5-HTP

Investigating genetic links between biological aging and adverse pregnancy outcomes.

1. Biogerontology. 2025 Feb 7;26(2):56. doi: 10.1007/s10522-025-10198-y. Investigating genetic links between biological aging and adverse pregnancy outcomes. Sun N(#)(1), Yang K(#)(1), Wang H(2), Zhou W(3). Author information: (1)Changzhou Maternal and Child Health Care Hospital, Changzhou Medic

Animal models of the serotonin syndrome: a systematic review.

2. Behav Brain Res. 2013 Nov 1;256:328-45. doi: 10.1016/j.bbr.2013.08.045. Epub 2013 Sep 1. Animal models of the serotonin syndrome: a systematic review. Haberzettl R(1), Bert B, Fink H, Fox MA. Author information: (1)Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Frei

Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis.

3. Aust N Z J Psychiatry. 2002 Aug;36(4):488-91. doi: 10.1046/j.1440-1614.2002.01046.x. Are tryptophan and 5-hydroxytryptophan effective treatments for depression? A meta-analysis. Shaw K(1), Turner J, Del Mar C. Author information: (1)School of Population Health, Department of Public Health, U

Tryptophan and 5-hydroxytryptophan for depression.

4. Cochrane Database Syst Rev. 2002;(1):CD003198. doi: 10.1002/14651858.CD003198. Tryptophan and 5-hydroxytryptophan for depression. Shaw K(1), Turner J, Del Mar C. Author information: (1)School of Population Health, University of Queensland, Public Health Building, Herston Rd, Herston, Queensla

Tryptophan and 5-hydroxytryptophan for depression.

5. Cochrane Database Syst Rev. 2001;2002(3):CD003198. doi: 10.1002/14651858.CD003198. Tryptophan and 5-hydroxytryptophan for depression. Shaw K(1), Turner J, Del Mar C. Author information: (1)Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, Oxon, UK, OX3 7JX. Update

The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial.

6. Nutrients. 2025 Aug 27;17(17):2773. doi: 10.3390/nu17172773. The Impact of 5-Hydroxytryptophan Supplementation on Cognitive Function and Mood in Singapore Older Adults: A Randomized Controlled Trial. Li S(1), Sutanto CN(1), Xia X(1), Kim JE(1)(2). Author information: (1)Department of Food & T

The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.

7. Clin Nutr. 2024 Mar;43(3):593-602. doi: 10.1016/j.clnu.2024.01.010. Epub 2024 Jan 17. The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial. Sutanto CN(1), Xia X(2), Heng CW(3), Tan YS(4), Lee DPS(5), F

The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT.

8. J Diet Suppl. 2023;20(4):621-630. doi: 10.1080/19390211.2022.2076760. Epub 2022 May 18. The Effects of 5-HTP on Body Composition: An 8-Week Preliminary RCT. Evans C(1), Mekhail V(1), Curtis J(2), Czartoryski P(1), Kaminski J(1), Ellerbroek A(1), Bustillo E(3), Jiannine L(1), Santana JC(4), An

Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level.

9. Sci Rep. 2021 Nov 4;11(1):21637. doi: 10.1038/s41598-021-01164-y. Tryptophan-enriched diet or 5-hydroxytryptophan supplementation given in a randomized controlled trial impacts social cognition on a neural and behavioral level. Zamoscik V(1)(2), Schmidt SNL(3), Bravo R(4), Ugartemendia L(4),

Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease.

10. Sleep Breath. 2022 Sep;26(3):1023-1031. doi: 10.1007/s11325-021-02417-w. Epub 2021 Aug 17. Preliminary finding of a randomized, double-blind, placebo-controlled, crossover study to evaluate the safety and efficacy of 5-hydroxytryptophan on REM sleep behavior disorder in Parkinson's disease.

Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels.

11. PLoS Biol. 2021 Jan 22;19(1):e3001070. doi: 10.1371/journal.pbio.3001070. eCollection 2021 Jan. Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels. Waclawiková B(1), Bullock A(1), Schwalbe M(1), Aranzamendi C(1), Nelema

Efficacy and safety of 5-Hydroxytryptophan on levodopa-induced motor complications in Parkinson's disease: A preliminary finding.

12. J Neurol Sci. 2020 Aug 15;415:116869. doi: 10.1016/j.jns.2020.116869. Epub 2020 Apr 29. Efficacy and safety of 5-Hydroxytryptophan on levodopa-induced motor complications in Parkinson's disease: A preliminary finding. Meloni M(1), Puligheddu M(2), Sanna F(3), Cannas A(4), Farris R(5), Tronci

PK/PD modeling of 5-hydroxytryptophan (5-HTP) challenge test with cortisol measurement in serum and saliva.

