롱잭
Longjack (Eurycoma)
📚 관련 논문 (24편)
1. Phytother Res. 2021 Dec;35(12):7039-7049. doi: 10.1002/ptr.7331. Epub 2021 Nov 18. An exploratory double-blind, randomized, placebo-controlled study to assess the efficacy of CitruSlim on body composition and lipid parameters in obese individuals. Hancke J(1), Srivastava S(2), Caceres DD(3)(
2. PLoS One. 2019 Mar 13;14(3):e0199799. doi: 10.1371/journal.pone.0199799. eCollection 2019. Pasakbumin A controls the growth of Mycobacterium tuberculosis by enhancing the autophagy and production of antibacterial mediators in mouse macrophages. Lee HJ(1), Ko HJ(2), Kim SH(3), Jung YJ(1). Aut
3. J Clin Pharm Ther. 2010 Dec;35(6):691-6. doi: 10.1111/j.1365-2710.2009.01147.x. Modification of propranolol's bioavailability by Eurycoma longifolia water-based extract. Salman SA(1), Amrah S, Wahab MS, Ismail Z, Ismail R, Yuen KH, Gan SH. Author information: (1)Department of Pharmacology, Sc
4. Int J Impot Res. 2024 Jun;36(4):348-364. doi: 10.1038/s41443-023-00763-9. Epub 2023 Sep 11. Do "testosterone boosters" really increase serum total testosterone? A systematic review. Morgado A(1), Tsampoukas G(2), Sokolakis I(3), Schoentgen N(4), Urkmez A(5), Sarikaya S(6). Author informatio
5. Medicina (Kaunas). 2022 Aug 4;58(8):1047. doi: 10.3390/medicina58081047. Eurycoma longifolia (Jack) Improves Serum Total Testosterone in Men: A Systematic Review and Meta-Analysis of Clinical Trials. Leisegang K(1), Finelli R(2), Sikka SC(3), Panner Selvam MK(3). Author information: (1)School
6. Int J Impot Res. 2021 Apr;33(3):311-317. doi: 10.1038/s41443-020-0285-x. Epub 2020 May 1. A systematic review and evidence-based analysis of ingredients in popular male testosterone and erectile dysfunction supplements. Kuchakulla M(1), Narasimman M(1), Soni Y(1), Leong JY(2), Patel P(3), Ram
7. Chin J Nat Med. 2017 Jan;15(1):71-80. doi: 10.1016/S1875-5364(17)30010-9. Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies. Thu HE(1), Mohamed IN(1), Hussain Z(2), Jayusman PA(1), Shuid AN(3). Author information: (1)Department of Phar
8. Complement Ther Med. 2015 Oct;23(5):693-8. doi: 10.1016/j.ctim.2015.07.009. Epub 2015 Jul 31. Efficacy of Tongkat Ali (Eurycoma longifolia) on erectile function improvement: systematic review and meta-analysis of randomized controlled trials. Kotirum S(1), Ismail SB(2), Chaiyakunapruk N(3).
9. J Diet Suppl. 2013 Mar;10(1):54-83. doi: 10.3109/19390211.2012.761467. An evidence-based systematic review of tongkat ali (Eurycoma longifolia) by the Natural Standard Research Collaboration. Ulbricht C(1), Conquer J, Flanagan K, Isaac R, Rusie E, Windsor RC. Author information: (1)Natural St
1. Nutrients. 2026 Apr 19;18(8):1289. doi: 10.3390/nu18081289. The Effects of Seaweed and Microalgae Supplementation on Exercise Performance and Recovery: A Systematic Review and Meta-Analysis. Wei Y(1), Liu S(2), You T(3), Liu X(4), Zhong W(2), Wu Y(2), Azhati S(1), Han Q(2), Jiang W(5), Liu C(2). Author information: (1)School of Education, Beijing Sport University, Beijing 100084, China. (2)School of Sports Science, Beijing Sport University, Beijing 100084, China. (3)School of Leisure Sports and Tourism, Beijing Sport University, Beijing 100084, China. (4)School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China. (5)China Volleyball Academy, Beijing Sport University, Beijing 100084, China. Objective: Seaweed and microalgae provide antioxidants, polyunsaturated fatty acids, and bioactive compounds that may enhance exercise performance and accelerate recovery. However, evidence remains inconsistent. This systematic review and meta-analysis aimed to evaluate the effects of algae-derived supplementation on exercise performance and physiological recovery outcomes in healthy and athletic adults. Methods: This review was registered in PROSPERO (CRD420251166723) and conducted in accordance with PRISMA 2020 guidelines. PubMed, Web of Science, Embase, Cochrane Library, EBSCO, and CNKI were systematically searched for randomized controlled trials (RCTs) evaluating algae supplementation in exercise contexts. Inclusion and exclusion criteria were defined based on the PICOS framework. Primary outcomes included VO2max, Time to exhaustion (TTE), maximal power output (WRmax), Time-Trial (TT) performance, and creatine kinase (CK). Standardized mean differences (SMDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Subgroup, sensitivity, and publication bias analyses were performed. Results: Twenty-two RCTs (n = 822) investigating Spirulina, Chlorella, brown-algal polysaccharides, or astaxanthin met inclusion criteria. Algae supplementation showed a suggestive improvement in VO2max (SMD = 0.88, 95% CI: 0.00-1.75) and significantly improved in TTE (SMD = 1.06, 95% CI: 0.16-1.96), with smaller effects on WRmax (SMD = 0.29, 95% CI: 0.03-0.55), and no significant benefit for TT performance (SMD = -0.27, 95% CI: -0.74 to 0.21). Regarding recovery, CK concentrations were significantly reduced (SMD = -0.78, 95% CI: -1.28 to -0.28). Subgroup analysis suggested greater effects for Chlorella supplementation, higher dosages, and aerobic training contexts; reductions in muscle-damage markers were more evident following resistance exercise. Sensitivity analyses supported the robustness of the main findings with minimal evidence of publication bias. Conclusions: Algae-derived supplements-particularly Spirulina and Chlorella-may modestly enhance aerobic exercise performance and attenuate exercise-induced muscle damage under certain conditions. Effects appear to depend on algae species, dosing strategies, intervention duration, and training modality. High-quality, multi-center RCTs incorporating mechanistic endpoints are needed to clarify optimal application and to develop athlete-specific recommendations. DOI: 10.3390/nu18081289 PMID: 42075102 [Indexed for MEDLINE]
