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A randomized controlled trial of L-taurine for fatigue in decompensated cirrhosis.

1. Hepatol Commun. 2026 Apr 24;10(5):e0938. doi: 10.1097/HC9.0000000000000938. eCollection 2026 May 1. A randomized controlled trial of L-taurine for fatigue in decompensated cirrhosis. Sasidharan S(1), Philips CA(2), Tharakan A(1), Ahamed R(1), Oommen TT(2), Menachery J(2), Varghese R(1), Augu

Taurine potentiates the anticonvulsive effect of the GABA(A) agonist muscimol and pentobarbital in the immature mouse hippocampus.

2. Epilepsia. 2019 Mar;60(3):464-474. doi: 10.1111/epi.14651. Epub 2019 Jan 25. Taurine potentiates the anticonvulsive effect of the GABA(A) agonist muscimol and pentobarbital in the immature mouse hippocampus. Winkler P(1), Luhmann HJ(1), Kilb W(1). Author information: (1)Institute of Physiolog

Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements.

3. Eur J Neurol. 2026 Apr;33(4):e70588. doi: 10.1111/ene.70588. Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements. Mancuso M(1)(2)(3), Bellusci M(4), Carelli V(5)(6), de Coo I(7), Diodato D(8), Distelmaier F(9), Hikmat O(10)(11), Hirano M(12), Horva

Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study.

1. Nutrients. 2022 Apr 22;14(9):1750. doi: 10.3390/nu14091750. Effects of Multi-Ingredient Pre-Workout Supplement and Caffeine on Bench Press Performance: A Single-Blind Cross-Over Study. Kruszewski M(1), Merchelski M(1), Kruszewski A(1), Tabęcki R(1), Aksenov MO(2)(3), Pągowski Ł(1). Author information: (1)Department of Physical Education, Józef Piłsudski Univesity of Physical Education in Warsaw, 00-809 Warszawa, Poland. (2)Department of Physical Education, Plekhanov Russian University of Economics, 36 Stremyanniy, 117997 Moscow, Russia. (3)Department of Physical Education, Banzarov Buryat State University Ulan Ude, 24a Smolina, 670000 Buryatia, Russia. The problem addressed in this study is the appropriateness of using different pre-training supplementation strategies and their ability to improve training performance and psychological measures. The aim of the study is the evaluation of the effectiveness of a multi-ingredient pre-workout supplement (MIPS) containing beta-alanine, L-citrulline malate, arginine alpha-ketoglutarate, L-taurine, L-tyrosine and caffeine compared to an exact dosage of anhydrous caffeine in bench press strength endurance, feeling scale (FS), felt arousal scale (FAS) and session rating of perceived exertion (sRPE). A group of fifteen resistance-trained males, weighing 83.92 ± 8.95 kg and having an average of 5.6 ± 3.38 years of training experience, tested their bench press 10 repetition maximum (79.01 ± 12.13). In a cross-over manner, they participated in two sessions where they were blinded to the order of supplementation they were given: either a MIPS including caffeine or caffeine alone. They completed the bench press strength endurance test with pre- and post-training psychological assessments containing FS, FAS and sRPE. Bench press repetition volume was greater after anhydrous caffeine than MIPS supplementation with no difference in psychological measures. These results indicate that MIPS supplementation is less ergogenic and cost effective than caffeine alone. DOI: 10.3390/nu14091750 PMCID: PMC9105861 PMID: 35565718 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest.

Melatonin for the treatment of gastroesophageal reflux disease.