13. Pharmacol Res Perspect. 2020 Apr;8(2):e00574. doi: 10.1002/prp2.574. PK/PD modeling of 5-hydroxytryptophan (5-HTP) challenge test with cortisol measurement in serum and saliva. Guan Z(1)(2), Jacobs G(1)(2), van Pelt H(3), Van Gerven JMA(1)(2), Burggraaf J(1)(2), Zhao W(4). Author informatio

Efficacy and safety of 5-hydroxytryptophan on depression and apathy in Parkinson's disease: a preliminary finding.

14. Eur J Neurol. 2020 May;27(5):779-786. doi: 10.1111/ene.14179. Epub 2020 Mar 13. Efficacy and safety of 5-hydroxytryptophan on depression and apathy in Parkinson's disease: a preliminary finding. Meloni M(1), Puligheddu M(2)(3), Carta M(4), Cannas A(3), Figorilli M(2), Defazio G(3). Author i

EPA and DHA as markers of nutraceutical treatment response in major depressive disorder.

15. Eur J Nutr. 2020 Sep;59(6):2439-2447. doi: 10.1007/s00394-019-02090-6. Epub 2019 Sep 25. EPA and DHA as markers of nutraceutical treatment response in major depressive disorder. van der Burg KP(#)(1), Cribb L(#)(2), Firth J(3)(4), Karmacoska D(3), Mischoulon D(5), Byrne GJ(6), Bousman C(7)(

Berberine alleviates soybean meal-induced enteritis in hybrid yellow catfish (Pelteobagrus fulvidraco ♀ × Pelteobagrus vachelli ♂) by regulating intestinal microbiota and tryptophan metabolism.

22. Anim Nutr. 2026 Mar 6;25:360-374. doi: 10.1016/j.aninu.2025.11.007. eCollection 2026 Jun. Berberine alleviates soybean meal-induced enteritis in hybrid yellow catfish (Pelteobagrus fulvidraco ♀ × Pelteobagrus vachelli ♂) by regulating intestinal microbiota and tryptophan metabolism. Zhang Z

Study on the potential mechanism of Artemisia integrifolia Linn. in diabetic nephropathy: multiscale analysis of network pharmacology and metabolomics.

26. J Ethnopharmacol. 2026 Jul 15;366:121615. doi: 10.1016/j.jep.2026.121615. Epub 2026 Apr 1. Study on the potential mechanism of Artemisia integrifolia Linn. in diabetic nephropathy: multiscale analysis of network pharmacology and metabolomics. Liu M(1), Su F(1), Bai C(1), Sun M(1), Zhang W(1)

Serotonin Synthesis Amplification to Augment the Therapeutic Efficacy of Serotonin Reuptake Inhibitor Antidepressants: Five Decades of Clinical Evidence.

46. J Clin Psychopharmacol. 2026 Apr 3. doi: 10.1097/JCP.0000000000002180. Online ahead of print. Serotonin Synthesis Amplification to Augment the Therapeutic Efficacy of Serotonin Reuptake Inhibitor Antidepressants: Five Decades of Clinical Evidence. Chaikali S(1), Jacobsen J(2). Author inform

Pharmaco-EEG-Based Classification of Psychotropic Activity of a Novel Chromone-Containing Allylmorpholine in Rats.

44. Adv Pharm Bull. 2025 Oct 11;15(4):891-905. doi: 10.34172/apb.025.45140. eCollection 2025 Nov. Pharmaco-EEG-Based Classification of Psychotropic Activity of a Novel Chromone-Containing Allylmorpholine in Rats. Sysoev YI(1)(2), Kurmazov NS(1)(3), Shitc DD(4), Puchik MM(4), Fedorova EV(1), Pet

Effects of in vitro fermentation of Astragalus polysaccharide on gut microbiota and neurotransmitter metabolites in patients with major depressive disorder.

40. Front Psychiatry. 2026 Feb 25;17:1752933. doi: 10.3389/fpsyt.2026.1752933. eCollection 2026. Effects of in vitro fermentation of Astragalus polysaccharide on gut microbiota and neurotransmitter metabolites in patients with major depressive disorder. Lin C(1), Mi YW(1), Zheng HW(2), Hou YB(1)

Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses.

50. Adv Sci (Weinh). 2026 Mar;13(18):e14269. doi: 10.1002/advs.202514269. Epub 2026 Jan 31. Gut-Metabolome-Proteome Interactions in Age-Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi-Omics Analyses. Yang T(1), Gao Z(2)(3)(4)(5), Huang H(6)(7), Zhang C(1), Tang Y(5

Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition of pyroptosis.