2. Nutrients. 2026 Apr 17;18(8):1272. doi: 10.3390/nu18081272. Effects of Resistance Exercise and Whey Protein Supplementation on Irisin Levels in Patients with MASLD Under a Calorie-Restricted Diet. Zhang FR(1), Kim CB(1)(2), Ahn D(1)(3), Sung J(1), Oh JH(1), Heo HR(1), Jo EA(1)(2), Kim HS(4), Park JJ(1)(2). Author information: (1)Department of Sport Science, Pusan National University, Busan 46241, Republic of Korea. (2)Research Institute of Human Ecology, Pusan National University, Busan 46241, Republic of Korea. (3)Department of Kinesiology and Sport Management, Texas Tech University, Lubbock, TX 79409, USA. (4)Gastroenterology, Soon Chun Hyang University Cheonan Hospital, Cheonan 31151, Republic of Korea. Objectives: The aim of this study was to explore the combined effects of resistance exercise and whey protein supplementation on plasma irisin levels in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) under a 30% calorie-restricted weight loss diet. Methods: Thirty adult patients with MASLD were randomized into the following three groups for a 4-week intervention: calorie restriction group (CR) (n = 8), CR with resistance exercise group (EX) (n = 11), and CR with resistance exercise and whey protein group (EX + P) (n = 11; 0.7 g/kg per day). All participants received boxed meals providing 70% of their total energy expenditure. The participants in the resistance exercise groups performed full-body resistance exercises 5 days/week (50-75% one-repetition maximum). Plasma irisin level, controlled attenuation parameter (CAP), and body composition were assessed before and after the intervention. Results: Plasma irisin levels significantly increased in the EX (+2.24 ng/mL, p = 0.016) and EX + P (+4.86 ng/mL, p = 0.004) groups but not in the CR group. Muscle mass increased significantly only in the EX + P group. The CAP decreased in all groups. The change in irisin level was negatively correlated with the change in CAP (r = -0.459, p = 0.032). Conclusions: Resistance exercise under calorie-restricted conditions effectively increased plasma irisin levels in patients with MASLD, whereas caloric restriction alone did not. Furthermore, a stronger increasing trend in the plasma irisin levels was observed with whey protein supplementation. An increase in irisin levels was significantly associated with hepatic fat reduction, suggesting that irisin may serve as a biomarker reflecting improvements in hepatic steatosis following lifestyle intervention. DOI: 10.3390/nu18081272 PMID: 42075090 [Indexed for MEDLINE]
3. Nutrients. 2026 Apr 17;18(8):1274. doi: 10.3390/nu18081274. The Role of Dietary Supplements in the Treatment of Endometriosis: A Critical Review. Wójtowicz M(1), Małek P(2), Olszanecka-Glinianowicz M(2). Author information: (1)Clinical Department of Gynecology and Obstetrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland. (2)Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. Background: There is a growing number of studies suggesting the effectiveness of dietary supplements in preventing and treating endometriosis. It has been suggested that deficiencies in vitamins D and E as well as zinc are associated with the increased risk of endometriosis development. Beneficial effects of magnesium, curcumin, resveratrol and epigallocatechin-3-gallate were found in experimental animal studies. A reduction in pain related to endometriosis was shown in women using omega-3 and alpha-lipoic acid. Meanwhile, decreasing endometriotic lesion size after the supplementation of omega-3, N-acetylcysteine, vitamin C and epigallocatechin-3-gallate was observed in animal and human studies. Thus, the aim of this critical review was to summarize the available data describing the effects of dietary supplements used in the treatment of endometriosis. Material and Methods: The PubMed, Embase, Cochrane, and Web of Science databases were searched for related studies until 15 December 2025. Finally, 34 studies were included in the synthesis. Results: Of these 34 studies, only 23 were randomized, placebo-controlled trials. There have been no RCTs evaluating the effectiveness of vitamin E, zinc, alpha-LA, EGCG and DIM in the treatment of endometriosis. Single studies evaluating the effectiveness of vitamin C, magnesium, resveratrol, NAC and PEA with PLD have not confirmed it. Meanwhile single studies evaluating the effectiveness of selenium, propolis and quercetin have confirmed it. Of the four studies assessing the effectiveness of vitamin D, two confirmed it and two did not; of the two studies assessing probiotics, one confirmed its effectiveness and one did not; of the two studies assessing curcumin, one confirmed its effectiveness and one did not; and of the three studies assessing omega-3, two confirmed its effectiveness and one did not. All four RCTs assessing the combination of vitamins C and E confirmed their effectiveness. Conclusions: Despite encouraging observations from experimental studies, the results of RCTs are less encouraging and do not allow for the formulation of recommendations concerning the use of supplements in the treatment of endometriosis symptoms according to EBM. DOI: 10.3390/nu18081274 PMID: 42075089 [Indexed for MEDLINE]
