베르베린 (황련 추출)

Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials.

1. Phytother Res. 2023 Dec;37(12):5541-5557. doi: 10.1002/ptr.7998. Epub 2023 Sep 7. Effects of berberine and barberry on selected inflammatory biomarkers in adults: A systematic review and dose-response meta-analysis of randomized clinical trials. Vahedi-Mazdabadi Y(1)(2), Shahinfar H(1)(2), T

Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials.

2. J Nutr. 2023 Oct;153(10):2939-2950. doi: 10.1016/j.tjnut.2023.08.016. Epub 2023 Aug 19. Overall and Sex-Specific Effect of Berberine on Glycemic and Insulin-Related Traits: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Zhao JV(1), Huang X(2), Zhang J(2), Chan YH(3), T

Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.

3. Drugs. 2023 Apr;83(5):403-427. doi: 10.1007/s40265-023-01841-4. Epub 2023 Mar 21. Overall and Sex-Specific Effect of Berberine for the Treatment of Dyslipidemia in Adults: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials. Blais JE(1)(2), Huang X(1), Zhao JV(3).

Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies.

4. Int J Mol Sci. 2023 Feb 4;24(4):3084. doi: 10.3390/ijms24043084. Effects of Berries, Phytochemicals, and Probiotics on Atherosclerosis through Gut Microbiota Modification: A Meta-Analysis of Animal Studies. Khalili L(1), Centner AM(1), Salazar G(1)(2). Author information: (1)Department of Nut

Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action.

5. Pharmacol Res. 2022 Nov;185:106481. doi: 10.1016/j.phrs.2022.106481. Epub 2022 Oct 3. Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action. Hu S(1), Wang J(2), Liu E(3), Zhang X(4), Xiang J(5), Li W(6), Wei P(7), Zeng

A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults.

6. Pharmacol Res. 2022 Sep;183:106402. doi: 10.1016/j.phrs.2022.106402. Epub 2022 Aug 18. A network meta-analysis on the comparative effect of nutraceuticals on lipid profile in adults. Osadnik T(1), Goławski M(1), Lewandowski P(1), Morze J(2), Osadnik K(1), Pawlas N(1), Lejawa M(1), Jakubiak G

Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials.

7. Clin Nutr ESPEN. 2022 Jun;49:181-186. doi: 10.1016/j.clnesp.2022.01.037. Epub 2022 Feb 15. Effects berberine-silymarin on liver enzymes: A systematic review and meta-analysis of randomized controlled trials. Mohtashaminia F(1), Amini MR(2), Sheikhhossein F(3), Djafarian K(3), Shab-Bidar S(4)

Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis.

8. J Ethnopharmacol. 2022 Jan 10;282:114617. doi: 10.1016/j.jep.2021.114617. Epub 2021 Sep 10. Efficacy and safety of berberine in preventing recurrence of colorectal adenomas: A systematic review and meta-analysis. Fang S(1), Guo S(2), Du S(3), Cao Z(4), Yang Y(5), Su X(6), Wei W(7). Author in

Efficacy and Safety of Armolipid Plus(®): An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

9. Nutrients. 2021 Feb 16;13(2):638. doi: 10.3390/nu13020638. Efficacy and Safety of Armolipid Plus(®): An Updated PRISMA Compliant Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials. Cicero AFG(1)(2)(3), Kennedy C(4), Knežević T(5), Bove M(1)(2), Georges CMG(6), Šatrau

The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials.

10. Clin Nutr ESPEN. 2020 Aug;38:43-49. doi: 10.1016/j.clnesp.2020.04.010. Epub 2020 May 6. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials. Asbaghi O(1), Ghanbari N(1),

Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial.

11. JAMA Netw Open. 2026 Jan 2;9(1):e2554152. doi: 10.1001/jamanetworkopen.2025.54152. Berberine and Adiposity in Diabetes-Free Individuals With Obesity and MASLD: A Randomized Clinical Trial. Lei L(1), Wang B(2), Zhao L(1), Li J(1), Yan X(1), Jiang J(3)(4), Wang L(4), Ren G(4), Li Y(1), Cheng

The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial.

12. Nutrients. 2025 Nov 16;17(22):3585. doi: 10.3390/nu17223585. The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial. Koperska A(1)(2), Miller-Kasprzak E(1), Seraszek-Jaros A(3), Musialik K(1)

Gut microbiota-mediated berberine metabolism ameliorates cholestatic liver disease by suppressing 5-hydroxytryptamine production.

