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Nutritional interventions for preventing and treating pressure ulcers.

1. Cochrane Database Syst Rev. 2024 Feb 12;2(2):CD003216. doi: 10.1002/14651858.CD003216.pub3. Nutritional interventions for preventing and treating pressure ulcers. Langer G(1), Wan CS(2)(3), Fink A(4), Schwingshackl L(5), Schoberer D(6). Author information: (1)Institute of Health and Nursing S

Acute L-Leucine Supplementation and Sprint Exercise Elicit Distinct Appetite and Inflammatory Responses in Persons with Overweight: A Randomized, Counterbalanced, and Crossover Design Study.

2. Nutrients. 2026 Feb 13;18(4):614. doi: 10.3390/nu18040614. Acute L-Leucine Supplementation and Sprint Exercise Elicit Distinct Appetite and Inflammatory Responses in Persons with Overweight: A Randomized, Counterbalanced, and Crossover Design Study. França E(1)(2), Thomatieli-Santos RV(1)(3),

Effects of Combined Intragastric Administration of Quinine with L-Leucine or L-Isoleucine on the Glycemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Healthy Males.

3. J Nutr. 2026 Feb;156(2):101259. doi: 10.1016/j.tjnut.2025.101259. Epub 2025 Dec 7. Effects of Combined Intragastric Administration of Quinine with L-Leucine or L-Isoleucine on the Glycemic Response to, and Gastric Emptying of, a Mixed-Nutrient Drink in Healthy Males. Sajjad M(1), Ghorbaninej

Disease-Modifying, Neuroprotective Effect of N-Acetyl-l-Leucine in Adult and Pediatric Patients With Niemann-Pick Disease Type C.

4. Neurology. 2025 Jul;105(1):e213589. doi: 10.1212/WNL.0000000000213589. Epub 2025 Jun 13. Disease-Modifying, Neuroprotective Effect of N-Acetyl-l-Leucine in Adult and Pediatric Patients With Niemann-Pick Disease Type C. Patterson MC(1), Ramaswami U(2), Donald A(3), Foltan T(4), Gautschi M(5),

Acute decrease in the plasma tryptophan-to-large-neutral-amino-acids ratio attenuates the effects of L-tryptophan on gut hormones and energy intake in healthy males: a randomized, cross-over, exploratory trial.

5. Am J Clin Nutr. 2025 Apr;121(4):816-825. doi: 10.1016/j.ajcnut.2025.02.016. Epub 2025 Feb 18. Acute decrease in the plasma tryptophan-to-large-neutral-amino-acids ratio attenuates the effects of L-tryptophan on gut hormones and energy intake in healthy males: a randomized, cross-over, explora

Efficacy and safety of N-acetyl-L-leucine in patients with ataxia telangiectasia: A randomized, double-blind, placebo-controlled, crossover clinical trial.

6. Eur J Paediatr Neurol. 2024 May;50:57-63. doi: 10.1016/j.ejpn.2024.04.009. Epub 2024 Apr 22. Efficacy and safety of N-acetyl-L-leucine in patients with ataxia telangiectasia: A randomized, double-blind, placebo-controlled, crossover clinical trial. Beyraghi-Tousi M(1), Sahebkar A(2), Houra M

Trial of N-Acetyl-l-Leucine in Niemann-Pick Disease Type C.

7. N Engl J Med. 2024 Feb 1;390(5):421-431. doi: 10.1056/NEJMoa2310151. Trial of N-Acetyl-l-Leucine in Niemann-Pick Disease Type C. Bremova-Ertl T(1), Ramaswami U(1), Brands M(1), Foltan T(1), Gautschi M(1), Gissen P(1), Gowing F(1), Hahn A(1), Jones S(1), Kay R(1), Kolnikova M(1), Arash-Kaps L(

A Randomized Controlled Trial on the Effects of Leucine-Supplement Combined with Nutritional Counseling on Body Composition in Mix Cancer Older Men.

