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The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes.

1. Clin Transl Sci. 2025 Feb;18(2):e70120. doi: 10.1111/cts.70120. The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes. Nguyen JT(1), Arian CM(2), Tanna RS(1), Cherel MG(1), L

A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption.

2. J Pharmacol Exp Ther. 2025 Jun;392(6):103597. doi: 10.1016/j.jpet.2025.103597. Epub 2025 May 3. A gut response: Application of human enteroid monolayers to probe the mechanism of the goldenseal-mediated inhibition of metformin intestinal absorption. Arian CM(1), O'Mahony ET(1), Manwill PK(2),

Mechanisms of intestinal pharmacokinetic natural product-drug interactions.

3. Drug Metab Rev. 2024 Aug;56(3):285-301. doi: 10.1080/03602532.2024.2386597. Epub 2024 Aug 12. Mechanisms of intestinal pharmacokinetic natural product-drug interactions. Oyanna VO(1), Clarke JD(1). Author information: (1)Department of Pharmaceutical Sciences, WA State University, Spokane, Wa

Unlocking the Goldenseal Reveals the Complexities of Natural Product-Drug Interactions.

4. J Pharmacol Exp Ther. 2023 Dec;387(3):249-251. doi: 10.1124/jpet.123.001863. Unlocking the Goldenseal Reveals the Complexities of Natural Product-Drug Interactions. Embuldeniya S(1), Goralski KB(2). Author information: (1)Department of Biology (S.E.), College of Pharmacy (S.E., K.B.G.), and

An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Understand Clinical Observations.

5. J Pharmacol Exp Ther. 2023 Dec;387(3):252-264. doi: 10.1124/jpet.123.001681. Epub 2023 Aug 4. An Integrative Approach to Elucidate Mechanisms Underlying the Pharmacokinetic Goldenseal-Midazolam Interaction: Application of In Vitro Assays and Physiologically Based Pharmacokinetic Models to Und

Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib.

6. Eur J Clin Pharmacol. 2022 Apr;78(4):597-611. doi: 10.1007/s00228-021-03266-y. Epub 2022 Jan 20. Physiologically based pharmacokinetic model predictions of natural product-drug interactions between goldenseal, berberine, imatinib and bosutinib. Adiwidjaja J(1)(2), Boddy AV(3), McLachlan AJ(4)

Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail.

7. Clin Pharmacol Ther. 2021 May;109(5):1342-1352. doi: 10.1002/cpt.2107. Epub 2020 Dec 23. Assessing Transporter-Mediated Natural Product-Drug Interactions Via In vitro-In Vivo Extrapolation: Clinical Evaluation With a Probe Cocktail. Nguyen JT(1), Tian DD(1), Tanna RS(1), Hadi DL(1)(2), Bansal

Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues.

8. Pharmacol Res. 2020 Oct;160:105085. doi: 10.1016/j.phrs.2020.105085. Epub 2020 Jul 16. Goldenseal (Hydrastis canadensis L.) and its active constituents: A critical review of their efficacy and toxicological issues. Mandal SK(1), Maji AK(2), Mishra SK(3), Ishfaq PM(3), Devkota HP(4), Silva AS

Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects.

9. Drug Metab Dispos. 2020 Oct;48(10):1018-1027. doi: 10.1124/dmd.120.091041. Epub 2020 Jun 26. Modulation of Major Human Liver Microsomal Cytochromes P450 by Component Alkaloids of Goldenseal: Time-Dependent Inhibition and Allosteric Effects. McDonald MG(1), Tian DD(2), Thummel KE(2), Paine MF(

Potential Pharmacokinetic Herb-Drug Interactions: Have we Overlooked the Importance of Human Carboxylesterases 1 and 2?

10. Curr Drug Metab. 2019;20(2):130-137. doi: 10.2174/1389200219666180330124050. Potential Pharmacokinetic Herb-Drug Interactions: Have we Overlooked the Importance of Human Carboxylesterases 1 and 2? Xu J(1), Qiu JC(1), Ji X(1), Guo HL(1), Wang X(1), Zhang B(2), Wang T(3), Chen F(1). Author in

Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions.

11. Planta Med. 2012 Sep;78(13):1458-77. doi: 10.1055/s-0032-1315117. Epub 2012 Aug 1. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Hermann R(1), von Richter O. Author information: (1)Clinical Research Appliance, Radolfzell, Germany. robert.hermann@cr

Natural health product-HIV drug interactions: a systematic review.

12. Int J STD AIDS. 2005 Mar;16(3):181-6. doi: 10.1258/0956462053420103. Natural health product-HIV drug interactions: a systematic review. Mills E(1), Montori V, Perri D, Phillips E, Koren G. Author information: (1)Department of Clinical Epidemiology and Biostatistics, McMaster University, Hami