비타민B 복합체

Complex Effects of B-Vitamin Combinations on Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials over Three Decades.

1. Nutrients. 2026 Mar 5;18(5):842. doi: 10.3390/nu18050842. Complex Effects of B-Vitamin Combinations on Cardiovascular Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials over Three Decades. Ren R(1), Yang A(2), Chow A(3), Wang K(4), Wang S(5), Leo C(6), Lu Y(7)(8),

Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis.

2. Ann Med. 2026 Dec;58(1):2622208. doi: 10.1080/07853890.2026.2622208. Epub 2026 Jan 30. Combined B-vitamin supplementation on homocysteine and vascular outcomes in coronary heart disease: a meta-analysis. Guo L(1), Shi X(2), Wang G(3), Han W(1), Ding R(1), Wang S(4), Yuan D(3). Author informa

Riboflavin supplements for blood pressure lowering in adults.

3. Cochrane Database Syst Rev. 2025 Oct 22;10(10):CD015464. doi: 10.1002/14651858.CD015464.pub2. Riboflavin supplements for blood pressure lowering in adults. Bradbury KE(1), Coffey S(2), Earle N(3), Ni Mhurchu C(1), Jull AB(4). Author information: (1)School of Population Health, University of A

Efficacy of B Vitamin Supplementation on Global Cognitive Function in Older Adults: A Systematic Review and Meta-analysis.

4. Nutr Rev. 2025 Dec 1;83(12):2256-2267. doi: 10.1093/nutrit/nuaf155. Efficacy of B Vitamin Supplementation on Global Cognitive Function in Older Adults: A Systematic Review and Meta-analysis. Berg J(1)(2), Grant R(2), Siervo M(3)(4)(5), Stephan BCM(3), Tully PJ(6)(7). Author information: (1)Sc

Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis.

5. Neurosci Biobehav Rev. 2025 Mar;170:106068. doi: 10.1016/j.neubiorev.2025.106068. Epub 2025 Feb 12. Causal relationship between B vitamins and neuropsychiatric disorders: A systematic review and meta-analysis. Ye M(1), Yang X(2), Yan J(3), Yao Y(2), Lv H(2), Yue Z(4), Lin X(5), Qian C(6), Li

A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

6. Nutrients. 2024 Jul 10;16(14):2199. doi: 10.3390/nu16142199. A Comparative Study Evaluating the Effectiveness of Folate-Based B Vitamin Intervention on Cognitive Function of Older Adults under Mandatory Folic Acid Fortification Policy: A Systematic Review and Meta-Analysis of Randomized Contr

B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials.

7. Osteoporos Int. 2024 Sep;35(9):1645-1659. doi: 10.1007/s00198-024-07150-0. Epub 2024 Jul 2. B vitamins and bone health: a meta-analysis with trial sequential analysis of randomized controlled trials. Luo Y(1)(2)(3), Zheng S(1)(2)(3), Jiang S(4), Yang G(1)(2), Pavel V(5), Ji H(1)(2), Zhou S(1

Role of Thiamine Supplementation in the Treatment of Chronic Heart Failure: An Updated Meta-Analysis of Randomized Controlled Trials.

8. Clin Cardiol. 2024 Jul;47(7):e24309. doi: 10.1002/clc.24309. Role of Thiamine Supplementation in the Treatment of Chronic Heart Failure: An Updated Meta-Analysis of Randomized Controlled Trials. He S(1), Wang S(2), Xu T(2), Wang S(2), Qi M(2), Chen Q(2), Lin L(2), Wu H(2), Gan P(2). Author i

The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials.

9. Nutrients. 2024 Apr 29;16(9):1345. doi: 10.3390/nu16091345. The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials. Sinop

From A to E: Uniting vitamins against stroke risk-A systematic review and network meta-analysis.

10. Eur J Clin Invest. 2024 Jun;54(6):e14165. doi: 10.1111/eci.14165. Epub 2024 Jan 30. From A to E: Uniting vitamins against stroke risk-A systematic review and network meta-analysis. Tripathi S(1), Nath M(1), Misra S(2), Kumar P(3). Author information: (1)Department of Neurology, All India In

A prospective, randomized, double-blind, placebo-controlled, multicenter study of thiamin plus folic acid in the treatment of cognitive impairment in patients undergoing maintenance hemodialysis.

