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The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix.

1. Molecules. 2020 Dec 14;25(24):5914. doi: 10.3390/molecules25245914. The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix. Kong XP(1)(2), Ren HQ(2)(3), Liu EYL(3)(4), Leung KW(2)(3), Guo SC(2)(3), Duan R(2)(3), Dong TTX(2)(3), Tsim KWK(2)(3). Author information: (1)Institute

Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex.

2. Molecules. 2019 Dec 13;24(24):4567. doi: 10.3390/molecules24244567. Synergistic Inhibition of Acetylcholinesterase by Alkaloids Derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex. Kong XP(1)(2), Liu EYL(1)(3), Chen ZC(1)(3), Xu ML(1)(3), Yu AXD(1)(3),

Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A.

3. J Alzheimers Dis. 2012;31(1):131-42. doi: 10.3233/JAD-2012-120274. Decreased accumulation of subcellular amyloid-β with improved mitochondrial function mediates the neuroprotective effect of huperzine A. Yang L(1), Ye CY, Huang XT, Tang XC, Zhang HY. Author information: (1)State Key Laborator

Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death.

4. Neurotox Res. 2008 Jan;13(1):49-61. doi: 10.1007/BF03033367. Huperzine A provides neuroprotection against several cell death inducers using in vitro model systems of motor neuron cell death. Hemendinger RA(1), Armstrong EJ 3rd, Persinski R, Todd J, Mougeot JL, Volvovitz F, Rosenfeld J. Autho

Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial.

5. Schizophr Res. 2007 May;92(1-3):273-5. doi: 10.1016/j.schres.2007.02.005. Epub 2007 Mar 26. Huperzine A as add-on therapy in patients with treatment-resistant schizophrenia: an open-labeled trial. Zhang ZJ, Tong Y, Wang XY, Yao SM, Jin GX, Wang XP. DOI: 10.1016/j.schres.2007.02.005 PMID: 173

Harmless herbs? Think again: merits of a complete medication history.

6. J Am Med Dir Assoc. 2006 Sep;7(7):446-7. doi: 10.1016/j.jamda.2006.05.013. Harmless herbs? Think again: merits of a complete medication history. Beier MT(1). Author information: (1)The University of Michigan, Ann Arbor, MI, USA. tanja@umich.edu DOI: 10.1016/j.jamda.2006.05.013 PMID: 16979090

Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells.

7. J Neurosci Res. 2006 Sep;84(4):903-11. doi: 10.1002/jnr.20987. Effects of huperzine A on amyloid precursor protein processing and beta-amyloid generation in human embryonic kidney 293 APP Swedish mutant cells. Peng Y(1), Jiang L, Lee DY, Schachter SC, Ma Z, Lemere CA. Author information: (1)C

Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism.

8. J Neurosci Res. 2006 May 1;83(6):1048-57. doi: 10.1002/jnr.20791. Huperzine A attenuates mitochondrial dysfunction in beta-amyloid-treated PC12 cells by reducing oxygen free radicals accumulation and improving mitochondrial energy metabolism. Gao X(1), Tang XC. Author information: (1)State K

Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements.

9. J Neurochem. 2005 Dec;95(5):1504-20. doi: 10.1111/j.1471-4159.2005.03512.x. Epub 2005 Nov 3. Molecular and pharmacological characterization of muscarinic receptors in retinal pigment epithelium: role in light-adaptive pigment movements. Phatarpekar PV(1), Durdan SF, Copeland CM, Crittenden EL

Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms.

10. Neurosci Lett. 2005 Feb 21;374(3):222-6. doi: 10.1016/j.neulet.2004.10.063. Epub 2004 Dec 10. Effect of acidic oligosaccharide sugar chain on scopolamine-induced memory impairment in rats and its related mechanisms. Fan Y(1), Hu J, Li J, Yang Z, Xin X, Wang J, Ding J, Geng M. Author informa

Pharmacokinetics and tolerability of oral dosage forms of huperzine a in healthy Chinese male volunteers: a randomized, single dose, three-period, six-sequence crossover study.

11. J Huazhong Univ Sci Technolog Med Sci. 2017 Oct;37(5):795-802. doi: 10.1007/s11596-017-1807-8. Epub 2017 Oct 20. Pharmacokinetics and tolerability of oral dosage forms of huperzine a in healthy Chinese male volunteers: a randomized, single dose, three-period, six-sequence crossover study. W

Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects.

