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Efficacy and safety of Echinacea purpurea in treating upper respiratory infections and complications of otitis media in children: Systematic review and meta-analysis.

1. Clin Nutr ESPEN. 2025 Jun;67:702-713. doi: 10.1016/j.clnesp.2025.04.025. Epub 2025 Apr 29. Efficacy and safety of Echinacea purpurea in treating upper respiratory infections and complications of otitis media in children: Systematic review and meta-analysis. Pham TP(1), Vu TM(2), Doan PM(3),

Echinacea Supplementation Does Not Impact Aerobic Capacity and Erythropoiesis in Athletes: A Meta-Analysis.

2. Nutrients. 2024 Jun 22;16(13):1991. doi: 10.3390/nu16131991. Echinacea Supplementation Does Not Impact Aerobic Capacity and Erythropoiesis in Athletes: A Meta-Analysis. Deccy S(1)(2), Bartkowiak C(1)(2), Rodricks N(1)(2), Paultre K(1)(2)(3)(4). Author information: (1)Department of Family Medi

Efficacy of Functional Foods, Beverages, and Supplements Claiming to Alleviate Air Travel Symptoms: Systematic Review and Meta-Analysis.

3. Nutrients. 2021 Mar 16;13(3):961. doi: 10.3390/nu13030961. Efficacy of Functional Foods, Beverages, and Supplements Claiming to Alleviate Air Travel Symptoms: Systematic Review and Meta-Analysis. Chan V(1), Wang L(1), Allman-Farinelli M(1). Author information: (1)Nutrition and Dietetics Group

Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children.

4. RETRACTED ARTICLE Eur J Clin Pharmacol. 2019 Mar;75(3):303-311. doi: 10.1007/s00228-018-2601-7. Epub 2018 Nov 21. Efficacy of vitamin C for the prevention and treatment of upper respiratory tract infection. A meta-analysis in children. Vorilhon P(1)(2)(3), Arpajou B(4), Vaillant Roussel H(4)

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies.

5. Phytother Res. 2016 May;30(5):691-700. doi: 10.1002/ptr.5591. Epub 2016 Feb 17. A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies. Izzo AA(1), Hoon-Kim S(2), Radhakrishnan R(3), Williamson EM(4). Author information: (1)Department of P

Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis.

6. Lancet Infect Dis. 2007 Jul;7(7):473-80. doi: 10.1016/S1473-3099(07)70160-3. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis. Shah SA(1), Sander S, White CM, Rinaldi M, Coleman CI. Author information: (1)University of Connecticut School of Pharmacy

Therapeutic Potential of a Natural Blend of Aronia melancarpa, Lonicera caerulea, and Echinacea purpurea Extracts in Treating Upper Respiratory Tract Infections: Preliminary Clinical and In Vitro Immunomodulatory Insights.

7. Int J Mol Sci. 2024 Dec 15;25(24):13436. doi: 10.3390/ijms252413436. Therapeutic Potential of a Natural Blend of Aronia melancarpa, Lonicera caerulea, and Echinacea purpurea Extracts in Treating Upper Respiratory Tract Infections: Preliminary Clinical and In Vitro Immunomodulatory Insights. Z

Investigating the effect of echinacea extraction syrup on the outcomes of lower respiratory infections in patients with COVID-19: a randomized clinical trial study.

8. Virol J. 2024 Dec 19;21(1):319. doi: 10.1186/s12985-024-02586-6. Investigating the effect of echinacea extraction syrup on the outcomes of lower respiratory infections in patients with COVID-19: a randomized clinical trial study. Kheirandish E(1), Mahdizadeh M(2), Mahdizadeh M(3), Rezaeitalab

Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms.

9. Biomolecules. 2024 Sep 19;14(9):1176. doi: 10.3390/biom14091176. Effects of Plant Meristem-Cell-Based Cosmetics on Menopausal Skin: Clinical Data and Mechanisms. Korkina L(1)(2), Kharaeva Z(3), Shokarova A(3), Barokova E(3), Mayer W(4), Trakhtman I(2), Dal Toso R(5), De Luca C(4). Author inf

A randomized, double-blind, placebo-controlled study on immune improvement effects of ethanolic extract of Echinacea purpurea (L.) Moench in Korean adults.