13. Clin Mol Hepatol. 2026 Jan;32(1):221-238. doi: 10.3350/cmh.2025.0577. Epub 2025 Oct 14. Gut microbiota-mediated berberine metabolism ameliorates cholestatic liver disease by suppressing 5-hydroxytryptamine production. Tu D(1), Lu C(1), Guo J(1), Chen Q(1), Li X(1), Wang Y(1), Cheng L(1), Jia

Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial.

14. Cell Rep Med. 2025 Sep 16;6(9):102293. doi: 10.1016/j.xcrm.2025.102293. Epub 2025 Aug 11. Berberine for preventing colorectal adenoma recurrence and neoplasm occurrence: 6-Year follow-up of a randomized clinical trial. Tan YJ(1), Zou TH(1), Yu K(2), Sheng JQ(3), Jin P(3), Zhang MJ(3), Zou XP

HTD1801 demonstrates promising potential for histologic improvements in metabolic dysfunction-associated steatohepatitis in both a preclinical and phase 2 study.

15. Clin Mol Hepatol. 2025 Jul;31(3):1071-1083. doi: 10.3350/cmh.2025.0145. Epub 2025 Apr 21. HTD1801 demonstrates promising potential for histologic improvements in metabolic dysfunction-associated steatohepatitis in both a preclinical and phase 2 study. Wong VW(1), Neff GW(2), Di Bisceglie AM

Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial.

18. JAMA Netw Open. 2025 Mar 3;8(3):e2462185. doi: 10.1001/jamanetworkopen.2024.62185. Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial. Ji L(1), Ma J(2), Ma Y(3), Cheng Z(4), Gan S(5), Yuan G(6), Liu D(7), Li S(8), Liu Y(9), Xue X(10), Bai J(11), Wan

The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial.

8. Eur J Nutr. 2025 Feb 25;64(2):102. doi: 10.1007/s00394-025-03618-9. The efficacy and safety of berberine in combination with cinnamon supplementation in patients with type 2 diabetes: a randomized clinical trial. Mansour A(#)(1), Sajjadi-Jazi SM(#)(1), Gerami H(1)(2), Khorasanian AS(1)(3), Mo

The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes.

8. Clin Transl Sci. 2025 Feb;18(2):e70120. doi: 10.1111/cts.70120. The Pharmacokinetic Interaction Between Metformin and the Natural Product Goldenseal Is Metformin Dose-Dependent: A Three-Arm Crossover Study in Adults With Type 2 Diabetes. Nguyen JT(1), Arian CM(2), Tanna RS(1), Cherel MG(1), L

Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes.

1. Physiol Rep. 2024 Aug;12(15):e16146. doi: 10.14814/phy2.16146. Inflammatory markers and noncoding-RNAs responses to low and high compressions of HIIT with or without berberine supplementation in middle-aged men with prediabetes. Nikseresht M(1), Dabidi Roshan V(1)(2), Nasiri K(1). Author inf

Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study.

21. Nutrients. 2024 Jul 16;16(14):2284. doi: 10.3390/nu16142284. Comparative Effects of Gymnema sylvestre and Berberine on Adipokines, Body Composition, and Metabolic Parameters in Obese Patients: A Randomized Study. Bandala C(1), Carro-Rodríguez J(1), Cárdenas-Rodríguez N(2), Peña-Montero I(3),

Inhibition of human liver cytochrome P450 2D6 (CYP6D2) by tetrahydropalmatine, protopine, and dehydrocorydaline and their oxidative metabolism.

29. Xenobiotica. 2026 Mar;56(3):240-248. doi: 10.1080/00498254.2026.2650150. Epub 2026 Apr 12. Inhibition of human liver cytochrome P450 2D6 (CYP6D2) by tetrahydropalmatine, protopine, and dehydrocorydaline and their oxidative metabolism. Zhao J(1), He X(2), Feng S(3), Cao S(1). Author informat

Self-Assembled Berberine-Sinapic Acid Nanomedicine for Synergistic Chemotherapy.

