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Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysis.

1. Mol Psychiatry. 2025 Dec;30(12):6020-6032. doi: 10.1038/s41380-025-03206-7. Epub 2025 Sep 5. Transdiagnostic reduction in cortical choline-containing compounds in anxiety disorders: a (1)H-magnetic resonance spectroscopy meta-analysis. Maddock RJ(1), Smucny J(2). Author information: (1)Depar

Effects of rumen-protected choline supplementation on lactation performance of dairy cows: A systematic review and dose-response meta-analysis.

2. J Dairy Sci. 2025 Sep;108(9):9516-9534. doi: 10.3168/jds.2024-25844. Epub 2025 Jul 3. Effects of rumen-protected choline supplementation on lactation performance of dairy cows: A systematic review and dose-response meta-analysis. Ghaffari MH(1), Rezaei-Ahvanooei MR(2), Piray AH(3), Bahrampour

Does supplementation of choline during or after pregnancies exposed to alcohol improve neurocognitive development of children? A meta-analysis.

3. Pediatr Neonatol. 2025 Jul;66(4):297-304. doi: 10.1016/j.pedneo.2025.02.001. Epub 2025 Apr 4. Does supplementation of choline during or after pregnancies exposed to alcohol improve neurocognitive development of children? A meta-analysis. Lino GM(1), de Carvalho IN(1), de Amorim VOA(1), Bresan

Impact of Methyl-Donor Micronutrient Supplementation on DNA Methylation Patterns: A Systematic Review and Meta-Analysis of in vitro, Animal, and Human Studies.

4. Lifestyle Genom. 2023;16(1):192-213. doi: 10.1159/000533193. Epub 2023 Nov 7. Impact of Methyl-Donor Micronutrient Supplementation on DNA Methylation Patterns: A Systematic Review and Meta-Analysis of in vitro, Animal, and Human Studies. da Mota JCNL(1), Ribeiro AA(1), Carvalho LM(1), Esteves

Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-Analysis.

5. Nutrients. 2023 Jan 12;15(2):386. doi: 10.3390/nu15020386. Is Citicoline Effective in Preventing and Slowing Down Dementia?-A Systematic Review and a Meta-Analysis. Bonvicini M(1), Travaglini S(2), Lelli D(3)(4), Antonelli Incalzi R(3)(5), Pedone C(3)(4). Author information: (1)Training Prog

Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies.

6. Adv Nutr. 2022 Dec 22;13(6):2445-2457. doi: 10.1093/advances/nmac082. Association between Maternal Choline, Fetal Brain Development, and Child Neurocognition: Systematic Review and Meta-Analysis of Human Studies. Obeid R(1), Derbyshire E(2), Schön C(3). Author information: (1)Department of Cl

ESPEN micronutrient guideline.

7. Clin Nutr. 2022 Jun;41(6):1357-1424. doi: 10.1016/j.clnu.2022.02.015. Epub 2022 Feb 26. ESPEN micronutrient guideline. Berger MM(1), Shenkin A(2), Schweinlin A(3), Amrein K(4), Augsburger M(5), Biesalski HK(6), Bischoff SC(7), Casaer MP(8), Gundogan K(9), Lepp HL(10), de Man AME(11), Muscogi

Meta-analysis of the effects of supplemental rumen-protected choline during the transition period on performance and health of parous dairy cows.

8. J Dairy Sci. 2020 Jan;103(1):282-300. doi: 10.3168/jds.2019-16842. Epub 2019 Oct 31. Meta-analysis of the effects of supplemental rumen-protected choline during the transition period on performance and health of parous dairy cows. Arshad U(1), Zenobi MG(1), Staples CR(1), Santos JEP(2). Auth

Choline and betaine consumption lowers cancer risk: a meta-analysis of epidemiologic studies.

9. Sci Rep. 2016 Oct 19;6:35547. doi: 10.1038/srep35547. Choline and betaine consumption lowers cancer risk: a meta-analysis of epidemiologic studies. Sun S(1), Li X(2), Ren A(1), Du M(3)(4), Du H(5), Shu Y(1), Zhu L(1), Wang W(6). Author information: (1)Department of Oncology, The First Affilia

Effect of dietary rumen-protected choline on milk production of dairy cows: a meta-analysis.

10. J Dairy Sci. 2010 Aug;93(8):3746-54. doi: 10.3168/jds.2010-3106. Effect of dietary rumen-protected choline on milk production of dairy cows: a meta-analysis. Sales J(1), Homolka P, Koukolová V. Author information: (1)Department of Nutrition and Feeding of Farm Animals, Institute of Animal S

Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.