11. Ren Fail. 2026 Dec;48(1):2658981. doi: 10.1080/0886022X.2026.2658981. Epub 2026 Apr 30. A prospective, randomized, double-blind, placebo-controlled, multicenter study of thiamin plus folic acid in the treatment of cognitive impairment in patients undergoing maintenance hemodialysis. Xie K(1

A randomized clinical trial assessing the efficacy of vitamin B prophylaxis in attenuating paclitaxel-induced neuropathy and the imperative use of gabapentin in diabetic ovarian cancer patients.

12. Med Oncol. 2026 Feb 6;43(3):141. doi: 10.1007/s12032-026-03252-3. A randomized clinical trial assessing the efficacy of vitamin B prophylaxis in attenuating paclitaxel-induced neuropathy and the imperative use of gabapentin in diabetic ovarian cancer patients. Haggagy M(1), Raslan F(2), Said

Hydroxocobalamin, thiamine, and pyridoxine as an adjunct to standard treatment in chronic low back pain: a randomized clinical trial.

13. Med Clin (Barc). 2026 Mar;166(3):107307. doi: 10.1016/j.medcli.2025.107307. Epub 2026 Jan 27. Hydroxocobalamin, thiamine, and pyridoxine as an adjunct to standard treatment in chronic low back pain: a randomized clinical trial. [Article in English, Spanish] Reyes-Alvarez MT(1), Chávez Miñan

Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour extracts, flavonoids and B vitamins. A placebo-controlled, double-blind, randomized clinical trial.

14. Nutr Metab Cardiovasc Dis. 2026 Mar;36(3):104470. doi: 10.1016/j.numecd.2025.104470. Epub 2025 Nov 14. Improved HDL, LDL and total cholesterol levels following a 3-month administration of Mentha spicata leaf extract and Amaranthus caudatus seed flour extracts, flavonoids and B vitamins. A pl

Vitamin B supplementation enhances the efficacy of non-steroidal anti-inflammatory drugs in patients with painful foot and ankle conditions: A multicenter, prospective, randomized controlled trial.

15. PLoS One. 2025 Nov 13;20(11):e0336373. doi: 10.1371/journal.pone.0336373. eCollection 2025. Vitamin B supplementation enhances the efficacy of non-steroidal anti-inflammatory drugs in patients with painful foot and ankle conditions: A multicenter, prospective, randomized controlled trial. S

Effects of nicotinamide supplementation in normal-tension glaucoma: a crossover placebo-controlled randomised clinical trial.

48. Br J Ophthalmol. 2026 Mar 20;110(4):417-424. doi: 10.1136/bjo-2025-328096. Effects of nicotinamide supplementation in normal-tension glaucoma: a crossover placebo-controlled randomised clinical trial. Ha A(1), Kim YK(2), Lee CK(3), Williams PA(4), Morgan JE(5)(6), Shin YI(7), Kim E(8), Kim M

Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial.

35. JAMA. 2025 Oct 7;334(13):1151-1159. doi: 10.1001/jama.2025.13668. Myo-inositol Supplementation to Prevent Pregnancy Complications in Polycystic Ovary Syndrome: A Randomized Clinical Trial. van der Wel AWT(1)(2), Frank CMC(3), Bout-Rebel R(4), Duijnhoven RG(1)(5), van Bree BE(6), Valkenburg O

Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events in pediatric and adolescent epilepsy: a prospective, double-blind, randomized, placebo-controlled trial.

6. Epilepsy Behav. 2025 Nov;172:110691. doi: 10.1016/j.yebeh.2025.110691. Epub 2025 Sep 5. Pyridoxine supplementation for levetiracetam-related neuropsychiatric adverse events in pediatric and adolescent epilepsy: a prospective, double-blind, randomized, placebo-controlled trial. Thananowan P(1

Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial.

41. Alzheimers Dement. 2025 Jul;21(7):e70521. doi: 10.1002/alz.70521. Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial. Kacerova T(1), Yates AG(1)(2), Dai J(1), Shepherd D(2), Pires E(1), de Jel S(3), Gong

A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women.

1. Naunyn Schmiedebergs Arch Pharmacol. 2025 Oct;398(10):14403-14411. doi: 10.1007/s00210-025-04205-9. Epub 2025 Apr 29. A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women. Dhivya K(1), Sarum

Potential application of vitamins to combat biofilm-mediated drug resistance by pathogenic bacteria.

