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The Effects of a Bacopa monnieri Extract (Bacumen(®)) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial.

1. Clin Drug Investig. 2025 Dec;45(12):967-982. doi: 10.1007/s40261-025-01492-1. Epub 2025 Oct 15. The Effects of a Bacopa monnieri Extract (Bacumen(®)) on Cognition, Stress, and Fatigue in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial. Lopresti AL(1)(2), Smith SJ(3). Aut

Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial.

2. Explore (NY). 2024 Sep-Oct;20(5):102990. doi: 10.1016/j.explore.2024.02.008. Epub 2024 Mar 3. Evaluating the effects of Bacopa monnieri on cognitive performance and sleep quality of patients with mild cognitive impairment: A triple-blinded, randomized, placebo-controlled trial. Delfan M(1),

Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study.

3. Nutr Neurosci. 2024 Nov;27(11):1293-1305. doi: 10.1080/1028415X.2024.2325227. Epub 2024 Mar 21. Neurocognitive effects a combined polyphenolic-rich herbal extract in healthy middle-aged adults - a randomised, double-blind, placebo-controlled study. Best T(1), Miller J(1), Teo WP(1)(2). Autho

Bacopa monnieri in Patients with Parkinson's Disease: A Pilot Study.

4. J Med Food. 2023 Feb;26(2):114-119. doi: 10.1089/jmf.2022.0106. Bacopa monnieri in Patients with Parkinson's Disease: A Pilot Study. Santos AFD(1), Souza MMQ(2), Amaral EC(2), Albuquerque ER(1), Bortoloti DS(3), Gasparotto Junior A(4), Lourenço ELB(2), Lovato ECW(5), Lívero FADR(6). Author in

Effects of Bacopa monnieri (CDRI 08®) in a population of males exhibiting inattention and hyperactivity aged 6 to 14 years: A randomized, double-blind, placebo-controlled trial.

5. Phytother Res. 2022 Feb;36(2):996-1012. doi: 10.1002/ptr.7372. Epub 2022 Jan 18. Effects of Bacopa monnieri (CDRI 08®) in a population of males exhibiting inattention and hyperactivity aged 6 to 14 years: A randomized, double-blind, placebo-controlled trial. Kean JD(1)(2)(3), Downey LA(3)(4),

Characterization of Metabolites in Plasma, Urine and Feces of Healthy Participants after Taking Brahmi Essence for Twelve Weeks Using LC-ESI-QTOF-MS Metabolomic Approach.

6. Molecules. 2021 May 15;26(10):2944. doi: 10.3390/molecules26102944. Characterization of Metabolites in Plasma, Urine and Feces of Healthy Participants after Taking Brahmi Essence for Twelve Weeks Using LC-ESI-QTOF-MS Metabolomic Approach. Minale G(1), Saesong T(1), Temkitthawon P(1), Waranuch

Bacoside-A enhances temozolomide-induced cytotoxicity in U87MG glioblastoma cells via ROS-mediated apoptosis and EGFR/MAPK inhibition.

7. Neuropharmacology. 2026 Jul 1;292:110922. doi: 10.1016/j.neuropharm.2026.110922. Epub 2026 Mar 14. Bacoside-A enhances temozolomide-induced cytotoxicity in U87MG glioblastoma cells via ROS-mediated apoptosis and EGFR/MAPK inhibition. Mohammed Unais AK(1), Aparna A(2), Mariya KS(3), Viswanadha

Enhancement of Doxorubicin Efficacy by Bacopaside II in Triple-Negative Breast Cancer Cells.

8. Biomolecules. 2025 Jan 3;15(1):55. doi: 10.3390/biom15010055. Enhancement of Doxorubicin Efficacy by Bacopaside II in Triple-Negative Breast Cancer Cells. Rad SK(1)(2), Yeo KKL(1)(2), Li R(1)(2), Wu F(1)(2), Liu S(1), Nourmohammadi S(1)(2), Murphy WM(3), Tomita Y(1)(2)(4), Price TJ(1)(2)(4),

Evaluation of Synergistic Activity of Ethanolic Leaf Extracts of Tephrosia Purpurea and Bacopa Monnieri in Ulcer Induced Rats.

9. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2024 Jul 24;40:e20240015. doi: 10.62958/j.cjap.2024.015. Evaluation of Synergistic Activity of Ethanolic Leaf Extracts of Tephrosia Purpurea and Bacopa Monnieri in Ulcer Induced Rats. Soumya P(1), Saha S(2), Palakurthy SR(3), Pasupluleti R(3). Author i

Bacopasides I and II Act in Synergy to Inhibit the Growth, Migration and Invasion of Breast Cancer Cell Lines.

