흑마늘
Black Garlic
📚 관련 논문 (18편)
1. Nutrients. 2023 Aug 23;15(17):3691. doi: 10.3390/nu15173691. Antihypertensive Effects of an Optimized Aged Garlic Extract in Subjects with Grade I Hypertension and Antihypertensive Drug Therapy: A Randomized, Triple-Blind Controlled Trial. Serrano JCE(1), Castro-Boqué E(2), García-Carrasco A(
2. Nutrients. 2022 Jan 18;14(3):405. doi: 10.3390/nu14030405. Effects of an Optimized Aged Garlic Extract on Cardiovascular Disease Risk Factors in Moderate Hypercholesterolemic Subjects: A Randomized, Crossover, Double-Blind, Sustainedand Controlled Study. Valls RM(1), Companys J(2), Calderón-P
3. Molecules. 2021 Mar 30;26(7):1924. doi: 10.3390/molecules26071924. The Inhibitory Effects of Plant Derivate Polyphenols on the Main Protease of SARS Coronavirus 2 and Their Structure-Activity Relationship. Nguyen TTH(1), Jung JH(2), Kim MK(2), Lim S(2), Choi JM(3), Chung B(3), Kim DW(4), Kim
4. Curr Diabetes Rev. 2024;20(3):e290823220467. doi: 10.2174/1573399820666230829103016. Types of Nursing Intervention on Improving Quality of Life among Patients with Diabetes Mellitus: A Systematic Review. Alam AS(1), Samiasih A(1), Mubin MF(1), Pranata S(1), Dhamanik R(1). Author information:
1. Am J Clin Nutr. 2024 Feb;119(2):511-526. doi: 10.1016/j.ajcnut.2023.10.016. Epub 2023 Dec 29. Measuring diet by metabolomics: a 14-d controlled feeding study of weighed food intake. Playdon MC(1), Tinker LF(2), Prentice RL(2), Loftfield E(3), Hayden KM(4), Van Horn L(5), Sampson JN(3), Stolzenberg-Solomon R(3), Lampe JW(2), Neuhouser ML(2), Moore SC(6). Author information: (1)Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT; Department of Population Health Sciences, University of Utah, Salt Lake City, UT; Cancer Control and Population Sciences Division, Huntsman Cancer Institute, Salt Lake City, UT; Division of Cancer Epidemiology and Genetics, National Cancer institute, Rockville, MD. (2)Cancer Prevention Program, Division of Public Health Sciences, Fred Hutchinson Cancer Center and University of Washington, Seattle, WA. (3)Division of Cancer Epidemiology and Genetics, National Cancer institute, Rockville, MD. (4)School of Medicine, Wake Forest Baptist Medical Center, Winston-Salem, NC. (5)Feinberg School of Medicine, Northwestern University, Chicago IL. (6)Division of Cancer Epidemiology and Genetics, National Cancer institute, Rockville, MD. Electronic address: moorest@mail.nih.gov. Comment in Am J Clin Nutr. 2024 Feb;119(2):244-245. doi: 10.1016/j.ajcnut.2023.11.021. BACKGROUND: Metabolomics has the potential to enhance dietary assessment by revealing objective measures of many aspects of human food intake. Although metabolomics studies indicate that hundreds of metabolites are associated with dietary intake, correlations have been modest (e.g., r < 0.50), and few have been evaluated in controlled feeding studies. OBJECTIVES: The aim of this study was to evaluate associations between metabolites and weighed food and beverage intake in a controlled feeding study of habitual diet. METHODS: Healthy postmenopausal females from the Women's Health Initiative (N = 153) were provided with a customized 2-wk controlled diet designed to emulate their usual diet. Metabolites were measured by liquid chromatography tandem mass spectrometry in end-of-study 24-h urine and fasting serum samples (1293 urine metabolites; 1113 serum metabolites). We calculated partial Pearson correlations between these metabolites and intake of 65 food groups, beverages, and supplements during the feeding study. The threshold for significance was Bonferroni-adjusted to account for multiple testing (5.94 × 10-07 for urine metabolites; 6.91 × 10-07 for serum metabolites). RESULTS: Significant diet-metabolite correlations were identified for 23 distinct foods, beverages, and supplements (171 distinct metabolites). Among foods, strong metabolite correlations (r ≥ 0.60) were evident for citrus (highest r = 0.80), dairy (r = 0.65), and broccoli (r = 0.63). Among