4. Nutrients. 2026 Apr 12;18(8):1215. doi: 10.3390/nu18081215. Effect of Beetroot Nitrate Supplementation on Nitric Oxide Pathways and Oxy-Inflammatory Biomarkers in Amateur Triathletes: A Randomized Cross-Over Pilot Study. Mrakic-Sposta S(1), Vezzoli A(1), Parenza M(2), Magno M(2), D'Angelo G(2), Nannipieri F(3), Battaglia S(3), Solfanelli L(3), Tacconi E(4), Dellanoce C(1), Montorsi M(1)(5), Pratali L(2). Author information: (1)Institute of Clinical Physiology, National Research Council (IFC-CNR), Piazza dell'Ospedale Maggiore, 3, 20162 Milan, Italy. (2)Institute of Clinical Physiology, National Research Council (IFC-CNR), Via Giuseppe Moruzzi 1, 56124 Pisa, Italy. (3)Medical Research, Abiogen Pharma, Via Antonio Meucci, 36, 56121 Pisa, Italy. (4)Private Practice, Via Matteo Degli Organi 1, 59100 Prato, Italy. (5)Department of Human Sciences and Promotion of the Quality of Life, San Raffaele Roma Open University, Via di Val Cannuta, 247, 00166 Roma, Italy. Background/Objectives: Nitric oxide (NO) is a key mediator of vascular, metabolic, and redox pathways, influencing exercise performance. Beetroot, a natural source of inorganic nitrate, increases NO bioavailability and may modulate oxidative stress and inflammation, though data in endurance athletes remain limited. The aim of this study was to assess the effects of a novel beetroot-based nitrate supplement (B-bNs) on NO metabolism, oxidative stress, and inflammation in non-professional triathletes. Methods: This was a randomized 2 × 2 cross-over pilot study with two 7-day periods (B-bNs vs. No treatment), separated by a 15-day washout (4 visits: Day 1, 7, 22 and 28). Samples were collected at baseline (T0), 2 h post-first dose (T1), and after 7 days (T2) for the supplementation period (B-bNs) and at T0 and T2 for the "no treatment" period. The following biomarkers from plasma and urine were evaluated: NO pathway (NO metabolites (NOx), nitrite (NO2), inducible nitric oxide synthase (iNOS), peroxynitrite, 3-nitrotyrosine (3-NT)), oxidative stress (reactive oxygen species (ROS) production, 8-isoprostane, superoxide dismutase (SOD) activity), and cytokines (IL-6, IL-10). A total of 10 male triathletes (mean age 48.1 ± 9.8 years and BMI 23.9 ± 2.2 kg/m2) participated in this study. Results: No adverse events were reported. After 7 days of supplementation (T2 vs. T0), significant increases in NOx in plasma and urine (about +155%), iNOS (+56%), peroxynitrite (+60%), 3-NT (+8.6%), ROS (+413%) and IL-6 (+73%) were recorded. These values resulted significantly higher compared to "no treatment" (all p = 0.002), with no significant differences for 3-NT, SOD, 8-isoprostane, IL-6, and IL-10. Conclusions: Beetroot-based nitrate supplementation may enhance the NO-related pathway in non-professional endurance athletes with nitric-peroxydation activation, occurring without evidence of lipid oxidative damage. Larger placebo-controlled trials with standardized diet/training and performance outcomes are needed to determine the functional significance of these preliminary findings. This study was registered in the ISRCTN registry (ISRCTN10885376). DOI: 10.3390/nu18081215 PMID: 42075028 [Indexed for MEDLINE]
5. Nutrients. 2026 Apr 10;18(8):1199. doi: 10.3390/nu18081199. The Effects of a Phytochemical Supplement Blend on Markers of Exercise-Induced Muscle Damage: A Randomised Controlled Trial. Thorley J(1)(2), Reynolds KM(1), Nickels M(1), Bailey SJ(1), Kingma R(3), Clifford T(1). Author information: (1)School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough LE11 3TU, UK. (2)School of Translational Medical Sciences, University of Nottingham, Nottingham NG7 2QL, UK. (3)VDF FutureCeuticals Inc., Momence, IL 60954, USA. BACKGROUND AND OBJECTIVES: This study examined the effects of a novel phytochemical supplement blend on markers of exercise-induced muscle damage. METHODS: In a randomised, parallel group design, 24 healthy participants (14 males) consumed 300 mg of a phytochemical blend (calcium fructoborate, turmeric and pomegranate; PB) or inert placebo for 9 days (n = 12 per condition). On day 7, participants performed 150 drop jumps to induce muscle damage. Markers of neuromuscular function, muscle soreness/pain, perceived exhaustion and sleep quality, were measured pre-exercise and 24, 48, and 72 h post-exercise; systemic markers of inflammation, muscle damage, and oxidative stress were measured on these days as well post-exercise and 2.5 h post-exercise. RESULTS: There was an interaction effect for pressure pain threshold in the vastus lateralis (p = 0.041), which was ~21% higher in PB 72 h post-exercise (p = 0.074; ds = 0.767). Perceived sleep quality was greater 72 h post-exercise in PB (p = 0.049; rrb = 0.423) and those in the PB condition reported feeling more recovered and less mentally drained post-exercise (p ≤ 0.043). There were no statistically significant between-condition differences for any markers of neuromuscular function, inflammation, oxidative stress or muscle damage (p > 0.05). CONCLUSION: In conclusion, a novel PB showed promise for attenuating muscle pain and perceived exhaustion, and improving sleep quality, in the days after muscle damaging exercise. The study protocol was pre-registered on the Open Science Framework Registry (registration number: qgw3a). DOI: 10.3390/nu18081199 PMID: 42075011 [Indexed for MEDLINE]
