버터버 (페타사이트)

Efficacy and Safety of Phytotherapy and Anthroposophic Medicine in Seasonal Allergic Rhinitis: A Systematic Review.

1. Int Arch Allergy Immunol. 2025;186(1):75-86. doi: 10.1159/000539645. Epub 2024 Jul 31. Efficacy and Safety of Phytotherapy and Anthroposophic Medicine in Seasonal Allergic Rhinitis: A Systematic Review. Braunwalder C(1), Ertl J(1), Wullschleger M(1), Timm E(1), Wolf U(1). Author information:

Medicinal plants for allergic rhinitis: A systematic review and meta-analysis.

2. PLoS One. 2024 Apr 11;19(4):e0297839. doi: 10.1371/journal.pone.0297839. eCollection 2024. Medicinal plants for allergic rhinitis: A systematic review and meta-analysis. Lim XY(1), Lau MS(1), Zolkifli NA(1), Sastu Zakaria UR(1), Mohd Rahim NS(1), Lai NM(2)(3), Tan TYC(1). Author information:

Foods and supplements in the management of migraine headaches.

3. Clin J Pain. 2009 Jun;25(5):446-52. doi: 10.1097/AJP.0b013e31819a6f65. Foods and supplements in the management of migraine headaches. Sun-Edelstein C(1), Mauskop A. Author information: (1)The New York Headache Center, New York, NY 10021, USA. drsun@nyheadache.com OBJECTIVE: Although a wide ra

Herbal medicines for the treatment of allergic rhinitis: a systematic review.

4. Ann Allergy Asthma Immunol. 2007 Dec;99(6):483-95. doi: 10.1016/S1081-1206(10)60375-4. Herbal medicines for the treatment of allergic rhinitis: a systematic review. Guo R(1), Pittler MH, Ernst E. Author information: (1)Department of Complementary Medicine, Peninsula Medical School, University

Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review.

5. Phytomedicine. 2006 Nov;13(9-10):743-6. doi: 10.1016/j.phymed.2006.02.008. Epub 2006 Sep 20. Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review. Agosti R(1), Duke RK, Chrubasik JE, Chrubasik S. Author information: (1)Headache Center Hirslande

Butterbur: an evidence-based systematic review by the natural standard research collaboration.

6. J Herb Pharmacother. 2005;5(3):119-43. Butterbur: an evidence-based systematic review by the natural standard research collaboration. Giles M(1), Ulbricht C, Khalsa KP, Kirkwood CD, Park C, Basch E; National Standard Research Collaboration. Author information: (1)University of Rhode Island,

Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study.

7. Phytomedicine. 2018 Jan 15;39:85-92. doi: 10.1016/j.phymed.2017.12.005. Epub 2017 Dec 12. Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study. Meier S(1), Haschke M(2), Za

Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial.

8. Phytother Res. 2009 Sep;23(9):1303-8. doi: 10.1002/ptr.2771. Fixed herbal drug combination with and without butterbur (Ze 185) for the treatment of patients with somatoform disorders: randomized, placebo-controlled pharmaco-clinical trial. Melzer J(1), Schrader E, Brattström A, Schellenberg R

Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study.

9. Eur J Pain. 2008 Apr;12(3):301-13. doi: 10.1016/j.ejpain.2007.06.003. Epub 2007 Jul 30. Butterbur root extract and music therapy in the prevention of childhood migraine: an explorative study. Oelkers-Ax R(1), Leins A, Parzer P, Hillecke T, Bolay HV, Fischer J, Bender S, Hermanns U, Resch F.

The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions.

10. J Investig Allergol Clin Immunol. 2006;16(3):156-61. The butterbur extract petasin has no effect on skin test reactivity induced by different stimuli: a randomized, double-blind crossover study using histamine, codeine, methacholine, and aeroallergen solutions. Gex-Collet C(1), Imhof L, Brat

Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339.

11. Phytother Res. 2005 Jun;19(6):530-7. doi: 10.1002/ptr.1705. Treating intermittent allergic rhinitis: a prospective, randomized, placebo and antihistamine-controlled study of Butterbur extract Ze 339. Schapowal A(1); Study Group. Author information: (1)Allergy Clinic, Landquart, Switzerland.

Petasites hybridus root (butterbur) is an effective preventive treatment for migraine.