beverages and supplements, strong correlations were evident for coffee (r = 0.86), alcohol (r = 0.69), multivitamins (r = 0.69), and vitamin E supplements (r = 0.65). Moderate correlations (r = 0.50-0.60) were also observed for avocado, fish, garlic, grains, onion, poultry, and black tea. Correlations were specific; each metabolite correlated with one food, beverage, or supplement, except for metabolites correlated with juice or multivitamins. CONCLUSIONS: Metabolite levels had moderate to strong correlations with weighed intake of habitually consumed foods, beverages, and supplements. These findings exceed in magnitude those previously observed in population studies and exemplify the strong potential of metabolomics to contribute to nutrition research. The Women's Health Initiative is registered at clinicaltrials.gov as NCT00000611. Copyright © 2023. Published by Elsevier Inc. DOI: 10.1016/j.ajcnut.2023.10.016 PMCID: PMC10884612 PMID: 38212160 [Indexed for MEDLINE]
2. Nutrients. 2018 Jun 24;10(7):812. doi: 10.3390/nu10070812. Allicin Bioavailability and Bioequivalence from Garlic Supplements and Garlic Foods. Lawson LD(1), Hunsaker SM(2). Author information: (1)Mérieux NutriSciences Corporate Office (Silliker, Inc.), 111 E. Wacker Dr. Ste. 2300, Chicago, IL 60601, USA. llawson2323@yahoo.com. (2)Mérieux NutriSciences Corporate Office (Silliker, Inc.), 111 E. Wacker Dr. Ste. 2300, Chicago, IL 60601, USA. scott.huns@gmail.com. Allicin is considered responsible for most of the pharmacological activity of crushed raw garlic cloves. However, when garlic supplements and garlic foods are consumed, allicin bioavailability or bioequivalence (ABB) has been unknown and in question because allicin formation from alliin and garlic alliinase usually occurs after consumption, under enzyme-inhibiting gastrointestinal conditions. The ABB from 13 garlic supplements and 9 garlic foods was determined by bioassay for 13 subjects by comparing the area under the 32-h concentration curve of breath allyl methyl sulfide (AMS), the main breath metabolite of allicin, to the area found after consuming a control (100% ABB) of known allicin content: homogenized raw garlic. For enteric tablets, ABB varied from 36⁻104%, but it was reduced to 22⁻57% when consumed with a high-protein meal, due to slower gastric emptying. Independent of meal type, non-enteric tablets gave high ABB (80⁻111%), while garlic powder capsules gave 26⁻109%. Kwai garlic powder tablets, which have been used in a large number of clinical trials, gave 80% ABB, validating it as representing raw garlic in those trials. ABB did not vary with alliinase activity, indicating that only a minimum level of activity is required. Enteric tablets (high-protein meal) disintegrated slower in women than men. The ABB of supplements was compared to that predicted in vitro by the dissolution test in the United States Pharmacopeia (USP); only partial agreement was found. Cooked or acidified garlic foods, which have no alliinase activity, gave higher ABB than expected: boiled (16%), roasted (30%), pickled (19%), and acid-minced (66%). Black garlic gave 5%. The mechanism for the higher than expected ABB for alliinase-inhibited garlic was explored; the results for an alliin-free/allicin-free extract indicate a partial role for the enhanced metabolism of γ-glutamyl S-allylcysteine and S-allylcysteine to AMS. In conclusion, these largely unexpected results (lower ABB for enteric tablets and higher ABB for all other products) provide guidelines for the qualities of garlic products to be used in future clinical trials and new standards for manufacturers of garlic powder supplements. They also give the consumer an awareness of how garlic foods might compare to the garlic powder supplements used to establish any allicin-related health benefit of garlic. DOI: 10.3390/nu10070812 PMCID: PMC6073756 PMID: 29937536 [Indexed for MEDLINE] Conflict of interest statement: The authors declare no conflict of interest.