6. Nutrients. 2026 Apr 10;18(8):1192. doi: 10.3390/nu18081192. Single-Dose Creatine Reduces Sleep Deprivation-Induced Deterioration in Cognitive Performance. Gordji-Nejad A(1), Matusch A(1), Hengstler L(1), Beer S(1), Kroll T(1), Klein S(1), Elmenhorst D(1)(2), Bauer A(1), Drzezga A(1)(2)(3). Author information: (1)Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, 52425 Jülich, Germany. (2)Department of Nuclear Medicine, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, Germany. (3)German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany. Background/Objectives: Creatine is a supplement that, beyond its physiological effects, has been shown to have positive effects on cognitive abilities. In our previous study, we showed that a single dose of 0.35 g/kg creatine induces changes in brain metabolism during sleep deprivation and reduces deterioration in cognitive performance. The present study investigates whether supplementation of a lower dose is associated with cognitive effects during sleep deprivation, focusing exclusively on cognitive performance outcomes. Methods: Twenty-nine healthy subjects performed cognitive tests at the evening baseline and 3, 5.5, and 7.5 h after receiving a single dose of creatine monohydrate (0.2 g/kg) or a placebo during a total of 21 h of sleep deprivation (SD). Results: The results show a mitigating effect of creatine on sleep deprivation-induced deterioration in logical and numerical tasks, language-related processing speed, and the Psychomotor Vigilance Test (PVT). Compared to males, females benefit more in logic, PVT and processing speed in language and logic tasks. Conclusions: Our results show that a dose of 0.2 g/kg creatine is associated with a reduced deterioration in cognitive performance during sleep deprivation. Although the effect is less pronounced than with a high dose of 0.35 g/kg, there is still an improvement of up to 12%. DOI: 10.3390/nu18081192 PMID: 42075005 [Indexed for MEDLINE]
7. Nutrients. 2026 Apr 9;18(8):1182. doi: 10.3390/nu18081182. Non-Mineral Antioxidant Supplementation in Endometriosis: Biological Rationale, Clinical Evidence, and Therapeutic Implications-A Narrative Review. Pokorska-Niewiada K(1), Janda-Milczarek K(2), Kayumov K(3), Ziętek M(4), Szczuko M(5). Author information: (1)Department of Toxicology, Dairy Technology and Food Storage, West Pomeranian University of Technology in Szczecin, 71-454 Szczecin, Poland. (2)Department of Biology, Parasitology and Pharmaceutical Botany, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland. (3)Department of Human and Animals Physiology, National University of Uzbekistan named after Mirzo Ulugbek, Tashkent 100174, Uzbekistan. (4)Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, Poland. (5)Department of Bromatology and Diagnostic Nutrition, Pomeranian Medical University, 70-111 Szczecin, Poland. Background/Objectives: Oxidative stress plays an important role in the pathophysiology of endometriosis, contributing to inflammation, immune dysregulation, and lesion progression. This has led to growing interest in antioxidant-based strategies as potential supportive interventions. Methods: A literature search was conducted using PubMed, Scopus, and Web of Science databases, covering studies published from database inception until the end of January 2026. The review focused on clinically relevant endpoints, including pain intensity, markers of inflammation and oxidative stress, reproductive parameters, and quality of life. Results: Among the analyzed interventions, the most consistent clinical effects were observed with melatonin, with randomized controlled trials indicating a moderate reduction in pain. N-acetylcysteine shows potentially beneficial effects; however, the available clinical data remain limited and heterogeneous. For other supplements, the evidence is inconsistent or insufficient to support clear clinical conclusions, and in many cases relies on indirect or mechanistic findings rather than well-established clinical outcomes. Conclusions: Current evidence does not support the use of non-mineral antioxidant supplements as standalone therapy for endometriosis. They may be considered as adjunctive strategies, although their clinical effectiveness remains uncertain and requires confirmation in well-designed randomized clinical trials. DOI: 10.3390/nu18081182 PMID: 42074994 [Indexed for MEDLINE]
8. Nutrients. 2026 Apr 9;18(8):1178. doi: 10.3390/nu18081178. DHA: Nutritional Programming During the First 1000 Days of Life. Sollena LM(1), Carta M(2), Insinga V(2), Gabriele B(2), Notarbartolo V(2), Sortino C(1), Giuffrè M(1)(2). Author information: (1)Neonatal Intensive Care Unit, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties "G. D'Alessandro", University of Palermo, 90127 Palermo, Italy. (2)Neonatology and Neonatal Intensive Care Unit, University Hospital Policlinico "Paolo Giaccone", 90127 Palermo, Italy. BACKGROUND: The first 1000 days of life, from conception to 2 years of age, represent a critical window during which nutrition can exert long-lasting effects on neurodevelopment, immune maturation, and susceptibility to prematurity-related morbidity. Docosahexaenoic acid (DHA) is a key structural n-3 long-chain polyunsaturated fatty acid of the brain and retina, characterized by rapid fetal accretion during the third trimester. METHODS: We conducted a narrative review of studies published from March 2015 up to December 2025, including randomized controlled trials, follow-up studies, and systematic reviews/meta-analyses about DHA supplementation during pregnancy, lactation, infancy and early childhood, and its role on development. RESULTS: Across the first 1000 days, DHA supplementation improves biochemical DHA status, particularly in populations with low baseline levels (moderate to high level of evidence), while clinical outcomes remain