달맞이꽃 (PMS)
Evening Primrose Oil (PMS)
📚 관련 논문 (19편)
1. J Psychosom Obstet Gynaecol. 2011 Mar;32(1):42-51. doi: 10.3109/0167482X.2010.538102. Epub 2010 Dec 21. Herbal treatments for alleviating premenstrual symptoms: a systematic review. Dante G(1), Facchinetti F. Author information: (1)Mother Infant Department, University of Modena and Reggio Emi
2. Can J Clin Pharmacol. 2009 Fall;16(3):e407-29. Epub 2009 Oct 29. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Whelan AM(1), Jurgens TM, Naylor H. Author information: (1)College of Pharmacy, Dalhousie University, Halifax, Nova Scotia. Anne.Marie
3. BMJ Clin Evid. 2007 May 1;2007:0806. Premenstrual syndrome. Kwan I(1), Onwude JL. Author information: (1)Royal College of obstetricians and gynaecologists, London, UK. INTRODUCTION: Premenstrual symptoms occur in 95% of women of reproductive age. Severe, debilitating symptoms (PMS) occur in
4. Menopause. 2003 Sep-Oct;10(5):465-76. doi: 10.1097/01.GME.0000058147.24036.B0. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Huntley AL(1), Ernst E. Author information: (1)Department of Complementary Medicine, Peninsula Medical School, Universities
1. Allergy. 2024 Jul;79(7):1708-1724. doi: 10.1111/all.16160. Epub 2024 May 23. A systematic review and meta-analysis of nutritional and dietary interventions in randomized controlled trials for skin symptoms in children with atopic dermatitis and without food allergy: An EAACI task force report. Vassilopoulou E(1)(2), Comotti A(3), Douladiris N(4), Konstantinou GΝ(5), Zuberbier T(6)(7), Alberti I(2), Agostoni C(2)(8), Berni Canani R(9), Bocsan IC(10), Corsello A(8), De Cosmi V(8)(11), Feketea G(10)(12), Laitinen K(13), Mazzocchi A(8), Monzani NA(8), Papadopoulos NG(4), Peroni DG(14), Pitsios C(15), Roth-Walter F(16)(17), Skypala I(18)(19), Tsabouri S(20), Baldeh AK(21), O'Mahony L(22), Venter C(23), Milani GP(2)(8). Author information: (1)Department of Nutritional Sciences and Dietetics, International Hellenic University, Thessaloniki, Greece. (2)Pediatric Area, Fondazione IRCCS Ca' Granda-Ospedale Maggiore Policlinico, Milan, Italy. (3)Occupational Medicine Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. (4)Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece. (5)Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, Thessaloniki, Greece. (6)Institute of Allergology, Charité - Universitätsmedizin Berlin, Berlin, Germany. (7)Allergology and Immunology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Berlin, Germany. (8)Department of Clinical Sciences and Community Health, University of Milan, Milano, Italy. (9)Department of Translational Medical Science, University of Naples "Federico II", Naples, Italy. (10)Department of Pharmacology, Toxicology and Clinical Pharmacology, "luliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. (11)Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità - Italian National Institute of Health, Rome, Italy. (12)Department of Pediatrics, "Karamandaneio" Children's Hospital of Patra, Patras, Greece. (13)Faculty of Medicine, Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology and Nutrition and Food Research Center, University of Turku, Turku, Finland. (14)Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy. (15)Medical School, University of Cyprus, Nicosia, Cyprus. (16)Department of Interdisciplinary Life Sciences, Messerli Research Institute, University of Veterinary Medicine, Vienna, Austria. (17)Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. (18)Royal Brompton & Harefield Hospitals, Part of Guys & St Thomas NHS Foundation Trust, London, UK. (19)Department of Inflammation & Repaid, Imperial College of London, London, UK. (20)Child Health Department, University of Ioannina School of Medicine, Ioannina, Greece. (21)Department of Public Health and Community Medicine, Sahlgrenska Academy, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden. (22)APC Microbiome Ireland, Department of Medicine, School of Microbiology, University College Cork, Cork, Ireland. (23)Pediatric Allergy and Clinical Immunology, Children's Hospital Colorado/University of Colorado, Aurora, Colorado, USA. This systematic review and meta-analysis aimed to consolidate evidence on dietary interventions for atopic eczema/dermatitis (AD) skin symptoms in children without food allergies, following PRISMA 2020 guidelines. Systematic review updates were conducted in May 2022 and June 2023, focusing on randomized placebo-controlled trials (RCTs) involving children with AD but without food allergies. Specific diets or supplements, such as vitamins, minerals, probiotics, prebiotics, symbiotics, or postbiotics, were explored in these trials. Exclusions comprised descriptive studies, systematic reviews, meta-analyses, letters, case reports, studies involving elimination diets, and those reporting on food allergens in children and adolescents. Additionally, studies assessing exacerbation of AD due to food allergy/sensitization and those evaluating elimination diets' effects on AD were excluded. Nutritional supplementation studies were eligible regardless of sensitization profile. Evaluation of their impact on AD clinical expression was performed using SCORAD scores, and a meta-analysis of SCORAD outcomes was conducted using random-effect models (CRD42022328702). The review encompassed 27 RCTs examining prebiotics, Vitamin D, evening primrose oil, and substituting cow's milk formula with partially hydrolyzed whey milk formula. A meta-analysis of 20 RCTs assessing probiotics, alone or combined with prebiotics, revealed a significant reduction in SCORAD scores, suggesting a consistent trend in alleviating AD symptoms in children without food allergies. Nonetheless, evidence for other dietary interventions remains limited, underscoring the necessity for well-designed intervention studies targeting multiple factors to understand etiological interactions and propose reliable manipulation strategies. © 2024 The Author(s). Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. DOI: 10.1111/all.16160 PMID: 38783644 [Indexed for MEDLINE]