3. Nutrition. 2014 Sep;30(9):1034-9. doi: 10.1016/j.nut.2014.02.014. Epub 2014 Mar 12. Reduction of blood lipid parameters by a 12-wk supplementation of aged black garlic: a randomized controlled trial. Jung ES(1), Park SH(1), Choi EK(1), Ryu BH(2), Park BH(3), Kim DS(4), Kim YG(5), Chae SW(6). Author information: (1)Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonbuk, Republic of Korea. (2)Doul Farming Corporation, Namhae Gohyun Chamyeon, Kyungnam, Republic of Korea. (3)Department of Biochemistry, Chonbuk National University Medical School, Jeonbuk, Republic of Korea. (4)Department of Laboratory Medicine, Chonbuk National University Medical School, Jeonbuk, Republic of Korea. (5)Department of Urology, Chonbuk National University Medical School, Jeonbuk, Republic of Korea. (6)Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonbuk, Republic of Korea; Department of Pharmacology, Chonbuk National University Medical School, Jeonbuk, Republic of Korea. Electronic address: soowan@jbnu.ac.kr. OBJECTIVE: The cholesterol-lowering effects of garlic as part of a healthy diet remain controversial. The aim of this study was to investigate whether supplementation with aged black garlic (ABG) could improve blood lipid profiles in patients with mild hypercholesterolemia. METHODS: We conducted a double-blind, randomized placebo-controlled trial. Sixty participants were randomly assigned to receive either ABG or placebo twice daily (total 6 g/d) before consumption of a meal every morning and evening for 12 wk. During the study, two participants dropped out of the ABG group, and three participants dropped out of the placebo group. Thus, the effects of AGB on fasting blood levels of lipids were evaluated in 28 participants and compared with the placebo group (n = 27). RESULTS: Among lipid components, no significant differences in triglycerides, low-density lipoprotein cholesterol, total cholesterol, or free fatty acid levels were observed between the two groups. However, ABG increased high-density lipoprotein cholesterol levels compared with the placebo group at the end of the study. Moreover, a significant decrease in the levels of alipoprotein B and a significant increase in the ratio of low-density lipoprotein cholesterol/alipoprotein B were observed in the ABG group. No adverse effects were reported in any of the patients. CONCLUSION: ABG supplementation reduced atherogenic markers and thus may have a cardioprotective effect beyond the gold standard medication in patients with mild hypercholesterolemia. Copyright © 2014 Elsevier Inc. All rights reserved. DOI: 10.1016/j.nut.2014.02.014 PMID: 24976429 [Indexed for MEDLINE]
4. Antiinflamm Antiallergy Agents Med Chem. 2014 Mar;13(1):68-74. doi: 10.2174/18715230113129990013. Effect of Nigella sativa and Allium sativum coadminstered with simvastatin in dyslipidemia patients: a prospective, randomized, double-blind trial. Ahmad Alobaidi AH(1). Author information: (1)Department of Biochemistry, Tikrit University, College of Medicine, Alyarmook ST, 12112, Tikrit, Iraq. aminahamed2006@yahoo.com. Dyslipidemia plays an important role in the provocation of cardiovascular disease. Psoriasis was associated with metabolic disorder and therefore the present study was performed to evaluate the therapeutic effect of combination of blackseed with garlic as a treatment for dyslipidemia. A randomized, double-blind, placebo controlled, two arms parallel study consisted of 4 week diet stabilization period that included a 4 week base line evaluation phase, followed by an 8 week treatment period. The study comprised men (n=127) and women (n=131) aged 24 to 57 years, who met the NCEP ATP III criteria for drug treatment of hyperlipidemia and dietary intervention. Three hundred patients were randomized to treatment and 258 completed the study. The lipid profile included total cholesterol, HDL-C, Non-HDL-C, LDL-C, and Triglyceride. There were no significant differences between the two treatment groups at the baseline for triglyceride, HDL, Non-HDL, LDL and total cholesterol. Following 8 weeks treatment with simvastatin plus placebo the reduction in Non-HDL, triglyceride, LDL and total cholesterol following treatment course was statistically highly significant (P= <0.01). However, the increase in HDL was significant (P=0.02). Patients who received simvastatin, plus black seed and garlic for 8 weeks of treatment show significant differences between baseline and after treatment course for all tested profiles (P=<0.01). This comparison of mean values reveals a high significant difference (P=<0.01) for cholesterol, triglyceride, Non-HDL, and LDL, and significant difference (P=0.03) for HDL between the two treatment groups. This study suggests that the evaluated combination was effective in correction of dyslipidemia. Large scale clinical trials comparing different doses are warranted. DOI: 10.2174/18715230113129990013 PMID: 23848231 [Indexed for MEDLINE]