46. Molecules. 2026 Feb 10;31(4):621. doi: 10.3390/molecules31040621. Self-Assembled Berberine-Sinapic Acid Nanomedicine for Synergistic Chemotherapy. Zhao Y(1), Lu Y(1), Ma Y(1), Wang S(1), Lv P(1), Xu H(1), Li Y(1), Feng W(1). Author information: (1)College of Pharmacy, Henan University of Chin

Synergistic effect of the rifaximin-berberine combination against Klebsiella pneumoniae: RfaH targeting supported by MD simulation.

34. Biomol Biomed. 2026 Jan 28;26(8):1368-1383. doi: 10.17305/bb.2026.13776. Synergistic effect of the rifaximin-berberine combination against Klebsiella pneumoniae: RfaH targeting supported by MD simulation. Ashraf A(1), Khan MA(2), Choudhury A(1), Kumari S(3), Alotaibi BS(4), Noor S(1), Adnan

Synergistic antifungal effects of botanical extracts against Candida albicans.

43. PLoS One. 2026 Jan 12;21(1):e0340665. doi: 10.1371/journal.pone.0340665. eCollection 2026. Synergistic antifungal effects of botanical extracts against Candida albicans. Cho E(1), Acosta K(1), Henkin J(1), Abzalimov R(2), Raskin I(1). Author information: (1)Department of Plant Biology, Rutge

Plant-derived efflux pump inhibitors potentiate Chlorin e6-based antimicrobial photodynamic therapy against Bacillus cereus and Escherichia coli.

30. Biochem Biophys Res Commun. 2026 Jan 25;797:153214. doi: 10.1016/j.bbrc.2025.153214. Epub 2025 Dec 26. Plant-derived efflux pump inhibitors potentiate Chlorin e6-based antimicrobial photodynamic therapy against Bacillus cereus and Escherichia coli. Talarczyk A(1), Kublicka A(2), Matczuk A(3)

A pH-sensitive smart hydrogel based on oxidized hyaluronic acid with synergistic antibacterial properties.

22. Colloids Surf B Biointerfaces. 2026 Mar;259:115295. doi: 10.1016/j.colsurfb.2025.115295. Epub 2025 Nov 20. A pH-sensitive smart hydrogel based on oxidized hyaluronic acid with synergistic antibacterial properties. Wan Z(1), Zhao Y(1), Zhang X(1), Li D(2), Zheng H(3). Author information: (1)

Elucidation of the compatibility mechanism of Yuanhuzhitong prescription in view of CYP-mediated herbal inter-component interactions.

48. Fitoterapia. 2025 Dec;187:106934. doi: 10.1016/j.fitote.2025.106934. Epub 2025 Oct 16. Elucidation of the compatibility mechanism of Yuanhuzhitong prescription in view of CYP-mediated herbal inter-component interactions. Li Z(1), Zhang X(2), Han Q(3), Zhou X(4), Cui T(1), Liu S(5), Zhao T(6)

Berberine sensitizes liver cancer cells to sorafenib by inducing SETDB1/NQO1/p53-dependent ferroptosis and genomic instability.

22. Eur J Pharmacol. 2025 Nov 15;1007:178211. doi: 10.1016/j.ejphar.2025.178211. Epub 2025 Oct 11. Berberine sensitizes liver cancer cells to sorafenib by inducing SETDB1/NQO1/p53-dependent ferroptosis and genomic instability. Li K(1), Yi X(1), Yu Z(1), Xue K(1), Wu Y(2), Zhao Y(3), Zhang E(4),

Berberine: a promising strategy to combat cetuximab-resistance in colorectal cancer.

45. BMC Cancer. 2025 Oct 6;25(1):1520. doi: 10.1186/s12885-025-15013-y. Berberine: a promising strategy to combat cetuximab-resistance in colorectal cancer. Ye J(#)(1), Sun B(#)(1)(2), Xia F(#)(3), Wang G(1)(4), Liu H(1), Ding J(1), Tong M(5)(6). Author information: (1)Department of Gastroenter

The synergistic administration of sanguinarine and curcumin ameliorates indomethacin-induced small intestinal injury in rats through the modulation of Nrf2 and NF-κB signaling pathways.

19. Biochem Biophys Res Commun. 2025 Sep 25;781:152551. doi: 10.1016/j.bbrc.2025.152551. Epub 2025 Aug 27. The synergistic administration of sanguinarine and curcumin ameliorates indomethacin-induced small intestinal injury in rats through the modulation of Nrf2 and NF-κB signaling pathways. Li