heterogeneous. During pregnancy, some benefits in specific cognitive and behavioral domains have been demonstrated, whereas effects on global cognition and long-term behavior are frequently null (moderate evidence). Visual outcomes appear favorable, with improvements in visual acuity (moderate evidence). In preterm infants, enteral DHA-often combined with arachidonic acid (ARA)-is feasible and well tolerated. DHA may reduce inflammatory markers and necrotizing enterocolitis risk when in equilibrium with ARA (low to moderate evidence), while no evidence supports the link between DHA and reduced risk of bronchopulmonary dysplasia and retinopathy of prematurity (moderate evidence). Neurodevelopmental outcomes are mixed: neuroimaging studies suggest enhanced white matter maturation with DHA + ARA, whereas most trials show no clear benefit regarding standardized developmental scores (moderate evidence). CONCLUSIONS: DHA is biologically essential during the first 1000 days, but its clinical impact depends on timing, dose, baseline status, and prematurity-related context. The balance between DHA and ARA, rather than DHA supplementation alone, emerges as a key determinant of clinical efficacy, supporting a shift toward precision-based nutritional strategies in early life. DOI: 10.3390/nu18081178 PMID: 42074991 [Indexed for MEDLINE]
9. Nutrients. 2026 Apr 8;18(8):1176. doi: 10.3390/nu18081176. Impact of Probiotics, Prebiotics and Synbiotics Supplementation in Chronic Kidney Disease: A Comprehensive Review of Clinical Trials. Di Renzo T(1), Reale A(1), Nazzaro S(1), Iovanna D(1), Evangelista D(1), Gautam V(2), Guida B(3), Carrano R(4), Cataldi M(5). Author information: (1)Institute of Food Sciences, National Research Council, 83100 Avellino, Italy. (2)Norton Neuroscience Institute, 200 E. Chestnut St., Louisville, KY 40202, USA. (3)Physiology Nutrition Unit, Department of Clinical Medicine and Surgery, University of Naples "Federico II", 80131 Naples, Italy. (4)Section of Nephrology, Department of Public Health, University of Naples "Federico II", 80131 Naples, Italy. (5)Section of Pharmacology, Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples "Federico II", 80131 Naples, Italy. Chronic kidney disease (CKD) is a progressive condition associated with metabolic disturbances, systemic inflammation, and the accumulation of gut-derived uremic toxins. Increasing evidence highlights the role of gut microbiota dysbiosis in the progression of CKD through the gut-kidney axis. Consequently, microbiome-targeted nutritional strategies, including probiotics, prebiotics, and synbiotics, have emerged as promising complementary approaches to modulate intestinal microbial composition and metabolic functions. This review summarizes and critically evaluates the current clinical evidence regarding the use of these interventions in CKD patients. Clinical studies indicate that supplementation with probiotics, prebiotics, and synbiotic formulations may promote beneficial shifts in the composition of the gut microbiota, enhance saccharolytic fermentation, and increase the production of short-chain fatty acids (SCFAs). These changes have been associated with reduced circulating levels of gut-derived uremic toxins such as indoxyl sulfate and p-cresyl sulfate, as well as with the attenuation of systemic inflammation and oxidative stress. However, available trials remain heterogeneous in terms of study design, probiotic strains, prebiotic substrates, dosing regimens, and patient populations, and are frequently limited by small sample sizes and short intervention durations. As a result, evidence for improvements in renal function and long-term clinical outcomes remains inconclusive. While synbiotics may offer theoretical advantages by combining microbial supplementation with targeted substrates that support microbial growth and metabolic activity, current evidence does not consistently demonstrate superior clinical efficacy. Overall, these interventions often improve surrogate biomarkers, but their effects on renal function and hard clinical outcomes remain uncertain. Larger, longer-duration multicenter randomized controlled trials with standardized formulations are needed to establish their clinical utility and to better elucidate microbiota-host interactions in CKD. Advancing this field may support the development of personalized microbiome-based therapeutic strategies aimed at modulating the gut-kidney axis and ultimately improving clinical outcomes in CKD patients. DOI: 10.3390/nu18081176 PMID: 42074989 [Indexed for MEDLINE]
10. Nutrients. 2026 Apr 8;18(8):1174. doi: 10.3390/nu18081174. A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Effect of Limosilactobacillus fermentum K8-Lb1 Postbiotic on Weight Management and Metabolic Health Outcomes. Papazova E(1), Mitschke S(2), Laue C(1), Schrezenmeir J(1)(3). Author information: (1)Clinical Research Center Kiel, Kiel Center of Innovation and Technology, Schauenburgerstraße 116, D-24118 Kiel, Germany. (2)Citruslabs, Las Vegas, NV 89118, USA. (3)University Medicine, Johannes-Gutenberg University, D-55131 Mainz, Germany. BACKGROUND: Recent research has highlighted the potential of postbiotics for addressing obesity and associated metabolic disorders. In this randomized, double-blind clinical trial, the efficacy of a postbiotic product in managing overweight and associated parameters was assessed. METHODS: Sixty individuals were randomized into two groups: one group (n = 30) received the Postbiotic (heat-killed L. fermentum strain K8-Lb1) and the other (n = 30) a