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Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials.

1. Adv Ther. 2019 May;36(5):1085-1099. doi: 10.1007/s12325-019-00921-w. Epub 2019 Mar 16. Efficacy of Chondroitin Sulfate in Patients with Knee Osteoarthritis: A Comprehensive Meta-Analysis Exploring Inconsistencies in Randomized, Placebo-Controlled Trials. Honvo G(1)(2), Bruyère O(3)(4), Geeri

Effects of Oral Chondroitin Sulfate on Osteoarthritis-Related Pain and Joint Structural Changes: Systematic Review and Meta-Analysis.

2. J Spec Oper Med. 2019 Spring;19(1):113-124. doi: 10.55460/JLSS-PG9B. Effects of Oral Chondroitin Sulfate on Osteoarthritis-Related Pain and Joint Structural Changes: Systematic Review and Meta-Analysis. Knapik JJ, Pope R, Hoedebecke SS, Schram B, Orr R. Osteoarthritis (OA) is a disorder invol

Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials.

3. Rheumatol Int. 2018 Aug;38(8):1413-1428. doi: 10.1007/s00296-018-4077-2. Epub 2018 Jun 11. Effect of glucosamine and chondroitin sulfate in symptomatic knee osteoarthritis: a systematic review and meta-analysis of randomized placebo-controlled trials. Simental-Mendía M(1), Sánchez-García A(2

A potential role for avocado- and soybean-based nutritional supplements in the management of osteoarthritis: a review.

4. Phys Sportsmed. 2010 Jun;38(2):71-81. doi: 10.3810/psm.2010.06.1785. A potential role for avocado- and soybean-based nutritional supplements in the management of osteoarthritis: a review. DiNubile NA(1). Author information: (1), , , , . Erratum in Phys Sportsmed. 2010 Oct;38(3):128. Ost

Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis.

5. Arch Intern Med. 2003 Jul 14;163(13):1514-22. doi: 10.1001/archinte.163.13.1514. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Richy F(1), Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Author information:

Effect of whole grain pancakes on postprandial cardiometabolic risk factors in healthy subjects: A randomized crossover trial.

6. Asia Pac J Clin Nutr. 2026 Apr;35(2):181-188. doi: 10.6133/apjcn.202604_35(2).0001. Effect of whole grain pancakes on postprandial cardiometabolic risk factors in healthy subjects: A randomized crossover trial. Ma Q(1), Sun T(1), Liu Z(1), Li D(2), Hu X(3). Author information: (1)College of

Plasma chondroitin sulfate predicts the effectiveness of fluid resuscitation strategies in patients with sepsis.

7. J Clin Invest. 2026 Feb 3;136(7):e202480. doi: 10.1172/JCI202480. eCollection 2026 Apr 1. Plasma chondroitin sulfate predicts the effectiveness of fluid resuscitation strategies in patients with sepsis. Oshima K(1), Yan B(2), Tao R(2)(3), Amorim G(2), Di Gravio C(4), McMurtry SA(5), Burke RC

Bifidobacterium animalis subsp. lactis Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis.

8. mSystems. 2025 Dec 17;10(12):e0086225. doi: 10.1128/msystems.00862-25. Epub 2025 Nov 28. Bifidobacterium animalis subsp. lactis Probio-M8 enhances chondroitin efficacy for knee osteoarthritis in postmenopausal women via the gut-joint axis. Wang K(#)(1)(2)(3)(4), Wang H(#)(5), Zhao Z(1)(2)(3)(

Randomized comparative multicenter study assessing two dispersive viscosurgical devices for cataract surgery.

9. J Cataract Refract Surg. 2026 Apr 1;52(4):339-347. doi: 10.1097/j.jcrs.0000000000001837. Randomized comparative multicenter study assessing two dispersive viscosurgical devices for cataract surgery. Fabian E(1), Janeková A, de Arriba Palomero P, Tañá-Rivero P, Böhringer D, Kretz FTA, Pašta J

Efficacy of Encorelane in Enhancing Barrier Function and Reducing Aging Signs in Sensitive Skin.

10. J Cosmet Dermatol. 2025 Sep;24(9):e70454. doi: 10.1111/jocd.70454. Efficacy of Encorelane in Enhancing Barrier Function and Reducing Aging Signs in Sensitive Skin. Wang L(1), Wang C(1), Jiang L(1), Hu H(1), Wu Y(1), Li Y(1), Sun P(1). Author information: (1)Research & Innovation Center, Proy

Randomised controlled trial: nutritional supplements to relieve irritable bowel syndrome symptoms by targeting the gut microbiota.