10. Molecules. 2019 Sep 30;24(19):3539. doi: 10.3390/molecules24193539. Bacopasides I and II Act in Synergy to Inhibit the Growth, Migration and Invasion of Breast Cancer Cell Lines. Palethorpe HM(1)(2), Smith E(3)(4), Tomita Y(5)(6), Nakhjavani M(7)(8), Yool AJ(9), Price TJ(10)(11)(12), Young J

Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents.

11. Molecules. 2014 Feb 24;19(2):2588-601. doi: 10.3390/molecules19022588. Inhibition of human cytochrome P450 enzymes by Bacopa monnieri standardized extract and constituents. Ramasamy S(1), Kiew LV(2), Chung LY(3). Author information: (1)Department of Pharmacy, Faculty of Medicine, University

Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis.

12. Phytomedicine. 2026 Apr;153:157915. doi: 10.1016/j.phymed.2026.157915. Epub 2026 Feb 2. Comparative effects of Bacopa monnieri and Ginkgo biloba on cognitive functions: A systematic review and network meta-analysis. Tiemtad P(1), Ingkaninan K(2), Temkitthawon P(3), Thimkorn P(4), Rattanachai

The efficacy of nutritional phytochemical compounds in improving cognition.

13. Int J Neuropsychopharmacol. 2026 Feb 2;29(2):pyag003. doi: 10.1093/ijnp/pyag003. The efficacy of nutritional phytochemical compounds in improving cognition. Marsh A(1)(2)(3), Quelch D(4)(5), Mackonochie M(6), Hejmadi M(7), Rolfe V(8). Author information: (1)School of Psychological Science, Un

Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review.

14. Nutrients. 2025 Apr 28;17(9):1482. doi: 10.3390/nu17091482. Efficiency of Different Supplements in Alleviating Symptoms of ADHD with or Without the Use of Stimulants: A Systematic Review. Al Shahab S(1), Al Balushi R(1), Qambar A(1), Abdulla R(1), Qader M(1), Abdulla S(1), Jahrami H(1)(2).

Effectiveness of Bacopa Monnieri (Brahmi) in the management of schizophrenia: a systematic review.

15. Nutr Neurosci. 2025 Jul;28(7):788-795. doi: 10.1080/1028415X.2024.2421782. Epub 2024 Nov 5. Effectiveness of Bacopa Monnieri (Brahmi) in the management of schizophrenia: a systematic review. Ayilara GO(1), Owoyele BV(1). Author information: (1)Neuroscience and Inflammation Unit, Department

Therapeutic Evaluation of Unani Medicine, Including Single Drugs and Polyherbal Formulations with Special Reference to Neurodegenerative Disorders.

39. Altern Ther Health Med. 2024 Sep;30(9):54-64. Therapeutic Evaluation of Unani Medicine, Including Single Drugs and Polyherbal Formulations with Special Reference to Neurodegenerative Disorders. Imran S, Ahmad W, Saltanat S. ETHNOPHARMACOLOGICAL RELEVANCE: Unani remedies are considered safe a

A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with and without subjective cognitive impairment.

32. Syst Rev. 2023 Aug 17;12(1):143. doi: 10.1186/s13643-023-02301-6. A systematic review of the safety and efficacy on cognitive function of herbal and nutritional medicines in older adults with and without subjective cognitive impairment. Cave AE(1), Chang DH(1), Münch GW(1)(2), Steiner-Lim GZ

Plant-derived nootropics and human cognition: A systematic review.

37. Crit Rev Food Sci Nutr. 2023;63(22):5521-5545. doi: 10.1080/10408398.2021.2021137. Epub 2022 Jan 3. Plant-derived nootropics and human cognition: A systematic review. Lorca C(1)(2)(3), Mulet M(2), Arévalo-Caro C(2), Sanchez MÁ(1), Perez A(1), Perrino M(1), Bach-Faig A(4)(5), Aguilar-Martínez

Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review.

39. J Altern Complement Med. 2021 Nov;27(11):940-958. doi: 10.1089/acm.2021.0135. Epub 2021 Aug 9. Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review. Crawford C(1)(2), Boyd C(1)(2), Deuster PA(1). Author information: (1)Consortium for

Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials.

29. Nutr Neurosci. 2022 Aug;25(8):1704-1730. doi: 10.1080/1028415X.2021.1892253. Epub 2021 Mar 2. Modulation of the hypothalamic-pituitary-adrenal (HPA) axis by plants and phytonutrients: a systematic review of human trials. Lopresti AL(1)(2), Smith SJ(1)(2), Drummond PD(2). Author information:

Herbal medicine for epilepsy seizures in Asia, Africa and Latin America: A systematic review.

50. J Ethnopharmacol. 2019 Apr 24;234:119-153. doi: 10.1016/j.jep.2018.12.049. Epub 2019 Jan 2. Herbal medicine for epilepsy seizures in Asia, Africa and Latin America: A systematic review. Auditeau E(1), Chassagne F(2), Bourdy G(3), Bounlu M(4), Jost J(5), Luna J(6), Ratsimbazafy V(7), Preux P