26. J Ethnopharmacol. 2026 Apr 6;360:121209. doi: 10.1016/j.jep.2026.121209. Epub 2026 Jan 13. Guhan Yangsheng Jing alleviates sleep deprivation-induced neuronal injury via neurotransmitter rebalancing, mitochondrial protection, and inhibition of pyroptosis. Fu X(1), Long Q(2), Wang Z(3), Yan S

Herba Patriniae with probiotics targets Escherichia fergusonii and the 5-hydroxytryptophan-trimethylamine N-oxide axis in Parkinson's disease.

8. Phytomedicine. 2026 Jan;150:157758. doi: 10.1016/j.phymed.2025.157758. Epub 2025 Dec 30. Herba Patriniae with probiotics targets Escherichia fergusonii and the 5-hydroxytryptophan-trimethylamine N-oxide axis in Parkinson's disease. Wu X(1), Zhang T(2), Feng J(3), Park S(4). Author informatio

Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma.

17. Int J Biol Sci. 2026 Jan 1;22(1):161-177. doi: 10.7150/ijbs.113217. eCollection 2026. Procyanidin Suppresses Tumor Growth by Activating the B-Cell MAPK Pathway through Remodulation of the Gut Microbiota and Metabolites in Hepatocellular Carcinoma. Huo R(1)(2), Gu CZ(1), Liu Y(3)(4), Wei ZX(

Contrasting Effects of Larval Escitalopram and Serotonin-Synthesis Inhibitor on Adult Phototaxis in Drosophila w(1118).

12. Life (Basel). 2025 Nov 20;15(11):1782. doi: 10.3390/life15111782. Contrasting Effects of Larval Escitalopram and Serotonin-Synthesis Inhibitor on Adult Phototaxis in Drosophila w(1118). Krams I(1)(2)(3), Kolbjonoks V(4), Popovs S(1)(3), Munkevics M(1)(2)(5), Krams R(6)(7), Trakimas G(3)(8),

Circadian disruption induces cognitive impairment through tryptophan-5-HT metabolic pathway dysregulation.

25. Sleep. 2026 Feb 10;49(2):zsaf258. doi: 10.1093/sleep/zsaf258. Circadian disruption induces cognitive impairment through tryptophan-5-HT metabolic pathway dysregulation. Liao J(1), Wang Y(1), Li J(1), Li P(1), Liu Y(1), Wu J(1), Zhao M(1), Huang H(1), Liu P(1)(2), Chen Y(1), Xu Y(1), Jiang Y(

Gut microbiota dysbiosis and disturbed tryptophan metabolism mediate cognitive impairment in mice with circadian rhythm disruption.

4. Brain Res Bull. 2025 Sep;229:111473. doi: 10.1016/j.brainresbull.2025.111473. Epub 2025 Jul 19. Gut microbiota dysbiosis and disturbed tryptophan metabolism mediate cognitive impairment in mice with circadian rhythm disruption. Song H(1), Zhang H(1), Qin X(1), Liu Y(1), Lai Y(1), Yang W(1), Z

Effects of Rumen-Protected 5-Hydroxytryptophan and Melatonin Supplementation on Antioxidant Capacity, Meat Quality, and Shelf Life of Hu Sheep.

18. Animals (Basel). 2025 May 29;15(11):1582. doi: 10.3390/ani15111582. Effects of Rumen-Protected 5-Hydroxytryptophan and Melatonin Supplementation on Antioxidant Capacity, Meat Quality, and Shelf Life of Hu Sheep. Xu S(1), Yang H(1), Ainiwaer Z(1), Fan W(1), Xu T(1), Yang K(1), Wang C(1). Auth

Cognitive and behavioral benefits of 2'-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota.

24. Microbiome. 2025 Apr 12;13(1):97. doi: 10.1186/s40168-025-02094-x. Cognitive and behavioral benefits of 2'-fucosyllactose in growing mice: the roles of 5-hydroxytryptophan and gut microbiota. Zhu L(1), Zhang Z(1), Luo T(1)(2), Li H(1)(2), Deng Z(3)(4), Li J(1)(2), Zheng L(1)(2), Liao J(1), W

Dietary 5-hydroxytryptophan supplementation improves growth performance and intestinal health of weaned piglets.

25. Porcine Health Manag. 2024 Dec 20;10(1):60. doi: 10.1186/s40813-024-00412-7. Dietary 5-hydroxytryptophan supplementation improves growth performance and intestinal health of weaned piglets. Xia Y(#)(1), Peng X(#)(1), Mao J(1), Luo J(1), Li H(1), Ma D(1), Yang Z(2). Author information: (1)Lab