2. Iran J Nurs Midwifery Res. 2023 Jul 24;28(4):430-435. doi: 10.4103/ijnmr.ijnmr_149_22. eCollection 2023 Jul-Aug. Comparison of the Effect of Fennel and Evening Primrose Oil on Menopausal Problems and Hormonal Levels: A Randomized Controlled Trial. Ghavi F(1), Shakeri F(2), Farahnaz H(3), Abdolahian S(4). Author information: (1)Department of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran. (2)Department of Midwifery, School of Nursing and Midwifery, Jahrom University of Medical Sciences, Jahrom, Iran. (3)Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Shiraz, Iran. (4)Department of Midwifery, Islamic Azad University Tehran, Medical Branch, Tehran, Iran. BACKGROUND: Using natural oral supplements is one of the methods of complementary medicine that has been widely welcomed in the last decade Since studies have reported contradictory results for effectiveness of herbal medicines during menopause and no other more effective herbal medicine has been suggested yet, the researchers of this study decided to compare the fennel and Evening Primrose Oil (EPO) and their effect on menopause problems and sex hormones. MATERIALS AND METHODS: The present study was a triple-blinded, controlled clinical trial with 125 participants randomly assigned to. An intervention group received fennel, another intervention group received evening primrose oil, and the placebo group received placebo twice daily for 8 weeks. Pre-intervention and post-intervention results were obtained using hormonal assay and the Menopause Rating Scale (MRS). RESULTS: In this study, the mean follicle-stimulating hormone (FSH) and estradiol levels changed significantly in the fennel and EPO groups compared to placebo (p < 0.001). The difference in the mean FSH score between the fennel group and EPO group was not significant (p = 0.304), but the difference in the mean estradiol level between these groups was significant (p = 0.043). Moreover, there was a significant difference in the mean MRS score between the intervention groups before the intervention (p < 0.05). However, the difference in the mean MRS score between the fennel and EPO groups was not significant after the intervention (p = 0.322). CONCLUSIONS: Consumption of fennel and EPO can significantly change FSH, estradiol, and psychological menopausal symptoms in postmenopausal women. Copyright: © 2023 Iranian Journal of Nursing and Midwifery Research. DOI: 10.4103/ijnmr.ijnmr_149_22 PMCID: PMC10484391 PMID: 37694196 Conflict of interest statement: Nothing to declare.
3. Sci Rep. 2023 Apr 20;13(1):6449. doi: 10.1038/s41598-023-28411-8. Anti-inflammatory effect of combining fish oil and evening primrose oil supplementation on breast cancer patients undergoing chemotherapy: a randomized placebo-controlled trial. Arsic A(1), Krstic P(2), Paunovic M(3), Nedovic J(4), Jakovljevic V(5), Vucic V(3). Author information: (1)Group for Nutritional Biochemistry and Dietology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia. aleksandraarsicimi@gmail.com. (2)Department of Hematology, Military Medical Academy, Belgrade, Serbia. (3)Group for Nutritional Biochemistry and Dietology, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Belgrade, Serbia. (4)Clinical Centre of Kragujevac, University of Kragujevac, Kragujevac, Serbia. (5)Department of Physiology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia. Breast cancer is the most common malignant tumor and one of the leading causes of cancer-related death in women throughout the world. This study is a parallel, randomized, double-blind, controlled, 12-week supplementation trial, investigating the anti-inflammatory effects of dietary intake of fish oil and evening primrose oil (EPO), in patients with breast cancer undergoing chemotherapy. The primary outcomes were changes in the nutritional status and inflammatory cytokines of patients during the study. The secondary outcomes were changes in hematological and biochemical parameters and fatty acid profile. Of the 32 eligible patients, half of them is randomly assigned to a treatment arm with fish oil and EPO (n = 16), or a control arm (n = 16) with mineral oil as a placebo. The intervention group was taking 2 gel capsules of fish oil and 3 gel capsules of EPO (400 mg eicosapentaenoic acid, 600 mg docosahexaenoic acid, and 351 mg gamma-linolenic acid) fish oil and evening primrose oil for 12 weeks, during their chemotherapy. The control/placebo group was taking 5 gel capsules of 1g of mineral oil. One of the patients dropped out due to discontinuation of the treatment (in the placebo group) and two did not show up at the post-treatment measurements (in the intervention group), thus, 29 women completed the study. The results showed an increase in plasma levels of docosapentaenoic acid (22:5n-3), docosahexaenoic acid (22:6n-3), total n-3PUFA, vaccenic acid (18:1n-7), and a decrease in n-6/n-3 PUFA ratio in the intervention group. An increase in the plasma level of dihomo-gamma-linolenic acid (20:3n-6) was observed in the placebo group. There was no difference in plasma levels of interleukin (IL) IL-8, IL-10, and tumor necrosis factor-alpha, while the level of IL-6 decreased in both groups and was significantly lower in the intervention group at the end of the study. In conclusion, this supplementation improved the PUFA status and decreased the level of IL-6 in breast cancer patients undergoing chemotherapy. Consequently, this treatment may help reduce cancer complications resulting from impaired lipid metabolism and inflammation. ClinicalTrials.gov Identifier: NCT03516253. Date of registration 04/05/2018. © 2023. The Author(s). DOI: 10.1038/s41598-023-28411-8 PMCID: PMC10119093 PMID: 37081029 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no competing interests.