10. Phytother Res. 2024 Jul;38(7):3645-3659. doi: 10.1002/ptr.8224. Epub 2024 May 14. A randomized, double-blind, placebo-controlled study on immune improvement effects of ethanolic extract of Echinacea purpurea (L.) Moench in Korean adults. Lee SK(1), Lee DR(1), Kim HL(1), Choi BK(1), Kwon KB(2

Echinacea angustifolia and Echinacea purpurea Supplementation Combined with Vaginal Hyaluronic Acid to Boost the Remission of Cervical Low-Grade Squamous Intraepithelial Lesions (L-SILs): A Randomized Controlled Trial.

11. Medicina (Kaunas). 2022 May 9;58(5):646. doi: 10.3390/medicina58050646. Echinacea angustifolia and Echinacea purpurea Supplementation Combined with Vaginal Hyaluronic Acid to Boost the Remission of Cervical Low-Grade Squamous Intraepithelial Lesions (L-SILs): A Randomized Controlled Trial. R

An investigation into the anxiety-relieving and mood-enhancing effects of Echinacea angustifolia (EP107™): A randomised, double-blind, placebo-controlled study.

12. J Affect Disord. 2021 Oct 1;293:229-237. doi: 10.1016/j.jad.2021.06.054. Epub 2021 Jun 24. An investigation into the anxiety-relieving and mood-enhancing effects of Echinacea angustifolia (EP107™): A randomised, double-blind, placebo-controlled study. Lopresti AL(1), Smith SJ(1). Author in

Echinacea purpurea (L.) Moench crude extract combined with citric acid inactivates Cronobacter sakazakii isolated from powdered infant formula.

13. J Dairy Sci. 2025 Feb;108(2):1351-1366. doi: 10.3168/jds.2024-25485. Epub 2024 Dec 9. Echinacea purpurea (L.) Moench crude extract combined with citric acid inactivates Cronobacter sakazakii isolated from powdered infant formula. Fei P(1), Yu Y(2), Liang C(3), Fang R(1), Jiang Y(4), Guo L(5)

Use of herbal medication in the perioperative period: Potential adverse drug interactions.

14. J Clin Anesth. 2024 Aug;95:111473. doi: 10.1016/j.jclinane.2024.111473. Epub 2024 Apr 12. Use of herbal medication in the perioperative period: Potential adverse drug interactions. Elvir Lazo OL(1), White PF(2), Lee C(3), Cruz Eng H(4), Matin JM(5), Lin C(6), Del Cid F(7), Yumul R(8). Auth

Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database.

15. Sci Rep. 2022 Aug 19;12(1):14178. doi: 10.1038/s41598-022-17704-z. Herb-anticancer drug interactions in real life based on VigiBase, the WHO global database. Pochet S(1), Lechon AS(1), Lescrainier C(2), De Vriese C(1), Mathieu V(1), Hamdani J(2), Souard F(3). Author information: (1)Departme

Dietary supplements, cytochrome metabolism, and pharmacogenetic considerations.

1. Ir J Med Sci. 2022 Oct;191(5):2357-2365. doi: 10.1007/s11845-021-02828-4. Epub 2021 Nov 4. Dietary supplements, cytochrome metabolism, and pharmacogenetic considerations. Matura JM(1), Shea LA(2), Bankes VA(1). Author information: (1)School of Pharmacy, Regis University, 3333 Regis Blvd, Denv

Herb-drug Interactions in Neuropsychiatric Pharmacotherapy - A Review of Clinically Relevant Findings.

12. Curr Neuropharmacol. 2022 Aug 3;20(9):1736-1751. doi: 10.2174/1570159X19666210809100357. Herb-drug Interactions in Neuropsychiatric Pharmacotherapy - A Review of Clinically Relevant Findings. Le TT(1), McGrath SR(1), Fasinu PS(2). Author information: (1)School of Pharmacy, College of Pharma

Interaction of Phytocompounds of Echinacea purpurea with ABCB1 and ABCG2 Efflux Transporters.

12. Mol Pharm. 2021 Apr 5;18(4):1622-1633. doi: 10.1021/acs.molpharmaceut.0c01075. Epub 2021 Mar 17. Interaction of Phytocompounds of Echinacea purpurea with ABCB1 and ABCG2 Efflux Transporters. Awortwe C(1)(2), Bruckmueller H(1)(3), Kaehler M(1), Cascorbi I(1). Author information: (1)Institute

Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and Commercial Formulations of Twenty-Nine Herbal Supplements.