12. Neurology. 2004 Dec 28;63(12):2240-4. doi: 10.1212/01.wnl.0000147290.68260.11. Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Lipton RB(1), Göbel H, Einhäupl KM, Wilks K, Mauskop A. Author information: (1)Department of Neurology, Albert Einstein Colleg

Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study.

13. Arch Otolaryngol Head Neck Surg. 2004 Dec;130(12):1381-6. doi: 10.1001/archotol.130.12.1381. Butterbur Ze339 for the treatment of intermittent allergic rhinitis: dose-dependent efficacy in a prospective, randomized, double-blind, placebo-controlled study. Schapowal A(1); Petasites Study Gro

Effects of butterbur treatment in intermittent allergic rhinitis: a placebo-controlled evaluation.

14. Ann Allergy Asthma Immunol. 2004 Jul;93(1):56-60. doi: 10.1016/S1081-1206(10)61447-0. Effects of butterbur treatment in intermittent allergic rhinitis: a placebo-controlled evaluation. Gray RD(1), Haggart K, Lee DK, Cull S, Lipworth BJ. Author information: (1)Asthma & Allergy Research Group

A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis.

15. Clin Exp Allergy. 2004 Apr;34(4):646-9. doi: 10.1111/j.1365-2222.2004.1903.x. A placebo-controlled evaluation of butterbur and fexofenadine on objective and subjective outcomes in perennial allergic rhinitis. Lee DK(1), Gray RD, Robb FM, Fujihara S, Lipworth BJ. Author information: (1)Asthma

The effects of butterbur on the histamine and allergen cutaneous response.

25. Ann Allergy Asthma Immunol. 2004 Feb;92(2):250-4. doi: 10.1016/S1081-1206(10)61556-6. The effects of butterbur on the histamine and allergen cutaneous response. Jackson CM(1), Lee DK, Lipworth BJ. Author information: (1)Tayside Centre for General Practice, University of Dundee, Dundee, Scotl

Protective Effects of a Propolis-Petasites japonicus Mixture on Scopolamine-Induced Memory Impairment in Mice.

3. J Microbiol Biotechnol. 2026 Apr 27;36:e2602019. doi: 10.4014/jmb.2602.02019. Protective Effects of a Propolis-Petasites japonicus Mixture on Scopolamine-Induced Memory Impairment in Mice. Kim MY(1)(2), Shin JY(3), Lim JH(3), Park JH(3), Hur YK(1), Yun SI(2), Cho BO(3), Jang SI(3)(4). Author

Genotoxic potential of Dianthus superbus var. superbus and Petasites paradoxus (Retz.) Baumg. methanolic extracts in Chinese hamster ovary cells.

12. Sci Rep. 2026 Apr 24;16(1):13641. doi: 10.1038/s41598-026-50267-x. Genotoxic potential of Dianthus superbus var. superbus and Petasites paradoxus (Retz.) Baumg. methanolic extracts in Chinese hamster ovary cells. Al-Naqeb G(1)(2), De Giuseppe R(3), Kalmpourtzidou A(3), Avesani L(4), Cena H(3

Petasites japonicus Leaves Alleviate Depression in Dextran Sulfate Sodium-Induced Colitis Mice Through the BDNF/TrkB Pathway and Modulation of Inflammation.

37. Int J Mol Sci. 2026 Apr 4;27(7):3274. doi: 10.3390/ijms27073274. Petasites japonicus Leaves Alleviate Depression in Dextran Sulfate Sodium-Induced Colitis Mice Through the BDNF/TrkB Pathway and Modulation of Inflammation. Na HR(1), Lee HL(1), Choi HJ(1), Heo YM(1), Ju YH(1), Kim HJ(1), Heo H

Salvia pratensis exhibits in vitro anti-cancer effects in triple-negative breast cancer through miR-34a-5p signaling.

4. Front Nutr. 2026 Mar 18;13:1786148. doi: 10.3389/fnut.2026.1786148. eCollection 2026. Salvia pratensis exhibits in vitro anti-cancer effects in triple-negative breast cancer through miR-34a-5p signaling. Gervasoni C(1)(2), Ceriani C(1)(2)(3), Lanzotti A(1)(2), Negri S(2)(4), Guzzo F(2)(4), P

Efficacy of Petasites hybridus in migraine prophylaxis: the first real-world study.