11. Am J Clin Nutr. 2026 Apr;123(4):101236. doi: 10.1016/j.ajcnut.2026.101236. Epub 2026 Feb 11. Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study. Trujillo-Gonza

Oral Choline Reduced Working Memory-Related Brain Activation in Postmenopausal Women: A Pilot Study.

12. Nutrients. 2026 Jan 30;18(3):459. doi: 10.3390/nu18030459. Oral Choline Reduced Working Memory-Related Brain Activation in Postmenopausal Women: A Pilot Study. Dumas JA(1), Testo A(1), Miller AS(1), Ozahl A(1), Potts C(2), Zhang J(3), Aboukhatwa M(4), Boyd J(5). Author information: (1)Depar

First-line [(18)F]F-choline PET/CT in primary hyperparathyroidism: a cost-effectiveness study from the diagnostic randomized APACH2 trial.

13. Eur J Nucl Med Mol Imaging. 2026 Apr;53(5):3291-3296. doi: 10.1007/s00259-025-07728-8. Epub 2026 Jan 6. First-line [(18)F]F-choline PET/CT in primary hyperparathyroidism: a cost-effectiveness study from the diagnostic randomized APACH2 trial. Quak E(1), Lasne-Cardon A(2), Cavarec M(3), Jegou

Assessment of vitamin A, vitamin B(2), vitamin B(12), vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial.

14. Eur J Nutr. 2025 Dec 19;65(1):9. doi: 10.1007/s00394-025-03814-7. Assessment of vitamin A, vitamin B(2), vitamin B(12), vitamin K, folate, and choline status following 4 months of multinutrient supplementation in healthy vegans: a randomised, double-blind, placebo-controlled trial. Zerback T

Plasma and Urinary TMAO and Methylamine Responses to Meat and Egg Ingestion: Links to Gut Microbiota Composition in Subjects With and Without Metabolic Syndrome.

15. Nutrients. 2025 Nov 27;17(23):3719. doi: 10.3390/nu17233719. Plasma and Urinary TMAO and Methylamine Responses to Meat and Egg Ingestion: Links to Gut Microbiota Composition in Subjects With and Without Metabolic Syndrome. Hefni ME(1)(2), Esberg A(3), Hellström P(4), Johansson I(3), Witthöft

Comparative Bioavailability of Vitamin C After Short-Term Consumption of Raw Fruits and Vegetables and Their Juices: A Randomized Crossover Study.

31. Nutrients. 2025 Oct 23;17(21):3331. doi: 10.3390/nu17213331. Comparative Bioavailability of Vitamin C After Short-Term Consumption of Raw Fruits and Vegetables and Their Juices: A Randomized Crossover Study. Choi M(1)(2), Baek J(2), Yun JM(3), Hong YS(3), Park E(2). Author information: (1)RI

A pilot and feasibility analysis of serum TMAO and choline in a randomized sample from the COSMOS trial.

38. Food Funct. 2025 Nov 10;16(22):8791-8800. doi: 10.1039/d5fo02596f. A pilot and feasibility analysis of serum TMAO and choline in a randomized sample from the COSMOS trial. Gavilán IS(1)(2), Li S(1), Sweet MG(3), Ratliff JG(3), Rist PM(1)(4), Kim E(1), Manson JE(1)(4), Sesso HD(1)(4), Neilson

Citicoline-Amantadine Trial in Traumatic Brain Injury: A Prospective Randomized Study.

3. J Neurotrauma. 2026 Jan;43(1-2):68-77. doi: 10.1177/08977151251375914. Epub 2025 Oct 1. Citicoline-Amantadine Trial in Traumatic Brain Injury: A Prospective Randomized Study. Badre DSEM(1), Elbeialy MAK(1), Fathy M(2). Author information: (1)Department of Anesthesia, ICU and Pain, Ain Shams

Effect of Daily Incorporation of Eggs in a Heart-Healthy Diet for 8 Weeks Compared with Their Exclusion on Cardio-Metabolic Risk Factors in Adults with Hyperlipidemia: A Randomized, Controlled, Crossover Trial.

50. J Am Nutr Assoc. 2026 Mar-Apr;45(3):237-249. doi: 10.1080/27697061.2025.2560431. Epub 2025 Sep 16. Effect of Daily Incorporation of Eggs in a Heart-Healthy Diet for 8 Weeks Compared with Their Exclusion on Cardio-Metabolic Risk Factors in Adults with Hyperlipidemia: A Randomized, Controlled,

Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial.

5. Obesity (Silver Spring). 2025 Sep;33(9):1694-1703. doi: 10.1002/oby.24354. Epub 2025 Jul 16. Benefits of Krill Oil Supplementation During Alternate-Day Fasting in Adults With Overweight and Obesity: A Randomized Trial. Alblaji M(1)(2), Gray SR(3)(4), Almesbehi T(1), Morrison DJ(5), Malkova D(

Synergistic effects of DHA and choline delivered via co-encapsulated microcapsules in infant formula Rice cereal: Enhanced cognitive function and molecular mechanisms in mice.