2. Altern Ther Health Med. 2008 Jul-Aug;14(4):54-8. Melatonin for the treatment of gastroesophageal reflux disease. Werbach MR. The enterochromaffin cells of the gastrointestinal (GI) tract secrete 400 times as much melatonin as the pineal gland; therefore, it is not surprising that research is finding that this indole plays an important role in GI functioning. In animal studies, it protects against GI ulcerations, and randomized clinical trials suggest its efficacy in treating functional dyspepsia and irritable bowel syndrome. Melatonin administration has been shown to protect against esophageal lesions in animals. Moreover, in a randomized, single-blind clinical trial of subjects with gastroesophageal reflux disease (GERD), the combination of melatonin with other natural supplements was found to be superior to omeprazole, a proton pump inhibitor (PPI). Its administration as a single treatment for GERD has not been previously reported. A 64-year-old Caucasian female who required treatment with a PPI for symptoms of GERD wished to substitute a natural treatment because of the risk of worsening her osteoporosis. She experienced a return of symptoms following each of three 20-day trials of a proprietary blend of D-limonene when attempts were made to discontinue the PPI. She then underwent a trial of a natural formula consisting of melatonin 6 mg, 5-hydroxytryptophan 100 mg, D,L-methionine 500 mg, betaine 100 mg, L-taurine 50 mg, riboflavin 1.7 mg, vitamin B6 0.8 mg, folic acid 400 microg, and calcium 50 mg. After 40 days, the PPI was withdrawn without a return of symptoms. Subsequently, an attempt to reduce melatonin to 3 mg resulted in symptoms, while all other ingredients were withdrawn with minimal symptoms during 10 months of follow-up. PMID: 18616070 [Indexed for MEDLINE]

Antioxidant Effect of Taurine on Chronic Heat-Stressed Broilers.

3. Adv Exp Med Biol. 2022;1370:161-169. doi: 10.1007/978-3-030-93337-1_16. Antioxidant Effect of Taurine on Chronic Heat-Stressed Broilers. Wang X(#)(1), Wang C(#)(2), Wang Z(#)(3), Li W(1), Sun W(1), Zhang F(1), Hong Y(1), Liu X(1), Liu X(1), Lyu Q(4), Hu J(#)(5). Author information: (1)Shenyang Agricultural University, Shenyang, Liaoning, People's Republic of China. (2)Shanghai aonaishi Biotechnology Co. Ltd., Shanghai, People's Republic of China. (3)Shanghai Wellhope Feed Co. Ltd., Shanghai, People's Republic of China. (4)Shenyang Agricultural University, Shenyang, Liaoning, People's Republic of China. lqf@syau.edu.cn. (5)Shenyang Agricultural University, Shenyang, Liaoning, People's Republic of China. hujianmin59@syau.edu.cn. (#)Contributed equally The purpose of this study was to investigate the effects of taurine on blood indices of broilers with chronic heat stress and to provide theoretical basis for the application of taurine in the anti-chronic heat stress of broilers. In the test, 240 AA + broilers at 7 days of age were randomly divided into five groups: the normal temperature control group (24 ± 2 °C) in group C, the heat stress control group (34 ± 2 °C) in HS group, and the LTau, MTau, and HTau groups in heat under stress conditions, 0.5 g/L, 2 g/L, and 8 g/L taurine, were added to the drinking water, and each group was repeated three times. After 2 weeks of feeding at normal temperature, heat stress began. The test period was 4 weeks. Blood was collected at 6 h, 12 h, 7 d, 14 d, 21 d, and 28 d after heat stress, and serum was separated. The results showed that compared with the HS group, MTau significantly increased the total serum protein content (P < 0.05), but the other groups were not significantly different (P > 0.05). The MTau and HTau groups contained significantly lowered serum uric acid levels than the HS group (P < 0.05). At 7d and 14d, the LTau, MTau, and HTau groups all exhibited significantly increased T3 and T4 concentrations (P < 0.05). There was no significant difference between the groups at other times (P > 0.05). Compared with the HS group, the MTau group contained significantly reduced serum CK activity, LDH activity, AST activity, and ALT activity (P < 0.05). Compared with the LTau, MTau, and HTau groups, serum MDA content was significantly increased in the heat-stressed broilers (P < 0.05). MTau group contained significantly increased T-AOC, SOD, CAT, and GSH-PX levels (P < 0.05). The other groups were not significantly different (P > 0.05). Compared with group C, serum HSP60 and HSP70 levels were significantly elevated in the HS group (P < 0.05). Compared with the HS group, the LTau and MTau groups contained significantly increased serum HSP60 and HSP70 concentrations (P < 0.05), but the other groups were not significantly different (P > 0.05). In conclusion, taurine can alleviate the symptoms of chronic heat stress of broilers, regulate the metabolism of the body, and improve the antioxidant activity of the body. © 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG. DOI: 10.1007/978-3-030-93337-1_16 PMID: 35882792 [Indexed for MEDLINE]

Effects of Taurine on Serum Indexes of Broilers with Chronic Heat Stress.

