L-시트룰린

Synergistic effect of long-term L-citruline supplementation combined with exercise on body composition in adults: A systematic review and meta-analysis of randomized controlled trials.

1. Complement Ther Med. 2026 Jun;98:103339. doi: 10.1016/j.ctim.2026.103339. Epub 2026 Mar 3. Synergistic effect of long-term L-citruline supplementation combined with exercise on body composition in adults: A systematic review and meta-analysis of randomized controlled trials. Wang W(1), Cai S

Effects of Citrulline or Watermelon Supplementation on Body Composition: A Systematic Review and Dose-Response Meta-Analysis.

2. Nutrients. 2025 Sep 30;17(19):3126. doi: 10.3390/nu17193126. Effects of Citrulline or Watermelon Supplementation on Body Composition: A Systematic Review and Dose-Response Meta-Analysis. Ashtary-Larky D(1), Mohammadi S(2), Mousavi SAH(3), Hajizadeh L(4), Candow DG(5), Forbes SC(6), Afrisham R

Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials.

3. Clin Nutr ESPEN. 2025 Oct;69:653-664. doi: 10.1016/j.clnesp.2025.07.1130. Epub 2025 Aug 9. Does l-citrulline supplementation and watermelon intake reduce blood pressure in middle-aged and older adults? A systematic review and meta-analysis of randomized controlled trials. Luo P(1), Chen J(2)

L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis.

4. BJOG. 2025 May;132(6):698-708. doi: 10.1111/1471-0528.18070. Epub 2025 Jan 12. L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis. Makama M(1)(2), McDougall ARA(1)(3), Cao J(1), Mills K(1), Nguyen PY(1), Hastie R(4), Ammerdorffer A

Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis.

5. Nutrients. 2023 Apr 21;15(8):1995. doi: 10.3390/nu15081995. Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis. Porto AA(1)(2), Gonzaga LA(1)(2), Benjamim CJR(3), Valenti VE

Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials.

6. J Int Soc Sports Nutr. 2021 Dec 29;18(1):76. doi: 10.1186/s12970-021-00472-y. Effect of food sources of nitrate, polyphenols, L-arginine and L-citrulline on endurance exercise performance: a systematic review and meta-analysis of randomised controlled trials. d'Unienville NMA(1)(2), Blake HT(

Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis.

7. Int J Sport Nutr Exerc Metab. 2021 Jul 1;31(4):350-358. doi: 10.1123/ijsnem.2020-0295. Epub 2021 May 19. Acute Effect of Citrulline Malate on Repetition Performance During Strength Training: A Systematic Review and Meta-Analysis. Vårvik FT(1), Bjørnsen T(1), Gonzalez AM(2). Author informatio

Effect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis.

8. J Sport Health Sci. 2020 Dec;9(6):553-561. doi: 10.1016/j.jshs.2020.02.003. Epub 2020 Feb 8. Effect of citrulline on post-exercise rating of perceived exertion, muscle soreness, and blood lactate levels: A systematic review and meta-analysis. Rhim HC(1), Kim SJ(1), Park J(1), Jang KM(2). Aut

Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials.

9. Curr Hypertens Rep. 2018 Oct 3;20(11):98. doi: 10.1007/s11906-018-0898-3. Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials. Mirenayat MS(1), Moradi S(2), Mohammadi H(1), Rouhani MH(3). Author information: (1)Students' Research

Skeletal Muscle and Circulating microRNAs Adaptations to 12-Week HIIT With or Without L-Citrulline in Obese Older Adults.

10. J Cachexia Sarcopenia Muscle. 2026 Apr;17(2):e70267. doi: 10.1002/jcsm.70267. Skeletal Muscle and Circulating microRNAs Adaptations to 12-Week HIIT With or Without L-Citrulline in Obese Older Adults. Mercier-Guery A(1)(2), Millet M(1), Croset M(1), Marcangeli V(3), Dulac M(3), Carvalho LP(4)

Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes.