5. Mol Neurobiol. 2011 Oct;44(2):142-59. doi: 10.1007/s12035-011-8168-2. Epub 2011 Mar 1. Neuroprotection by spice-derived nutraceuticals: you are what you eat! Kannappan R(1), Gupta SC, Kim JH, Reuter S, Aggarwal BB. Author information: (1)Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Numerous lines of evidence indicate that chronic inflammation plays a major role in the development of various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, brain tumor, and meningitis. Why these diseases are more common among people from some countries than others is not fully understood, but lifestyle factors have been linked to the development of neurodegenerative diseases. For example, the incidence of certain neurodegenerative diseases among people living in the Asian subcontinent, where people regularly consume spices, is much lower than in countries of the western world. Extensive research over the last 10 years has indicated that nutraceuticals derived from such spices as turmeric, red pepper, black pepper, licorice, clove, ginger, garlic, coriander, and cinnamon target inflammatory pathways, thereby may prevent neurodegenerative diseases. How these nutraceuticals modulate various pathways and how they exert neuroprotection are the focus of this review. DOI: 10.1007/s12035-011-8168-2 PMCID: PMC3183139 PMID: 21360003 [Indexed for MEDLINE]
6. Am J Obstet Gynecol. 2003 May;188(5 Suppl):S44-55. doi: 10.1067/mob.2003.402. Herbs commonly used by women: an evidence-based review. Tesch BJ(1). Author information: (1)Division of General Internal Medicine, Medical College of Wisconsin, Milwaukee 53226, USA. OBJECTIVE: To review the evidence of herbs commonly used by women. DATA SOURCES: Articles were located by searching Medline, Cochrane Database of Systemic Reviews, and the Combined Health Information Database and by hand searching the reference lists of recent systematic reviews. The databases were searched in January 2000 and October 2000 by using the Latin and common name of each herb. METHODS OF STUDY SELECTION: Preference was given to randomized, placebo-controlled trials. When available, English language studies were reviewed. If not, data are presented from review articles that summarize the foreign study. RESULTS: Many women use herbal therapies. In the United States, herbs are considered dietary supplements. The Food and Drug Administration (FDA) cannot remove them from the market unless they are proven unsafe. The herb industry plans to improve monitoring. Many prospective randomized controlled trials are being funded. Gingko biloba seems to slow the progression of dementia but increases the risk of bleeding. St John's Wort is efficacious for treating mild to moderate depression but has many drug interactions. Ginseng seems to improve well being in perimenopausal women, but it is often impure and has side effects and drug interactions. Garlic slightly lowers blood pressure and lipids. Echinacea slightly decreases the duration of colds but does not prevent them. Valerian is beneficial for insomnia, but there is no long-term safety data. Black cohosh may help the symptoms of perimenopause, and chasteberry may improve premenstrual syndrome. More study is needed on both herbs. CONCLUSION: Some herbs are medically useful, but the American public would benefit from increased regulation. Manufacturers should be able to ensure that herbs contain pure ingredients. Side effects and drug interactions should be listed. Well-designed studies are being conducted. The results will be helpful to physicians and patients when the clinical evidence becomes available. DOI: 10.1067/mob.2003.402 PMID: 12748451 [Indexed for MEDLINE]
7. Dis Mon. 2002 Oct;48(10):671-96. Herbs commonly used by women: an evidence-based review. Tesch BJ. OBJECTIVE: To review the evidence of herbs commonly used by women. DATA SOURCES: Articles were located by searching Medline, Cochrane Database of Systemic Reviews, and the Combined Health Information Database and by hand searching the reference lists of recent systematic reviews. The databases were searched in January 2000 and October 2000 by using the Latin and common name of each herb. METHODS OF STUDY SELECTION: Preference was given to randomized, placebo-controlled trials. When available, English language studies were reviewed. If not, data are presented from review articles that summarize the foreign study. RESULTS: Many women use herbal therapies. In the United States, herbs are considered dietary supplements. The Food and Drug Administration (FDA) cannot remove them from the market unless they are proven unsafe. The herb industry plans to improve monitoring. Many prospective randomized controlled trials are being funded. Gingko biloba seems to slow the progression of dementia but increases the risk of bleeding. St John's Wort is efficacious for treating mild to moderate depression but has many drug interactions. Ginseng seems to improve well being in perimenopausal women, but it is often impure and has side effects and drug interactions. Garlic