4. Adv Exp Med Biol. 2022;1370:153-160. doi: 10.1007/978-3-030-93337-1_15. Effects of Taurine on Serum Indexes of Broilers with Chronic Heat Stress. Yang Q(1), Wang X(1), Wang C(2), Wang Z(3), Li W(1), Sun W(1), Zhang F(1), Hong Y(1), Liu X(1), Liu X(1), Lyu Q(4), Hu J(5). Author information: (1)Shenyang Agricultural University, Shenyang, Liaoning, People's Republic of China. (2)Shanghai aonaishi Biotechnology Co., Ltd, Shanghai, People's Republic of China. (3)Shanghai Wellhope Feed Co., Ltd., Shanghai, People's Republic of China. (4)Shenyang Agricultural University, Shenyang, Liaoning, People's Republic of China. lqf@syau.edu.cn. (5)Shenyang Agricultural University, Shenyang, Liaoning, People's Republic of China. hujianmin59@syau.edu.cn. The aim of this study was to investigate the effects of taurine on tissue injury, protein metabolism, and basal metabolism of broilers after chronic heat stress by detecting serum physiological and biochemical indices. In the test, 240 AA + broilers at 7 days of age were randomly divided into five groups: the normal temperature control group (24 ± 2 °C) in group C, the heat stress control group (34 ± 2 °C) in HS group, and the LTau, MTau, and HTau groups in heat under stress conditions, 0.5, 2, and 8 g/L taurine were added to the drinking water, and each group was repeated three times. After 2 weeks of feeding at normal temperature, heat stress began. The test period was 4 weeks. Blood was collected at 6 h, 12 h, 7 d, 14 d, 21 d, and 28 d after heat stress, and serum was separated. The results showed that compared with the HS group, the MTau group had significantly higher total serum protein content (P < 0.05), while the other groups were not significantly different (P > 0.05). The MTau and HTau groups had significantly lower serum uric acid levels than the HS group (P < 0.05). At 7d and 14d, the LTau, MTau, and HTau groups all showed significantly increased T3 and T4 concentrations (P < 0.05). There was no significant difference between the groups thereafter (P > 0.05). Compared with HS group, the MTau group contained significantly reduced serum CK activity, LDH activity, AST activity, and ALT activity (P < 0.05). In conclusion, the effects of taurine on tissue damage, protein metabolism, and basal metabolism of broilers after chronic heat stress were studied by measuring serum physiological and biochemical indices. To provide a theoretical basis for the application of taurine in acute heat-stressed broilers. © 2022. The Author(s), under exclusive license to Springer Nature Switzerland AG. DOI: 10.1007/978-3-030-93337-1_15 PMID: 35882791 [Indexed for MEDLINE]

The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study.

