Des. 2023;29(21):1671-1700. doi: 10.2174/1381612829666230726112510. The Effects of Lycopene and Tomato Consumption on Cardiovascular Risk Factors in Adults: A Grade Assessment Systematic Review and Meta-analysis. Zamani M(1), Behmanesh Nia F(2), Ghaedi K(3), Mohammadpour S(4), Amira

Effectiveness of non-pharmaceutical intervention on sperm quality: a systematic review and network meta-analysis.

8. Aging (Albany NY). 2023 May 17;15(10):4253-4268. doi: 10.18632/aging.204727. Epub 2023 May 17. Effectiveness of non-pharmaceutical intervention on sperm quality: a systematic review and network meta-analysis. Chen Z(1)(2), Hong Z(1)(2), Wang S(1)(2), Qiu J(1)(2), Wang Q(1)(2), Zeng Y(1)(2),

Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review.

9. Nutrients. 2023 Mar 22;15(6):1538. doi: 10.3390/nu15061538. Dietary and Nutraceutical Interventions as an Adjunct to Non-Surgical Periodontal Therapy-A Systematic Review. Woelber JP(1), Reichenbächer K(1), Groß T(1), Vach K(2), Ratka-Krüger P(1), Bartha V(3). Author information: (1)Departmen

The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials.

10. Crit Rev Food Sci Nutr. 2024 Jun;64(18):6198-6217. doi: 10.1080/10408398.2022.2164557. Epub 2023 Jan 6. The effect of tomato and lycopene on clinical characteristics and molecular markers of UV-induced skin deterioration: A systematic review and meta-analysis of intervention trials. Zhang X

Tomato-Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity.

11. Mol Nutr Food Res. 2026 Mar;70(5):e70420. doi: 10.1002/mnfr.70420. Tomato-Soy Juice Reduces Inflammation and Modulates the Urinary Metabolome in Adults With Obesity. Sholola MJ(1), Miller J(1), Bilbrey EA(2), Novotny JA(3), Francis DM(4), Mace TA(5), Cooperstone JL(1)(2). Author information

Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial.

12. Anticancer Res. 2026 Mar;46(3):1599-1608. doi: 10.21873/anticanres.18055. Overall Survival of Glioblastoma Patients Treated With a Combination of 7 Micronutrients: A Nutraceutical Trial. Rooprai HK(1), Lawrence P(2), Ashkan K(3), Beaney R(4), Pilkington GJ(5), Gullan RW(1). Author informati

Effects of Randomized Multivitamin Supplementation on Carotenoids and α-Tocopherol in the COcoa Supplement and Multivitamin Outcomes Study.

13. J Acad Nutr Diet. 2026 May;126(5):156299. doi: 10.1016/j.jand.2026.156299. Epub 2026 Jan 24. Effects of Randomized Multivitamin Supplementation on Carotenoids and α-Tocopherol in the COcoa Supplement and Multivitamin Outcomes Study. Christopher CN(1), Erdman JW Jr(2), Kim E(3), Black M(2), R

Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study.

14. BMC Med. 2025 Nov 10;23(1):627. doi: 10.1186/s12916-025-04440-0. Lycopene intake and prostate cancer risk in men at high cardiovascular risk: a prospective cohort study. López-Solís R(1)(2), Castro-Barquero S(2)(3)(4), Donat-Vargas C(1)(2)(3), Corrado M(1)(2)(3), Arancibia-Riveros C(1)(2), M

Improvement of vascular endothelial function by intake of lycopene-rich tomato juice in healthy adults: a randomized, placebo-controlled, double-blind, parallel-group comparative study.

15. Food Funct. 2025 Sep 29;16(19):7812-7822. doi: 10.1039/d5fo01397f. Improvement of vascular endothelial function by intake of lycopene-rich tomato juice in healthy adults: a randomized, placebo-controlled, double-blind, parallel-group comparative study. Yoshida K(1), Nakazawa Y(1), Takahashi

Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled trial.

35. Am J Clin Nutr. 2025 Nov;122(5):1289-1297. doi: 10.1016/j.ajcnut.2025.08.012. Epub 2025 Aug 27. Apolipoprotein E ε4-dependent associations between carotenoids and cognitive decline: Findings from the MIND (Mediterranean-DASH Intervention for Neurodegenerative delay) randomized controlled tri

Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial.

36. Mol Nutr Food Res. 2025 Jul;69(13):e70115. doi: 10.1002/mnfr.70115. Epub 2025 May 12. Tomato Puree Enrichment in a High-Fat Meal Reduces Postprandial Plasma and Adipose Tissue Inflammation Biomarkers in Healthy Male Adults: A Crossover Randomized Controlled Trial. Sani L(1), Astier J(1), Ou

Association of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma and Skin Carotenoid Concentrations in Adults Provided a Lycopene-Rich Juice.

22. J Nutr. 2024 Jul;154(7):1985-1993. doi: 10.1016/j.tjnut.2024.05.022. Epub 2024 May 24. Association of Candidate Single-Nucleotide Polymorphism Genotypes With Plasma and Skin Carotenoid Concentrations in Adults Provided a Lycopene-Rich Juice. Norman AC(1), Palmer DG(2), Moran NE(3), Roemmich

Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial.