Placebo control. Body weight, waist circumference, body composition, vital signs, blood biomarkers and questionnaires for quality of life, eating behavior, eating control and gastrointestinal symptoms were assessed. RESULTS: After a 12-week intervention, body fat mass (primary parameter) was significantly (p = 0.016) reduced in the Postbiotic group (98.15 ± 3.32% of baseline) compared to the Placebo group (100.41 ± 3.39%). In line with this, body weight (p = 0.047) and waist circumference (p = 0.034) were significantly reduced and visceral fat tended to be reduced (p = 0.053). Accordingly, the Postbiotic group tended (p = 0.066) to feel more in control of their body weight. Despite weight loss, muscle mass tended (p = 0.062) to increase. ALT, AST and GGT tended to be reduced, which may indicate an improvement in liver steatosis. Estimated average glucose (eAG) differed significantly between the groups in individuals with normal fasting glucose levels. The ability to concentrate significantly (p = 0.014) improved. CONCLUSIONS: Under an ad libitum diet, the postbiotic L. fermentum strain K8-Lb1 reduced body fat mass, body weight, and waist circumference, improved the ability to concentrate, and showed a trend towards an increase in muscle mass. The results of this pilot trial need confirmation by a pivotal trial. DOI: 10.3390/nu18081174 PMID: 42074987 [Indexed for MEDLINE]
11. Int J Mol Sci. 2026 Apr 19;27(8):3644. doi: 10.3390/ijms27083644. Effects of Daily Saskatoon Berry Supplementation on Cardiometabolic Health, Gut Microbiota, and Short-Chain Fatty Acids in Healthy Adults. Lee E(1), Hui A(1), Lee H(2), Sun J(1), Shen GX(1). Author information: (1)Department of Internal Medicine, University of Manitoba, Winnipeg, MB R3E 3P4, Canada. (2)Rossmere Medical Centre, Winnipeg, MB R2K 2M5, Canada. Saskatoon berry (SB), a traditional food of Indigenous people, has been associated with cardiometabolic benefits in animal models; however, its effects on humans remain unclear. This study investigated the effects of dried SB consumption on cardiometabolic outcomes, gut microbiota, and short-chain fatty acids (SCFAs) profiles in healthy adults. In a 10-week, single-arm, and open-label trial, 20 healthy adults consumed 40 g/day of freeze-dried whole SB. Biochemical measures, physical exams, dietary records, participant feedback, and fecal samples were collected before and after the intervention. Gut microbiota composition and fecal SCFAs were profiled using 16S-rRNA sequencing and gas chromatography-mass spectrometry, respectively. SB intake significantly reduced fasting plasma glucose, total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), non-high-density lipoprotein-cholesterol (non-HDL-c), systolic blood pressure, and high-sensitivity C-reactive protein, while increasing dietary fiber intake. Fiber intake was negatively correlated with TC, LDL-c and non-HDL-c (p < 0.05). The relative abundance of fecal Prevotellaceae increased after SB consumption and was positively correlated with multiple fecal SCFAs (p < 0.05-0.0001), while being negatively associated with lipid profiles and blood pressure. No adverse cardiovascular, hepatic, or renal dysfunction were observed; however, the significant increase in sugar intake may pose a risk for elevated blood glucose. Therefore, limiting other high-sugar foods during SB supplementation may be advisable for individuals with glucose intolerance. Overall, SB intake improved glucose and lipid metabolism and lowered blood pressure and inflammatory markers in healthy adults. These cardiometabolic benefits may be mediated by fiber and anthocyanins in SB and through modulation of gut microbiota and SCFA production; however, further confirmation is needed in subsequent randomized controlled trials. DOI: 10.3390/ijms27083644 PMID: 42074282 [Indexed for MEDLINE]
12. Georgian Med News. 2026 Feb;(371):162-169. THE EFFECT OF TRIVALENT CHROMIUM ON METABOLIC SYNDROME: A NARRATIVE REVIEW. Kairgali A(1), Aringazina R(2), Jakanov M(3), Haghpanah A(4), Sarkulov M(1). Author information: (1)1Department of Surgical Diseases N2 with Urology, Non-profit JSC "West Kazakhstan Marat Ospanov Medical University", Aktobe, Kazakhstan. (2)2Department of Internal Diseases N1, Non-profit JSC "West Kazakhstan Marat Ospanov Medical University", Aktobe, Kazakhstan. (3)3Department of General Surgery, Non-profit JSC "West Kazakhstan Marat Ospanov Medical University", Aktobe, Kazakhstan. (4)4Department of Urology, Shiraz University of Medical Sciences, Shiraz, Iran. INTRODUCTION: Trivalent chromium is an essential trace element involved in carbohydrate and lipid metabolism. The widespread global prevalence of metabolic syndrome and its close association with cardiovascular diseases and type 2 diabetes mellitus have increased scientific interest in the potential metabolic effects of chromium. However, currently available evidence regarding its clinical significance remains inconsistent. METHODS: This narrative review describes the role of trivalent chromium in the context of metabolic syndrome. A systematic literature search was conducted in the Scopus and Web of Science databases for studies published between 2015 and 2025. The review included randomized controlled trials, observational studies, experimental studies, systematic reviews, and meta-analyses that investigated chromium intake, supplementation, or the association between chromium levels and components of metabolic syndrome. RESULTS: The reviewed studies reported heterogeneous findings regarding the effects of trivalent chromium