slightly lowers blood pressure and lipids. Echinacea slightly decreases the duration of colds but does not prevent them. Valerian is beneficial for insomnia, but there is no long-term safety data. Black cohosh may help the symptoms of perimenopause, and chasteberry may improve premenstrual syndrome. More study is needed on both herbs. CONCLUSION: Some herbs are medically useful, but the American public would benefit from increased regulation. Manufacturers should be able to ensure that herbs contain pure ingredients. Side effects and drug interactions should be listed. Well-designed studies are being conducted. The results will be helpful to physicians and patients when the clinical evidence becomes available. PMID: 12562054 [Indexed for MEDLINE]
8. Nutrition. 2000 May;16(5):330-8. doi: 10.1016/s0899-9007(00)00257-4. Sickle cell anemia: a potential nutritional approach for a molecular disease. Ohnishi ST(1), Ohnishi T, Ogunmola GB. Author information: (1)Philadelphia Biomedical Research Institute, King of Prussia, Pennsylvania 19406, USA. stohnishi@aol.com Comment in Nutrition. 2000 Nov-Dec;16(11-12):1098-100. doi: 10.1016/s0899-9007(00)00445-7. A certain population of red blood cells in patients with sickle cell anemia has an elevated density and possesses an abnormal membrane. These "dense cells" have a tendency to adhere to neutrophils, platelets, and vascular endothelial cells, and, thus, they could trigger vasoocclusion and the subsequent painful crisis from which these patients suffer. We developed a laboratory method of preparing such dense cells and found that nutritional antioxidant supplements, hydroxyl radical scavengers, and iron-binding agents could inhibit the formation of dense cells in vitro. The concentrations at which effective nutritional supplements could inhibit dense cell formation by 50% were 4.0 mg/mL for aged garlic extract, 0.38 mg/mL for black tea extract, 0.13 mg/mL for green tea extract, 0.07 mg/mL for Pycnogenol, 930 microM for alpha-lipoic acid, 270 microM for vitamin E, 45 microM for coenzyme Q(10), and 32 microM for beta-carotene. Both an ex vivo study and a pilot clinical trial demonstrated that a cocktail consisting of daily doses of 6 g of aged garlic extract, 4-6 g of vitamin C, and 800 to 1200 IU of vitamin E may indeed be beneficial to the patients. DOI: 10.1016/s0899-9007(00)00257-4 PMID: 10793299 [Indexed for MEDLINE]
9. Medicine (Baltimore). 2020 Dec 18;99(51):e23737. doi: 10.1097/MD.0000000000023737. Chinese herbal medicine for the treatment of small intestinal bacterial overgrowth (SIBO): A protocol for systematic review and meta-analysis. Ren X(1), Di Z(2), Zhang Z(1), Fu B(1), Wang Y(1), Huang C(1), Du Y(2). Author information: (1)Hebei University of Chinese Medicine. (2)The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang City, Hebei, China. BACKGROUND: Chinese medicine has a unique theory and the Chinese herbal medicine treatment is based on the integral concepts and syndrome differentiation of the Traditional Chinese Medicine system. Although antibiotics remain the mainstay of SIBO treatment, various alternative or adjunctive therapies are available, including prokinetic agents, dietary interventions, probiotics, and herbal combinations. There is accumulating evidence demonstrating the antimicrobial properties of a growing number of herbs including garlic, black cumin, cloves, cinnamon, thyme, all-spices, bay leaves, mustard, and rosemary. This has prompted an interest in herbal therapy for the treatment of SIBO. Currently, there is no systematic review focusing on efficacy of CHM in the treatment of SIBO with PCOS, so our meta-analysis aims to comprehensively explore it. Meanwhile we will provide high-quality evidence to help patients, clinicians as well as health policymakers select better treatment strategy of PCOS. METHODS: We will search the following sources without restrictions for date, language, or publication status: PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL) Cochrane Library, EMBASE and China National Knowledge Infrastructure. We will apply a combination of Medical Subject Heading (MeSH) and free-text terms incorporating database-specific controlled vocabularies and text words to implement search strategies. We will also search the ongoing trials registered in the World Health Organization's International Clinical Trials Registry Platform. Besides, the previous relevant reviews conducted on CHM for SIBO and reference lists of included studies will also be searched. RESULTS: This study will provide a reliable basis for the treatment of SIBO with CHM. CONCLUSIONS: The findings will be an available reference to evaluate the efficacy and safety of CHM in the treatment of SIBO. REGISTRATION NUMBER: INPLASY202080004. Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. DOI: 10.1097/MD.0000000000023737 PMCID: PMC7748159 PMID: 33371127 [Indexed for MEDLINE] Conflict of interest statement: The authors have no conflicts of interest to disclose.