11. Nutrients. 2025 Nov 28;17(23):3739. doi: 10.3390/nu17233739. Effects of L-Citrulline Supplementation on Endothelial Function, Arterial Stiffness, and Blood Glucose Level in the Fasted and Acute Hyperglycemic States in Middle-Aged and Older Adults with Type 2 Diabetes. Kang Y(1)(2)(3), Dillon

Dose-Response Effect of Watermelon Consumption on Ambulatory Blood Pressure in Adults with Elevated Blood Pressure: A Randomized Controlled Pilot Trial.

12. Nutrients. 2025 Sep 26;17(19):3073. doi: 10.3390/nu17193073. Dose-Response Effect of Watermelon Consumption on Ambulatory Blood Pressure in Adults with Elevated Blood Pressure: A Randomized Controlled Pilot Trial. Singh K(1), Liao H(2), Edirisinghe I(1), Burton-Freeman B(1), Sandhu AK(1)(3).

Bacterial taxonomic and functional changes following oral lyophilized donor fecal microbiota transplantation in patients with ulcerative colitis.

13. mSystems. 2025 Oct 22;10(10):e0099125. doi: 10.1128/msystems.00991-25. Epub 2025 Sep 15. Bacterial taxonomic and functional changes following oral lyophilized donor fecal microbiota transplantation in patients with ulcerative colitis. Raich SS(#)(1), Majzoub ME(#)(1), Haifer C(2)(3), Paramso

Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-trained men: a double-blind placebo-controlled trial.

14. J Int Soc Sports Nutr. 2025 Dec;22(1):2513944. doi: 10.1080/15502783.2025.2513944. Epub 2025 Jun 5. Changes in resistance training performance, rating of perceived exertion, and blood biomarkers after six weeks of supplementation with L-citrulline vs. L-citrulline DL-malate in resistance-tra

Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations.

15. J Sports Sci Med. 2025 Jun 1;24(2):258-268. doi: 10.52082/jssm.2025.258. eCollection 2025 Jun. Combined Vs. Single Supplementation of L-Citrulline and Sodium Bicarbonate During Sprint Interval Training in Basketball Players: Effects on Physical Performance and Hormonal Adaptations. Wang Y(1

Effect of different sports drink compositions on endurance performance and substrate oxidation: a randomized, double-blind, placebo-controlled crossover study in trained athletes.

50. J Int Soc Sports Nutr. 2025 Dec;22(1):2516004. doi: 10.1080/15502783.2025.2516004. Epub 2025 Jun 4. Effect of different sports drink compositions on endurance performance and substrate oxidation: a randomized, double-blind, placebo-controlled crossover study in trained athletes. Ketelhut S(

The Antioxidant Power of Bergamot Polyphenolic Fraction Gold Potentiates the Effects of L-Citrulline in Athlete Performance and Vasodilation in a Pilot Study.

32. Nutrients. 2025 Mar 21;17(7):1106. doi: 10.3390/nu17071106. The Antioxidant Power of Bergamot Polyphenolic Fraction Gold Potentiates the Effects of L-Citrulline in Athlete Performance and Vasodilation in a Pilot Study. Mollace R(1)(2), Macrì R(1), Serra M(1), Ritorto G(1), Ussia S(1), Scaran

Effects of Combined Versus Single Supplementation of Creatine, Beta-Alanine, and L-Citrulline During Short Sprint Interval Training on Basketball Players' Performance: A Double-Blind Randomized Placebo-Controlled Trial.

16. Int J Sports Physiol Perform. 2025 Feb 25;20(4):559-567. doi: 10.1123/ijspp.2024-0310. Print 2025 Apr 1. Effects of Combined Versus Single Supplementation of Creatine, Beta-Alanine, and L-Citrulline During Short Sprint Interval Training on Basketball Players' Performance: A Double-Blind Rand

Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial.

17. Nutrients. 2025 Jan 23;17(3):402. doi: 10.3390/nu17030402. Impact of L-Citrulline Supplementation and HIIT on Lipid Profile, Arterial Stiffness, and Fat Mass in Obese Adolescents with Metabolic-Dysfunction-Associated Fatty Liver Disease: A Randomized Clinical Trial. Rodríguez-Carrillo AA(1)

The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males.