4. Nutrients. 2022 Jul 21;14(14):2980. doi: 10.3390/nu14142980. Effect of Evening Primrose Oil Supplementation on Selected Parameters of Skin Condition in a Group of Patients Treated with Isotretinoin-A Randomized Double-Blind Trial. Kaźmierska A(1), Bolesławska I(1), Polańska A(2), Dańczak-Pazdrowska A(3), Jagielski P(4), Drzymała-Czyż S(1), Adamski Z(3), Przysławski J(1). Author information: (1)Department of Bromatology, Poznan University of Medical Sciences, 60-806 Poznan, Poland. (2)Laboratory of Connective Tissue Diseases, Department of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. (3)Department of Dermatology, Poznan University of Medical Sciences, 60-806 Poznan, Poland. (4)Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland. Background: Retinoids, which include isotretinoin, reduce sebum levels, the degree of epidermal wetness (CORN) and cause an increase in transepidermal water loss (TEWL). Weight gain has also been observed in isotretinoin-treated patients. An agent that can reduce the severity of isotretinoin side effects is evening primrose oil (Oenothera paradoxa). The purpose of this study was to evaluate the effect of evening primrose oil supplementation in patients with acne vulgaris treated with isotretinoin on skin hydration status (CORN), transepidermal water loss (TEWL), skin oiliness (sebum) and changes in body weight and BMI. Methods: Patients diagnosed with acne were assigned to the isotretinoin-treated group (n = 25) or the isotretinoin and evening primrose oil-treated group (n = 25). The intervention lasted 9 months. CORN (with a corneometer), TEWL (with a tewameter) and sebum (with a sebumeter) were assessed twice, as well as body weight and BMI (Tanita MC-780). Results: The isotretinoin-treated group showed statistically significant reductions in CORN (p = 0.015), TEWL (p = 0.004) and sebum (p < 0.001) after the intervention. In the group treated with isotretinoin and evening primrose oil, TEWL and sebum levels also decreased significantly (p < 0.05), while CORN levels increased from 42.0 ± 9.70 to 50.9 ± 10.4 (p = 0.017). A significant decrease in body weight (p < 0.001) and BMI (p < 0.001) was observed in both groups after 9 months of intervention. Conclusions: During isotretinoin treatment, supplementation with evening primrose oil increased skin hydration. However, there were no differences between groups in transepidermal water loss, skin oiliness, weight loss and BMI. DOI: 10.3390/nu14142980 PMCID: PMC9317771 PMID: 35889936 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest.
5. Clin Transl Sci. 2022 Oct;15(10):2378-2391. doi: 10.1111/cts.13366. Epub 2022 Jul 25. Supplementation with omega-3 or omega-6 fatty acids attenuates platelet reactivity in postmenopausal women. Yamaguchi A(1), Stanger L(1), Freedman JC(2), Prieur A(1), Thav R(1)(3), Tena J(2), Holman TR(2), Holinstat M(1)(4). Author information: (1)Department of Pharmacology, University of Michigan Medical School, Ann Arbor, Michigan, USA. (2)Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, California, USA. (3)Cranbrook Schools, Bloomfield Hills, Michigan, USA. (4)Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA. Postmenopausal women are at increased risk for a cardiovascular event due to platelet hyperactivity. There is evidence suggesting that ω-3 polyunsaturated fatty acids (PUFAs) and ω-6 PUFAs have cardioprotective effects in these women. However, a mechanistic understanding of how these fatty acids regulate platelet function is unknown. In this study, we supplemented postmenopausal women with fish oil (ω-3 fatty acids) or evening primrose oil (ω-6 fatty acids) and investigated the effects on their platelet activity. The effects of fatty acid supplementation on platelet aggregation, dense granule secretion, and activation of integrin αIIbβ3 at basal levels and in response to agonist were tested in postmenopausal women following a supplementation and washout period. Supplementation with fish oil or primrose oil attenuated the thrombin receptor PAR4-induced platelet aggregation. Supplementation with ω-3 or ω-6 fatty acids decreased platelet dense granule secretion and attenuated basal levels of integrin αIIbβ3 activation. Interestingly, after the washout period following supplementation with primrose oil, platelet aggregation was similarly attenuated. Additionally, for either treatment, the observed protective effects post-supplementation on platelet dense granule secretion and basal levels of integrin activation were sustained after the washout period, suggesting a long-term shift in platelet reactivity due to fatty acid supplementation. These findings begin to elucidate the underlying mechanistic effects of ω-3 and ω-6 fatty acids on platelet reactivity in postmenopausal women. Hence, this study supports the beneficial effects of fish oil or primrose oil supplementation as a therapeutic intervention to reduce the risk of thrombotic events in postmenopausal women. https://clinicaltrials.gov/ct2/show/NCT02629497. © 2022 The Authors. Clinical and Translational Science published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. DOI: 10.1111/cts.13366 PMCID: PMC9579391 PMID: 35791734 [Indexed for MEDLINE] Conflict of interest statement: Dr. Holinstat is a consultant and equity holder for Veralox therapeutics and a consultant for Cereno Scientific. All other authors declared no competing interests for this work.