5. Drug Metab Dispos. 2020 Oct;48(10):1084-1091. doi: 10.1124/dmd.120.000033. Epub 2020 Jul 27. Application of Cryopreserved Human Intestinal Mucosa and Cryopreserved Human Enterocytes in the Evaluation of Herb-Drug Interactions: Evaluation of CYP3A Inhibitory Potential of Grapefruit Juice and C

Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2.

6. Nat Prod Rep. 2019 Jun 19;36(6):869-888. doi: 10.1039/c9np00011a. Synergy and antagonism in natural product extracts: when 1 + 1 does not equal 2. Caesar LK(1), Cech NB. Author information: (1)Department of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, Nort

Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015.

13. J Integr Med. 2019 Sep;17(5):338-343. doi: 10.1016/j.joim.2019.04.007. Epub 2019 Apr 30. Analysis of spontaneous adverse drug reactions to echinacea, valerian, black cohosh and ginkgo in Australia from 2000 to 2015. Hoban CL(1), Byard RW(2), Musgrave IF(3). Author information: (1)Discipline

Potential Interactions of Biologically Based Complementary Medicine in Gynecological Oncology.

35. Integr Cancer Ther. 2019 Jan-Dec;18:1534735419846392. doi: 10.1177/1534735419846392. Potential Interactions of Biologically Based Complementary Medicine in Gynecological Oncology. Drozdoff L(1), Klein E(1), Kalder M(2), Brambs C(2), Kiechle M(1), Paepke D(1). Author information: (1)1 Techni

Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology.

25. Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Apr;134(2):95-99. doi: 10.1016/j.anorl.2016.11.001. Epub 2016 Nov 30. Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology. Laccourreye O(1), Werner A(2), Laccourreye L(2), Bonfils P(2). Author information: (1)

Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review.

6. Lupus Sci Med. 2025 Dec 31;12(2):e001803. doi: 10.1136/lupus-2025-001803. Identifying immunostimulatory herbal supplements that may flare autoimmune skin diseases: a systematic scoping review. Weiner JD(1)(2), Hill A(1)(2), Shen C(1)(2), On A(1)(2), Werth VP(3)(2). Author information: (1)Derm

A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside-a phenylethanoid glycoside.

30. Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar;398(3):2071-2106. doi: 10.1007/s00210-024-03460-6. Epub 2024 Oct 3. A systematic review of the traditional uses, chemistry, and curative aptitude of echinacoside-a phenylethanoid glycoside. Baidya R(1), Sarkar B(2). Author information: (1)Group

Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review.

47. Nutrients. 2022 Nov 1;14(21):4604. doi: 10.3390/nu14214604. Select Dietary Supplement Ingredients for Preserving and Protecting the Immune System in Healthy Individuals: A Systematic Review. Crawford C(1)(2), Brown LL(3), Costello RB(3), Deuster PA(1). Author information: (1)Consortium for H

Echinacea for the prevention and treatment of upper respiratory tract infections: A systematic review and meta-analysis.

10. Complement Ther Med. 2019 Jun;44:18-26. doi: 10.1016/j.ctim.2019.03.011. Epub 2019 Mar 19. Echinacea for the prevention and treatment of upper respiratory tract infections: A systematic review and meta-analysis. David S(1), Cunningham R(2). Author information: (1)23 Amble Grove Jesmond, New

Interaction of herbal products with prescribed medications: A systematic review and meta-analysis.

31. Pharmacol Res. 2019 Mar;141:397-408. doi: 10.1016/j.phrs.2019.01.028. Epub 2019 Jan 17. Interaction of herbal products with prescribed medications: A systematic review and meta-analysis. Awortwe C(1), Bruckmueller H(2), Cascorbi I(3). Author information: (1)Institute of Experimental and Cli

Alternative therapies for chronic rhinosinusitis: A review.

16. Ear Nose Throat J. 2018 Mar;97(3):E25-E33. Alternative therapies for chronic rhinosinusitis: A review. Griffin AS(1), Cabot P, Wallwork B, Panizza B. Author information: (1)Department of Otolaryngology-Head and Neck Surgery, Princess Alexandra Hospital, 199 Ipswich Rd., Woolloongabba, QLD 41