6. Food Res Int. 2026 Feb 1;225:118164. doi: 10.1016/j.foodres.2025.118164. Epub 2025 Dec 21. Synergistic effects of DHA and choline delivered via co-encapsulated microcapsules in infant formula Rice cereal: Enhanced cognitive function and molecular mechanisms in mice. Liu X(1), Xie Z(2), Zhang

Angelica sinensis and Scutellaria baicalensis synergistically alleviates metabolic dysfunction-associated steatohepatitis via promoting adipose tissue-to-liver tissue communication.

5. Phytomedicine. 2025 Nov 25;148:157329. doi: 10.1016/j.phymed.2025.157329. Epub 2025 Sep 24. Angelica sinensis and Scutellaria baicalensis synergistically alleviates metabolic dysfunction-associated steatohepatitis via promoting adipose tissue-to-liver tissue communication. Zhao M(1), Tao X(1

Neurotoxic synergy of copper and PVC microplastics triggers apoptosis via the BDNF/miR132/FOXO3a pathway for the first time in fish brain.

30. Comp Biochem Physiol C Toxicol Pharmacol. 2025 Nov;297:110265. doi: 10.1016/j.cbpc.2025.110265. Epub 2025 Jul 10. Neurotoxic synergy of copper and PVC microplastics triggers apoptosis via the BDNF/miR132/FOXO3a pathway for the first time in fish brain. Bakhasha J(1), Saxena V(1), Arya N(1),

The synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats.

3. Mol Biol Rep. 2025 Jan 30;52(1):176. doi: 10.1007/s11033-025-10255-2. The synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats. Abdel-Aziz N(1), El-Bahkery A(1), Ibrahim EA(2). Author information: (1)Radiation Biology Research D

Potentiation of Imipramine-Induced Anti-hyperalgesic and Anti-Nociceptive Effects by Citicoline in the Sciatic Nerve Ligated Mice.

9. Arch Iran Med. 2024 Aug 1;27(8):456-464. doi: 10.34172/aim.28772. Epub 2024 Aug 1. Potentiation of Imipramine-Induced Anti-hyperalgesic and Anti-Nociceptive Effects by Citicoline in the Sciatic Nerve Ligated Mice. Raissi-Dehkordi N(1), Raissi-Dehkordi N(1), Hajikarimloo B(1), Khakpai F(2)(3),

The additive effect between bupropion and citicoline upon induction of anti-nociceptive effect in nerve-ligated mice.

40. Neurol Res. 2024 Oct;46(10):939-946. doi: 10.1080/01616412.2024.2370203. Epub 2024 Jul 3. The additive effect between bupropion and citicoline upon induction of anti-nociceptive effect in nerve-ligated mice. Raissi-Dehkordi N(1), Hajikarimloo B(1), Raissi-Dehkordi N(1), Khakpai F(2), Zarrin

A Metabolomic Analysis of Sensitivity and Specificity of 23 Previously Proposed Biomarkers for Renal Transporter-Mediated Drug-Drug Interactions.

32. Clin Pharmacol Ther. 2023 Nov;114(5):1058-1072. doi: 10.1002/cpt.3017. Epub 2023 Aug 18. A Metabolomic Analysis of Sensitivity and Specificity of 23 Previously Proposed Biomarkers for Renal Transporter-Mediated Drug-Drug Interactions. Gessner A(1), Müller F(1)(2), Wenisch P(3), Heinrich MR(3

[Drug synergism as a basis for rational neuroprotection].

42. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(5):17-22. doi: 10.17116/jnevro202212205117. [Drug synergism as a basis for rational neuroprotection]. [Article in Russian; Abstract available in Russian from the publisher] Putilina MV(1), Teplova NV(1). Author information: (1)Pirogov Russian N

Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs.

38. Pharm Biol. 2022 Dec;60(1):359-373. doi: 10.1080/13880209.2022.2036767. Evodiamine decreased the systemic exposure of pravastatin in non-alcoholic steatohepatitis rats due to the up-regulation of hepatic OATPs. Liang R(1)(2), Ge W(1), Li B(1)(2), Cui W(1), Ma X(1), Pan Y(1), Li G(1). Author

Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine.

46. J Neurochem. 2022 Jan;160(2):172-184. doi: 10.1111/jnc.15553. Epub 2021 Dec 15. Hydromethylthionine enhancement of central cholinergic signalling is blocked by rivastigmine and memantine. Kondak C(1)(2), Riedel G(1), Harrington CR(1)(3), Wischik CM(1)(3), Klein J(2). Author information: (1)I