6. Nutrients. 2022 Mar 23;14(7):1342. doi: 10.3390/nu14071342. Effect of Evening Primrose Oil Supplementation on Biochemical Parameters and Nutrition of Patients Treated with Isotretinoin for Acne Vulgaris: A Randomized Double-Blind Trial. Kaźmierska A(1), Bolesławska I(1), Jagielski P(2), Polańska A(3), Dańczak-Pazdrowska A(4), Kosewski G(1), Adamski Z(4), Przysławski J(1). Author information: (1)Department of Bromatology, Poznan University of Medical Sciences, 60-806 Poznan, Poland. (2)Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, 31-066 Krakow, Poland. (3)Laboratory of Connective Tissue Diseases, Department of Dermatology and Venereology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. (4)Department of Dermatology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. Background: Acne vulgaris is one of the most common skin diseases. One of the therapeutic options recommended for severe acne or acne that has not responded to previous therapies is isotretinoin. However, its use may lead to adverse changes in the serum lipid profile and increased levels of transaminases. In this study, we evaluated the effect of supplementation with evening primrose oil in acne vulgaris patients treated with isotretinoin on blood lipid parameters and transaminase activity. Methods: Study participants were randomly assigned to two treatments: conventional with isotretinoin (25 patients) and novel with isotretinoin combined with evening primrose oil (4 × 510 mg/day; 25 patients) for 9 months. Results: Compared to isotretinoin treatment, isotretinoin treatment combined with evening primrose oil had a positive effect on TCH concentrations (mean: 198 vs. 161, p < 0.001), LDL (95.9 vs. 60.2, p < 0.001), HDL (51.0 vs. 48.0, p < 0.001), TG (114 vs. 95.0, p < 0.001), ALT (24.0 vs. 22.0, p < 0.001), and AST (28.0 vs. 22.0, p < 0.001), but had no effect on the energy and ingredient content of the diets (p > 0.05) after treatment. Conclusion: Evening primrose oil was found to have beneficial effects on lipid profiles and transaminase activity during isotretinoin treatment. However, longer studies are needed to make more reliable decisions regarding the use of evening primrose oil and its safety in clinical practice. The evening primrose oil treatment group also showed a reduction in dietary energy due to a reduction in dietary protein and carbohydrates. DOI: 10.3390/nu14071342 PMCID: PMC9002552 PMID: 35405955 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest.
7. J Diet Suppl. 2022;19(2):168-183. doi: 10.1080/19390211.2020.1853648. Epub 2020 Dec 17. Efficacy and Safety of Nutraceutical on Menopausal Symptoms in Post-Menopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Rattanatantikul T(1), Maiprasert M(1)(2), Sugkraroek P(1)(3), Bumrungpert A(1)(2). Author information: (1)Master of Science Program in Anti-Aging & Regenerative Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand. (2)Research Center of Nutraceuticals and Natural Products for Health & Anti-Aging, College of Integrative Medicine, Dhurakij Pundit University, Bangkok, Thailand. (3)Women's Center and VitalLife Scientific Wellness Center, Bumrungrad International Hospital, Bangkok, Thailand. BACKGROUND: Menopausal symptoms severely reduce the quality of life of post-menopausal women worldwide. Nutraceuticals are widely prescribed as a viable and safer alternative and complementary approach to standard therapies. The aim of this study was to evaluate the clinical efficacy and safety of a nutraceutical in post-menopausal women. METHODS: The study was designed as a randomized, double-blinded, placebo-controlled clinical trial. Post-menopausal women aged 45-60 years old were enrolled and randomly assigned to either treatment (n = 50) or placebo group (n = 51). The intervention, a proprietary combination of soy isoflavone, black cohosh, chasteberry and evening primrose oil extracts, and the placebo, were administered to each group for total of 12 weeks. Menopausal symptoms, endocrine profiles, and blood chemistry were evaluated at baseline, 6 weeks, and 12 weeks of the study. RESULTS: Nutraceutical supplementation demonstrated a statistically significant reduction in hot flushes and sweating (p < 0.0001), sleep problems (p < 0.0005), depressed mood (p = 0.0004) and irritability symptoms (p < 0.0003) compared with the placebo group. There were no significant differences in hormonal levels between the test and placebo groups, however levels of C-reactive protein were significantly decreased. Moreover, serum LDL-C and triglyceride levels were significantly lower than baseline levels in the treatment group at 6- and 12-week timepoints. No adverse effects were reported during the treatment. CONCLUSION: These data indicate that a nutraceutical containing a combination of four medicinal herbs effectively and safely improved menopausal symptoms, as well as general health indicators, in post-menopausal women. DOI: 10.1080/19390211.2020.1853648 PMID: 33331798 [Indexed for MEDLINE]