8. Nutrients. 2024 Jan 9;16(2):210. doi: 10.3390/nu16020210. A Randomized Controlled Trial on the Effects of Leucine-Supplement Combined with Nutritional Counseling on Body Composition in Mix Cancer Older Men. Soares JDP(1), Siqueira JM(1), Brito FDSB(2), Pimentel GD(1). Author information: (1)F

Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women.

9. J Strength Cond Res. 2024 Mar 1;38(3):526-532. doi: 10.1519/JSC.0000000000004661. Epub 2023 Dec 13. Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women. Chapman-Lopez TJ(1), Funderburk LK(1)(2), Heileson JL(1)(

The impact of leucine supplementation on body composition and glucose tolerance following energy restriction: an 8-week RCT in adults at risk of the metabolic syndrome.

10. Eur J Clin Nutr. 2024 Feb;78(2):155-162. doi: 10.1038/s41430-023-01360-1. Epub 2023 Nov 3. The impact of leucine supplementation on body composition and glucose tolerance following energy restriction: an 8-week RCT in adults at risk of the metabolic syndrome. Pathak K(1), Zhao Y(2), Calton

N-acetyl-L-leucine for Niemann-Pick type C: a multinational double-blind randomized placebo-controlled crossover study.

11. Trials. 2023 May 29;24(1):361. doi: 10.1186/s13063-023-07399-6. N-acetyl-L-leucine for Niemann-Pick type C: a multinational double-blind randomized placebo-controlled crossover study. Fields T(1), M Bremova T(2), Billington I(3), Churchill GC(4), Evans W(5)(6), Fields C(3), Galione A(4), Kay

Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep.

12. J Endocrinol. 2020 Oct;247(1):115-126. doi: 10.1530/JOE-20-0243. Leucine acutely potentiates glucose-stimulated insulin secretion in fetal sheep. Boehmer BH(1), Baker PR(1), Brown LD(1), Wesolowski SR(1), Rozance PJ(1). Author information: (1)Department of Pediatrics, University of Colorado S

Improved Physical Stability and Aerosolization of Inhalable Amorphous Ciprofloxacin Powder Formulations by Incorporating Synergistic Colistin.

13. Mol Pharm. 2018 Sep 4;15(9):4004-4020. doi: 10.1021/acs.molpharmaceut.8b00445. Epub 2018 Aug 3. Improved Physical Stability and Aerosolization of Inhalable Amorphous Ciprofloxacin Powder Formulations by Incorporating Synergistic Colistin. Shetty N(1), Ahn P(1), Park H(1), Bhujbal S(1), Zemly

Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.

14. Bioorg Med Chem Lett. 2015 Jan 15;25(2):292-6. doi: 10.1016/j.bmcl.2014.11.047. Epub 2014 Nov 24. Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2. Thomas JB(1),

Leptin and leucine synergistically regulate protein metabolism in C2C12 myotubes and mouse skeletal muscles.

15. Br J Nutr. 2013 Jul 28;110(2):256-64. doi: 10.1017/S0007114512004849. Epub 2012 Dec 5. Leptin and leucine synergistically regulate protein metabolism in C2C12 myotubes and mouse skeletal muscles. Mao X(1), Zeng X, Huang Z, Wang J, Qiao S. Author information: (1)State Key Laboratory on Anima

Saturated long-chain fatty acids activate inflammatory signaling in astrocytes.

42. J Neurochem. 2012 Mar;120(6):1060-71. doi: 10.1111/j.1471-4159.2012.07660.x. Epub 2012 Feb 6. Saturated long-chain fatty acids activate inflammatory signaling in astrocytes. Gupta S(1), Knight AG, Gupta S, Keller JN, Bruce-Keller AJ. Author information: (1)Pennington Biomedical Research Cent

L-Leucine induces growth arrest and persistent ERK activation in glioma cells.