10. Biosci Rep. 2019 Aug 9;39(8):BSR20182254. doi: 10.1042/BSR20182254. Print 2019 Aug 30. Lactobacillus bulgaricus improves antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus: a randomized control trial. Si L(1), Lin R(2), Jia Y(1), Jian W(1), Yu Q(1), Wang M(1), Yang S(3). Author information: (1)Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun 130000, China. (2)Department of Genral Surgery, The Second Hospital of Jilin University, Changchun 130000, China. (3)Department of Gynecology and Obstetrics, The Second Hospital of Jilin University, Changchun 130000, China yangshulimd@163.com. Objectives:Lactobacillus bulgaricus may improve antioxidant capacity of black garlic in the prevention of gestational diabetes mellitus (GDM).Methods: Black garlic was prepared with or without L. bulgaricus Volatile and polysaccharides were analyzed by using LC-MS, Fourier Transform infrared (FTIR) and 13C nuclear magnetic resonance (NMR). The study design was parallel randomized controlled trial and 226 GDM patients were randomly assigned into BG (black garlic and L. bulgaricus) and CG (black garlic) groups, and allocation ratio was 1:1. The treatment duration was 40 weeks. Fasting blood glucose (FBG) and 1- and 2-h blood glucose (1hBG and 2hBG) after oral glucose tolerance test (OGTT) were detected. Antioxidant function of black garlic was determined by measuring plasma malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and total antioxidant capacity (T-AOC) in GDM patients. The comparison between two groups was made using two independent samples t test.Results: The intake of nutrients was similar between two groups (P>0.05). L. bulgaricus promoted the transformation of the glucopyranoside to glucofuranoside. L. bulgaricus increased the abilities of black garlic for scavenging hydroxyl radicals, 2,2'-azino-bis (3-ethylbenzenthiazoline-6-sulfonic) acid (ABTS) and DPPH free radicals. L. bulgaricus reduced the levels of FBG, 1hBG and 2hBG, and incidence of perinatal complications (P<0.01). Plasma MDA level in the BG group was lower than in the CG group, whereas the levels of SOD, GSH-PX and T-AOC in the BG group were higher than in the CG group (P<0.01).Conclusions:L. bulgaricus improves antioxidant capacity of black garlic in the prevention of GDM. © 2019 The Author(s). DOI: 10.1042/BSR20182254 PMCID: PMC6689107 PMID: 31362999 [Indexed for MEDLINE] Conflict of interest statement: The authors declare that there are no competing interests associated with the manuscript.
11. Endocr Metab Immune Disord Drug Targets. 2019;19(7):1075-1082. doi: 10.2174/1871530319666190206213420. A Randomized Controlled Trial of a Herbal Compound for Improving Metabolic Parameters in Diabetic Patients with Uncontrolled Dyslipidemia. Ghorbani A(1), Zarvandi M(2), Rakhshandeh H(1)(3). Author information: (1)Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran. (2)Department of Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. (3)Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. OBJECTIVE: The aim of this randomized controlled trial was to investigate the effects of a polyherbal compound consisting of Aloe vera, black seed, fenugreek, garlic, milk thistle, and psyllium on diabetic patients with uncontrolled dyslipidemia. METHODS: Fifty patients with type 2 diabetes who had dyslipidemia in spite of statin therapy were randomly allocated to two groups: control group (n = 25) receiving a conventional therapy with hypolipidemic and hypoglycemic drugs and intervention group (n = 25) receiving both the conventional therapy and the herbal compound (one sachet twice daily) for 12 weeks. Each sachet contained 300 mg of Aloe vera leaf gel, 1.8 g of black seed, 300 mg of garlic, 2.5 g of fenugreek seed, 1 g of psyllium seed, and 500 mg of milk thistle seed. RESULTS: The levels of serum triglyceride, total cholesterol, low-density lipoprotein, and HbA1c showed a significant in-group improvement in the intervention group. However, the effects of the herbal compound on fasting blood glucose remained insignificant. The compound had no unwanted effect on the kidney function parameters (urea, creatinine) and serum liver enzymes (alanine aminotransferase and aspartate transaminase). CONCLUSION: The tested herbal compound, as an add-on to statin therapy, was effective in lowering the serum lipids in diabetic patients with uncontrolled dyslipidemia. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. DOI: 10.2174/1871530319666190206213420 PMID: 30727929 [Indexed for MEDLINE]