19. Eur J Prev Cardiol. 2024 Jun 3;31(8):922-934. doi: 10.1093/eurjpc/zwad363. Association between tomato consumption and blood pressure in an older population at high cardiovascular risk: observational analysis of PREDIMED trial. Murcia-Lesmes D(1)(2), Domínguez-López I(1)(2)(3), Laveriano-Santo

Safety, Tolerability, and Pharmacokinetics of β-Cryptoxanthin Supplementation in Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial.

18. Nutrients. 2023 May 16;15(10):2325. doi: 10.3390/nu15102325. Safety, Tolerability, and Pharmacokinetics of β-Cryptoxanthin Supplementation in Healthy Women: A Double-Blind, Randomized, Placebo-Controlled Clinical Trial. Tan KML(1)(2), Chee J(1), Lim KLM(1), Ng M(1)(3), Gong M(1), Xu J(1), Tin

Synergistic Anti-Inflammatory Effects of Phenolics from Purple Potato and Lycopene Using Mono- and Coculture Cell Models.

12. J Agric Food Chem. 2026 Jan 14;74(1):590-603. doi: 10.1021/acs.jafc.5c07341. Epub 2025 Dec 28. Synergistic Anti-Inflammatory Effects of Phenolics from Purple Potato and Lycopene Using Mono- and Coculture Cell Models. Yu J(1), Zheng S(1)(2), Deng Z(1)(3), Tsao R(4), Mueed A(1), Zhang H(4), Li

Investigation of ponatinib metabolism and drug-drug interactions with lycopene and shikonin in vitro and invivo.

6. Chem Biol Interact. 2024 Dec 1;404:111265. doi: 10.1016/j.cbi.2024.111265. Epub 2024 Oct 11. Investigation of ponatinib metabolism and drug-drug interactions with lycopene and shikonin in vitro and invivo. Chen J(1), Hong F(2), Xia H(3), Shen Y(1), Chen X(3), Wu H(3), Lin G(4), Zhan R(5). A

Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway.

11. Biochem Biophys Res Commun. 2022 Jul 12;613:53-60. doi: 10.1016/j.bbrc.2022.04.126. Epub 2022 Apr 30. Lycopene enhances the sensitivity of castration-resistant prostate cancer to enzalutamide through the AKT/EZH2/ androgen receptor signaling pathway. Chen X(1), Yang G(2), Liu M(2), Quan Z(2)

Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats.

49. Sci Rep. 2021 Jul 7;11(1):13979. doi: 10.1038/s41598-021-93196-7. Synergistic protective effects of lycopene and N-acetylcysteine against cisplatin-induced hepatorenal toxicity in rats. Elsayed A(1), Elkomy A(1), Elkammar R(2), Youssef G(3), Abdelhiee EY(4), Abdo W(5), Fadl SE(6), Soliman A(

Synergistic antioxidant effects of phenolic acids and carotenes on H(2)O(2)-induced H9c2 cells: Role of cell membrane transporters.

17. Food Chem. 2021 Mar 30;341(Pt 2):128000. doi: 10.1016/j.foodchem.2020.128000. Epub 2020 Sep 6. Synergistic antioxidant effects of phenolic acids and carotenes on H(2)O(2)-induced H9c2 cells: Role of cell membrane transporters. Pan Y(1), Deng ZY(2), Chen X(1), Zhang B(1), Fan Y(1), Li H(3).

Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor- kappa B (NF-κB) pathway.

49. Turk J Med Sci. 2021 Feb 26;51(1):368-374. doi: 10.3906/sag-2005-413. Lycopene sensitizes the cervical cancer cells to cisplatin via targeting nuclear factor- kappa B (NF-κB) pathway. Aktepe OH(1), Şahin TK(2), Güner G(1), Arik Z(1), Yalçin Ş(1). Author information: (1)Department of Medical

PEGylated Nanoliposomes Potentiated Oral Combination Therapy for Effective Cancer Treatment.

19. Curr Drug Deliv. 2020;17(9):728-735. doi: 10.2174/1567201817666200724170708. PEGylated Nanoliposomes Potentiated Oral Combination Therapy for Effective Cancer Treatment. Singh A(1), Neupane YR(2), Mangla B(1), Shafi S(3), Kohli K(1). Author information: (1)Department of Pharmaceutics, School

Synergistic antioxidant effects of petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway.

36. J Food Sci. 2020 Jun;85(6):1752-1763. doi: 10.1111/1750-3841.15153. Epub 2020 May 31. Synergistic antioxidant effects of petunidin and lycopene in H9c2 cells submitted to hydrogen peroxide: Role of Akt/Nrf2 pathway. Zheng S(1), Deng Z(1)(2), Chen F(3), Zheng L(1), Pan Y(1), Xing Q(1), Tsao R

Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro.

50. J Food Biochem. 2019 Apr;43(4):e12802. doi: 10.1111/jfbc.12802. Epub 2019 Feb 11. Lycopene, sulforaphane, quercetin, and curcumin applied together show improved antiproliferative potential in colon cancer cells in vitro. Langner E(1)(2), Lemieszek MK(1), Rzeski W(1)(3). Author information:

Synergistic protection of matrine and lycopene against lipopolysaccharide‑induced acute lung injury in mice.

48. Mol Med Rep. 2019 Jul;20(1):455-462. doi: 10.3892/mmr.2019.10278. Epub 2019 May 22. Synergistic protection of matrine and lycopene against lipopolysaccharide‑induced acute lung injury in mice. Li WW(1), Wang TY(2), Cao B(3), Liu B(2), Rong YM(1), Wang JJ(2), Wei F(2), Wei LQ(2), Chen H(3),