3. Front Neurol. 2026 Mar 12;17:1784624. doi: 10.3389/fneur.2026.1784624. eCollection 2026. Efficacy of Petasites hybridus in migraine prophylaxis: the first real-world study. Silva-Néto RP(1). Author information: (1)Department of Neurology, Federal University of the Parnaíba Delta, Parnaíba,

Clinical impact of butterbur shoot extract in dogs with oral melanoma: a combined phase 1 and 2 clinical trial.

13. BMC Vet Res. 2026 Feb 20;22(1):191. doi: 10.1186/s12917-026-05326-w. Clinical impact of butterbur shoot extract in dogs with oral melanoma: a combined phase 1 and 2 clinical trial. Noguchi S(1)(2), Furuya M(3), Honda K(4), Ito R(4), Akao Y(5). Author information: (1)Veterinary Medical Center

Evaluation of the antimigraine and anti-neuroinflammatory activity of purified constituents of Petasites hybridus L. in a migraine-like pain model in mice.

16. Inflammopharmacology. 2026 Feb;34(2):1159-1172. doi: 10.1007/s10787-025-02107-z. Epub 2026 Jan 20. Evaluation of the antimigraine and anti-neuroinflammatory activity of purified constituents of Petasites hybridus L. in a migraine-like pain model in mice. Kulinowski Ł(1), Targowska-Duda K(2),

Anti-Photoaging Effects of a Standardized Hot Water Extract of Petasites japonicus Leaves in Ultraviolet B-Exposed Hairless Mice.

20. Pharmaceuticals (Basel). 2025 Oct 3;18(10):1490. doi: 10.3390/ph18101490. Anti-Photoaging Effects of a Standardized Hot Water Extract of Petasites japonicus Leaves in Ultraviolet B-Exposed Hairless Mice. Song HA(1)(2), Park MJ(1)(2), Lee CW(1)(2), Park S(3), Lee JK(2), Chung KS(1), Lee KT(1)

Petasites japonicus-propolis mixture attenuates airway inflammation in a mouse model of PM(10) and ovalbumin-induced respiratory disease.

21. Exp Ther Med. 2025 Aug 14;30(4):200. doi: 10.3892/etm.2025.12950. eCollection 2025 Oct. Petasites japonicus-propolis mixture attenuates airway inflammation in a mouse model of PM(10) and ovalbumin-induced respiratory disease. Park JH(1), Shin JY(2), Che DN(2), Kim MY(1)(3), Hur YK(1), Song G

Efficacy and Safety of P. hybridus Leaf Extract Ze 339 for the Treatment of Allergic Rhinitis.

24. Adv Respir Med. 2025 Jun 3;93(3):13. doi: 10.3390/arm93030013. Efficacy and Safety of P. hybridus Leaf Extract Ze 339 for the Treatment of Allergic Rhinitis. Merk VM(1), Boonen G(1), Butterweck V(1), Schapowal A(2). Author information: (1)Medical Department, Max Zeller Söhne AG, 8590 Romansh

Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice.

7. J Med Food. 2010 Oct;13(5):1216-23. doi: 10.1089/jmf.2009.1380. Butterbur (Petasites japonicus Max.) extract improves lipid profiles and antioxidant activities in monosodium L-glutamate-challenged mice. Park CH(1), Kim MY, Sok DE, Kim JH, Lee JH, Kim MR. Author information: (1)College of Phar

Green Synthesis of New Derivatives of Iminothiazole Using Cefixime and Removing Organic Pollutants from Aqueous Environment by Employing Cu@KF/Clinoptilolite NPs.

27. Comb Chem High Throughput Screen. 2025;28(16):2794-2809. doi: 10.2174/0113862073298128240918110357. Green Synthesis of New Derivatives of Iminothiazole Using Cefixime and Removing Organic Pollutants from Aqueous Environment by Employing Cu@KF/Clinoptilolite NPs. Zamani-Hargalani F(1), Shafa

Inhibition of SARS-CoV-2 infection and replication by Petasites hybridus CO2-extract (Ze 339).

18. Biomed Pharmacother. 2024 Jan;170:115959. doi: 10.1016/j.biopha.2023.115959. Epub 2023 Dec 7. Inhibition of SARS-CoV-2 infection and replication by Petasites hybridus CO2-extract (Ze 339). Jakwerth CA(1), Grass V(2), Erb A(3), Pichlmair A(2), Boonen G(4), Butterweck V(4), Schmidt-Weber CB(3