on components of metabolic syndrome. While some studies demonstrated improvements in glucose metabolism, insulin sensitivity, and lipid profiles, other studies reported no clear or statistically significant effects. The inconsistency of results has been attributed to differences in study design, studied populations, types and dosages of chromium supplementation, and duration of interventions. DISCUSSION: The lack of uniform research methodologies, limited sample sizes, and the absence of standardized protocols for chromium supplementation hinder the comparability of results. In addition, the heterogeneity of the studied populations limits the reliability of the available data. CONCLUSION: Available evidence does not support the widespread clinical use of trivalent chromium. Therefore, further large-scale studies are required to determine its efficacy and safety. PMID: 42069438 [Indexed for MEDLINE]
13. Biotechnol J. 2026 May;21(5):e70233. doi: 10.1002/biot.70233. Lactiplantibacillus plantarum Z6 Improves Functional Constipation in Infants. Zhou X(1), Hu G(2), Wu J(3), Duan Y(4), Zhu B(5), Deng W(6), Shen Y(7), Wang X(7), Li S(7), Wei J(5), Zhang C(8), Lei X(7), Chen T(1)(2)(5)(8). Author information: (1)Department of Obstetrics & Gynecology, the Second People's Hospital of Jingdezhen, Jingdezhen, Jiangxi, China. (2)School of Life Sciences, Nanchang University, Nanchang, Jiangxi, China. (3)Second Clinical Medical College, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. (4)PKUMed-Wisbiom Joint Laboratory for Human Microbiome Research, School of Medicine, Peking University, Beijing, China. (5)National Engineering Research Center for Bioengineering Drugs and the Technologies, Jiangxi Province Key Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. (6)Clinical Laboratory, Key Laboratory of Jingdezhen for Cellular and Molecular Medicine, the Second People's Hospital of Jingdezhen, Jingdezhen, Jiangxi, China. (7)Department of Paediatrics, the Second People's Hospital of Jingdezhen, Jingdezhen, Jiangxi, China. (8)Jiangxi Province Key Laboratory of Bioengineering Drugs, School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China. OBJECTIVE: To evaluate the efficacy and safety of Lactiplantibacillus plantarum Z6 (L. plantarum Z6) supplementation in infants with functional constipation (FC) and to explore its effects on gut microbiota composition. STUDY DESIGN: In this randomized, placebo-controlled trial, 100 infants diagnosed with FC were enrolled and allocated to receive either L. plantarum Z6 or placebo. Clinical outcomes, including weekly bowel movement frequency, Bristol stool scale scores, and Wexner constipation scores, were assessed. Serum 5-hydroxytryptamine (5-HT) levels and fecal microbiota profiles were analyzed to evaluate neurogastrointestinal and microbial responses. RESULTS: L. plantarum Z6 supplementation significantly increased weekly bowel movements and Bristol stool scores while reducing Wexner scores (p < 0.05). Serum 5-HT concentrations were elevated, indicating improved gastrointestinal motility. Gut microbiota analysis revealed enhanced α-diversity, higher abundances of Bifidobacterium, Gemmiger, and Lactobacillus, and reduced Streptococcus. Correlation analysis demonstrated a positive association between L. plantarum Z6 intake and Bifidobacterium enrichment, suggesting targeted modulation of beneficial taxa. CONCLUSIONS: L. plantarum Z6 is a safe and effective probiotic intervention for infantile functional constipation. The results highlight its potential to improve bowel function and beneficially reshape the gut microbiota, offering a microbiota-targeted therapeutic strategy for pediatric gastrointestinal disorders. Chinese Clinical Trial Registry ID: ChiCTR2300073079. © 2026 Wiley‐VCH GmbH. DOI: 10.1002/biot.70233 PMID: 42068035 [Indexed for MEDLINE]
14. BMC Musculoskelet Disord. 2026 May 1;27(1):372. doi: 10.1186/s12891-026-09802-0. Tr14 gel compared to diclofenac gel after acute unilateral ankle sprain: an Individual Patient Data (IPD) meta-analysis of two multi-center trials. Vester J(1), Gerdesmeyer L(2), Kerkhoffs G(3). Author information: (1)idv Data Analysis & Study Planning, Gauting, Germany. (2)Klinik für Orthopädie und Unfallchirurgie, Universitätsklinikum Schleswig-Holstein, Kiel, Germany. gerdesmeyer@aol.com. (3)Department of Orthopaedic Surgery and Sports Medicine, Amsterdam Movement Sciences, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands. BACKGROUND: Traumeel (Tr14) and diclofenac gels are commonly prescribed topical treatments for Grade I-II acute lateral ankle sprain (LAS). A meta-analysis of two multi-center trials was performed to compare their clinical efficacy and supplement the evidence in support of topical treatments. METHODS: Data from two Phase III prospective, randomised, double-blind, reference-controlled clinical trials, TAASS (2013) and TRAUMED (2024) were examined. An Individual Patient Data (IPD) meta-analysis was performed on those with an initial pain VAS (Visual Analogue Scale) score ≥ 50 mm, using the statistical analysis plan from the latter to ensure methodological consistency. RESULTS: A total of 628 patients underwent meta-analysis (mean baseline pain VAS = 72.3, mean age = 32.5). The primary endpoint of the IPD meta-analysis, Area Under the Curve (AUC) of pain VAS scores, indicated beneficial effects of Tr14 gel compared with diclofenac gel, statistically significant on Days 4, 7, and 14 (Day 4 mean difference MDAUC-META = -6.9 [95%CI -13.7 to -0.1], PAUC-META = 0.05; Day 7 MDAUC-META = -26.3 [95%CI -40.4 to -12.2], PAUC-META = 0.0003; Day 14 MDAUC-META = -63.6 [95%CI -92.3 to -34.8]), PAUC-META < 0.0001). A robust Wilcoxon-Mann-Whitney (WMW) analysis revealed percent changes from baseline in pain and function that were significantly superior for Tr14 gel in the pre-planned method of synthesis, compared to diclofenac gel, on all days (all PMETA < 0.05). Finally, translational effect sizes indicated less than "small" superiority on Day 4 (SMD 0.15, OR 0.78, NNT 23), and "small-medium-sized" superiority on Days 7 and 14 (Day 7: SMD 0.31, OR 0.59, NNT 12; Day 14: SMD 0.37, OR 0.53, NNT 10) for pain measured by VAS, as compared to diclofenac gel. CONCLUSION: The IPD meta-analysis of the TAASS and TRAUMED trials confirms the efficacy of Tr14 gel. In-depth analysis reveals it is a statistically favourable treatment with respect to pain, and function, compared to the gold-standard diclofenac gel. Taking this together, Tr14 gel represents a statistically favourable treatment option for Grade I-II ankle sprain within the context of the analysed endpoints. © 2026. The Author(s). DOI: 10.1186/s12891-026-09802-0 PMCID: PMC13135254 PMID: 42067889 [Indexed for MEDLINE] Conflict of interest statement: Declarations. Ethics approval and consent to participate: The purpose of the trials was explained to all participants, supplemented by an information sheet. All participants signed the Informed Consent Form (ICF). Consent for publication is not applicable (due to participating patients being unidentifiable). Competing interests: The authors declare no competing interests.
15. Am J Clin Nutr. 2026 Apr 29:101338. doi: 10.1016/j.ajcnut.2026.101338. Online ahead of print. Effect of calcium supplementation in pregnancy on maternal anemia and iron status: Secondary analyses of two randomized trials in India and Tanzania. Ali NB(1), Sudfeld CR(2), Muhihi A(3), Thomas T(4), Perumal N(5), Sando MM(3), Masanja HM(6), Partap U(7), Duggan CP(8), Kurpad AV(9), Dwarkanath P(10), Pembe AB(11), Fawzi WW(12). Author information: (1)Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA; Division of Maternal and Child Health, International Centre for Diarrheal Disease Research, Bangladesh, Dhaka, Bangladesh. Electronic address: naziabinteali@g.harvard.edu. (2)Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA. (3)Africa Academy for Public Health, Dar es Salaam, Tanzania. (4)Department of Biostatistics, St. John's Research Medical College, Bangalore, India. (5)Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, South Carolina, USA. (6)Ifakara Health Institute, Dar es Salaam, Tanzania. (7)Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA. (8)Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA; Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts. (9)Department of Physiology & Nutrition, St. John's Medical College & St. John's Research Institute, Bangalore, India. (10)Division of Nutrition, St. John's Research Institute, Bangalore, India. (11)Department of Obstetrics and Gynaecology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. (12)Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA. INTRODUCTION: While recent trials have shown daily prenatal low-dose 500 mg calcium supplementation to be noninferior to the recommended high-dose 1500 mg regimen for prevention of preeclampsia, its effects on maternal anemia and iron status remain unclear. METHODS: We conducted two individually randomized, non-inferiority trials in India and Tanzania (N=11,000 each) comparing daily 500 mg to 1500 mg calcium supplementation during pregnancy. All participants received standard IFA (60 mg iron) and were counseled to take calcium supplements several hours apart from the IFA. All participants had hemoglobin measured at baseline and at 32 weeks of gestation, while a random subset of participants had ferritin quantified at the same time points. Using an intention-to-treat approach, we assessed effects of 500 mg compared to 1500 mg calcium supplementation on mean hemoglobin and inflammation-adjusted serum ferritin (log-scale) using generalized linear models, and on anemia and iron deficiency anemia using log-binomial models. RESULTS: Third-trimester hemoglobin and serum ferritin were measured in 8,953 and 1,336 participants in India, respectively. In Tanzania, 8,496 participants had hemoglobin, and 882 had ferritin assessed. In both trials, there was no difference between 500 and 1500 mg calcium supplementation on third-trimester hemoglobin [India: mean difference (MD) 0.01 (95% confidence interval (CI): -0.03, 0.04); Tanzania: MD -0.02 (95% CI: -0.07, 0.03)], anemia [India: relative risk (RR) 1.01 (95% CI: 0.95, 1.07); Tanzania: RR 1.00 (95% CI: 0.96, 1.05)], or iron deficiency anemia [India: RR 1.20 (95% CI: 0.93, 1.57); Tanzania: RR 0.94 (95% CI: 0.77, 1.15)]. CONCLUSION: Low and high-dose calcium supplementation showed no differences in third-trimester hematologic outcomes. Future studies should assess the effects of co-administering or combining calcium and IFA into a single tablet on adherence and bioavailability of iron. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov identifier, NCT03350516; Clinical Trials Registry India number, CTRI/018/2/12119; and Tanzania Medicines and Medical Devices Authority Trials Registry number, TFDA0018/TR/010/. Copyright © 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. DOI: 10.1016/j.ajcnut.2026.101338 PMID: 42067065 Conflict of interest statement: Competing interests The authors declare no competing interests.
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