12. Breast Cancer Res Treat. 2019 Jan;173(1):145-154. doi: 10.1007/s10549-018-4982-9. Epub 2018 Sep 26. Dietary intervention among breast cancer survivors increased adherence to a Mediterranean-style, anti-inflammatory dietary pattern: the Rx for Better Breast Health Randomized Controlled Trial. Zuniga KE(1), Parma DL(2), Muñoz E(2), Spaniol M(2), Wargovich M(3), Ramirez AG(2). Author information: (1)School of Family and Consumer Sciences, Nutrition and Foods, Texas State University, San Marcos, USA. k_z17@txstate.edu. (2)Department of Epidemiology and Biostatistics, Institute for Health Promotion Research, UT Health San Antonio, San Antonio, USA. (3)Department of Molecular Medicine, UT Health San Antonio, San Antonio, USA. PURPOSE: The goal of this education and culinary-based dietary intervention was to increase adherence to a Mediterranean-style, anti-inflammatory dietary pattern in breast cancer survivors (BCS) by promoting the consumption of anti-inflammatory foods, herbs, and spices. METHODS: Overweight and obese, early-stage, BCS were randomized to the Intervention (n = 76) or Control (n = 77). The 6-month intervention included monthly nutrition and cooking workshops, Motivational Interviewing telephone calls, and individualized newsletters. Control participants received monthly informational brochures and no navigational services. Dietary intakes were collected via questionnaire and 3-day food records at baseline and 6 months. RESULTS: One hundred twenty-five BCS (n = 60 I; n = 65 C) completed post-testing (81.7%) and were included in analyses. Adherence to Mediterranean diet guidelines significantly increased in the intervention group, but not in the control group (+ 22.5% vs. + 2.7%, P < 0.001). Upon further analysis of adherence to individual dietary guidelines, the intervention group significantly improved adherence to only three guidelines: consuming ≥ 3 servings of fish or shellfish/week, reducing red meat intake to < 1 serving/day, and limiting consumption of commercial sweets and baked goods to < 3 times/week. The intervention arm increased the use of spices and herbs compared to control (+ 146.2% vs. +33.3%, P < 0.001), including significantly more frequent consumption of cinnamon, turmeric, garlic, ginger, black pepper, and rosemary. CONCLUSION: An education and culinary-based intervention in BCS successfully increased adherence to a more Mediterranean-style, anti-inflammatory dietary pattern by increasing the consumption of anti-inflammatory foods, spices, and herbs and decreasing the consumption of pro-inflammatory foods. DOI: 10.1007/s10549-018-4982-9 PMCID: PMC6387648 PMID: 30259284 [Indexed for MEDLINE] Conflict of interest statement: Conflict of Interest: The authors declare that they have no conflict of interest.
13. J Transl Med. 2015 Jan 16;13:7. doi: 10.1186/s12967-014-0360-5. Effects of culinary spices and psychological stress on postprandial lipemia and lipase activity: results of a randomized crossover study and in vitro experiments. McCrea CE(1), West SG(2), Kris-Etherton PM(3), Lambert JD(4), Gaugler TL(5), Teeter DL(6), Sauder KA(7), Gu Y(8), Glisan SL(9), Skulas-Ray AC(10). Author information: (1)Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA. cem5435@psu.edu. (2)Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA. sgw2@psu.edu. (3)Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Lab, University Park, PA, 16802, USA. pmk3@psu.edu. (4)Department of Food Science, Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, 332 Food Science Building, University Park, PA, 16802, USA. jdl134@psu.edu. (5)Department of Mathematics, Lafayette College, 225A Pardee Hall, Easton, PA, 18042, USA. gauglert@lafayette.edu. (6)Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA. danette.teeter@gmail.com. (7)Department of Biobehavioral Health, The Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA, 16802, USA. kaf22@psu.edu. (8)Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, PA, 16802, USA. guyeyi@gmail.com. (9)Department of Food Science, The Pennsylvania State University, 332 Food Science Building, University Park, PA, 16802, USA. slg320@psu.edu. (10)Department of Nutritional Sciences, The Pennsylvania State University, 110 Chandlee Lab, University Park, PA, 16802, USA. aus164@psu.edu. BACKGROUND: Data suggest that culinary spices are a potent, low-calorie modality for improving physiological responses