34. Amino Acids. 2012 Aug;43(2):717-24. doi: 10.1007/s00726-011-1122-9. Epub 2011 Oct 19. L-Leucine induces growth arrest and persistent ERK activation in glioma cells. Takeuchi S(1), Nawashiro H, Wada K, Nomura N, Toyooka T, Otani N, Osada H, Matsuo H, Shinomiya N. Author information: (1)Depar

Synergistic effects of sour taste and low temperature in suppressing the bitterness of Aminoleban® EN.

41. Chem Pharm Bull (Tokyo). 2011;59(5):536-40. doi: 10.1248/cpb.59.536. Synergistic effects of sour taste and low temperature in suppressing the bitterness of Aminoleban® EN. Haraguchi T(1), Yoshida M, Hazekawa M, Uchida T. Author information: (1)School of Pharmaceutical Sciences, Mukogawa Wome

PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis.

24. Anticancer Res. 2010 Jan;30(1):157-66. PPARgamma ligand 15-deoxy-delta 12,14-prostaglandin J2 sensitizes human colon carcinoma cells to TWEAK-induced apoptosis. Dionne S(1), Levy E, Levesque D, Seidman EG. Author information: (1)FRCPC FACG, McGill Center for IBD Research, C10.145, Montreal G

Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis.

38. Neurobiol Dis. 2009 Jul;35(1):75-81. doi: 10.1016/j.nbd.2009.04.004. Epub 2009 Apr 18. Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis. Hilgier W(1), Freśko I, Klemenska E, Beresewicz A, Oja SS, Saransaari P, Albrecht J, Ziel

Combination of amino acids reduces pigmentation in B16F0 melanoma cells.

34. Biol Pharm Bull. 2007 Apr;30(4):677-81. doi: 10.1248/bpb.30.677. Combination of amino acids reduces pigmentation in B16F0 melanoma cells. Ishikawa M(1), Kawase I, Ishii F. Author information: (1)Drug Evaluation Department, Life Science Institute, SSP CO., LTD, Japan. Amino acids, the buildin

The Impact of Amino Acids on Postprandial Glucose and Insulin Kinetics in Humans: A Quantitative Overview.

45. Nutrients. 2020 Oct 21;12(10):3211. doi: 10.3390/nu12103211. The Impact of Amino Acids on Postprandial Glucose and Insulin Kinetics in Humans: A Quantitative Overview. Sloun BV(1)(2), Goossens GH(1)(3), Erdos B(1)(2), Lenz M(4)(5), Riel NV(6), Arts ICW(1)(2)(7). Author information: (1)TiFN,

Does L-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review.

33. Amino Acids. 2018 Dec;50(12):1663-1678. doi: 10.1007/s00726-018-2658-8. Epub 2018 Sep 27. Does L-leucine supplementation cause any effect on glucose homeostasis in rodent models of glucose intolerance? A systematic review. Brunetta HS(1)(2), de Camargo CQ(1)(3), Nunes EA(4)(5)(6). Author in

WITHDRAWN: Amino acids for amyotrophic lateral sclerosis / motor neuron disease.

45. Cochrane Database Syst Rev. 2008 Apr 16;(2):CD003457. doi: 10.1002/14651858.CD003457.pub2. WITHDRAWN: Amino acids for amyotrophic lateral sclerosis / motor neuron disease. Parton M(1), Mitsumoto H, Leigh PN. Author information: (1)National Hospital for Neurology and Neurosurgery, Centre for

Amino acids for amyotrophic lateral sclerosis / motor neuron disease.

19. Cochrane Database Syst Rev. 2003;(4):CD003457. doi: 10.1002/14651858.CD003457. Amino acids for amyotrophic lateral sclerosis / motor neuron disease. Parton M(1), Mitsumoto H, Leigh PN. Author information: (1)Department of Neurology, Guy's, King's and St. Thomas's School of Medicine and The I