8. Clin Rheumatol. 2019 Sep;38(9):2443-2450. doi: 10.1007/s10067-019-04569-3. Epub 2019 May 10. Influence of different supplementation on platelet aggregation in patients with rheumatoid arthritis. Tomic-Smiljanic M(1), Vasiljevic D(2), Lucic-Tomic A(3), Andjelkovic N(3), Jakovljevic V(4)(5), Bolovich S(5), Veselinovic M(6). Author information: (1)Public Health Center, DZ Rakovica, 22 Kraljice Jelene, 11000, Belgrade, Serbia. (2)Faculty of Medical Sciences, Department of Hygiene and Ecology, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Serbia. (3)Faculty of Medical Sciences, Department of Internal medicine, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Serbia. (4)Faculty of Medical Sciences, Department of Physiology, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Serbia. (5)Department of Human Pathology, 1st Moscow State Medical, University IM Sechenov, Trubetskaya Street 8, Str. 2, Moscow, Russia, 119991. (6)Faculty of Medical Sciences, Department of Internal medicine, University of Kragujevac, 69 Svetozara Markovica, 34000, Kragujevac, Serbia. veselinovic.m@sbb.rs. INTRODUCTION: Long-chain n-3 polyunsaturated fatty acids (n-3 PUFAs; eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) have been reported to reduce platelet aggregation. Our aim was to prospectively assess the potential influence of different supplementation omega-3 PUFA on the antiplatelet effects in rheumatoid arthritis (RA) patients. METHODS: The study included 60 patients with RA at the Department of Rheumatology, Clinical Center Kragujevac. Patients were divided into three groups depending on who used concentrated fish oil only or concentrated fish oil in combination with evening primrose oil or control group without supplementation in a period of 3 months. Platelet aggregation was measured using the multiplate analyzer and expressed through the value of adenosine diphosphate (ADP) test, aranchidonic acid-induced aggregation (ASPI) test, thrombin receptor-activating peptide (TRAP) test (to assess baseline platelet aggregation), and the ratio of ADP/TRAP and ASPI/TRAP representing the degree of inhibition of platelet aggregation compared to the basal value. The platelet function analysis in whole blood was performed 18-24 h before starting supplementation and after 90 days. Considerations were taken in the representation of demographic, clinical characteristics, and laboratory parameters between the groups. RESULTS: Patients who used concentrated fish oil only had a significantly lower value of the ratio of ADP/TRAP (0.68 ± 0.20) compared to patients without supplementation (0.83 ± 0.12; p = 0.008), while there was no statistically significant difference in values of other laboratory parameters of platelet function between other groups. CONCLUSIONS: Co-administration of supplementation-concentrated fish oil may reduce platelet aggregation in adults with RA. KEY POINTS: • Omega-3 PUFAs are essential for health and are known to possess anti-inflammatory properties, improving cardiovascular health as well as benefiting inflammatory diseases.. • In this paper, we report on anti-aggregation effects n-3 PUFAs and ɤ-linolenic acid in RA. • The risk of cardiovascular morbidity and mortality is increased in RA, and dietary supplementation of n-3 PUFA may have preventive potential for the cardiovascular management in rheumatoid arthritis. DOI: 10.1007/s10067-019-04569-3 PMID: 31076942 [Indexed for MEDLINE]
9. RETRACTED ARTICLE Endocr Res. 2018 Feb;43(1):1-10. doi: 10.1080/07435800.2017.1346661. Epub 2017 Jul 25. The effects of vitamin D and evening primrose oil co-supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with polycystic ovary syndrome: A randomized, double-blind, placebo-controlled trial. Nasri K(1), Akrami S(1), Rahimi M(2), Taghizadeh M(3), Behfar M(3), Mazandaranian MR(3), Kheiry A(3), Memarzadeh MR(4), Asemi Z(3). Author information: (1)a Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics , School of Medicine, Arak University of Medical Sciences , Arak , Iran. (2)b Department of Gynecology and Obstetrics, School of Medicine , Iran University of Medical Sciences , Tehran , Iran. (3)c Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences , Kashan , I.R . Iran. (4)d Barij Medicinal Plants Research Center , Kashan , I.R . Iran. Retraction in Endocr Res. 2024 Jan 2;49(1):75. doi: 10.1080/07435800.2023.2266257. Expression of concern in Endocr Res. 2021 Feb;46(1):44. doi: 10.1080/07435800.2020.1843877. PURPOSE OF THE STUDY: There was inconsistent evidence about the benefit of vitamin D plus evening primrose oil (EPO) supplement intake on lipid profiles and reduced oxidative stress among women with polycystic ovary syndrome (PCOS). The current study was performed to evaluate the effects of vitamin D plus EPO supplementation on lipid profiles and biomarkers of oxidative stress in vitamin D-deficient women with PCOS. MATERIALS AND METHODS: This randomized, double-blind, placebo-controlled trial was performed among 60 vitamin D-deficient women with PCOS. Participants were randomly assigned into two groups to receive either 1000 IU vitamin D3 plus 1000 mg EPO (n = 30) or placebo (n = 30) for 12 weeks. Metabolic profiles were quantified at baseline and after the 12-week intervention. RESULTS: Compared with the placebo group, women in vitamin D and EPO co-supplementation group had significant increases in serum 25-hydroxyvitamin D (25(OH)D) (+10.7 ± 8.4 vs. -0.5 ± 1.6 ng/mL, p < 0.001) and plasma total glutathione (GSH) (+62.7 ± 58.0 vs. -0.7 ± 122.7 µmol/L, p = 0.01), while there were significant decreases in triglycerides (-7.3 ± 23.8 vs. +6.9 ± 26.3 mg/dL, p = 0.03), very low-density lipoprotein (VLDL) cholesterol levels (-1.5 ± 4.7 vs. +1.4 ± 5.3 mg/dL, p = 0.03), total/high-density lipoprotein cholesterol ratio (-0.3 ± 0.4 vs. -0.02 ± 0.4, p = 0.02), and malondialdehyde (MDA) concentration (-0.4 ± 0.4 vs. +0.5 ± 1.8 µmol/L, p = 0.008). CONCLUSION: Overall, vitamin D and EPO co-supplementation for 12 weeks among vitamin D-deficient women with PCOS significantly improved triglycerides, VLDL cholesterol, GSH, and MDA levels. DOI: 10.1080/07435800.2017.1346661 PMID: 28742409 [Indexed for MEDLINE]