to high fat meals. In a pilot study (N = 6 healthy adults), we showed that a meal containing a high antioxidant spice blend attenuated postprandial lipemia by 30% compared to a low spice meal. Our goal was to confirm this effect in a larger sample and to consider the influence of acute psychological stress on fat metabolism. Further, we used in vitro methods to evaluate the inhibitory effect of spices on digestive enzymes. METHODS: In a 2 x 2, randomized, 4-period crossover design, we compared the effects of 14.5 g spices (black pepper, cinnamon, cloves, garlic, ginger, oregano, paprika, rosemary, and turmeric) vs. placebo incorporated into a high fat meal (1000 kcal, 45 g fat), followed by psychological stress (Trier Social Stress Test) vs. rest on postprandial metabolism in 20 healthy but overweight adults. Blood was sampled at baseline and at 105, 140, 180, and 210 minutes for analysis of triglycerides, glucose, and insulin. Additional in vitro analyses examined the effect of the spice blend and constituent spices on the activity of pancreatic lipase (PL) and secreted phospholipase A₂ (PLA₂). Mixed models were used to model the effects of spices and stress (SAS v9.3). RESULTS: Serum triglycerides, glucose and insulin were elevated following the meal (p < 0.01). Spices reduced post-meal triglycerides by 31% when the meal was followed by the rest condition (p = 0.048), but this effect was not present during stress. There was no effect of the spice blend on glucose or insulin; however, acute stress significantly increased both of these measures (p < 0.01; mean increase of 47% and 19%, respectively). The spice blend and several of the individual spices dose-dependently inhibited PL and PLA2 activity in vitro. CONCLUSIONS: Inclusion of spices may attenuate postprandial lipemia via inhibition of PL and PLA₂. However, the impact of psychological stress negates any influence of the spice blend on triglycerides, and further, increases blood glucose and insulin. TRIAL REGISTRATION: ClinicalTrials.gov as NCT00954902 . DOI: 10.1186/s12967-014-0360-5 PMCID: PMC4322464 PMID: 25592751 [Indexed for MEDLINE]
14. Arch Intern Med. 1998 Jun 8;158(11):1189-94. doi: 10.1001/archinte.158.11.1189. Garlic powder and plasma lipids and lipoproteins: a multicenter, randomized, placebo-controlled trial. Isaacsohn JL(1), Moser M, Stein EA, Dudley K, Davey JA, Liskov E, Black HR. Author information: (1)The Christ Hospital Cardiovascular Research Center, Cincinnati, Ohio, USA. ejlmarc@aol.com BACKGROUND: Garlic powder tablets have been reported to lower serum cholesterol levels. There is widespread belief among the general public that garlic powder tablets aid in controlling cholesterol levels. However, much of the prior data demonstrating the cholesterol-lowering effect of garlic tablets involved studies that were inadequately controlled. OBJECTIVE: To determine the lipid-lowering effect of garlic powder tablets in patients with hypercholesterolemia. METHODS: This was a randomized, double-blind, placebo-controlled, 12-week, parallel treatment study carried out in 2 outpatient lipid clinics. Entry into the study after 8 weeks of diet stabilization required a mean low-density lipoprotein cholesterol level on 2 visits of 4.1 mmol/L (160 mg/dL) or lower and a triglyceride level of 4.0 mmol/L (350 mg/dL) or lower. The active treatment arm received tablets containing 300 mg of garlic powder (Kwai) 3 times per day, given with meals (total, 900 mg/d). This is equivalent to approximately 2.7 g or approximately 1 clove of fresh garlic per day. The placebo arm received an identical-looking tablet, also given 3 times per day with meals. The main outcome measures included levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol after 12 weeks of treatment. RESULTS: Twenty-eight patients (43% male; mean +/- SD age, 58 +/- 14 years) received garlic powder treatment and 22 (68% male; mean +/- SD age, 57 +/- 13 years) received placebo treatment. There were no significant lipid or lipoprotein changes in either the placebo- or garlic-treated groups and no significant difference between changes in the placebo-treated group compared with changes in the garlic-treated patients. CONCLUSION: Garlic powder (900 mg/d) treatment for 12 weeks was ineffective in lowering cholesterol levels in patients with hypercholesterolemia. DOI: 10.1001/archinte.158.11.1189 PMID: 9625398 [Indexed for MEDLINE]
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