12. Acta Pharmacol Sin. 2016 Jul;37(7):994-1001. doi: 10.1038/aps.2016.24. Epub 2016 May 16. Population pharmacokinetic modeling and simulation of huperzine A in elderly Chinese subjects. Sheng L(1), Qu Y(2), Yan J(3), Liu GY(4), Wang WL(2), Wang YJ(4), Wang HY(4), Zhang MQ(4), Lu C(4), Liu Y(4

Evaluating computational and experimental approaches in early-stage Alzheimer's drug discovery: a systematic review.

13. J Comput Aided Mol Des. 2025 Jun 6;39(1):27. doi: 10.1007/s10822-025-00610-7. Evaluating computational and experimental approaches in early-stage Alzheimer's drug discovery: a systematic review. Azmal M(1), Paul JK(1), Shohan MNH(1), Haque ANMSNB(1), Mrinmoy M(1), Talukder OF(1), Ghosh A(2).

The Efficacy and Safety of Alzheimer's Disease Therapies: An Updated Umbrella Review.

14. J Alzheimers Dis. 2022;85(3):1195-1204. doi: 10.3233/JAD-215423. The Efficacy and Safety of Alzheimer's Disease Therapies: An Updated Umbrella Review. Fan F(1), Liu H(1), Shi X(1), Ai Y(1), Liu Q(1), Cheng Y(1)(2). Author information: (1)Key Laboratory of Ethnomedicine of Ministry of Educati

The effect of anti-dementia drugs on Alzheimer disease-induced cognitive impairment: A network meta-analysis.

15. Medicine (Baltimore). 2019 Jul;98(27):e16091. doi: 10.1097/MD.0000000000016091. The effect of anti-dementia drugs on Alzheimer disease-induced cognitive impairment: A network meta-analysis. Cui CC(1), Sun Y, Wang XY, Zhang Y, Xing Y. Author information: (1)China-Japan Union Hospital of Jilin

[Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis].

44. Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(3):582-588. doi: 10.19540/j.cnki.cjcmm.20180925.008. [Efficacy and safety of huperzine A in treating patients with mild cognitive impairment: a systematic review and Meta-analysis]. [Article in Chinese] Huang P(1), Li B(2), Guo YH(3), Feng S(4), Hu J(4

Traditional Chinese herbal medicine for vascular dementia.

37. Cochrane Database Syst Rev. 2018 Dec 6;12(12):CD010284. doi: 10.1002/14651858.CD010284.pub2. Traditional Chinese herbal medicine for vascular dementia. Chan ES(1), Bautista DT, Zhu Y, You Y, Long JT, Li W, Chen C. Author information: (1)Cochrane Singapore, Singapore Clinical Research Institu

Identification of the optimal cognitive drugs among Alzheimer's disease: a Bayesian meta-analytic review.

3. Clin Interv Aging. 2018 Oct 18;13:2061-2073. doi: 10.2147/CIA.S184968. eCollection 2018. Identification of the optimal cognitive drugs among Alzheimer's disease: a Bayesian meta-analytic review. Liang J(1), Li J(1), Jia R(1), Wang Y(1), Wu R(1), Zhang H(1), Hang L(1), Xu Y(1). Author inform

Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis.

12. Curr Drug Targets. 2017;18(13):1499-1517. doi: 10.2174/1389450118666161108124414. Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis. Sanadgol N(1)(2)(3), Zahedani SS(4), Sharifzadeh M(3)(5), Khalseh

Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis.

28. Hum Psychopharmacol. 2016 Jul;31(4):286-95. doi: 10.1002/hup.2537. Epub 2016 Jun 15. Adjunctive huperzine A for cognitive deficits in schizophrenia: a systematic review and meta-analysis. Zheng W(1), Xiang YQ(2)(3)(4), Li XB(2)(3)(4), Ungvari GS(5), Chiu HF(6), Sun F(7), D'Arcy C(8), Meng X

Interventions to delay functional decline in people with dementia: a systematic review of systematic reviews.

31. BMJ Open. 2016 Apr 27;6(4):e010767. doi: 10.1136/bmjopen-2015-010767. Interventions to delay functional decline in people with dementia: a systematic review of systematic reviews. Laver K(1), Dyer S(1), Whitehead C(1), Clemson L(2), Crotty M(1). Author information: (1)Department of Rehabilit

Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials.

25. PLoS One. 2013 Sep 23;8(9):e74916. doi: 10.1371/journal.pone.0074916. eCollection 2013. Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials. Yang G(1), Wang Y, Tian J, Liu JP. Author information: (1)Centre for Evidence-based Chinese Medic