11. J Nutr Sci. 2025 Jul 11;14:e46. doi: 10.1017/jns.2025.10021. eCollection 2025. Randomised controlled trial: nutritional supplements to relieve irritable bowel syndrome symptoms by targeting the gut microbiota. van den Belt M(1), Liu Z(2), Janssen Duijghuijsen L(1), Zoetendal EG(2), Witteman

Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study.

12. Sci Rep. 2025 Jul 15;15(1):25625. doi: 10.1038/s41598-025-11723-2. Effects of cartilage-supporting nutritional supplementation on knee osteoarthritis symptoms and quality of life in a 12-week randomized double-blind placebo-controlled pilot study. Fladerer-Grollitsch JP(1)(2), Klein T(3), Ko

[Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations].

13. Ter Arkh. 2025 Jun 8;97(5):419-426. doi: 10.26442/00403660.2025.05.203272. [Combination therapy for exacerbations of pain in osteoarthritis with non-fixed combinations]. [Article in Russian; Abstract available in Russian from the publisher] Naumov AV(1), Unkovskiy AV(1), Khovasova NO(1), Fok

Carry-over effects in GAG therapy efficacy trial solution for bladder pain syndrome/interstitial cystitis (GETSBI study): an interim analysis.

14. BMJ Open. 2025 Jun 5;15(6):e092757. doi: 10.1136/bmjopen-2024-092757. Carry-over effects in GAG therapy efficacy trial solution for bladder pain syndrome/interstitial cystitis (GETSBI study): an interim analysis. van Ginkel C(1), Groenewoud JMM(2), Hoogeboom TJ(3), Heesakkers J(4), Martens F

Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinary tract infections: a single-blind randomized controlled trial.

15. Expert Rev Anti Infect Ther. 2025 Jul;23(7):523-530. doi: 10.1080/14787210.2025.2487162. Epub 2025 Apr 3. Adding collagen, propolis plus quercetin, bacillus coagulans, hyaluronic acid and chondroitin sulphate to D-mannose avoids symptoms and prevents recurrence in women with recurrent urinar

Stromal modifying CHST15 siRNA enhances antitumor effect synergistically with anti-PD-1 immune checkpoint antibody in murine pancreatic cancer.

33. Sci Rep. 2025 Jul 1;15(1):20365. doi: 10.1038/s41598-025-09445-6. Stromal modifying CHST15 siRNA enhances antitumor effect synergistically with anti-PD-1 immune checkpoint antibody in murine pancreatic cancer. Ye J(1)(2), Suizu F(3)(4), Yamakawa K(1), Yoneyama H(5), Kondo J(6), Kato M(7), Ni

Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer.

40. Int J Biol Macromol. 2025 Jun;311(Pt 4):144083. doi: 10.1016/j.ijbiomac.2025.144083. Epub 2025 May 9. Environmental responsive dual-drug synergistic and dual-targeted polymer micelles based on chondroitin sulfate for treatment of breast cancer. Hu L(1), Ma H(1), Yang C(1), Wang K(1), Ji X(1)

Redox-responsive chondroitin sulfate-based micelle system for enhanced chemotherapy and inflammation suppression to synergistically antitumor therapy.

5. Int J Biol Macromol. 2025 Jun;311(Pt 2):143686. doi: 10.1016/j.ijbiomac.2025.143686. Epub 2025 Apr 29. Redox-responsive chondroitin sulfate-based micelle system for enhanced chemotherapy and inflammation suppression to synergistically antitumor therapy. Long M(1), Chen W(2), Li J(2), Kong W(2

Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms.

23. Microb Pathog. 2024 Dec;197:107086. doi: 10.1016/j.micpath.2024.107086. Epub 2024 Oct 28. Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms. Priya PS(1), Murugan R(2), Srileka R(

pH and ROS Dual-Sensitive Nanocarriers for the Targeted Co-Delivery and On-Demand Sequential Release of Tofacitinib and Glucosamine for Synergistic Rheumatoid Arthritis Treatment.

27. Small. 2024 Jun;20(24):e2308520. doi: 10.1002/smll.202308520. Epub 2024 Jan 2. pH and ROS Dual-Sensitive Nanocarriers for the Targeted Co-Delivery and On-Demand Sequential Release of Tofacitinib and Glucosamine for Synergistic Rheumatoid Arthritis Treatment. Chen G(1)(2), Deng S(3), Liu S(1)

Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane.