10. Biosci Biotechnol Biochem. 2017 Feb;81(2):372-375. doi: 10.1080/09168451.2016.1230007. Epub 2016 Sep 26. The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males. Suzuki T(1), Morita M(1), Hayashi T(2), Kamimura A(1). Author infor

Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability.

49. Biochem Biophys Res Commun. 2014 Nov 7;454(1):53-7. doi: 10.1016/j.bbrc.2014.10.029. Epub 2014 Oct 14. Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability. Morita M(1), Hayashi T(2), Ochiai M

Increase in brain tumor permeability in glioma-bearing rats with nitric oxide donors.

19. Clin Cancer Res. 2008 Jun 15;14(12):4002-9. doi: 10.1158/1078-0432.CCR-07-1826. Increase in brain tumor permeability in glioma-bearing rats with nitric oxide donors. Yin D(1), Wang X, Konda BM, Ong JM, Hu J, Sacapano MR, Ko MK, Espinoza AJ, Irvin DK, Shu Y, Black KL. Author information: (1)

Screening of bitterness-suppressing agents for quinine: the use of molecularly imprinted polymers.

2. J Pharm Sci. 2005 Feb;94(2):353-62. doi: 10.1002/jps.20248. Screening of bitterness-suppressing agents for quinine: the use of molecularly imprinted polymers. Ogawa T(1), Hoshina K, Haginaka J, Honda C, Tanimoto T, Uchida T. Author information: (1)School of Pharmaceutical Sciences, Mukogawa W

Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes.

36. J Renin Angiotensin Aldosterone Syst. 2004 Mar;5(1):33-8. doi: 10.3317/jraas.2004.006. Effects of ACE inhibition and AT1-receptor blockade on haemodynamic responses to L-arginine in Type 1 diabetes. Komers R(1), Simkova R, Kazdova L, Ruzickova J, Pelikanova T. Author information: (1)Diabete

Effects of cocoa extracts on endothelium-dependent relaxation.

27. J Nutr. 2000 Aug;130(8S Suppl):2105S-8S. doi: 10.1093/jn/130.8.2105S. Effects of cocoa extracts on endothelium-dependent relaxation. Karim M(1), McCormick K, Kappagoda CT. Author information: (1)Department of Internal Medicine, University of California Davis, California 95616-8636, USA. The

Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase.

15. J Leukoc Biol. 2000 Mar;67(3):327-34. doi: 10.1002/jlb.67.3.327. Regulation of ICAM-1/CD54 expression on human endothelial cells by hydrogen peroxide involves inducible NO synthase. Zadeh MS(1), Kolb JP, Geromin D, D'Anna R, Boulmerka A, Marconi A, Dugas B, Marsac C, D'Alessio P. Author inf

Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells.

31. Blood. 1996 Nov 1;88(9):3528-34. Role of nitric oxide in the anti-tumoral effect of retinoic acid and 1,25-dihydroxyvitamin D3 on human promonocytic leukemic cells. Dugas N(1), Mossalayi MD, Calenda A, Léotard A, Bécherel P, Mentz F, Ouaaz F, Arock M, Debré P, Dornand J, Dugas B. Author inf

[Role of nitric oxide in the modulation of the vascular response to angiotensin II in hypertensive rats].

9. Arch Inst Cardiol Mex. 1996 Jul-Aug;66(4):306-12. [Role of nitric oxide in the modulation of the vascular response to angiotensin II in hypertensive rats]. [Article in Spanish] Sánchez Mendoza A(1), Vázquez Cruz B, Escalante Acosta BA. Author information: (1)Centro de Investigación y Estudio

Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study.

23. J Int Soc Sports Nutr. 2016 Feb 19;13:6. doi: 10.1186/s12970-016-0117-z. eCollection 2016. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study. Suzuki T(1), Morita M(1), Kobayashi

Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements.

10. Eur J Neurol. 2026 Apr;33(4):e70588. doi: 10.1111/ene.70588. Diagnostic Criteria and Management of MELAS and Stroke-Like Episodes: Consensus-Based Statements. Mancuso M(1)(2)(3), Bellusci M(4), Carelli V(5)(6), de Coo I(7), Diodato D(8), Distelmaier F(9), Hikmat O(10)(11), Hirano M(12), Horv