10. Skin Pharmacol Physiol. 2017;30(3):146-158. doi: 10.1159/000464470. Epub 2017 May 20. An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants. Genovese L(1), Corbo A, Sibilla S. Author information: (1)Minerva Research Labs Ltd., London, UK. BACKGROUND: Skin aging is a multifactorial phenomenon which causes alterations in skin physiological functions and, most visibly, phenotypic changes. In particular, during the aging process, hyaluronic acid, collagen, and elastin fibers undergo structural and functional changes. AIMS: This study aimed to give an insight into the photo-protective benefits and efficacy of an oral liquid nutricosmeceutical containing collagen bioactive peptides and antioxidants to counteract the signs of aging. METHODS: A double-blind, randomized, placebo-controlled clinical trial was conducted by an independent esthetic clinic on 120 healthy volunteer subjects for 90 days. Subjects were divided into 2 groups: 60 subjects consumed 1 bottle (50 mL) of the nutricosmeceutical daily and the other 60 consumed 1 bottle (50 mL) of the placebo. Outcome measures were related to skin elasticity (expressed as Young's elasticity modulus) and skin architecture (histological analysis). In addition, the subjects recruited in this study underwent observational assessments through self-assessment questionnaires. RESULTS AND CONCLUSIONS: Overall, we demonstrated a significant increase in skin elasticity (+7.5%), p ≤ 0.001 and an improvement in skin texture after daily oral consumption of the nutricosmeceutical. We also obtained a positive patient feedback through the self-assessment questionnaires. Taken together these results show that this nutricosmeceutical supplement may have photo-protective effects and help improve skin health. © 2017 S. Karger AG, Basel. DOI: 10.1159/000464470 PMID: 28528342 [Indexed for MEDLINE]
11. Nutrients. 2017 Mar 25;9(4):325. doi: 10.3390/nu9040325. Clinical Benefits of n-3 PUFA and ɤ-Linolenic Acid in Patients with Rheumatoid Arthritis. Veselinovic M(1), Vasiljevic D(2), Vucic V(3), Arsic A(3), Petrovic S(4), Tomic-Lucic A(5), Savic M(6), Zivanovic S(7), Stojic V(8), Jakovljevic V(9). Author information: (1)Department of Internal medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia. veselinovic.m@sbb.rs. (2)Department of Hygiene, Institute for Public Health, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia. dvg_gana@yahoo.com. (3)Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Beograd 11000, Serbia. vesna.vucic.imr@gmail.com. (4)Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, Beograd 11000, Serbia. snjezana570.imr12@gmail.com. (5)Department of Internal medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia. sanlusa@ptt.rs. (6)Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia. maja.jovanovic.2008.38@gmail.com. (7)Faculty of Hotel Management and Tourism, Department of Natural Sciences and medicine, University of Kragujevac, Kragujevac 34000, Serbia. zivanovicsandra@hotmail.com. (8)Faculty of Medical Sciences, University of Kragujevac, Kragujevac 34000, Serbia. vladisavastojic@medf.kg.ac.rs. (9)Faculty of Medical Sciences, University of Kragujevac, Physiology, Kragujevac 34000, Serbia. drvladakgbg@yahoo.com. (1) Background: Marine n-3 polyunsaturated fatty acids (PUFA) and ɤ-linolenic acid (GLA) are well-known anti-inflammatory agents that may help in the treatment of inflammatory disorders. Their effects were examined in patients with rheumatoid arthritis; (2) Methods: Sixty patients with active rheumatoid arthritis were involved in a prospective, randomized trial of a 12 week supplementation with fish oil (group I), fish oil with primrose evening oil (group II), or with no supplementation (group III). Clinical and laboratory evaluations were done at the beginning and at the end of the study; (3) Results: The Disease Activity Score 28 (DAS 28 score), number of tender joints and visual analogue scale (VAS) score decreased notably after supplementation in groups I and II (p < 0.001). In plasma phospholipids the n-6/n-3 fatty acids ratio declined from 15.47 ± 5.51 to 10.62 ± 5.07 (p = 0.005), and from 18.15 ± 5.04 to 13.50 ± 4.81 (p = 0.005) in groups I and II respectively. The combination of n-3 PUFA and GLA (group II) increased ɤ-linolenic acid (0.00 ± 0.00 to 0.13 ± 0.11, p < 0.001), which was undetectable in all groups before the treatments; (4) Conclusion: Daily supplementation with n-3 fatty acids alone or in combination with GLA exerted significant clinical benefits and certain changes in disease activity. DOI: 10.3390/nu9040325 PMCID: PMC5409664 PMID: 28346333 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest.