45. Molecules. 2023 Dec 13;28(24):8068. doi: 10.3390/molecules28248068. Investigation of Drug-Interaction Potential for Arthritis Dietary Supplements: Chondroitin Sulfate, Glucosamine, and Methylsulfonylmethane. Kim SM(1), Jo SY(1), Park HY(2), Lee YR(2), Yu JS(1), Yoo HH(1). Author information:

A chondroitin sulfate proteoglycan 4‑specific monoclonal antibody inhibits melanoma cell invasion in a spheroid model.

43. Int J Oncol. 2021 Sep;59(3):70. doi: 10.3892/ijo.2021.5250. Epub 2021 Jul 28. A chondroitin sulfate proteoglycan 4‑specific monoclonal antibody inhibits melanoma cell invasion in a spheroid model. Uranowska K(1), Samadaei M(2), Kalic T(1), Pinter M(2), Breiteneder H(3), Hafner C(1). Author

The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis.

17. Minerva Med. 2019 Oct;110(5):419-424. doi: 10.23736/S0026-4806.19.06063-4. Epub 2019 Apr 1. The influence of probiotic diet and chondroitin sulfate administration on Ptgs2, Tgfb1 and Col2a1 expression in rat knee cartilage during monoiodoacetate-induced osteoarthritis. Korotkyi OH(1), Vovk

Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors.

8. PLoS One. 2019 Jan 9;14(1):e0210608. doi: 10.1371/journal.pone.0210608. eCollection 2019. Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors. Yu X(1), Dobrikov M(2), Keir ST(2), Gromeier M(2), Pastan IH(3), Reisfeld R(4), Bigner DD(1)(2), Chan

Diltiazem Promotes Regenerative Axon Growth.

27. Mol Neurobiol. 2019 Jun;56(6):3948-3957. doi: 10.1007/s12035-018-1349-5. Epub 2018 Sep 19. Diltiazem Promotes Regenerative Axon Growth. Huebner EA(1)(2), Budel S(2), Jiang Z(2), Omura T(1), Ho TS(1), Barrett L(1), Merkel JS(3), Pereira LM(4), Andrews NA(1), Wang X(2), Singh B(1), Kapur K(1),

Role of NCAN rs2228603 polymorphism in the incidence of nonalcoholic fatty liver disease: a case-control study.

35. Lipids Health Dis. 2016 Nov 26;15(1):207. doi: 10.1186/s12944-016-0367-4. Role of NCAN rs2228603 polymorphism in the incidence of nonalcoholic fatty liver disease: a case-control study. Wu MJ(1), Yuan C(1), Lu LL(2)(3), An BQ(1), Xuan SY(4)(5), Xin YN(6)(7). Author information: (1)Department

Low dose NSAIDs and sysadoas in the management of knee osteoarthritis.

20. Aging Clin Exp Res. 2025 Nov 6;37(1):317. doi: 10.1007/s40520-025-03221-2. Low dose NSAIDs and sysadoas in the management of knee osteoarthritis. Migliore A(1), De Lucia O(2), de Sire A(3)(4), Šajbidor A(5)(6), Šenolt L(7)(8), Szántó S(9), Fontova JC(10), Flechtenmacher J(11), Mobasheri A(12)

French Societies of Rheumatology and of Physical and Rehabilitation Medicine recommendations for the management of people living with hand osteoarthritis.

23. Joint Bone Spine. 2026 Mar;93(2):106000. doi: 10.1016/j.jbspin.2025.106000. Epub 2025 Nov 1. French Societies of Rheumatology and of Physical and Rehabilitation Medicine recommendations for the management of people living with hand osteoarthritis. Courties A(1), Daste C(2), Homs AF(3), Kouki

Emerging trends in anticoagulation therapy: a bibliometric analysis of DOACs and endogenous coagulation pathway inhibitors.

23. Naunyn Schmiedebergs Arch Pharmacol. 2025 Dec;398(12):17675-17693. doi: 10.1007/s00210-025-04352-z. Epub 2025 Jun 18. Emerging trends in anticoagulation therapy: a bibliometric analysis of DOACs and endogenous coagulation pathway inhibitors. Zhu Z(1), Huang R(2), He H(1), Zhao R(1), Li X(1),

Effectiveness and Safety of SYSADOAs Used in Eastern and Western Regions for the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials-SYSADOAs Are Effective and Safe for Knee OA.

13. Medicina (Kaunas). 2025 Feb 13;61(2):331. doi: 10.3390/medicina61020331. Effectiveness and Safety of SYSADOAs Used in Eastern and Western Regions for the Treatment of Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials-SYSADOAs Are Effective and Safe for