5. Vet Ophthalmol. 2006 Sep-Oct;9(5):311-6. doi: 10.1111/j.1463-5224.2006.00492.x. The effect of a topical antioxidant formulation including N-acetyl carnosine on canine cataract: a preliminary study. Williams DL(1), Munday P. Author information: (1)Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge, CB3 OES, England, UK. doctordlwilliams@aol.com OBJECTIVE: To determine the efficacy of a topical antioxidant formulation including N-acetyl carnosine in the treatment of canine cataract in a preliminary nonplacebo, controlled, unmasked study. ANIMALS STUDIED: Thirty dogs of varying breeds and ages with a spectrum of lens opacities ranging from nuclear sclerosis to total mature cataract. METHODS: Dogs were treated three times daily with topical 2% N-acetyl carnosine in a buffered vehicle containing the antioxidants glutathione, cysteine ascorbate, L-taurine and riboflavin (Ocluvet, Practivet, Phoenix, AZ, USA). Dogs were examined prior to treatment and at 2, 4 and 8 weeks during treatment, by direct and indirect ophthalmoscopy and slit-lamp biomicroscopy after pharmacologic pupil dilation. Photographic documentation of lens opacity was achieved by retroillumination photography, with three photographs taken at each examination time-point. A lens opacification index (LOI), determined by integration of the grayscale level of each pixel across the image, was evaluated by computerized image analysis of digitized images. Alteration in mean LOI was determined for each animal, having normalized the initial LOI. RESULTS: Fifty-eight eyes of 30 dogs were evaluated, 22 with mature cataract, 13 with immature cataract, 9 with cataract associated with other intraocular disease such as uveitis and 14 with nuclear sclerosis alone. One dog was unilaterally anophthalmic after previous enucleation and one had a phthytic eye after previous uveitis-induced glaucoma. Image analysis showed a reduction in mean LOI in all cataract groups (mean resolution in opacity of 2.3 +/- 0.33% for all cataracts), although this was only statistically significant in those eyes with immature cataract (mean resolution of opacity 4.5 +/- 0.33%) or nuclear sclerosis (mean decrease in opacity 5 +/- 0.37%). Reduction in lens opacity was seen in eyes with mature cataract (0.5 +/- 0.4%) and in miscellaneous cataract associated with intraocular inflammation (1.3 +/- 0.4%), but these changes were not statistically significant. Owner evaluation of visual capability, however, suggested improvement in vision in 80% of cases by the end of the study. CONCLUSIONS: This study demonstrates some marginal reduction in lens opacification in a substantial number of cases of canine cataract with the use of a topical nutritional antioxidant formulation including N-acetyl carnosine. Lens opacification was improved with treatment in eyes with immature cataract or nuclear sclerosis while in eyes with mature cataract or cataract with associated intraocular inflammatory pathology less reduction was seen. DOI: 10.1111/j.1463-5224.2006.00492.x PMID: 16939459 [Indexed for MEDLINE]

Effects of taurine on human embryo development in vitro.

6. Hum Reprod. 1999 Sep;14(9):2350-6. doi: 10.1093/humrep/14.9.2350. Effects of taurine on human embryo development in vitro. Devreker F(1), Van den Bergh M, Biramane J, Winston RL, Englert Y, Hardy K. Author information: (1)Scientific Collaborator at the Belgian National Funds for Scientific Research, Clinic of Fertility, Department of Obstetrics and Gynaecology, Hospital Erasme, Route de Lennik 808, 1070 Brussels, Belgium and, Department of Reproductive Scienc. Glutamine and taurine are reported to be beneficial for mouse embryo development in vitro, and we have recently shown that glutamine improves human blastocyst formation in vitro. This randomized study compared the development of supernumerary human embryos in the presence of 1 mmol/l glutamine and/or 5 mmol/l taurine from the 2-4-cell stage to the blastocyst stage. Blastocyst development and cell numbers were similar in the presence of glutamine or taurine: 52.6% and 58.3% of the embryos reached the blastocyst stage, respectively. Pyruvate uptake was similar in the presence of glutamine or taurine throughout development, as was lactate production after the 8-cell stage. Before this stage, lactate production was 4-fold higher in the presence of taurine (P < 0.001). The proportion of embryos reaching the blastocyst stage was similar with glutamine alone or with glutamine and taurine (62.5% and 47.2% respectively), as were the blastocyst cell numbers (63.0 +/- 4.6 and 61.0 +/- 5.1 respectively). In conclusion, taurine supports development of 2-4-cell human embryos to the blastocyst stage, although it does not further augment the beneficial effects of glutamine. DOI: 10.1093/humrep/14.9.2350 PMID: 10469709 [Indexed for MEDLINE]