4. Future Microbiol. 2025 Oct;20(15):1031-1047. doi: 10.1080/17460913.2025.2572934. Epub 2025 Oct 12. Potential application of vitamins to combat biofilm-mediated drug resistance by pathogenic bacteria. Konatam S(1), Panigrahi S(1), Tandi A(1), Roy DN(1). Author information: (1)Department of Bi

Synergistically effects of n-3 PUFA and B vitamins prevent diabetic cognitive dysfunction through promoting TET2-mediated active DNA demethylation.

9. Clin Nutr. 2025 Feb;45:111-123. doi: 10.1016/j.clnu.2025.01.002. Epub 2025 Jan 6. Synergistically effects of n-3 PUFA and B vitamins prevent diabetic cognitive dysfunction through promoting TET2-mediated active DNA demethylation. Chen L(1), Liu R(2), He X(3), Fang J(2), Zhou L(2), Qi Z(2), Ta

Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats.

12. Cell Biochem Funct. 2024 Dec;42(8):e70028. doi: 10.1002/cbf.70028. Synergistic Effect of Donepezil and Neurotropic B Vitamins on Dysregulated Antioxidant, Inflammation and Neurotransmitter Status in Aluminium Chloride-Induced Neurotoxicity in Rats. Ekundayo BE(1), Adewale OB(1), Obafemi BA(2

Nicotinamide (vitamin B3) treatment improves response to G-CSF in severe congenital neutropenia patients.

2. Br J Haematol. 2021 Feb;192(4):788-792. doi: 10.1111/bjh.17313. Epub 2021 Jan 20. Nicotinamide (vitamin B3) treatment improves response to G-CSF in severe congenital neutropenia patients. Deordieva E(1), Shvets O(1), Voronin K(1), Maschan A(1), Welte K(2)(3), Skokowa J(3), Novichkova G(1), S

Synergistic interaction between B vitamins and statins to counter nociception in rats.

2. Drug Dev Res. 2021 May;82(3):440-447. doi: 10.1002/ddr.21767. Epub 2020 Dec 10. Synergistic interaction between B vitamins and statins to counter nociception in rats. Skiold LJ(1)(2), Estefania RP(1), Carolina GMP(3), Mery LR(2), Fernando CE(2), Jair LC(1). Author information: (1)Departament

Dietary supplement use by older adults with chronic venous leg ulcers: A retrospective, descriptive study.

40. Wound Repair Regen. 2020 Jul;28(4):561-572. doi: 10.1111/wrr.12821. Epub 2020 May 4. Dietary supplement use by older adults with chronic venous leg ulcers: A retrospective, descriptive study. McDaniel JC(1). Author information: (1)College of Nursing, The Ohio State University, Columbus, Ohi

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin.

42. Int J Mol Sci. 2020 Jan 31;21(3):950. doi: 10.3390/ijms21030950. Riboflavin: The Health Benefits of a Forgotten Natural Vitamin. Suwannasom N(1)(2), Kao I(1), Pruß A(1), Georgieva R(1)(3), Bäumler H(1). Author information: (1)Institute of Transfusion Medicine, Center of Tumor Medicine, Chari

Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1.

40. J Cell Biochem. 2020 Jan;121(1):574-586. doi: 10.1002/jcb.29303. Epub 2019 Aug 12. Nicotinamide increases the sensitivity of chronic myeloid leukemia cells to doxorubicin via the inhibition of SIRT1. Pan S(1), Leng J(1), Deng X(1), Ruan H(1), Zhou L(1), Jamal M(1), Xiao R(1), Xiong J(1), Yi

Effects of Folic Acid Therapy on the New-Onset Proteinuria in Chinese Hypertensive Patients: A Post Hoc Analysis of the Renal Substudy of CSPPT (China Stroke Primary Prevention Trial).

28. Hypertension. 2017 Aug;70(2):300-306. doi: 10.1161/HYPERTENSIONAHA.117.09404. Epub 2017 Jun 12. Effects of Folic Acid Therapy on the New-Onset Proteinuria in Chinese Hypertensive Patients: A Post Hoc Analysis of the Renal Substudy of CSPPT (China Stroke Primary Prevention Trial). Li Y(1), L

Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism.

38. Arch Biochem Biophys. 2017 Jun 1;623-624:58-63. doi: 10.1016/j.abb.2017.05.006. Epub 2017 May 10. Thiamine potentiates chemoprotective effects of ibuprofen in DEN induced hepatic cancer via alteration of oxidative stress and inflammatory mechanism. Afzal M(1), Kazmi I(2), Khan R(3), Rana P(3