12. Complement Ther Med. 2015 Oct;23(5):652-7. doi: 10.1016/j.ctim.2015.07.003. Epub 2015 Jul 17. Alteration of delta-6-desaturase (FADS2), secretory phospholipase-A2 (sPLA2) enzymes by Hot-nature diet with co-supplemented hemp seed, evening primrose oils intervention in multiple sclerosis patients. Rezapour-Firouzi S(1), Arefhosseini SR(2), Ebrahimi-Mamaghani M(3), Baradaran B(4), Sadeghihokmabad E(5), Mostafaei S(6), Torbati M(7), Chehreh M(8). Author information: (1)Neurosciences Research Center, University of Medical Sciences at Tabriz, Iran; School of Nutrition and Health, University of Medical Sciences at Tabriz, Iran; Department of Immunology, Microbiology and Genetics, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address: s.rfirozi@gmail.com. (2)School of Nutrition and Health, University of Medical Sciences at Tabriz, Iran; Nutrition Research Center, University of Medical Sciences at Tabriz, Iran. Electronic address: arefhosseinir@tbzmed.ac.ir. (3)School of Nutrition and Health, University of Medical Sciences at Tabriz, Iran. Electronic address: ebrahimimamagani@tbzmed.ac.ir. (4)Immunology Research Center, University of Medical Sciences at Tabriz, Iran. Electronic address: Behzad_im@yahoo.com. (5)Neurosciences Research Center, University of Medical Sciences at Tabriz, Iran. Electronic address: aeass@yahoo.com. (6)Neurosciences Research Center, University of Medical Sciences at Tabriz, Iran. Electronic address: somaiyehmostafaei@yahoo.com. (7)Department of Food Science and Technology Faculty of Nutrition, Food & Drug Organization, University of Medical Sciences at Tabriz, Iran. Electronic address: drtorbati@yahoo.com. (8)Islamic Azad University, Tabriz, Iran. Electronic address: mchehreh@yahoo.com. BACKGROUND: The effect of nutrition and dietary supplements as environmental factors has been suggested as possible factors affecting both disease risk and progression in on the course of multiple sclerosis with complex genetic-risk profiles. This study was aimed to assess regulation of surface-membrane enzymes such as Delta-6-desaturase (FADS2), secretory Phospholipase A2(sPLA2) by hemp seed and evening primrose oils as well as Hot-natured dietary intervention in relapsing remitting multiple sclerosis (RRMS) patients. METHODS AND MATERIALS: In this double blind, randomized trial, 100 RRMS patients with Extended disability status score (EDSS)<6 were allocated into 3 groups: "Group A" who received co-supplemented hemp seed and evening primrose oils along with advised Hot nature diet; "Group B", who received olive oil; "Group C", who received the co-supplemented oils. Clinically EDSS and functional score as well as biochemical parameters [blood cells polyunsaturated fatty acid (PUFA), FADS2, sPLA2] were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration 6.80±4.33 years). There was no significant difference in studies parameters at baseline. After 6 months, significant improvements in EDSS and functional score were found in the groups A and C while EDSS and pyramidal score showed significant increase in group B. Alteration of biochemical parameters showed improvement in groups A and C whereas there was worsening condition for group B after the intervention. CONCLUSION: The co-supplemented hemp seed and evening primrose oils with Hot nature diet can have beneficial effects in improving clinical symptoms and signs in RRMS patients which were confirmed by regulation of surface-membrane enzymes. Copyright © 2015 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.ctim.2015.07.003 PMID: 26365444 [Indexed for MEDLINE]
13. Complement Ther Med. 2014 Dec;22(6):986-93. doi: 10.1016/j.ctim.2014.10.004. Epub 2014 Oct 31. Activity of liver enzymes in multiple sclerosis patients with Hot-nature diet and co-supplemented hemp seed, evening primrose oils intervention. Rezapour-Firouzi S(1), Arefhosseini SR(2), Ebrahimi-Mamaghani M(3), Baradaran B(4), Sadeghihokmabad E(5), Torbati M(6), Mostafaei S(7), Chehreh M(8), Zamani F(9). Author information: (1)Neurosciences Research Center, University of Medical Sciences, Tabriz, Iran; School of Nutrition and Health, University of Medical Sciences, Tabriz, Iran. Electronic address: s.rfirozi@gmail.com. (2)Neurosciences Research Center, University of Medical Sciences, Tabriz, Iran; School of Nutrition and Health, University of Medical Sciences, Tabriz, Iran. Electronic address: arefhosseinir@tbzmed.ac.ir. (3)School of Nutrition and Health, University of Medical Sciences, Tabriz, Iran. Electronic address: ebrahimimamagani@tbzmed.ac.ir. (4)Immunology Research Center, University of Medical Sciences, Tabriz, Iran. Electronic address: Behzad_im@yahoo.com. (5)Neurosciences Research Center, University of Medical Sciences, Tabriz, Iran. Electronic address: aeass@yahoo.com. (6)Food &drug organization, University of Medical Sciences, Tabriz, Iran. Electronic address: drtorbati@yahoo.com. (7)Neurosciences Research Center, University of Medical Sciences, Tabriz, Iran. Electronic address: somaiyehmostafaei@yahoo.com. (8)Islamic Azad University, Tabriz, Iran. Electronic address: mchehreh@yahoo.com. (9)Immunology Research Center, University of Medical Sciences, Tabriz, Iran. Electronic address: fatemeh.zamanipour@yahoo.com. BACKGROUND: It is unknown whether diets with a high dietary total antioxidant capacity (TAC) can modify oxidative stress, low-grade inflammation, or liver dysfunction, all of which are risk factors for multiple sclerosis disease. This study assesses alanine amino-transferase (ALT), aspartate-aminotransferase (AST) and gamma-glutamyl transferase (GGT) activities in MS patients treated with co-supplemented hemp seed and evening primrose oils as well as Hot-nature diet and the therapeutic potential this intervention. METHODS AND MATERIALS: In this double blind, randomized trial, 100 MS patients with EDSS<6 were allocated into 3 groups: "group A", who received co-supplemented hemp seed and evening primrose oils with advised Hot-nature diet; "group B",who received olive oil; and "group C", who received the co-supplemented oils. Clinically, EDSS as well as serum level of liver enzymes (GGT, AST, and ALT) were assessed at baseline and after 6 months. RESULTS: Mean follow-up was 180±2.9 SD days (N=65, 23 M and 42 F aged 34.25±8.07 years with disease duration of 6.80±4.33 years). There was no significant difference in the study parameters at baseline. Serum levels of liver enzymes (GGT, AST, and ALT) were serially monitored. Intervention was associated with liver function alteration in three groups. Significance decreased in EDSS score and the levels of liver enzymes were found in groups A and C, whereas elevated serum liver enzymes and EDSS score were observed in group B after the intervention. CONCLUSION: Selecting foods according to their Total antioxidant capacity such as co-supplemented hemp seed and evening primrose oils with Hot-nature diet affects antioxidant intake and can have beneficial effects on improving EDSS score and activity of liver enzymes in RRMS patients. Copyright © 2014 Elsevier Ltd. All rights reserved. DOI: 10.1016/j.ctim.2014.10.004 PMID: 25453518 [Indexed for MEDLINE]
14. Curr Opin Obstet Gynecol. 2014 Apr;26(2):83-91. doi: 10.1097/GCO.0000000000000052. Herbal therapies in pregnancy: what works? Dante G(1), Bellei G, Neri I, Facchinetti F. Author information: (1)Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy. PURPOSE OF REVIEW: The aim of this article is two-fold: to report the prevalence of herbal products used by pregnant women and to evaluate the evidence of efficacy and safety of the most popular remedies. RECENT FINDINGS: Of the 671 articles identified, 15 randomized controlled trials (RCTs) and 16 non-RCTs were eligible. Ginger was the most investigated remedy and it was consistently reported to ameliorate nausea and vomiting in pregnancy. Although raspberry, blue cohosh, castor oil, and evening primrose oil are believed to facilitate labor in traditional medicine, very few scientific data support such indication. Moreover, they have been associated with severe adverse events. Data on the safety of Hypericum perforatum in pregnancy or lactation are reassuring, whereas efficacy was demonstrated only in nonpregnant individuals. There is still insufficient evidence regarding the efficacy and safety of Echinacea, garlic, and cranberry in pregnancy. SUMMARY: Epidemiological studies reported a wide range of use of herbal remedies in pregnancy. Too few studies have been devoted to the safety and efficacy of singular herbs. With the exception of ginger, there are no consistent data to support the use of any other herbal supplement during pregnancy. Severe adverse events have been reported using blue cohosh and evening primrose oil. DOI: 10.1097/GCO.0000000000000052 PMID: 24535321 [Indexed for MEDLINE]
15. Afr J Tradit Complement Altern Med. 2013 Oct 3;10(6):519-27. doi: 10.4314/ajtcam.v10i6.22. eCollection 2013. Erythrocyte membrane fatty acids in multiple sclerosis patients and hot-nature dietary intervention with co-supplemented hemp-seed and evening-primrose oils. Rezapour-Firouzi S(1), Arefhosseini SR, Ebrahimi-Mamaghani M, Farhoudi M, Baradaran B, Ali TM, Zamani F. Author information: (1)School of Nutrition and Health, Tabriz University of Medical Sciences, Iran ; Neurosciences Research Center, Tabriz University of Medical Sciences, Iran. The risk of developing multiple sclerosis (MS) is associated with increased dietary intake of saturated fatty acids. For many years it has been suspected that this disease might be associated with an imbalance between unsaturated and saturated fatty acids. We determined erythrocyte membrane fatty acids levels in Hot nature dietary intervention with co-supplemented hemp seed and evening primrose oils in multiple sclerosis patients. To determine the erythrocyte membrane fatty acids levels and correlate it with expanded disability status scale (EDSS) at baseline after 6 months intervention in MS patients by gas chromatography, in this double blind, randomized trial, 100 RRMS patients with EDSS<6 were allocated into three groups: "Group A" that received co-supplemented hemp seed and evening primrose oils with advised Hot nature diet. "Group B" received olive oil and "Group C" received the co-supplemented oils. The results showed that the mean follow-up was 180 ± 2.9SD days (N=65, 23 M and 42 F aged 34.25 ± 8.07 years with disease duration of 6.80 ± 4.33 years). There was no significant difference in the study parameters at baseline. After 6 months, EDSS, Immunological parameters and the erythrocyte cell membrane with regard to specific fatty acids showed improvement in the group A and C, whereas there was worsening condition for the group B after the intervention. We concluded that Hot-nature dietary intervention with co-supplemented hemp seed and evening primrose oils caused an increase PUFAs in MS patients and improvement in the erythrocyte membrane fatty acids composition. This could be an indication of restored plasma stores, and a reflection of disease severity reduction. DOI: 10.4314/ajtcam.v10i6.22 PMCID: PMC3847395 PMID: 24311880 [Indexed for MEDLINE]
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